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Protein

Zinc finger protein 513

Gene

Znf513

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that plays a role in retinal development and maintenance.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 172C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 513
Gene namesi
Name:Znf513
Synonyms:Zfp513
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2141255. Zfp513.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003530931 – 541Zinc finger protein 513Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1
Modified residuei96PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6PD29.
PeptideAtlasiQ6PD29.
PRIDEiQ6PD29.

PTM databases

iPTMnetiQ6PD29.
PhosphoSitePlusiQ6PD29.

Expressioni

Tissue specificityi

Widely expressed. In the eye, expression is greatest in the retina and least in the lens and cornea.1 Publication

Gene expression databases

BgeeiENSMUSG00000043059.
ExpressionAtlasiQ6PD29. baseline and differential.
GenevisibleiQ6PD29. MM.

Interactioni

Subunit structurei

Binds DNA. Can associate with the proximal promoter regions of PAX6 and SP4, and their known targets including ARR3, RHO, OPN1MW2 and OPN1SW.1 Publication

Protein-protein interaction databases

BioGridi221569. 5 interactors.
IntActiQ6PD29. 1 interactor.
STRINGi10090.ENSMUSP00000110238.

Structurei

3D structure databases

ProteinModelPortaliQ6PD29.
SMRiQ6PD29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 141Gly-richAdd BLAST87

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 172C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132304.
HOGENOMiHOG000081792.
HOVERGENiHBG097012.
InParanoidiQ6PD29.
OMAiTSFLPDC.
OrthoDBiEOG091G05JD.
TreeFamiTF350015.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PD29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRKQSHPQ PVKCEGVKVD TEDSFDEGPG ALVLESDLLL GQDLEFEEEE
60 70 80 90 100
EEDEGDGHND QLMGFERDSE GDSQGARPGL PYGLSDDESG GGRALSAESE
110 120 130 140 150
VEEPARGPGE ARGERPGPAC QLCGGPTGEG PCCGAGGPGG GPPLPPRLLY
160 170 180 190 200
SCRLCAFVSH YSSHLKRHMQ THSGEKPFRC GRCPYASAQL VNLTRHTRTH
210 220 230 240 250
TGEKPYRCPH CPFACSSLGN LRRHQRTHTG PPTPPCPTCG FRCCAPRPTR
260 270 280 290 300
PPSPTEQEGT MPRRSEDALI LPDLSLHVPP GGASFLPDCG QLRGEGESLC
310 320 330 340 350
GTGSEPLPEL LFPWTCRGCG QELEEGEGSR LGAAMCGRCM RGEAGGVATG
360 370 380 390 400
GPQGPGDKGF ACSLCPFATH YPNHLARHMK THSGEKPFRC ARCPYASAHL
410 420 430 440 450
DNLKRHQRVH TGEKPYKCPL CPYACGNLAN LKRHGRIHSG DKPFRCSLCN
460 470 480 490 500
YSCNQSMNLK RHMLRHTGEK PFRCATCAYT TGHWDNYKRH QKVHGHGGAG
510 520 530 540
GPGLSAPEGW APPHSPPSVL STRGPAALGA TGSRALHSDS P
Length:541
Mass (Da):58,067
Last modified:November 4, 2008 - v2
Checksum:i4F284BE3EBCABB7F
GO
Isoform 2 (identifier: Q6PD29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MPRRKQSHPQPVKCEGVK → MGTAWEGDSTSTLPSL

Show »
Length:539
Mass (Da):57,614
Checksum:i28071A14ACDF13B1
GO

Sequence cautioni

The sequence AAH58976 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC35001 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti504L → R in BAC35001 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0356261 – 18MPRRK…CEGVK → MGTAWEGDSTSTLPSL in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052459 mRNA. Translation: BAC35001.1. Sequence problems.
AK154195 mRNA. Translation: BAE32430.1.
BC058976 mRNA. Translation: AAH58976.1. Different initiation.
CCDSiCCDS19178.2. [Q6PD29-1]
CCDS51458.1. [Q6PD29-2]
RefSeqiNP_001171372.1. NM_001177901.1. [Q6PD29-2]
NP_780520.3. NM_175311.4. [Q6PD29-1]
XP_006503720.2. XM_006503657.2.
UniGeneiMm.45033.

Genome annotation databases

EnsembliENSMUST00000031562; ENSMUSP00000031562; ENSMUSG00000043059. [Q6PD29-2]
ENSMUST00000114590; ENSMUSP00000110238; ENSMUSG00000043059. [Q6PD29-1]
GeneIDi101023.
KEGGimmu:101023.
UCSCiuc008wxn.1. mouse. [Q6PD29-2]
uc008wxo.2. mouse. [Q6PD29-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052459 mRNA. Translation: BAC35001.1. Sequence problems.
AK154195 mRNA. Translation: BAE32430.1.
BC058976 mRNA. Translation: AAH58976.1. Different initiation.
CCDSiCCDS19178.2. [Q6PD29-1]
CCDS51458.1. [Q6PD29-2]
RefSeqiNP_001171372.1. NM_001177901.1. [Q6PD29-2]
NP_780520.3. NM_175311.4. [Q6PD29-1]
XP_006503720.2. XM_006503657.2.
UniGeneiMm.45033.

3D structure databases

ProteinModelPortaliQ6PD29.
SMRiQ6PD29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221569. 5 interactors.
IntActiQ6PD29. 1 interactor.
STRINGi10090.ENSMUSP00000110238.

PTM databases

iPTMnetiQ6PD29.
PhosphoSitePlusiQ6PD29.

Proteomic databases

PaxDbiQ6PD29.
PeptideAtlasiQ6PD29.
PRIDEiQ6PD29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031562; ENSMUSP00000031562; ENSMUSG00000043059. [Q6PD29-2]
ENSMUST00000114590; ENSMUSP00000110238; ENSMUSG00000043059. [Q6PD29-1]
GeneIDi101023.
KEGGimmu:101023.
UCSCiuc008wxn.1. mouse. [Q6PD29-2]
uc008wxo.2. mouse. [Q6PD29-1]

Organism-specific databases

CTDi101023.
MGIiMGI:2141255. Zfp513.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132304.
HOGENOMiHOG000081792.
HOVERGENiHBG097012.
InParanoidiQ6PD29.
OMAiTSFLPDC.
OrthoDBiEOG091G05JD.
TreeFamiTF350015.

Miscellaneous databases

PROiQ6PD29.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043059.
ExpressionAtlasiQ6PD29. baseline and differential.
GenevisibleiQ6PD29. MM.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN513_MOUSE
AccessioniPrimary (citable) accession number: Q6PD29
Secondary accession number(s): Q3U4K1, Q8BWH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.