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Protein

UPF0668 protein C10orf76 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0668 protein C10orf76 homolog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1918867. 9130011E15Rik.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei520 – 538HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845161 – 689UPF0668 protein C10orf76 homologAdd BLAST689

Proteomic databases

EPDiQ6PD19.
PaxDbiQ6PD19.
PeptideAtlasiQ6PD19.
PRIDEiQ6PD19.

PTM databases

iPTMnetiQ6PD19.
PhosphoSitePlusiQ6PD19.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039901.
CleanExiMM_9130011E15RIK.
GenevisibleiQ6PD19. MM.

Interactioni

Subunit structurei

Interacts with PI4KB.By similarity

Protein-protein interaction databases

BioGridi214816. 1 interactor.
STRINGi10090.ENSMUSP00000048454.

Structurei

3D structure databases

ProteinModelPortaliQ6PD19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0668 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4654. Eukaryota.
ENOG410XQ3P. LUCA.
GeneTreeiENSGT00390000002554.
HOGENOMiHOG000006637.
HOVERGENiHBG058251.
InParanoidiQ6PD19.
OMAiQNALFEH.
OrthoDBiEOG091G03C8.
PhylomeDBiQ6PD19.
TreeFamiTF300220.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view]
PfamiPF08427. DUF1741. 1 hit.
[Graphical view]
SMARTiSM01158. DUF1741. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PD19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF
60 70 80 90 100
LMKVNLEYLE GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA
110 120 130 140 150
LQTLCALIRG VHQKNKSTSG FDIINMLMGF DKAELCMKNL MESLDSLLCA
160 170 180 190 200
EGSESLKSLC LKLLLCLVTV TDNISQNTIL EYVMINSIFE AILQILSHPP
210 220 230 240 250
SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT LNGMGLVITQ
260 270 280 290 300
ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKL SVQTNEAILL
310 320 330 340 350
ALYEAVHLNR NFITVLAQSH PEMGLVTAPA SPTPTTPATP LGTTPPSSDV
360 370 380 390 400
ISSVELSLDA DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC
410 420 430 440 450
IAEDQYANAF LHDDNMNFRV NLHRMPMRHR KKAADKNLPC RPLVCAVLDL
460 470 480 490 500
MVEFIVTHMM KEFPMDLYLR CVQVVHKLLC YQKKCRVRLH YTWRELWSAL
510 520 530 540 550
INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT FLPTPSSYDE
560 570 580 590 600
LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF
610 620 630 640 650
NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH
660 670 680
KEAAFFKELV RSISTNVRRN LAFHTLSQEA LLKEFSTIS
Length:689
Mass (Da):78,632
Last modified:November 4, 2008 - v2
Checksum:iB7D19DBA66A99312
GO
Isoform 2 (identifier: Q6PD19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:265
Mass (Da):31,100
Checksum:i4D8DEAEA66382BFC
GO
Isoform 3 (identifier: Q6PD19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-514: ALINLLKFLMSNETVL → GIILKLSGSAASTYTF
     515-689: Missing.

Note: No experimental confirmation available.
Show »
Length:514
Mass (Da):58,191
Checksum:iC1E531D95DA5323E
GO

Sequence cautioni

The sequence AAH46389 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0356711 – 424Missing in isoform 2. 1 PublicationAdd BLAST424
Alternative sequenceiVSP_035672499 – 514ALINL…NETVL → GIILKLSGSAASTYTF in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_035673515 – 689Missing in isoform 3. 1 PublicationAdd BLAST175

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159765 mRNA. Translation: BAE35355.1.
AC131185 Genomic DNA. No translation available.
AC150685 Genomic DNA. No translation available.
BC046389 mRNA. Translation: AAH46389.1. Sequence problems.
BC048392 mRNA. Translation: AAH48392.1.
BC058989 mRNA. Translation: AAH58989.1.
CCDSiCCDS50454.1. [Q6PD19-1]
RefSeqiNP_938038.2. NM_198296.2. [Q6PD19-1]
XP_011245647.1. XM_011247345.2. [Q6PD19-1]
UniGeneiMm.210949.

Genome annotation databases

EnsembliENSMUST00000045396; ENSMUSP00000048454; ENSMUSG00000039901. [Q6PD19-1]
GeneIDi71617.
KEGGimmu:71617.
UCSCiuc008hrv.1. mouse. [Q6PD19-1]
uc008hrw.1. mouse. [Q6PD19-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159765 mRNA. Translation: BAE35355.1.
AC131185 Genomic DNA. No translation available.
AC150685 Genomic DNA. No translation available.
BC046389 mRNA. Translation: AAH46389.1. Sequence problems.
BC048392 mRNA. Translation: AAH48392.1.
BC058989 mRNA. Translation: AAH58989.1.
CCDSiCCDS50454.1. [Q6PD19-1]
RefSeqiNP_938038.2. NM_198296.2. [Q6PD19-1]
XP_011245647.1. XM_011247345.2. [Q6PD19-1]
UniGeneiMm.210949.

3D structure databases

ProteinModelPortaliQ6PD19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214816. 1 interactor.
STRINGi10090.ENSMUSP00000048454.

PTM databases

iPTMnetiQ6PD19.
PhosphoSitePlusiQ6PD19.

Proteomic databases

EPDiQ6PD19.
PaxDbiQ6PD19.
PeptideAtlasiQ6PD19.
PRIDEiQ6PD19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045396; ENSMUSP00000048454; ENSMUSG00000039901. [Q6PD19-1]
GeneIDi71617.
KEGGimmu:71617.
UCSCiuc008hrv.1. mouse. [Q6PD19-1]
uc008hrw.1. mouse. [Q6PD19-3]

Organism-specific databases

MGIiMGI:1918867. 9130011E15Rik.

Phylogenomic databases

eggNOGiKOG4654. Eukaryota.
ENOG410XQ3P. LUCA.
GeneTreeiENSGT00390000002554.
HOGENOMiHOG000006637.
HOVERGENiHBG058251.
InParanoidiQ6PD19.
OMAiQNALFEH.
OrthoDBiEOG091G03C8.
PhylomeDBiQ6PD19.
TreeFamiTF300220.

Miscellaneous databases

PROiQ6PD19.

Gene expression databases

BgeeiENSMUSG00000039901.
CleanExiMM_9130011E15RIK.
GenevisibleiQ6PD19. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view]
PfamiPF08427. DUF1741. 1 hit.
[Graphical view]
SMARTiSM01158. DUF1741. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCJ076_MOUSE
AccessioniPrimary (citable) accession number: Q6PD19
Secondary accession number(s): Q3TWB1, Q80V50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.