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Q6PD10

- IP6K1_MOUSE

UniProt

Q6PD10 - IP6K1_MOUSE

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Protein
Inositol hexakisphosphate kinase 1
Gene
Ip6k1, Ihpk1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  3. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC
  5. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro

GO - Biological processi

  1. inositol metabolic process Source: MGI
  2. inositol phosphate biosynthetic process Source: MGI
  3. phosphatidylinositol phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.21. 3474.
ReactomeiREACT_196480. Synthesis of IPs in the nucleus.
REACT_196482. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene namesi
Name:Ip6k1
Synonyms:Ihpk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1351633. Ip6k1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleolus Source: Ensembl
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Inositol hexakisphosphate kinase 1
PRO_0000066875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PD10.
PaxDbiQ6PD10.
PRIDEiQ6PD10.

PTM databases

PhosphoSiteiQ6PD10.

Expressioni

Tissue specificityi

Highly expressed in brain and testis. Detected at much lower levels in heart, kidney, liver, lung and spleen.1 Publication

Gene expression databases

ArrayExpressiQ6PD10.
BgeeiQ6PD10.
CleanExiMM_IHPK1.
GenevestigatoriQ6PD10.

Structurei

3D structure databases

ProteinModelPortaliQ6PD10.
SMRiQ6PD10. Positions 206-424.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni220 – 2289Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOVERGENiHBG052140.
InParanoidiQ6PD10.
KOiK07756.
OMAiQTMEVGK.
OrthoDBiEOG747PHX.
PhylomeDBiQ6PD10.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PD10-1 [UniParc]FASTAAdd to Basket

« Hide

MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP    50
LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE 100
TVEQDDTPER EQPRRKHSRR SLHRSGSGSD HKEEKASLSF ETSESSQEAK 150
SPKVELHSHS DVPFQMLDSN SGLSSEKISY NPWSLRCHKQ QLSRMRSESK 200
DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ 250
STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG 300
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL 350
KHVDMGLPEV PPPCGPSTSP SSTSLEAGPS SPPKVDVRMI DFAHSTFKGF 400
RDDPTVHDGP DRGYVFGLEN LISIMEQMRD ENQ 433
Length:433
Mass (Da):49,307
Last modified:July 5, 2004 - v1
Checksum:i30BDF7B9DD473607
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti428 – 4292MR → VP in AAF15056. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177144 mRNA. Translation: AAF15056.1.
BC059006 mRNA. Translation: AAH59006.1.
CCDSiCCDS23514.1.
RefSeqiNP_038813.2. NM_013785.2.
UniGeneiMm.276155.

Genome annotation databases

EnsembliENSMUST00000035214; ENSMUSP00000035214; ENSMUSG00000032594.
GeneIDi27399.
KEGGimmu:27399.
UCSCiuc009roc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177144 mRNA. Translation: AAF15056.1 .
BC059006 mRNA. Translation: AAH59006.1 .
CCDSi CCDS23514.1.
RefSeqi NP_038813.2. NM_013785.2.
UniGenei Mm.276155.

3D structure databases

ProteinModelPortali Q6PD10.
SMRi Q6PD10. Positions 206-424.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6PD10.

Proteomic databases

MaxQBi Q6PD10.
PaxDbi Q6PD10.
PRIDEi Q6PD10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035214 ; ENSMUSP00000035214 ; ENSMUSG00000032594 .
GeneIDi 27399.
KEGGi mmu:27399.
UCSCi uc009roc.1. mouse.

Organism-specific databases

CTDi 9807.
MGIi MGI:1351633. Ip6k1.

Phylogenomic databases

eggNOGi NOG274869.
GeneTreei ENSGT00390000014381.
HOVERGENi HBG052140.
InParanoidi Q6PD10.
KOi K07756.
OMAi QTMEVGK.
OrthoDBi EOG747PHX.
PhylomeDBi Q6PD10.
TreeFami TF314066.

Enzyme and pathway databases

BRENDAi 2.7.4.21. 3474.
Reactomei REACT_196480. Synthesis of IPs in the nucleus.
REACT_196482. Synthesis of pyrophosphates in the cytosol.

Miscellaneous databases

ChiTaRSi IP6K1. mouse.
NextBioi 305384.
PROi Q6PD10.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PD10.
Bgeei Q6PD10.
CleanExi MM_IHPK1.
Genevestigatori Q6PD10.

Family and domain databases

InterProi IPR005522. IPK.
[Graphical view ]
PANTHERi PTHR12400. PTHR12400. 1 hit.
Pfami PF03770. IPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases."
    Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.
    Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiIP6K1_MOUSE
AccessioniPrimary (citable) accession number: Q6PD10
Secondary accession number(s): Q9QXV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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