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Reviewed, UniProtKB/Swiss-Prot Q6PDD0 (UD2A2_MOUSE)

Last modified May 5, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-glucuronosyltransferase 2A2
      Short name=UDPGT 2A2
    EC=2.4.1.17
Gene names
Name: Ugt2a2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Miscellaneous

The human orthologous protein seems not to exist.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 528507UDP-glucuronosyltransferase 2A2
PRO_0000299144

Regions

Topological domain22 – 494473Extracellular Potential
Transmembrane495 – 51521 Potential
Topological domain516 – 52813Cytoplasmic Potential

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q6PDD0-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B022C47E9B3922B0

FASTA52859,967
        10         20         30         40         50         60 
MIKKVLQLLI FHLTLAEIVL SGNVVVWPTD GSHWLNIKIL LEELVQRNHS VTVLAPSETL 

        70         80         90        100        110        120 
FINSRLDAFI NFEEIPVSYT KSKIDEIIEH MIALWLDHRP TPLTMWTFYK ELGNLLATFY 

       130        140        150        160        170        180 
TTNKQMCDGV LNNPTVMERL QKGGFDVLLA DPVTMCGELV ALKLGIPFVY TLRFSPAFTV 

       190        200        210        220        230        240 
ERHCGKIPAP ISYVPAALSE LTDQMSFGER VKNIISYSLQ DYIFKTYWGE WNSYYSKVLG 

       250        260        270        280        290        300 
RPTTLCETMG KAEIWLMRTY WDFEFPRPYL PNFEFVGGLH CKPAKPLPKE MEEFVQTSGE 

       310        320        330        340        350        360 
HGIVVFSLGS MVKNLTDEKA NLIASALAQI PQKVLWRYKG KIPDTLGSNT RLFDWIPQND 

       370        380        390        400        410        420 
LLGHPKTRAF ITHGGTNGIY EAIYHGIPMV GVPMFADQPD NIAHMKAKGA AVEVNMNTMT 

       430        440        450        460        470        480 
SSDLLNALRT VINEPSYKEN AMRLSRIHHD QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH 

       490        500        510        520 
DLSWFQYHSL DVIGFLLACV ASAILLVAKC CLFIFQKVGK TGKKKKRD

« Hide

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.

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Cross-references

Sequence databases

BC058786 mRNA. Translation: AAH58786.1.
IPIIPI00453957.
RefSeqNP_001019319.1.
UniGeneMm.154806

3D structure databases

SMRQ6PDD0. Positions 284-445.
ModBaseSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Genome annotation databases

EnsemblENSMUSG00000029268. Mus musculus. [Contig view]
GeneID552899.
KEGGmmu:552899.

Organism-specific databases

MGIMGI:3576095. Ugt2a2.

Phylogenomic databases

HOGENOMQ6PDD0.
HOVERGENQ6PDD0.
OMAQ6PDD0. NSYYSKV.

Enzyme and pathway databases

BRENDA2.4.1.17. 244.

Gene expression databases

ArrayExpressQ6PDD0.
BgeeQ6PDD0.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. UDP_glucos_trans. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio414326.
SOURCESearch...

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Entry information

Entry nameUD2A2_MOUSE
AccessionPrimary (citable) accession number: Q6PDD0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: May 5, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents