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Q6PD10 (IP6K1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol hexakisphosphate kinase 1

Short name=InsP6 kinase 1
EC=2.7.4.21
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene names
Name:Ip6k1
Synonyms:Ihpk1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Ref.1

Catalytic activity

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.

ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Highly expressed in brain and testis. Detected at much lower levels in heart, kidney, liver, lung and spleen. Ref.1

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Inositol hexakisphosphate kinase 1
PRO_0000066875

Regions

Region220 – 2289Substrate binding By similarity

Amino acid modifications

Modified residue1511Phosphoserine By similarity

Experimental info

Sequence conflict428 – 4292MR → VP in AAF15056. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6PD10 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 30BDF7B9DD473607

FASTA43349,307
        10         20         30         40         50         60 
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE 

        70         80         90        100        110        120 
SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTPER EQPRRKHSRR 

       130        140        150        160        170        180 
SLHRSGSGSD HKEEKASLSF ETSESSQEAK SPKVELHSHS DVPFQMLDSN SGLSSEKISY 

       190        200        210        220        230        240 
NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK 

       250        260        270        280        290        300 
AARQMRKCEQ STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG 

       310        320        330        340        350        360 
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL KHVDMGLPEV 

       370        380        390        400        410        420 
PPPCGPSTSP SSTSLEAGPS SPPKVDVRMI DFAHSTFKGF RDDPTVHDGP DRGYVFGLEN 

       430 
LISIMEQMRD ENQ 

« Hide

References

« Hide 'large scale' references
[1]"Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases."
Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H.
Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF177144 mRNA. Translation: AAF15056.1.
BC059006 mRNA. Translation: AAH59006.1.
CCDSCCDS23514.1.
RefSeqNP_038813.2. NM_013785.2.
UniGeneMm.276155.

3D structure databases

ProteinModelPortalQ6PD10.
SMRQ6PD10. Positions 206-424.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6PD10.

Proteomic databases

MaxQBQ6PD10.
PaxDbQ6PD10.
PRIDEQ6PD10.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035214; ENSMUSP00000035214; ENSMUSG00000032594.
GeneID27399.
KEGGmmu:27399.
UCSCuc009roc.1. mouse.

Organism-specific databases

CTD9807.
MGIMGI:1351633. Ip6k1.

Phylogenomic databases

eggNOGNOG274869.
GeneTreeENSGT00390000014381.
HOVERGENHBG052140.
InParanoidQ6PD10.
KOK07756.
OMAQTMEVGK.
OrthoDBEOG747PHX.
PhylomeDBQ6PD10.
TreeFamTF314066.

Enzyme and pathway databases

BRENDA2.7.4.21. 3474.

Gene expression databases

ArrayExpressQ6PD10.
BgeeQ6PD10.
CleanExMM_IHPK1.
GenevestigatorQ6PD10.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
PANTHERPTHR12400. PTHR12400. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIP6K1. mouse.
NextBio305384.
PROQ6PD10.
SOURCESearch...

Entry information

Entry nameIP6K1_MOUSE
AccessionPrimary (citable) accession number: Q6PD10
Secondary accession number(s): Q9QXV6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot