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Protein

V-type proton ATPase subunit E 1

Gene

Atp6v1e1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit E 1
Short name:
V-ATPase subunit E 1
Alternative name(s):
Vacuolar proton pump subunit E 1
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735157. Atp6v1e1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 226225V-type proton ATPase subunit E 1PRO_0000282342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei56 – 561PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6PCU2.
PRIDEiQ6PCU2.

PTM databases

iPTMnetiQ6PCU2.
PhosphoSiteiQ6PCU2.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with ALDOC. Interacts with RAB11B (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi255610. 1 interaction.
IntActiQ6PCU2. 2 interactions.
STRINGi10116.ENSRNOP00000016495.

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase E subunit family.Curated

Phylogenomic databases

eggNOGiKOG1664. Eukaryota.
COG1390. LUCA.
HOGENOMiHOG000202506.
HOVERGENiHBG002309.
InParanoidiQ6PCU2.
KOiK02150.
PhylomeDBiQ6PCU2.

Family and domain databases

HAMAPiMF_00311. ATP_synth_E_arch. 1 hit.
InterProiIPR002842. ATPase_V1/A1-cplx_esu.
[Graphical view]
PfamiPF01991. vATP-synt_E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PCU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSDADVQK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR
60 70 80 90 100
LKIMEYYEKK EKQIEQQKKI QMSNLMNQAR LKVLRARDDL ITDLLNEAKQ
110 120 130 140 150
RLSKVVKDTT RYQVLLDGLV LQGLYQLLEP RMIVRCRKQD FPLVKAAVQK
160 170 180 190 200
AIPMYKIATK KDVDVQIDLE AYLPEDIAGG VEIYNGDRKI KVSNTLESRL
210 220
DLIAQQMMPE VRGALFGANA NRKFLD
Length:226
Mass (Da):26,128
Last modified:July 5, 2004 - v1
Checksum:i5DCAAC2C77F09A08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059155 mRNA. Translation: AAH59155.1.
RefSeqiNP_942040.1. NM_198745.2.
UniGeneiRn.103171.

Genome annotation databases

GeneIDi297566.
KEGGirno:297566.
UCSCiRGD:735157. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059155 mRNA. Translation: AAH59155.1.
RefSeqiNP_942040.1. NM_198745.2.
UniGeneiRn.103171.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi255610. 1 interaction.
IntActiQ6PCU2. 2 interactions.
STRINGi10116.ENSRNOP00000016495.

PTM databases

iPTMnetiQ6PCU2.
PhosphoSiteiQ6PCU2.

Proteomic databases

PaxDbiQ6PCU2.
PRIDEiQ6PCU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi297566.
KEGGirno:297566.
UCSCiRGD:735157. rat.

Organism-specific databases

CTDi529.
RGDi735157. Atp6v1e1.

Phylogenomic databases

eggNOGiKOG1664. Eukaryota.
COG1390. LUCA.
HOGENOMiHOG000202506.
HOVERGENiHBG002309.
InParanoidiQ6PCU2.
KOiK02150.
PhylomeDBiQ6PCU2.

Miscellaneous databases

PROiQ6PCU2.

Family and domain databases

HAMAPiMF_00311. ATP_synth_E_arch. 1 hit.
InterProiIPR002842. ATPase_V1/A1-cplx_esu.
[Graphical view]
PfamiPF01991. vATP-synt_E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATE1_RAT
AccessioniPrimary (citable) accession number: Q6PCU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.