Q6PD74 (AAGAB_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 66.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alpha- and gamma-adaptin-binding protein p34 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 315 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May play a role in membrane traffic By similarity. |
| Subunit structure | Interacts with AP1G1 and AP2A1 By similarity. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from direct assay. Source: LIFEdb |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 315 | 315 | Alpha- and gamma-adaptin-binding protein p34 | PRO_0000058134 | |||||
Amino acid modifications | |||||||||
| Modified residue | 310 | 1 | Phosphoserine Ref.5 Ref.6 Ref.7 | ||||||
| Modified residue | 311 | 1 | Phosphoserine Ref.5 Ref.6 Ref.7 | ||||||
Natural variations | |||||||||
| Natural variant | 132 | 1 | I → L. Ref.1 Ref.2 Ref.3 Corresponds to variant rs7173826 [ dbSNP | Ensembl ]. | VAR_021533 | |||||
Experimental info | |||||||||
| Sequence conflict | 26 | 1 | I → T Ref.2 | ||||||
| Sequence conflict | 26 | 1 | I → T Ref.3 | ||||||
| Sequence conflict | 77 | 1 | V → A in CAG38571. Ref.3 | ||||||
| Sequence conflict | 88 | 1 | Q → R Ref.2 | ||||||
| Sequence conflict | 88 | 1 | Q → R Ref.3 | ||||||
| Sequence conflict | 131 | 1 | C → S Ref.2 | ||||||
| Sequence conflict | 131 | 1 | C → S Ref.3 | ||||||
| Sequence conflict | 265 | 1 | L → P Ref.2 | ||||||
| Sequence conflict | 265 | 1 | L → P Ref.3 | ||||||
| Sequence conflict | 313 | 1 | E → G Ref.2 | ||||||
| Sequence conflict | 313 | 1 | E → G Ref.3 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-132. Tissue: Embryo. |
| [2] | "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A.Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-132. Tissue: Kidney. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-132. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix and Uterus. |
| [5] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310 AND SER-311, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [6] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310 AND SER-311, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [7] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310 AND SER-311, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK021568 mRNA. Translation: BAB13845.1. AL136715 mRNA. Translation: CAB66649.1. CR533540 mRNA. Translation: CAG38571.1. BC001975 mRNA. Translation: AAH01975.1. BC047026 mRNA. Translation: AAH47026.1. BC058886 mRNA. Translation: AAH58886.1. |
| IPI | IPI00100193. |
| RefSeq | NP_078942.3. NM_024666.3. |
| UniGene | Hs.254642. |
3D structure databases | |
| ProteinModelPortal | Q6PD74. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q6PD74. 2 interactions. |
| MINT | MINT-1373784. |
PTM databases | |
| PhosphoSite | Q6PD74. |
Polymorphism databases | |
| DMDM | 62286981. |
Proteomic databases | |
| PeptideAtlas | Q6PD74. |
| PRIDE | Q6PD74. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000261880; ENSP00000261880; ENSG00000103591. |
| GeneID | 79719. |
| KEGG | hsa:79719. |
| UCSC | uc002aqk.2. human. |
Organism-specific databases | |
| CTD | 79719. |
| GeneCards | GC15M067493. |
| H-InvDB | HIX0012371. |
| HGNC | HGNC:25662. AAGAB. |
| HPA | HPA039371. HPA040174. |
| neXtProt | NX_Q6PD74. |
| PharmGKB | PA165478457. |
| GenAtlas | Search... |
Phylogenomic databases | |
| GeneTree | ENSGT00390000007218. |
| HOGENOM | HBG713687. |
| InParanoid | Q6PD74. |
| OMA | GSADPCH. |
| OrthoDB | EOG4QFWDP. |
| PhylomeDB | Q6PD74. |
Gene expression databases | |
| ArrayExpress | Q6PD74. |
| Bgee | Q6PD74. |
| Genevestigator | Q6PD74. |
| GermOnline | ENSG00000103591. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR019341. Alpha/Gamma-adaptin-bd_p34. [Graphical view] |
| Pfam | PF10199. Adaptin_binding. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 69069. |
Entry information
| Entry name | AAGAB_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6PD74 Secondary accession number(s): Q6FI86 Q9HAK0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |

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