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Protein

Gamma-glutamyltransferase 6

Gene

Ggt6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Hydrolase, Transferase

Keywords - Biological processi

Glutathione biosynthesis

Enzyme and pathway databases

SABIO-RKQ6PDE7.
UniPathwayiUPA00204.

Protein family/group databases

MEROPSiT03.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyltransferase 6 (EC:2.3.2.2)
Short name:
GGT 6
Alternative name(s):
Gamma-glutamyltranspeptidase 6
Glutathione hydrolase 6 (EC:3.4.19.13)
Cleaved into the following 2 chains:
Gene namesi
Name:Ggt6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918772. Ggt6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence analysisAdd
BLAST
Transmembranei52 – 7221Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini73 – 497425ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 497Gamma-glutamyltransferase 6 light chainPRO_0000314957
Chaini1 – ?Gamma-glutamyltransferase 6 heavy chainPRO_0000314956

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence analysis
Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

EPDiQ6PDE7.
PaxDbiQ6PDE7.
PeptideAtlasiQ6PDE7.
PRIDEiQ6PDE7.

PTM databases

iPTMnetiQ6PDE7.
PhosphoSiteiQ6PDE7.

Expressioni

Gene expression databases

BgeeiQ6PDE7.
CleanExiMM_GGT6.
ExpressionAtlasiQ6PDE7. baseline and differential.
GenevisibleiQ6PDE7. MM.

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075773.

Structurei

3D structure databases

ProteinModelPortaliQ6PDE7.
SMRiQ6PDE7. Positions 94-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 3212Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000112719.
HOVERGENiHBG055504.
InParanoidiQ6PDE7.
KOiK00681.
OMAiCPLLCHA.
OrthoDBiEOG789CBS.
PhylomeDBiQ6PDE7.
TreeFamiTF338758.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 3 hits.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PDE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDATTGPVHY HKLQLWEPGV ESEEEEEEEE EEIAEPLVLS LRRLQNTPRN
60 70 80 90 100
EVGGLPGAWA RLLAGLLLLA VSSSLALRQL HSRDSPRGNL GSVAPPASRH
110 120 130 140 150
SHRPGVYHHS AIISPAATCS QLGQELLVAG GNVVDAGVGA ALCLAVVHPH
160 170 180 190 200
ATGLGATFWG LFYNSSSGNS TALTAGPTQL LAPGLGLPTG LPALHLLHAH
210 220 230 240 250
FGRLPWPHLL TKPAMLAEKG FEVDAPLANA LAIQGTKGLC PLFCHTNGTP
260 270 280 290 300
LGLGARATNP NLAAVLRSAA LASSPDLAGK ALLNPLVRDL GLELPSAQPV
310 320 330 340 350
PSLEPALQLL LPRGVLFTTP GPSAGPELVE LLESTLHSRT PSSAPCPPFL
360 370 380 390 400
QTAETPVSSA LATVDSNGSM LLLISSINSS FGSGHLSPST GVLLSNLEAS
410 420 430 440 450
PAPSAWACPL ILRDNLDDTE ADMLGMVASG ISRGAKAMTC TLLNHLATPQ
460 470 480 490
IPQQPQHQRP TESPGICGQG ALLQAVVHAE HAHVSSVPSG CCPFQGY
Length:497
Mass (Da):51,467
Last modified:July 5, 2004 - v1
Checksum:i2E9C8CCD73F8AD42
GO
Isoform 2 (identifier: Q6PDE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-154: Missing.

