ID   IP6K1_MOUSE             Reviewed;         433 AA.
AC   Q6PD10; Q9QXV6;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 136.
DE   RecName: Full=Inositol hexakisphosphate kinase 1;
DE            Short=InsP6 kinase 1;
DE            EC=2.7.4.21;
DE   AltName: Full=Inositol hexaphosphate kinase 1;
GN   Name=Ip6k1; Synonyms=Ihpk1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=10574768; DOI=10.1016/s0960-9822(00)80055-x;
RA   Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.;
RT   "Synthesis of diphosphoinositol pentakisphosphate by a newly identified
RT   family of higher inositol polyphosphate kinases.";
RL   Curr. Biol. 9:1323-1326(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Converts inositol hexakisphosphate (InsP6) to
CC       diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts
CC       1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
CC       {ECO:0000269|PubMed:10574768}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-
CC         inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628,
CC         ChEBI:CHEBI:456216; EC=2.7.4.21;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP
CC         + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate
CC         + ADP; Xref=Rhea:RHEA:37467, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:74946, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216;
CC         EC=2.7.4.21;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain and testis. Detected at
CC       much lower levels in heart, kidney, liver, lung and spleen.
CC       {ECO:0000269|PubMed:10574768}.
CC   -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC       {ECO:0000305}.
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DR   EMBL; AF177144; AAF15056.1; -; mRNA.
DR   EMBL; BC059006; AAH59006.1; -; mRNA.
DR   CCDS; CCDS23514.1; -.
DR   RefSeq; NP_038813.2; NM_013785.2.
DR   AlphaFoldDB; Q6PD10; -.
DR   SMR; Q6PD10; -.
DR   BioGRID; 205206; 3.
DR   STRING; 10090.ENSMUSP00000035214; -.
DR   iPTMnet; Q6PD10; -.
DR   PhosphoSitePlus; Q6PD10; -.
DR   MaxQB; Q6PD10; -.
DR   PaxDb; 10090-ENSMUSP00000035214; -.
DR   ProteomicsDB; 269495; -.
DR   Pumba; Q6PD10; -.
DR   Antibodypedia; 30640; 263 antibodies from 28 providers.
DR   DNASU; 27399; -.
DR   Ensembl; ENSMUST00000035214.11; ENSMUSP00000035214.5; ENSMUSG00000032594.12.
DR   GeneID; 27399; -.
DR   KEGG; mmu:27399; -.
DR   UCSC; uc009roc.1; mouse.
DR   AGR; MGI:1351633; -.
DR   CTD; 9807; -.
DR   MGI; MGI:1351633; Ip6k1.
DR   VEuPathDB; HostDB:ENSMUSG00000032594; -.
DR   eggNOG; KOG1620; Eukaryota.
DR   GeneTree; ENSGT00940000157802; -.
DR   HOGENOM; CLU_014862_0_0_1; -.
DR   InParanoid; Q6PD10; -.
DR   OMA; ECRAEPY; -.
DR   OrthoDB; 20436at2759; -.
DR   PhylomeDB; Q6PD10; -.
DR   TreeFam; TF314066; -.
DR   BRENDA; 2.7.1.158; 3474.
DR   BRENDA; 2.7.4.21; 3474.
DR   Reactome; R-MMU-1855167; Synthesis of pyrophosphates in the cytosol.
DR   Reactome; R-MMU-1855191; Synthesis of IPs in the nucleus.
DR   SABIO-RK; Q6PD10; -.
DR   BioGRID-ORCS; 27399; 4 hits in 78 CRISPR screens.
DR   ChiTaRS; Ip6k1; mouse.
DR   PRO; PR:Q6PD10; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q6PD10; Protein.
DR   Bgee; ENSMUSG00000032594; Expressed in spermatid and 260 other cell types or tissues.
DR   ExpressionAtlas; Q6PD10; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0052723; F:inositol hexakisphosphate 1-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052724; F:inositol hexakisphosphate 3-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000832; F:inositol hexakisphosphate 5-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000828; F:inositol hexakisphosphate kinase activity; ISO:MGI.
DR   GO; GO:0000827; F:inositol-1,3,4,5,6-pentakisphosphate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006020; P:inositol metabolic process; ISO:MGI.
DR   GO; GO:0032958; P:inositol phosphate biosynthetic process; ISO:MGI.
DR   GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IMP:YuBioLab.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.470.160; Inositol polyphosphate kinase; 1.
DR   InterPro; IPR005522; IPK.
DR   InterPro; IPR038286; IPK_sf.
DR   PANTHER; PTHR12400:SF73; INOSITOL HEXAKISPHOSPHATE KINASE 1; 1.
DR   PANTHER; PTHR12400; INOSITOL POLYPHOSPHATE KINASE; 1.
DR   Pfam; PF03770; IPK; 1.
DR   SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR   Genevisible; Q6PD10; MM.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Transferase.
FT   CHAIN           1..433
FT                   /note="Inositol hexakisphosphate kinase 1"
FT                   /id="PRO_0000066875"
FT   REGION          100..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          359..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         220..228
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         151
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92551"
FT   CONFLICT        428..429
FT                   /note="MR -> VP (in Ref. 1; AAF15056)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   433 AA;  49307 MW;  30BDF7B9DD473607 CRC64;
     MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE
     SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTPER EQPRRKHSRR
     SLHRSGSGSD HKEEKASLSF ETSESSQEAK SPKVELHSHS DVPFQMLDSN SGLSSEKISY
     NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK
     AARQMRKCEQ STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
     LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL KHVDMGLPEV
     PPPCGPSTSP SSTSLEAGPS SPPKVDVRMI DFAHSTFKGF RDDPTVHDGP DRGYVFGLEN
     LISIMEQMRD ENQ
//