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Protein

Inositol hexakisphosphate kinase 1

Gene

Ip6k1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.21 3474
ReactomeiR-MMU-1855167 Synthesis of pyrophosphates in the cytosol
R-MMU-1855191 Synthesis of IPs in the nucleus
SABIO-RKiQ6PD10

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene namesi
Name:Ip6k1
Synonyms:Ihpk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1351633 Ip6k1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668751 – 433Inositol hexakisphosphate kinase 1Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PD10
PaxDbiQ6PD10
PRIDEiQ6PD10

PTM databases

iPTMnetiQ6PD10
PhosphoSitePlusiQ6PD10

Expressioni

Tissue specificityi

Highly expressed in brain and testis. Detected at much lower levels in heart, kidney, liver, lung and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000032594
CleanExiMM_IHPK1
ExpressionAtlasiQ6PD10 baseline and differential
GenevisibleiQ6PD10 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035214

Structurei

3D structure databases

ProteinModelPortaliQ6PD10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 228Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620 Eukaryota
ENOG410YB60 LUCA
GeneTreeiENSGT00390000014381
HOVERGENiHBG052140
InParanoidiQ6PD10
KOiK07756
OMAiIHSDVPF
OrthoDBiEOG091G0JK2
PhylomeDBiQ6PD10
TreeFamiTF314066

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PD10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP
60 70 80 90 100
LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE
110 120 130 140 150
TVEQDDTPER EQPRRKHSRR SLHRSGSGSD HKEEKASLSF ETSESSQEAK
160 170 180 190 200
SPKVELHSHS DVPFQMLDSN SGLSSEKISY NPWSLRCHKQ QLSRMRSESK
210 220 230 240 250
DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ
260 270 280 290 300
STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
310 320 330 340 350
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL
360 370 380 390 400
KHVDMGLPEV PPPCGPSTSP SSTSLEAGPS SPPKVDVRMI DFAHSTFKGF
410 420 430
RDDPTVHDGP DRGYVFGLEN LISIMEQMRD ENQ
Length:433
Mass (Da):49,307
Last modified:July 5, 2004 - v1
Checksum:i30BDF7B9DD473607
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428 – 429MR → VP in AAF15056 (PubMed:10574768).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177144 mRNA Translation: AAF15056.1
BC059006 mRNA Translation: AAH59006.1
CCDSiCCDS23514.1
RefSeqiNP_038813.2, NM_013785.2
UniGeneiMm.276155

Genome annotation databases

EnsembliENSMUST00000035214; ENSMUSP00000035214; ENSMUSG00000032594
GeneIDi27399
KEGGimmu:27399
UCSCiuc009roc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIP6K1_MOUSE
AccessioniPrimary (citable) accession number: Q6PD10
Secondary accession number(s): Q9QXV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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