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Protein

UDP-glucuronosyltransferase 2A2

Gene

Ugt2a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A2 (EC:2.4.1.17)
Short name:
UDPGT 2A2
Gene namesi
Name:Ugt2a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3576095. Ugt2a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 494ExtracellularSequence analysisAdd BLAST473
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 528CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000029914422 – 528UDP-glucuronosyltransferase 2A2Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6PDD0.
PaxDbiQ6PDD0.
PRIDEiQ6PDD0.

PTM databases

iPTMnetiQ6PDD0.
PhosphoSitePlusiQ6PDD0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029268.
ExpressionAtlasiQ6PDD0. baseline and differential.
GenevisibleiQ6PDD0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078740.

Structurei

3D structure databases

ProteinModelPortaliQ6PDD0.
SMRiQ6PDD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ6PDD0.
KOiK00699.
OMAiTTHRIWE.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PDD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKVLQLLI FHLTLAEIVL SGNVVVWPTD GSHWLNIKIL LEELVQRNHS
60 70 80 90 100
VTVLAPSETL FINSRLDAFI NFEEIPVSYT KSKIDEIIEH MIALWLDHRP
110 120 130 140 150
TPLTMWTFYK ELGNLLATFY TTNKQMCDGV LNNPTVMERL QKGGFDVLLA
160 170 180 190 200
DPVTMCGELV ALKLGIPFVY TLRFSPAFTV ERHCGKIPAP ISYVPAALSE
210 220 230 240 250
LTDQMSFGER VKNIISYSLQ DYIFKTYWGE WNSYYSKVLG RPTTLCETMG
260 270 280 290 300
KAEIWLMRTY WDFEFPRPYL PNFEFVGGLH CKPAKPLPKE MEEFVQTSGE
310 320 330 340 350
HGIVVFSLGS MVKNLTDEKA NLIASALAQI PQKVLWRYKG KIPDTLGSNT
360 370 380 390 400
RLFDWIPQND LLGHPKTRAF ITHGGTNGIY EAIYHGIPMV GVPMFADQPD
410 420 430 440 450
NIAHMKAKGA AVEVNMNTMT SSDLLNALRT VINEPSYKEN AMRLSRIHHD
460 470 480 490 500
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH DLSWFQYHSL DVIGFLLACV
510 520
ASAILLVAKC CLFIFQKVGK TGKKKKRD
Length:528
Mass (Da):59,967
Last modified:July 5, 2004 - v1
Checksum:iB022C47E9B3922B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058786 mRNA. Translation: AAH58786.1.
CCDSiCCDS19390.1.
RefSeqiNP_001019319.1. NM_001024148.1.
UniGeneiMm.26794.

Genome annotation databases

EnsembliENSMUST00000079811; ENSMUSP00000078740; ENSMUSG00000029268.
GeneIDi552899.
KEGGimmu:552899.
UCSCiuc008xyj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058786 mRNA. Translation: AAH58786.1.
CCDSiCCDS19390.1.
RefSeqiNP_001019319.1. NM_001024148.1.
UniGeneiMm.26794.

3D structure databases

ProteinModelPortaliQ6PDD0.
SMRiQ6PDD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078740.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ6PDD0.
PhosphoSitePlusiQ6PDD0.

Proteomic databases

MaxQBiQ6PDD0.
PaxDbiQ6PDD0.
PRIDEiQ6PDD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079811; ENSMUSP00000078740; ENSMUSG00000029268.
GeneIDi552899.
KEGGimmu:552899.
UCSCiuc008xyj.2. mouse.

Organism-specific databases

CTDi574537.
MGIiMGI:3576095. Ugt2a2.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ6PDD0.
KOiK00699.
OMAiTTHRIWE.
TreeFamiTF315472.

Miscellaneous databases

PROiQ6PDD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029268.
ExpressionAtlasiQ6PDD0. baseline and differential.
GenevisibleiQ6PDD0. MM.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD2A2_MOUSE
AccessioniPrimary (citable) accession number: Q6PDD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.