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Q6PDD0

- UD2A2_MOUSE

UniProt

Q6PDD0 - UD2A2_MOUSE

Protein

UDP-glucuronosyltransferase 2A2

Gene

Ugt2a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2A2 (EC:2.4.1.17)
    Short name:
    UDPGT 2A2
    Gene namesi
    Name:Ugt2a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:3576095. Ugt2a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 528507UDP-glucuronosyltransferase 2A2PRO_0000299144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ6PDD0.

    Expressioni

    Gene expression databases

    BgeeiQ6PDD0.
    GenevestigatoriQ6PDD0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000078740.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PDD0.
    SMRiQ6PDD0. Positions 223-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 494473ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini516 – 52813CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00640000091260.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    InParanoidiQ6PDD0.
    KOiK00699.
    OMAiSPMELAV.
    OrthoDBiEOG7GBFWS.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6PDD0-1 [UniParc]FASTAAdd to Basket

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    MIKKVLQLLI FHLTLAEIVL SGNVVVWPTD GSHWLNIKIL LEELVQRNHS    50
    VTVLAPSETL FINSRLDAFI NFEEIPVSYT KSKIDEIIEH MIALWLDHRP 100
    TPLTMWTFYK ELGNLLATFY TTNKQMCDGV LNNPTVMERL QKGGFDVLLA 150
    DPVTMCGELV ALKLGIPFVY TLRFSPAFTV ERHCGKIPAP ISYVPAALSE 200
    LTDQMSFGER VKNIISYSLQ DYIFKTYWGE WNSYYSKVLG RPTTLCETMG 250
    KAEIWLMRTY WDFEFPRPYL PNFEFVGGLH CKPAKPLPKE MEEFVQTSGE 300
    HGIVVFSLGS MVKNLTDEKA NLIASALAQI PQKVLWRYKG KIPDTLGSNT 350
    RLFDWIPQND LLGHPKTRAF ITHGGTNGIY EAIYHGIPMV GVPMFADQPD 400
    NIAHMKAKGA AVEVNMNTMT SSDLLNALRT VINEPSYKEN AMRLSRIHHD 450
    QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH DLSWFQYHSL DVIGFLLACV 500
    ASAILLVAKC CLFIFQKVGK TGKKKKRD 528
    Length:528
    Mass (Da):59,967
    Last modified:July 5, 2004 - v1
    Checksum:iB022C47E9B3922B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC058786 mRNA. Translation: AAH58786.1.
    CCDSiCCDS19390.1.
    RefSeqiNP_001019319.1. NM_001024148.1.
    UniGeneiMm.26794.

    Genome annotation databases

    EnsembliENSMUST00000079811; ENSMUSP00000078740; ENSMUSG00000029268.
    GeneIDi552899.
    KEGGimmu:552899.
    UCSCiuc008xyj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC058786 mRNA. Translation: AAH58786.1 .
    CCDSi CCDS19390.1.
    RefSeqi NP_001019319.1. NM_001024148.1.
    UniGenei Mm.26794.

    3D structure databases

    ProteinModelPortali Q6PDD0.
    SMRi Q6PDD0. Positions 223-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000078740.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PRIDEi Q6PDD0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079811 ; ENSMUSP00000078740 ; ENSMUSG00000029268 .
    GeneIDi 552899.
    KEGGi mmu:552899.
    UCSCi uc008xyj.2. mouse.

    Organism-specific databases

    CTDi 574537.
    MGIi MGI:3576095. Ugt2a2.

    Phylogenomic databases

    GeneTreei ENSGT00640000091260.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    InParanoidi Q6PDD0.
    KOi K00699.
    OMAi SPMELAV.
    OrthoDBi EOG7GBFWS.
    TreeFami TF315472.

    Miscellaneous databases

    NextBioi 414326.
    PROi Q6PDD0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PDD0.
    Genevestigatori Q6PDD0.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiUD2A2_MOUSE
    AccessioniPrimary (citable) accession number: Q6PDD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3