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Q6PD19 (CJ076_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UPF0668 protein C10orf76 homolog
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length689 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UPF0668 family.

Sequence caution

The sequence AAH46389.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PD19-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PD19-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.
Isoform 3 (identifier: Q6PD19-3)

The sequence of this isoform differs from the canonical sequence as follows:
     499-514: ALINLLKFLMSNETVL → GIILKLSGSAASTYTF
     515-689: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 689689UPF0668 protein C10orf76 homolog
PRO_0000284516

Regions

Transmembrane520 – 53819Helical; Potential

Natural variations

Alternative sequence1 – 424424Missing in isoform 2.
VSP_035671
Alternative sequence499 – 51416ALINL…NETVL → GIILKLSGSAASTYTF in isoform 3.
VSP_035672
Alternative sequence515 – 689175Missing in isoform 3.
VSP_035673

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 4, 2008. Version 2.
Checksum: B7D19DBA66A99312

FASTA68978,632
        10         20         30         40         50         60 
MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF LMKVNLEYLE 

        70         80         90        100        110        120 
GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA LQTLCALIRG VHQKNKSTSG 

       130        140        150        160        170        180 
FDIINMLMGF DKAELCMKNL MESLDSLLCA EGSESLKSLC LKLLLCLVTV TDNISQNTIL 

       190        200        210        220        230        240 
EYVMINSIFE AILQILSHPP SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT 

       250        260        270        280        290        300 
LNGMGLVITQ ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKL SVQTNEAILL 

       310        320        330        340        350        360 
ALYEAVHLNR NFITVLAQSH PEMGLVTAPA SPTPTTPATP LGTTPPSSDV ISSVELSLDA 

       370        380        390        400        410        420 
DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC IAEDQYANAF LHDDNMNFRV 

       430        440        450        460        470        480 
NLHRMPMRHR KKAADKNLPC RPLVCAVLDL MVEFIVTHMM KEFPMDLYLR CVQVVHKLLC 

       490        500        510        520        530        540 
YQKKCRVRLH YTWRELWSAL INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT 

       550        560        570        580        590        600 
FLPTPSSYDE LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF 

       610        620        630        640        650        660 
NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH KEAAFFKELV 

       670        680 
RSISTNVRRN LAFHTLSQEA LLKEFSTIS 

« Hide

Isoform 2 [UniParc].

Checksum: 4D8DEAEA66382BFC
Show »

FASTA26531,100
Isoform 3 [UniParc].

Checksum: C1E531D95DA5323E
Show »

FASTA51458,191

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6J.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-689 (ISOFORM 1).
Strain: C57BL/6 and FVB/N.
Tissue: Brain, Mammary tumor and Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK159765 mRNA. Translation: BAE35355.1.
AC131185 Genomic DNA. No translation available.
AC150685 Genomic DNA. No translation available.
BC046389 mRNA. Translation: AAH46389.1. Sequence problems.
BC048392 mRNA. Translation: AAH48392.1.
BC058989 mRNA. Translation: AAH58989.1.
CCDSCCDS50454.1. [Q6PD19-1]
RefSeqNP_938038.2. NM_198296.2. [Q6PD19-1]
UniGeneMm.210949.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid214816. 1 interaction.

PTM databases

PhosphoSiteQ6PD19.

Proteomic databases

MaxQBQ6PD19.
PaxDbQ6PD19.
PRIDEQ6PD19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045396; ENSMUSP00000048454; ENSMUSG00000039901. [Q6PD19-1]
GeneID71617.
KEGGmmu:71617.
UCSCuc008hrv.1. mouse. [Q6PD19-1]
uc008hrw.1. mouse. [Q6PD19-3]

Organism-specific databases

MGIMGI:1918867. 9130011E15Rik.

Phylogenomic databases

eggNOGNOG275204.
GeneTreeENSGT00390000002554.
HOGENOMHOG000006637.
HOVERGENHBG058251.
InParanoidQ6PD19.
OMATYDFTHA.
OrthoDBEOG76X5ZQ.
PhylomeDBQ6PD19.
TreeFamTF300220.

Gene expression databases

BgeeQ6PD19.
CleanExMM_9130011E15RIK.
GenevestigatorQ6PD19.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view]
PfamPF08427. DUF1741. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 4 hits.
ProtoNetSearch...

Other

NextBio334103.

Entry information

Entry nameCJ076_MOUSE
AccessionPrimary (citable) accession number: Q6PD19
Secondary accession number(s): Q3TWB1, Q80V50
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 4, 2008
Last modified: July 9, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot