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Q6PDD0

- UD2A2_MOUSE

UniProt

Q6PDD0 - UD2A2_MOUSE

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Protein

UDP-glucuronosyltransferase 2A2

Gene
Ugt2a2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A2 (EC:2.4.1.17)
Short name:
UDPGT 2A2
Gene namesi
Name:Ugt2a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:3576095. Ugt2a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 494473Extracellular Reviewed predictionAdd
BLAST
Transmembranei495 – 51521Helical; Reviewed predictionAdd
BLAST
Topological domaini516 – 52813Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 528507UDP-glucuronosyltransferase 2A2PRO_0000299144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6PDD0.

Expressioni

Gene expression databases

BgeeiQ6PDD0.
GenevestigatoriQ6PDD0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078740.

Structurei

3D structure databases

ProteinModelPortaliQ6PDD0.
SMRiQ6PDD0. Positions 223-446.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00640000091260.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ6PDD0.
KOiK00699.
OMAiSPMELAV.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PDD0-1 [UniParc]FASTAAdd to Basket

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MIKKVLQLLI FHLTLAEIVL SGNVVVWPTD GSHWLNIKIL LEELVQRNHS    50
VTVLAPSETL FINSRLDAFI NFEEIPVSYT KSKIDEIIEH MIALWLDHRP 100
TPLTMWTFYK ELGNLLATFY TTNKQMCDGV LNNPTVMERL QKGGFDVLLA 150
DPVTMCGELV ALKLGIPFVY TLRFSPAFTV ERHCGKIPAP ISYVPAALSE 200
LTDQMSFGER VKNIISYSLQ DYIFKTYWGE WNSYYSKVLG RPTTLCETMG 250
KAEIWLMRTY WDFEFPRPYL PNFEFVGGLH CKPAKPLPKE MEEFVQTSGE 300
HGIVVFSLGS MVKNLTDEKA NLIASALAQI PQKVLWRYKG KIPDTLGSNT 350
RLFDWIPQND LLGHPKTRAF ITHGGTNGIY EAIYHGIPMV GVPMFADQPD 400
NIAHMKAKGA AVEVNMNTMT SSDLLNALRT VINEPSYKEN AMRLSRIHHD 450
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH DLSWFQYHSL DVIGFLLACV 500
ASAILLVAKC CLFIFQKVGK TGKKKKRD 528
Length:528
Mass (Da):59,967
Last modified:July 5, 2004 - v1
Checksum:iB022C47E9B3922B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC058786 mRNA. Translation: AAH58786.1.
CCDSiCCDS19390.1.
RefSeqiNP_001019319.1. NM_001024148.1.
UniGeneiMm.26794.

Genome annotation databases

EnsembliENSMUST00000079811; ENSMUSP00000078740; ENSMUSG00000029268.
GeneIDi552899.
KEGGimmu:552899.
UCSCiuc008xyj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC058786 mRNA. Translation: AAH58786.1 .
CCDSi CCDS19390.1.
RefSeqi NP_001019319.1. NM_001024148.1.
UniGenei Mm.26794.

3D structure databases

ProteinModelPortali Q6PDD0.
SMRi Q6PDD0. Positions 223-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000078740.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEi Q6PDD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079811 ; ENSMUSP00000078740 ; ENSMUSG00000029268 .
GeneIDi 552899.
KEGGi mmu:552899.
UCSCi uc008xyj.2. mouse.

Organism-specific databases

CTDi 574537.
MGIi MGI:3576095. Ugt2a2.

Phylogenomic databases

GeneTreei ENSGT00640000091260.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi Q6PDD0.
KOi K00699.
OMAi SPMELAV.
OrthoDBi EOG7GBFWS.
TreeFami TF315472.

Miscellaneous databases

NextBioi 414326.
PROi Q6PDD0.
SOURCEi Search...

Gene expression databases

Bgeei Q6PDD0.
Genevestigatori Q6PDD0.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiUD2A2_MOUSE
AccessioniPrimary (citable) accession number: Q6PDD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi