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Q6PDD0 (UD2A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2A2

Short name=UDPGT 2A2
EC=2.4.1.17
Gene names
Name:Ugt2a2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 528507UDP-glucuronosyltransferase 2A2
PRO_0000299144

Regions

Topological domain22 – 494473Extracellular Potential
Transmembrane495 – 51521Helical; Potential
Topological domain516 – 52813Cytoplasmic Potential

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6PDD0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B022C47E9B3922B0

FASTA52859,967
        10         20         30         40         50         60 
MIKKVLQLLI FHLTLAEIVL SGNVVVWPTD GSHWLNIKIL LEELVQRNHS VTVLAPSETL 

        70         80         90        100        110        120 
FINSRLDAFI NFEEIPVSYT KSKIDEIIEH MIALWLDHRP TPLTMWTFYK ELGNLLATFY 

       130        140        150        160        170        180 
TTNKQMCDGV LNNPTVMERL QKGGFDVLLA DPVTMCGELV ALKLGIPFVY TLRFSPAFTV 

       190        200        210        220        230        240 
ERHCGKIPAP ISYVPAALSE LTDQMSFGER VKNIISYSLQ DYIFKTYWGE WNSYYSKVLG 

       250        260        270        280        290        300 
RPTTLCETMG KAEIWLMRTY WDFEFPRPYL PNFEFVGGLH CKPAKPLPKE MEEFVQTSGE 

       310        320        330        340        350        360 
HGIVVFSLGS MVKNLTDEKA NLIASALAQI PQKVLWRYKG KIPDTLGSNT RLFDWIPQND 

       370        380        390        400        410        420 
LLGHPKTRAF ITHGGTNGIY EAIYHGIPMV GVPMFADQPD NIAHMKAKGA AVEVNMNTMT 

       430        440        450        460        470        480 
SSDLLNALRT VINEPSYKEN AMRLSRIHHD QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH 

       490        500        510        520 
DLSWFQYHSL DVIGFLLACV ASAILLVAKC CLFIFQKVGK TGKKKKRD 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC058786 mRNA. Translation: AAH58786.1.
RefSeqNP_001019319.1. NM_001024148.1.
UniGeneMm.26794.

3D structure databases

ProteinModelPortalQ6PDD0.
SMRQ6PDD0. Positions 223-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000078740.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEQ6PDD0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079811; ENSMUSP00000078740; ENSMUSG00000029268.
GeneID552899.
KEGGmmu:552899.
UCSCuc008xyj.2. mouse.

Organism-specific databases

CTD574537.
MGIMGI:3576095. Ugt2a2.

Phylogenomic databases

GeneTreeENSGT00640000091260.
HOGENOMHOG000220831.
HOVERGENHBG004033.
InParanoidQ6PDD0.
KOK00699.
OrthoDBEOG7GBFWS.
TreeFamTF315472.

Gene expression databases

BgeeQ6PDD0.
GenevestigatorQ6PDD0.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio414326.
PROQ6PDD0.
SOURCESearch...

Entry information

Entry nameUD2A2_MOUSE
AccessionPrimary (citable) accession number: Q6PDD0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot