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Protein

UPF0668 protein C10orf76 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0668 protein C10orf76 homolog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1918867. 9130011E15Rik.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei520 – 53819HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689UPF0668 protein C10orf76 homologPRO_0000284516Add
BLAST

Proteomic databases

MaxQBiQ6PD19.
PaxDbiQ6PD19.
PRIDEiQ6PD19.

PTM databases

PhosphoSiteiQ6PD19.

Expressioni

Gene expression databases

BgeeiQ6PD19.
CleanExiMM_9130011E15RIK.
GenevisibleiQ6PD19. MM.

Interactioni

Protein-protein interaction databases

BioGridi214816. 1 interaction.
STRINGi10090.ENSMUSP00000048454.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0668 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275204.
GeneTreeiENSGT00390000002554.
HOGENOMiHOG000006637.
HOVERGENiHBG058251.
InParanoidiQ6PD19.
OMAiFIVSHLM.
OrthoDBiEOG76X5ZQ.
PhylomeDBiQ6PD19.
TreeFamiTF300220.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view]
PfamiPF08427. DUF1741. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PD19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF
60 70 80 90 100
LMKVNLEYLE GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA
110 120 130 140 150
LQTLCALIRG VHQKNKSTSG FDIINMLMGF DKAELCMKNL MESLDSLLCA
160 170 180 190 200
EGSESLKSLC LKLLLCLVTV TDNISQNTIL EYVMINSIFE AILQILSHPP
210 220 230 240 250
SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT LNGMGLVITQ
260 270 280 290 300
ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKL SVQTNEAILL
310 320 330 340 350
ALYEAVHLNR NFITVLAQSH PEMGLVTAPA SPTPTTPATP LGTTPPSSDV
360 370 380 390 400
ISSVELSLDA DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC
410 420 430 440 450
IAEDQYANAF LHDDNMNFRV NLHRMPMRHR KKAADKNLPC RPLVCAVLDL
460 470 480 490 500
MVEFIVTHMM KEFPMDLYLR CVQVVHKLLC YQKKCRVRLH YTWRELWSAL
510 520 530 540 550
INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT FLPTPSSYDE
560 570 580 590 600
LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF
610 620 630 640 650
NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH
660 670 680
KEAAFFKELV RSISTNVRRN LAFHTLSQEA LLKEFSTIS
Length:689
Mass (Da):78,632
Last modified:November 4, 2008 - v2
Checksum:iB7D19DBA66A99312
GO
Isoform 2 (identifier: Q6PD19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:265
Mass (Da):31,100
Checksum:i4D8DEAEA66382BFC
GO
Isoform 3 (identifier: Q6PD19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-514: ALINLLKFLMSNETVL → GIILKLSGSAASTYTF
     515-689: Missing.

Note: No experimental confirmation available.
Show »
Length:514
Mass (Da):58,191
Checksum:iC1E531D95DA5323E
GO

Sequence cautioni

The sequence AAH46389.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 424424Missing in isoform 2. 1 PublicationVSP_035671Add
BLAST
Alternative sequencei499 – 51416ALINL…NETVL → GIILKLSGSAASTYTF in isoform 3. 1 PublicationVSP_035672Add
BLAST
Alternative sequencei515 – 689175Missing in isoform 3. 1 PublicationVSP_035673Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159765 mRNA. Translation: BAE35355.1.
AC131185 Genomic DNA. No translation available.
AC150685 Genomic DNA. No translation available.
BC046389 mRNA. Translation: AAH46389.1. Sequence problems.
BC048392 mRNA. Translation: AAH48392.1.
BC058989 mRNA. Translation: AAH58989.1.
CCDSiCCDS50454.1. [Q6PD19-1]
RefSeqiNP_938038.2. NM_198296.2. [Q6PD19-1]
XP_011245647.1. XM_011247345.1. [Q6PD19-1]
XP_011245649.1. XM_011247347.1. [Q6PD19-3]
UniGeneiMm.210949.

Genome annotation databases

EnsembliENSMUST00000045396; ENSMUSP00000048454; ENSMUSG00000039901. [Q6PD19-1]
GeneIDi71617.
KEGGimmu:71617.
UCSCiuc008hrv.1. mouse. [Q6PD19-1]
uc008hrw.1. mouse. [Q6PD19-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159765 mRNA. Translation: BAE35355.1.
AC131185 Genomic DNA. No translation available.
AC150685 Genomic DNA. No translation available.
BC046389 mRNA. Translation: AAH46389.1. Sequence problems.
BC048392 mRNA. Translation: AAH48392.1.
BC058989 mRNA. Translation: AAH58989.1.
CCDSiCCDS50454.1. [Q6PD19-1]
RefSeqiNP_938038.2. NM_198296.2. [Q6PD19-1]
XP_011245647.1. XM_011247345.1. [Q6PD19-1]
XP_011245649.1. XM_011247347.1. [Q6PD19-3]
UniGeneiMm.210949.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214816. 1 interaction.
STRINGi10090.ENSMUSP00000048454.

PTM databases

PhosphoSiteiQ6PD19.

Proteomic databases

MaxQBiQ6PD19.
PaxDbiQ6PD19.
PRIDEiQ6PD19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045396; ENSMUSP00000048454; ENSMUSG00000039901. [Q6PD19-1]
GeneIDi71617.
KEGGimmu:71617.
UCSCiuc008hrv.1. mouse. [Q6PD19-1]
uc008hrw.1. mouse. [Q6PD19-3]

Organism-specific databases

MGIiMGI:1918867. 9130011E15Rik.

Phylogenomic databases

eggNOGiNOG275204.
GeneTreeiENSGT00390000002554.
HOGENOMiHOG000006637.
HOVERGENiHBG058251.
InParanoidiQ6PD19.
OMAiFIVSHLM.
OrthoDBiEOG76X5ZQ.
PhylomeDBiQ6PD19.
TreeFamiTF300220.

Miscellaneous databases

NextBioi334103.
PROiQ6PD19.

Gene expression databases

BgeeiQ6PD19.
CleanExiMM_9130011E15RIK.
GenevisibleiQ6PD19. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view]
PfamiPF08427. DUF1741. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-689 (ISOFORM 1).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain, Mammary tumor and Olfactory epithelium.

Entry informationi

Entry nameiCJ076_MOUSE
AccessioniPrimary (citable) accession number: Q6PD19
Secondary accession number(s): Q3TWB1, Q80V50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 4, 2008
Last modified: July 22, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.