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Protein

UDP-glucuronosyltransferase 2A2

Gene

Ugt2a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A2 (EC:2.4.1.17)
Short name:
UDPGT 2A2
Gene namesi
Name:Ugt2a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3576095. Ugt2a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 494473ExtracellularSequence AnalysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST
Topological domaini516 – 52813CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 528507UDP-glucuronosyltransferase 2A2PRO_0000299144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6PDD0.

Expressioni

Gene expression databases

BgeeiQ6PDD0.
ExpressionAtlasiQ6PDD0. baseline.
GenevisibleiQ6PDD0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078740.

Structurei

3D structure databases

ProteinModelPortaliQ6PDD0.
SMRiQ6PDD0. Positions 223-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ6PDD0.
KOiK00699.
OMAiELAVWWI.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PDD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKVLQLLI FHLTLAEIVL SGNVVVWPTD GSHWLNIKIL LEELVQRNHS
60 70 80 90 100
VTVLAPSETL FINSRLDAFI NFEEIPVSYT KSKIDEIIEH MIALWLDHRP
110 120 130 140 150
TPLTMWTFYK ELGNLLATFY TTNKQMCDGV LNNPTVMERL QKGGFDVLLA
160 170 180 190 200
DPVTMCGELV ALKLGIPFVY TLRFSPAFTV ERHCGKIPAP ISYVPAALSE
210 220 230 240 250
LTDQMSFGER VKNIISYSLQ DYIFKTYWGE WNSYYSKVLG RPTTLCETMG
260 270 280 290 300
KAEIWLMRTY WDFEFPRPYL PNFEFVGGLH CKPAKPLPKE MEEFVQTSGE
310 320 330 340 350
HGIVVFSLGS MVKNLTDEKA NLIASALAQI PQKVLWRYKG KIPDTLGSNT
360 370 380 390 400
RLFDWIPQND LLGHPKTRAF ITHGGTNGIY EAIYHGIPMV GVPMFADQPD
410 420 430 440 450
NIAHMKAKGA AVEVNMNTMT SSDLLNALRT VINEPSYKEN AMRLSRIHHD
460 470 480 490 500
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH DLSWFQYHSL DVIGFLLACV
510 520
ASAILLVAKC CLFIFQKVGK TGKKKKRD
Length:528
Mass (Da):59,967
Last modified:July 5, 2004 - v1
Checksum:iB022C47E9B3922B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058786 mRNA. Translation: AAH58786.1.
CCDSiCCDS19390.1.
RefSeqiNP_001019319.1. NM_001024148.1.
UniGeneiMm.26794.

Genome annotation databases

EnsembliENSMUST00000079811; ENSMUSP00000078740; ENSMUSG00000029268.
GeneIDi552899.
KEGGimmu:552899.
UCSCiuc008xyj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058786 mRNA. Translation: AAH58786.1.
CCDSiCCDS19390.1.
RefSeqiNP_001019319.1. NM_001024148.1.
UniGeneiMm.26794.

3D structure databases

ProteinModelPortaliQ6PDD0.
SMRiQ6PDD0. Positions 223-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078740.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEiQ6PDD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079811; ENSMUSP00000078740; ENSMUSG00000029268.
GeneIDi552899.
KEGGimmu:552899.
UCSCiuc008xyj.2. mouse.

Organism-specific databases

CTDi574537.
MGIiMGI:3576095. Ugt2a2.

Phylogenomic databases

GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ6PDD0.
KOiK00699.
OMAiELAVWWI.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Miscellaneous databases

NextBioi414326.
PROiQ6PDD0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PDD0.
ExpressionAtlasiQ6PDD0. baseline.
GenevisibleiQ6PDD0. MM.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiUD2A2_MOUSE
AccessioniPrimary (citable) accession number: Q6PDD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.