Show »
Length:459
Mass (Da):47,872
Checksum:i6DA5E6BCD9C3F71D
GO

Sequence cautioni

The sequence BAB31233.1 differs from that shown. Reason: Frameshift at positions 329 and 338. Curated
The sequence BAB31233.1 differs from that shown. Reason: Erroneous termination at position 354. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti304 – 3041E → K in BAB31233 (PubMed:16141072).Curated
Sequence conflicti315 – 3195VLFTT → GLLTN in BAB31233 (PubMed:16141072).Curated
Sequence conflicti329 – 3291V → G in BAB31233 (PubMed:16141072).Curated
Sequence conflicti334 – 3341S → F in BAB31233 (PubMed:16141072).Curated
Sequence conflicti339 – 3391R → G in BAB31233 (PubMed:16141072).Curated
Sequence conflicti343 – 3431S → F in BAB31233 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 15438Missing in isoform 2. CuratedVSP_030452Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018485 mRNA. Translation: BAB31233.1. Sequence problems.
AL662812 Genomic DNA. Translation: CAI52002.1.
AL662812 Genomic DNA. Translation: CAI52003.1.
BC058747 mRNA. Translation: AAH58747.1.
CCDSiCCDS36216.1. [Q6PDE7-1]
RefSeqiNP_082095.2. NM_027819.2. [Q6PDE7-1]
XP_006534305.1. XM_006534242.2. [Q6PDE7-1]
UniGeneiMm.23336.

Genome annotation databases

EnsembliENSMUST00000076443; ENSMUSP00000075773; ENSMUSG00000040471. [Q6PDE7-1]
ENSMUST00000100903; ENSMUSP00000098463; ENSMUSG00000040471. [Q6PDE7-2]
GeneIDi71522.
KEGGimmu:71522.
UCSCiuc007jyw.1. mouse. [Q6PDE7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018485 mRNA. Translation: BAB31233.1. Sequence problems.
AL662812 Genomic DNA. Translation: CAI52002.1.
AL662812 Genomic DNA. Translation: CAI52003.1.
BC058747 mRNA. Translation: AAH58747.1.
CCDSiCCDS36216.1. [Q6PDE7-1]
RefSeqiNP_082095.2. NM_027819.2. [Q6PDE7-1]
XP_006534305.1. XM_006534242.2. [Q6PDE7-1]
UniGeneiMm.23336.

3D structure databases

ProteinModelPortaliQ6PDE7.
SMRiQ6PDE7. Positions 94-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075773.

Protein family/group databases

MEROPSiT03.022.

PTM databases

iPTMnetiQ6PDE7.
PhosphoSiteiQ6PDE7.

Proteomic databases

EPDiQ6PDE7.
PaxDbiQ6PDE7.
PeptideAtlasiQ6PDE7.
PRIDEiQ6PDE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076443; ENSMUSP00000075773; ENSMUSG00000040471. [Q6PDE7-1]
ENSMUST00000100903; ENSMUSP00000098463; ENSMUSG00000040471. [Q6PDE7-2]
GeneIDi71522.
KEGGimmu:71522.
UCSCiuc007jyw.1. mouse. [Q6PDE7-1]

Organism-specific databases

CTDi124975.
MGIiMGI:1918772. Ggt6.

Phylogenomic databases

eggNOGiKOG2410. Eukaryota.
COG0405. LUCA.
GeneTreeiENSGT00550000074591.
HOGENOMiHOG000112719.
HOVERGENiHBG055504.
InParanoidiQ6PDE7.
KOiK00681.
OMAiCPLLCHA.
OrthoDBiEOG789CBS.
PhylomeDBiQ6PDE7.
TreeFamiTF338758.

Enzyme and pathway databases

UniPathwayiUPA00204.
SABIO-RKQ6PDE7.

Miscellaneous databases

PROiQ6PDE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PDE7.
CleanExiMM_GGT6.
ExpressionAtlasiQ6PDE7. baseline and differential.
GenevisibleiQ6PDE7. MM.

Family and domain databases

InterProiIPR000101. GGT_peptidase.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
PANTHERiPTHR11686. PTHR11686. 1 hit.
PfamiPF01019. G_glu_transpept. 3 hits.
[Graphical view]
PRINTSiPR01210. GGTRANSPTASE.
SUPFAMiSSF56235. SSF56235. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Colon.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiGGT6_MOUSE
AccessioniPrimary (citable) accession number: Q6PDE7
Secondary accession number(s): Q5F245, Q9D347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.