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Protein

GPI transamidase component PIG-S

Gene

Pigs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-162791. Attachment of GPI anchor to uPAR.
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI transamidase component PIG-S
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class S protein
Gene namesi
Name:Pigs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2687325. Pigs.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1817CytoplasmicSequence analysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Topological domaini40 – 520481LumenalSequence analysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence analysisAdd
BLAST
Topological domaini542 – 55514CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 555554GPI transamidase component PIG-SPRO_0000218605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence analysis
Glycosylationi370 – 3701N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6PD26.
MaxQBiQ6PD26.
PaxDbiQ6PD26.
PRIDEiQ6PD26.

PTM databases

PhosphoSiteiQ6PD26.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041958.
ExpressionAtlasiQ6PD26. baseline and differential.
GenevisibleiQ6PD26. MM.

Interactioni

Subunit structurei

Forms a complex with PIGK/GPI8, PIGT, PIGU and GAA1.By similarity

Protein-protein interaction databases

IntActiQ6PD26. 1 interaction.
STRINGi10090.ENSMUSP00000044871.

Structurei

3D structure databases

ProteinModelPortaliQ6PD26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2459. Eukaryota.
ENOG410XR9U. LUCA.
GeneTreeiENSGT00390000017203.
HOGENOMiHOG000067980.
HOVERGENiHBG031822.
InParanoidiQ6PD26.
KOiK05291.
OMAiMSYIGPE.
OrthoDBiEOG091G06XK.
PhylomeDBiQ6PD26.
TreeFamiTF105857.

Family and domain databases

InterProiIPR019540. PtdIno-glycan_biosynth_class_S.
[Graphical view]
PANTHERiPTHR21072. PTHR21072. 1 hit.
PfamiPF10510. PIG-S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PD26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGAAATD LEVVRGKRSA LFFAAVAILL GLPLWWKTTE TYRAPLPYSD
60 70 80 90 100
ISGLNALLLR LMVPVTVVFT RDSVPLDDQE KLPFTVVHER EIPLKYKMKI
110 120 130 140 150
KCRFQKAYRR ALEHEEEALS LGSVHEAEAM LAEPEKQAEG SLTVYVISEH
160 170 180 190 200
SSLLPQDMMS YIGPERTAVV RGLIHREAFN IIGRRIVQVA QAMSLTEDVL
210 220 230 240 250
AAALADHLPE DKWSSDKRRP LKSSLGYEIT FSLLNPDPKS HDVHWDIEGA
260 270 280 290 300
VQRFVQPFLN RLSVAGNFSV DSQILYYAML GVNPRFDPAS SSYSLAMHSL
310 320 330 340 350
PHVINPVESR LGSSAASLYP VLHFLLYVPE LAHSPLYIQD KDGAPVATNA
360 370 380 390 400
FHSPRWGGIM VYNVDPKIYN ASELPVRVEV DMVRVMEVFL AQLRLLFGIA
410 420 430 440 450
QPQVPPKCLL SGPKSEGLMT WELDRLLWAR SVENLATATT TLTSLAQLLG
460 470 480 490 500
KISNIVIKDD VASEVYRAVA AVQKAAKALA LGHLSSAFAA SQEAVTSSER
510 520 530 540 550
AFFDPSLLHL LYFPDDQKFA IYIPLFLPMA VPILLSLVKI FQETRKSWKK

PEKID
Length:555
Mass (Da):61,711
Last modified:January 23, 2007 - v3
Checksum:i79B6599AD98659DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591070 Genomic DNA. Translation: CAI24317.1.
BC058979 mRNA. Translation: AAH58979.1.
CCDSiCCDS25100.1.
RefSeqiNP_958808.1. NM_201406.1.
UniGeneiMm.295908.

Genome annotation databases

EnsembliENSMUST00000048073; ENSMUSP00000044871; ENSMUSG00000041958.
GeneIDi276846.
KEGGimmu:276846.
UCSCiuc007kiz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591070 Genomic DNA. Translation: CAI24317.1.
BC058979 mRNA. Translation: AAH58979.1.
CCDSiCCDS25100.1.
RefSeqiNP_958808.1. NM_201406.1.
UniGeneiMm.295908.

3D structure databases

ProteinModelPortaliQ6PD26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PD26. 1 interaction.
STRINGi10090.ENSMUSP00000044871.

PTM databases

PhosphoSiteiQ6PD26.

Proteomic databases

EPDiQ6PD26.
MaxQBiQ6PD26.
PaxDbiQ6PD26.
PRIDEiQ6PD26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048073; ENSMUSP00000044871; ENSMUSG00000041958.
GeneIDi276846.
KEGGimmu:276846.
UCSCiuc007kiz.1. mouse.

Organism-specific databases

CTDi94005.
MGIiMGI:2687325. Pigs.

Phylogenomic databases

eggNOGiKOG2459. Eukaryota.
ENOG410XR9U. LUCA.
GeneTreeiENSGT00390000017203.
HOGENOMiHOG000067980.
HOVERGENiHBG031822.
InParanoidiQ6PD26.
KOiK05291.
OMAiMSYIGPE.
OrthoDBiEOG091G06XK.
PhylomeDBiQ6PD26.
TreeFamiTF105857.

Enzyme and pathway databases

UniPathwayiUPA00196.
ReactomeiR-MMU-162791. Attachment of GPI anchor to uPAR.

Miscellaneous databases

PROiQ6PD26.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041958.
ExpressionAtlasiQ6PD26. baseline and differential.
GenevisibleiQ6PD26. MM.

Family and domain databases

InterProiIPR019540. PtdIno-glycan_biosynth_class_S.
[Graphical view]
PANTHERiPTHR21072. PTHR21072. 1 hit.
PfamiPF10510. PIG-S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGS_MOUSE
AccessioniPrimary (citable) accession number: Q6PD26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.