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Protein

Inositol hexakisphosphate kinase 1

Gene

Ip6k1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.21. 3474.
ReactomeiREACT_316421. Synthesis of pyrophosphates in the cytosol.
REACT_333840. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene namesi
Name:Ip6k1
Synonyms:Ihpk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1351633. Ip6k1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Inositol hexakisphosphate kinase 1PRO_0000066875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PD10.
PaxDbiQ6PD10.
PRIDEiQ6PD10.

PTM databases

PhosphoSiteiQ6PD10.

Expressioni

Tissue specificityi

Highly expressed in brain and testis. Detected at much lower levels in heart, kidney, liver, lung and spleen.1 Publication

Gene expression databases

BgeeiQ6PD10.
CleanExiMM_IHPK1.
ExpressionAtlasiQ6PD10. baseline and differential.
GenevisibleiQ6PD10. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035214.

Structurei

3D structure databases

ProteinModelPortaliQ6PD10.
SMRiQ6PD10. Positions 206-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni220 – 2289Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOVERGENiHBG052140.
InParanoidiQ6PD10.
KOiK07756.
OMAiQTMEVGK.
OrthoDBiEOG747PHX.
PhylomeDBiQ6PD10.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PD10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP
60 70 80 90 100
LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE
110 120 130 140 150
TVEQDDTPER EQPRRKHSRR SLHRSGSGSD HKEEKASLSF ETSESSQEAK
160 170 180 190 200
SPKVELHSHS DVPFQMLDSN SGLSSEKISY NPWSLRCHKQ QLSRMRSESK
210 220 230 240 250
DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ
260 270 280 290 300
STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
310 320 330 340 350
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL
360 370 380 390 400
KHVDMGLPEV PPPCGPSTSP SSTSLEAGPS SPPKVDVRMI DFAHSTFKGF
410 420 430
RDDPTVHDGP DRGYVFGLEN LISIMEQMRD ENQ
Length:433
Mass (Da):49,307
Last modified:July 5, 2004 - v1
Checksum:i30BDF7B9DD473607
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti428 – 4292MR → VP in AAF15056 (PubMed:10574768).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177144 mRNA. Translation: AAF15056.1.
BC059006 mRNA. Translation: AAH59006.1.
CCDSiCCDS23514.1.
RefSeqiNP_038813.2. NM_013785.2.
UniGeneiMm.276155.

Genome annotation databases

EnsembliENSMUST00000035214; ENSMUSP00000035214; ENSMUSG00000032594.
GeneIDi27399.
KEGGimmu:27399.
UCSCiuc009roc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177144 mRNA. Translation: AAF15056.1.
BC059006 mRNA. Translation: AAH59006.1.
CCDSiCCDS23514.1.
RefSeqiNP_038813.2. NM_013785.2.
UniGeneiMm.276155.

3D structure databases

ProteinModelPortaliQ6PD10.
SMRiQ6PD10. Positions 206-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035214.

PTM databases

PhosphoSiteiQ6PD10.

Proteomic databases

MaxQBiQ6PD10.
PaxDbiQ6PD10.
PRIDEiQ6PD10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035214; ENSMUSP00000035214; ENSMUSG00000032594.
GeneIDi27399.
KEGGimmu:27399.
UCSCiuc009roc.1. mouse.

Organism-specific databases

CTDi9807.
MGIiMGI:1351633. Ip6k1.

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOVERGENiHBG052140.
InParanoidiQ6PD10.
KOiK07756.
OMAiQTMEVGK.
OrthoDBiEOG747PHX.
PhylomeDBiQ6PD10.
TreeFamiTF314066.

Enzyme and pathway databases

BRENDAi2.7.4.21. 3474.
ReactomeiREACT_316421. Synthesis of pyrophosphates in the cytosol.
REACT_333840. Synthesis of IPs in the nucleus.

Miscellaneous databases

ChiTaRSiIp6k1. mouse.
NextBioi305384.
PROiQ6PD10.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PD10.
CleanExiMM_IHPK1.
ExpressionAtlasiQ6PD10. baseline and differential.
GenevisibleiQ6PD10. MM.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases."
    Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.
    Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiIP6K1_MOUSE
AccessioniPrimary (citable) accession number: Q6PD10
Secondary accession number(s): Q9QXV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.