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Q6PD19

- CJ076_MOUSE

UniProt

Q6PD19 - CJ076_MOUSE

Protein

UPF0668 protein C10orf76 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0668 protein C10orf76 homolog
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1918867. 9130011E15Rik.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689UPF0668 protein C10orf76 homologPRO_0000284516Add
    BLAST

    Proteomic databases

    MaxQBiQ6PD19.
    PaxDbiQ6PD19.
    PRIDEiQ6PD19.

    PTM databases

    PhosphoSiteiQ6PD19.

    Expressioni

    Gene expression databases

    BgeeiQ6PD19.
    CleanExiMM_9130011E15RIK.
    GenevestigatoriQ6PD19.

    Interactioni

    Protein-protein interaction databases

    BioGridi214816. 1 interaction.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei520 – 53819HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0668 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG275204.
    GeneTreeiENSGT00390000002554.
    HOGENOMiHOG000006637.
    HOVERGENiHBG058251.
    InParanoidiQ6PD19.
    OMAiTYDFTHA.
    OrthoDBiEOG76X5ZQ.
    PhylomeDBiQ6PD19.
    TreeFamiTF300220.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR013636. DUF1741.
    [Graphical view]
    PfamiPF08427. DUF1741. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PD19-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF    50
    LMKVNLEYLE GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA 100
    LQTLCALIRG VHQKNKSTSG FDIINMLMGF DKAELCMKNL MESLDSLLCA 150
    EGSESLKSLC LKLLLCLVTV TDNISQNTIL EYVMINSIFE AILQILSHPP 200
    SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT LNGMGLVITQ 250
    ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKL SVQTNEAILL 300
    ALYEAVHLNR NFITVLAQSH PEMGLVTAPA SPTPTTPATP LGTTPPSSDV 350
    ISSVELSLDA DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC 400
    IAEDQYANAF LHDDNMNFRV NLHRMPMRHR KKAADKNLPC RPLVCAVLDL 450
    MVEFIVTHMM KEFPMDLYLR CVQVVHKLLC YQKKCRVRLH YTWRELWSAL 500
    INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT FLPTPSSYDE 550
    LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF 600
    NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH 650
    KEAAFFKELV RSISTNVRRN LAFHTLSQEA LLKEFSTIS 689
    Length:689
    Mass (Da):78,632
    Last modified:November 4, 2008 - v2
    Checksum:iB7D19DBA66A99312
    GO
    Isoform 2 (identifier: Q6PD19-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-424: Missing.

    Show »
    Length:265
    Mass (Da):31,100
    Checksum:i4D8DEAEA66382BFC
    GO
    Isoform 3 (identifier: Q6PD19-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         499-514: ALINLLKFLMSNETVL → GIILKLSGSAASTYTF
         515-689: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:514
    Mass (Da):58,191
    Checksum:iC1E531D95DA5323E
    GO

    Sequence cautioni

    The sequence AAH46389.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 424424Missing in isoform 2. 1 PublicationVSP_035671Add
    BLAST
    Alternative sequencei499 – 51416ALINL…NETVL → GIILKLSGSAASTYTF in isoform 3. 1 PublicationVSP_035672Add
    BLAST
    Alternative sequencei515 – 689175Missing in isoform 3. 1 PublicationVSP_035673Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK159765 mRNA. Translation: BAE35355.1.
    AC131185 Genomic DNA. No translation available.
    AC150685 Genomic DNA. No translation available.
    BC046389 mRNA. Translation: AAH46389.1. Sequence problems.
    BC048392 mRNA. Translation: AAH48392.1.
    BC058989 mRNA. Translation: AAH58989.1.
    CCDSiCCDS50454.1. [Q6PD19-1]
    RefSeqiNP_938038.2. NM_198296.2. [Q6PD19-1]
    UniGeneiMm.210949.

    Genome annotation databases

    EnsembliENSMUST00000045396; ENSMUSP00000048454; ENSMUSG00000039901. [Q6PD19-1]
    GeneIDi71617.
    KEGGimmu:71617.
    UCSCiuc008hrv.1. mouse. [Q6PD19-1]
    uc008hrw.1. mouse. [Q6PD19-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK159765 mRNA. Translation: BAE35355.1 .
    AC131185 Genomic DNA. No translation available.
    AC150685 Genomic DNA. No translation available.
    BC046389 mRNA. Translation: AAH46389.1 . Sequence problems.
    BC048392 mRNA. Translation: AAH48392.1 .
    BC058989 mRNA. Translation: AAH58989.1 .
    CCDSi CCDS50454.1. [Q6PD19-1 ]
    RefSeqi NP_938038.2. NM_198296.2. [Q6PD19-1 ]
    UniGenei Mm.210949.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214816. 1 interaction.

    PTM databases

    PhosphoSitei Q6PD19.

    Proteomic databases

    MaxQBi Q6PD19.
    PaxDbi Q6PD19.
    PRIDEi Q6PD19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045396 ; ENSMUSP00000048454 ; ENSMUSG00000039901 . [Q6PD19-1 ]
    GeneIDi 71617.
    KEGGi mmu:71617.
    UCSCi uc008hrv.1. mouse. [Q6PD19-1 ]
    uc008hrw.1. mouse. [Q6PD19-3 ]

    Organism-specific databases

    MGIi MGI:1918867. 9130011E15Rik.

    Phylogenomic databases

    eggNOGi NOG275204.
    GeneTreei ENSGT00390000002554.
    HOGENOMi HOG000006637.
    HOVERGENi HBG058251.
    InParanoidi Q6PD19.
    OMAi TYDFTHA.
    OrthoDBi EOG76X5ZQ.
    PhylomeDBi Q6PD19.
    TreeFami TF300220.

    Miscellaneous databases

    NextBioi 334103.

    Gene expression databases

    Bgeei Q6PD19.
    CleanExi MM_9130011E15RIK.
    Genevestigatori Q6PD19.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR013636. DUF1741.
    [Graphical view ]
    Pfami PF08427. DUF1741. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-689 (ISOFORM 1).
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain, Mammary tumor and Olfactory epithelium.

    Entry informationi

    Entry nameiCJ076_MOUSE
    AccessioniPrimary (citable) accession number: Q6PD19
    Secondary accession number(s): Q3TWB1, Q80V50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3