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Protein

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

Gene

Ppp2r5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-196299. Beta-catenin phosphorylation cascade.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-389513. CTLA4 inhibitory signaling.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-5673000. RAF activation.
R-MMU-5675221. Negative regulation of MAPK pathway.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Alternative name(s):
PP2A B subunit isoform B'-alpha
PP2A B subunit isoform B56-alpha
PP2A B subunit isoform PR61-alpha
Short name:
PR61alpha
PP2A B subunit isoform R5-alpha
Gene namesi
Name:Ppp2r5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2388479. Ppp2r5a.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Chromosomecentromere By similarity

  • Note: From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase (By similarity).By similarity

GO - Cellular componenti

  • chromosome, centromeric region Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • cytosol Source: Reactome
  • M band Source: BHF-UCL
  • membrane Source: Ensembl
  • nucleus Source: UniProtKB-SubCell
  • protein phosphatase type 2A complex Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000714492 – 486Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformAdd BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei41PhosphoserineBy similarity1
Modified residuei42PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6PD03.
MaxQBiQ6PD03.
PaxDbiQ6PD03.
PRIDEiQ6PD03.

PTM databases

iPTMnetiQ6PD03.
PhosphoSitePlusiQ6PD03.

Expressioni

Tissue specificityi

Widely expressed with highest levels in thymus and ovary.1 Publication

Gene expression databases

BgeeiENSMUSG00000026626.
ExpressionAtlasiQ6PD03. baseline and differential.
GenevisibleiQ6PD03. MM.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230562. 1 interactor.
IntActiQ6PD03. 2 interactors.
MINTiMINT-4086248.
STRINGi10090.ENSMUSP00000070726.

Structurei

3D structure databases

ProteinModelPortaliQ6PD03.
SMRiQ6PD03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2085. Eukaryota.
ENOG410XQJW. LUCA.
GeneTreeiENSGT00550000074525.
HOGENOMiHOG000067326.
HOVERGENiHBG000009.
InParanoidiQ6PD03.
KOiK11584.
OMAiKLQNCCF.
OrthoDBiEOG091G06HU.
PhylomeDBiQ6PD03.
TreeFamiTF105556.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR002554. PP2A_B56.
[Graphical view]
PANTHERiPTHR10257. PTHR10257. 1 hit.
PfamiPF01603. B56. 1 hit.
[Graphical view]
PIRSFiPIRSF028043. PP2A_B56. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PD03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPSPPAPV ACAAISASEK VDGFTRKSVR KAQRQKRSQG SSQFRSQGSQ
60 70 80 90 100
AELHPLPQLK DATSNEQQEL FCQKLQQCCV LFDFMDSVSD LKSKEIKRAT
110 120 130 140 150
LNELVEYVST NRGVIVESAY SDIVKMISAN IFRTLPPSDN PDFDPEEDEP
160 170 180 190 200
TLEASWPHIQ LVYEFFLRFL ESPDFQPSIA KRYIDQKFVQ QLLELFDSED
210 220 230 240 250
PRERDFLKTV LHRIYGKFLG LRAFIRKQIN NIFLRFIYET EHFNGVAELL
260 270 280 290 300
EILGSIINGF ALPLKAEHKQ FLMKVLIPMH TAKGLALFHA QLAYCVVQFL
310 320 330 340 350
EKDTTLTEPV IRGLLKFWPK TCSQKEVMFL GEIEEILDVI EPTQFKKIEE
360 370 380 390 400
PLFKQISKCV SSSHFQVAER ALYFWNNEYI LSLIEENIDK ILPIMFASLY
410 420 430 440 450
KISKEHWNQT IVALVYNVLK TLMEMNGKLF DDLTSSYKAE RQREKKKELE
460 470 480
REELWKKLEE LQLKKALEKQ NNAYNMHSIR SSTSAK
Length:486
Mass (Da):56,347
Last modified:July 5, 2004 - v1
Checksum:iBC9B0B80446C1AD2
GO

Sequence cautioni

The sequence AAH23062 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023062 mRNA. Translation: AAH23062.1. Different initiation.
BC059026 mRNA. Translation: AAH59026.1.
BK000647 mRNA. Translation: DAA01426.1.
CCDSiCCDS15620.1.
RefSeqiNP_659129.2. NM_144880.4.
UniGeneiMm.205569.

Genome annotation databases

EnsembliENSMUST00000067976; ENSMUSP00000070726; ENSMUSG00000026626.
GeneIDi226849.
KEGGimmu:226849.
UCSCiuc007eci.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023062 mRNA. Translation: AAH23062.1. Different initiation.
BC059026 mRNA. Translation: AAH59026.1.
BK000647 mRNA. Translation: DAA01426.1.
CCDSiCCDS15620.1.
RefSeqiNP_659129.2. NM_144880.4.
UniGeneiMm.205569.

3D structure databases

ProteinModelPortaliQ6PD03.
SMRiQ6PD03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230562. 1 interactor.
IntActiQ6PD03. 2 interactors.
MINTiMINT-4086248.
STRINGi10090.ENSMUSP00000070726.

PTM databases

iPTMnetiQ6PD03.
PhosphoSitePlusiQ6PD03.

Proteomic databases

EPDiQ6PD03.
MaxQBiQ6PD03.
PaxDbiQ6PD03.
PRIDEiQ6PD03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067976; ENSMUSP00000070726; ENSMUSG00000026626.
GeneIDi226849.
KEGGimmu:226849.
UCSCiuc007eci.1. mouse.

Organism-specific databases

CTDi5525.
MGIiMGI:2388479. Ppp2r5a.

Phylogenomic databases

eggNOGiKOG2085. Eukaryota.
ENOG410XQJW. LUCA.
GeneTreeiENSGT00550000074525.
HOGENOMiHOG000067326.
HOVERGENiHBG000009.
InParanoidiQ6PD03.
KOiK11584.
OMAiKLQNCCF.
OrthoDBiEOG091G06HU.
PhylomeDBiQ6PD03.
TreeFamiTF105556.

Enzyme and pathway databases

ReactomeiR-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-196299. Beta-catenin phosphorylation cascade.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-389513. CTLA4 inhibitory signaling.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-5673000. RAF activation.
R-MMU-5675221. Negative regulation of MAPK pathway.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-68877. Mitotic Prometaphase.

Miscellaneous databases

PROiQ6PD03.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026626.
ExpressionAtlasiQ6PD03. baseline and differential.
GenevisibleiQ6PD03. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR002554. PP2A_B56.
[Graphical view]
PANTHERiPTHR10257. PTHR10257. 1 hit.
PfamiPF01603. B56. 1 hit.
[Graphical view]
PIRSFiPIRSF028043. PP2A_B56. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei2A5A_MOUSE
AccessioniPrimary (citable) accession number: Q6PD03
Secondary accession number(s): Q8R1U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.