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Protein

Zinc finger protein 513

Gene

Znf513

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that plays a role in retinal development and maintenance.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri150 – 17223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 513
Gene namesi
Name:Znf513
Synonyms:Zfp513
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2141255. Zfp513.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Zinc finger protein 513PRO_0000353093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei96 – 961PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PD29.
MaxQBiQ6PD29.
PaxDbiQ6PD29.
PRIDEiQ6PD29.

PTM databases

PhosphoSiteiQ6PD29.

Expressioni

Tissue specificityi

Widely expressed. In the eye, expression is greatest in the retina and least in the lens and cornea.1 Publication

Gene expression databases

BgeeiQ6PD29.
ExpressionAtlasiQ6PD29. baseline and differential.
GenevisibleiQ6PD29. MM.

Interactioni

Subunit structurei

Binds DNA. Can associate with the proximal promoter regions of PAX6 and SP4, and their known targets including ARR3, RHO, OPN1MW2 and OPN1SW.1 Publication

Protein-protein interaction databases

BioGridi221569. 5 interactions.
IntActiQ6PD29. 1 interaction.
STRINGi10090.ENSMUSP00000110238.

Structurei

3D structure databases

ProteinModelPortaliQ6PD29.
SMRiQ6PD29. Positions 162-240, 373-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 14187Gly-richAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri150 – 17223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri206 – 22823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125424.
HOGENOMiHOG000081792.
HOVERGENiHBG097012.
InParanoidiQ6PD29.
OMAiTSFLPDC.
OrthoDBiEOG72ZCDT.
TreeFamiTF350015.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PD29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRKQSHPQ PVKCEGVKVD TEDSFDEGPG ALVLESDLLL GQDLEFEEEE
60 70 80 90 100
EEDEGDGHND QLMGFERDSE GDSQGARPGL PYGLSDDESG GGRALSAESE
110 120 130 140 150
VEEPARGPGE ARGERPGPAC QLCGGPTGEG PCCGAGGPGG GPPLPPRLLY
160 170 180 190 200
SCRLCAFVSH YSSHLKRHMQ THSGEKPFRC GRCPYASAQL VNLTRHTRTH
210 220 230 240 250
TGEKPYRCPH CPFACSSLGN LRRHQRTHTG PPTPPCPTCG FRCCAPRPTR
260 270 280 290 300
PPSPTEQEGT MPRRSEDALI LPDLSLHVPP GGASFLPDCG QLRGEGESLC
310 320 330 340 350
GTGSEPLPEL LFPWTCRGCG QELEEGEGSR LGAAMCGRCM RGEAGGVATG
360 370 380 390 400
GPQGPGDKGF ACSLCPFATH YPNHLARHMK THSGEKPFRC ARCPYASAHL
410 420 430 440 450
DNLKRHQRVH TGEKPYKCPL CPYACGNLAN LKRHGRIHSG DKPFRCSLCN
460 470 480 490 500
YSCNQSMNLK RHMLRHTGEK PFRCATCAYT TGHWDNYKRH QKVHGHGGAG
510 520 530 540
GPGLSAPEGW APPHSPPSVL STRGPAALGA TGSRALHSDS P
Length:541
Mass (Da):58,067
Last modified:November 4, 2008 - v2
Checksum:i4F284BE3EBCABB7F
GO
Isoform 2 (identifier: Q6PD29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MPRRKQSHPQPVKCEGVK → MGTAWEGDSTSTLPSL

Show »
Length:539
Mass (Da):57,614
Checksum:i28071A14ACDF13B1
GO

Sequence cautioni

The sequence AAH58976.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC35001.1 differs from that shown.Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti504 – 5041L → R in BAC35001 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818MPRRK…CEGVK → MGTAWEGDSTSTLPSL in isoform 2. 1 PublicationVSP_035626Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052459 mRNA. Translation: BAC35001.1. Sequence problems.
AK154195 mRNA. Translation: BAE32430.1.
BC058976 mRNA. Translation: AAH58976.1. Different initiation.
CCDSiCCDS19178.2. [Q6PD29-1]
CCDS51458.1. [Q6PD29-2]
RefSeqiNP_001171372.1. NM_001177901.1. [Q6PD29-2]
NP_780520.3. NM_175311.4. [Q6PD29-1]
UniGeneiMm.45033.

Genome annotation databases

EnsembliENSMUST00000031562; ENSMUSP00000031562; ENSMUSG00000043059. [Q6PD29-2]
ENSMUST00000114590; ENSMUSP00000110238; ENSMUSG00000043059. [Q6PD29-1]
GeneIDi101023.
KEGGimmu:101023.
UCSCiuc008wxn.1. mouse. [Q6PD29-2]
uc008wxo.2. mouse. [Q6PD29-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052459 mRNA. Translation: BAC35001.1. Sequence problems.
AK154195 mRNA. Translation: BAE32430.1.
BC058976 mRNA. Translation: AAH58976.1. Different initiation.
CCDSiCCDS19178.2. [Q6PD29-1]
CCDS51458.1. [Q6PD29-2]
RefSeqiNP_001171372.1. NM_001177901.1. [Q6PD29-2]
NP_780520.3. NM_175311.4. [Q6PD29-1]
UniGeneiMm.45033.

3D structure databases

ProteinModelPortaliQ6PD29.
SMRiQ6PD29. Positions 162-240, 373-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221569. 5 interactions.
IntActiQ6PD29. 1 interaction.
STRINGi10090.ENSMUSP00000110238.

PTM databases

PhosphoSiteiQ6PD29.

Proteomic databases

EPDiQ6PD29.
MaxQBiQ6PD29.
PaxDbiQ6PD29.
PRIDEiQ6PD29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031562; ENSMUSP00000031562; ENSMUSG00000043059. [Q6PD29-2]
ENSMUST00000114590; ENSMUSP00000110238; ENSMUSG00000043059. [Q6PD29-1]
GeneIDi101023.
KEGGimmu:101023.
UCSCiuc008wxn.1. mouse. [Q6PD29-2]
uc008wxo.2. mouse. [Q6PD29-1]

Organism-specific databases

CTDi101023.
MGIiMGI:2141255. Zfp513.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125424.
HOGENOMiHOG000081792.
HOVERGENiHBG097012.
InParanoidiQ6PD29.
OMAiTSFLPDC.
OrthoDBiEOG72ZCDT.
TreeFamiTF350015.

Miscellaneous databases

NextBioi354730.
PROiQ6PD29.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PD29.
ExpressionAtlasiQ6PD29. baseline and differential.
GenevisibleiQ6PD29. MM.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Embryonic lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "A mutation in ZNF513, a putative regulator of photoreceptor development, causes autosomal-recessive retinitis pigmentosa."
    Li L., Nakaya N., Chavali V.R., Ma Z., Jiao X., Sieving P.A., Riazuddin S., Tomarev S.I., Ayyagari R., Riazuddin S.A., Hejtmancik J.F.
    Am. J. Hum. Genet. 87:400-409(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Spleen.

Entry informationi

Entry nameiZN513_MOUSE
AccessioniPrimary (citable) accession number: Q6PD29
Secondary accession number(s): Q3U4K1, Q8BWH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 4, 2008
Last modified: March 16, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.