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Protein

F-box/LRR-repeat protein 19

Gene

FBXL19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri32 – 78CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri85 – 151PHD-typePROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 19
Alternative name(s):
F-box and leucine-rich repeat protein 19
Gene namesi
Name:FBXL19
Synonyms:FBL19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25300. FBXL19.

Subcellular locationi

GO - Cellular componenti

  • SCF ubiquitin ligase complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54620.
OpenTargetsiENSG00000099364.
PharmGKBiPA134911396.

Polymorphism and mutation databases

BioMutaiFBXL19.
DMDMi322510127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198681 – 694F-box/LRR-repeat protein 19Add BLAST694

Proteomic databases

EPDiQ6PCT2.
MaxQBiQ6PCT2.
PaxDbiQ6PCT2.
PeptideAtlasiQ6PCT2.
PRIDEiQ6PCT2.

PTM databases

iPTMnetiQ6PCT2.
PhosphoSitePlusiQ6PCT2.

Expressioni

Gene expression databases

BgeeiENSG00000099364.
ExpressionAtlasiQ6PCT2. baseline and differential.
GenevisibleiQ6PCT2. HS.

Organism-specific databases

HPAiHPA035317.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Il1rl1P147193EBI-6664563,EBI-525078From a different organism.

Protein-protein interaction databases

BioGridi120078. 19 interactors.
IntActiQ6PCT2. 17 interactors.
STRINGi9606.ENSP00000369666.

Structurei

3D structure databases

ProteinModelPortaliQ6PCT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini418 – 464F-boxAdd BLAST47
Repeati492 – 517LRR 1Add BLAST26
Repeati518 – 541LRR 2Add BLAST24
Repeati581 – 606LRR 3Add BLAST26
Repeati607 – 636LRR 4Add BLAST30
Repeati637 – 661LRR 5Add BLAST25
Repeati662 – 694LRR 6Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 25Poly-Ser4
Compositional biasi33 – 47Arg-richAdd BLAST15
Compositional biasi186 – 302Pro-richAdd BLAST117
Compositional biasi324 – 342Ser-richAdd BLAST19
Compositional biasi375 – 425Pro-richAdd BLAST51

Sequence similaritiesi

Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation
Contains 1 F-box domain.Curated
Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri32 – 78CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri85 – 151PHD-typePROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

Leucine-rich repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1633. Eukaryota.
KOG1947. Eukaryota.
ENOG410ZJED. LUCA.
GeneTreeiENSGT00550000074396.
HOGENOMiHOG000112677.
HOVERGENiHBG061227.
InParanoidiQ6PCT2.
KOiK10285.
OMAiMCQMLER.
OrthoDBiEOG091G04FK.
PhylomeDBiQ6PCT2.
TreeFamiTF338452.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF16866. PHD_4. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 2 hits.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PCT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGMKVPGKGE SGPSALLTPP MSSSSRGPGA GARRRRTRCR RCRACVRTEC
60 70 80 90 100
GDCHFCRDMK KFGGPGRMKQ SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV
110 120 130 140 150
EGEEEKFGLS LMECTICNEI VHPGCLKMGK AEGVINAEIP NCWECPRCTQ
160 170 180 190 200
EGRTSKDSGE GPGRRRADNG EEGASLGSGW KLTEEPPLPP PPPRRKGPLP
210 220 230 240 250
AGPPPEDVPG PPKRKEREAG NEPPTPRKKV KGGRERHLKK VGGDACLLRG
260 270 280 290 300
SDPGGPGLLP PRVLNPSQAF SSCHPGLPPE NWEKPKPPLA SAEGPAVPSP
310 320 330 340 350
SPQREKLERF KRMCQLLERV PDTSSSSSDS DSDSDSSGTS LSEDEAPGEA
360 370 380 390 400
RNGRRPARGS SGEKENRGGR RAVRPGSGGP LLSWPLGPAP PPRPPQLERH
410 420 430 440 450
VVRPPPRSPE PDTLPLAAGS DHPLPRAAWL RVFQHLGPRE LCICMRVCRT
460 470 480 490 500
WSRWCYDKRL WPRMDLSRRK SLTPPMLSGV VRRQPRALDL SWTGVSKKQL
510 520 530 540 550
MWLLNRLQGL QELVLSGCSW LSVSALGSAP LPALRLLDLR WIEDVKDSQL
560 570 580 590 600
RELLLPPPDT KPGQTESRGR LQGVAELRLA GLELTDASLR LLLRHAPQLS
610 620 630 640 650
ALDLSHCAHV GDPSVHLLTA PTSPLRETLV HLNLAGCHRL TDHCLPLFRR
660 670 680 690
CPRLRRLDLR SCRQLSPEAC ARLAAAGPPG PFRCPEEKLL LKDS
Length:694
Mass (Da):75,707
Last modified:February 8, 2011 - v3
Checksum:i8D8A3BC4C86AD396
GO
Isoform 2 (identifier: Q6PCT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-283: Missing.

Show »
Length:651
Mass (Da):71,329
Checksum:i282689D6317F33E1
GO
Isoform 3 (identifier: Q6PCT2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-694: HCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS → PAGLGPWAPGLYNTVCYKTQNLP

Show »
Length:665
Mass (Da):72,253
Checksum:iB85235994C4852C5
GO

Sequence cautioni

The sequence AAH59173 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC05410 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013015241 – 283Missing in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_040503643 – 694HCLPL…LLKDS → PAGLGPWAPGLYNTVCYKTQ NLP in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135048 Genomic DNA. No translation available.
BC059173 mRNA. Translation: AAH59173.1. Different initiation.
AK098777 mRNA. Translation: BAC05410.1. Different initiation.
AL137589 mRNA. Translation: CAB70830.1.
CCDSiCCDS45465.1. [Q6PCT2-1]
PIRiT46301.
RefSeqiNP_001093254.2. NM_001099784.2. [Q6PCT2-1]
NP_001269280.1. NM_001282351.1.
UniGeneiHs.152149.

Genome annotation databases

EnsembliENST00000380310; ENSP00000369666; ENSG00000099364. [Q6PCT2-1]
GeneIDi54620.
KEGGihsa:54620.
UCSCiuc002eab.2. human. [Q6PCT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135048 Genomic DNA. No translation available.
BC059173 mRNA. Translation: AAH59173.1. Different initiation.
AK098777 mRNA. Translation: BAC05410.1. Different initiation.
AL137589 mRNA. Translation: CAB70830.1.
CCDSiCCDS45465.1. [Q6PCT2-1]
PIRiT46301.
RefSeqiNP_001093254.2. NM_001099784.2. [Q6PCT2-1]
NP_001269280.1. NM_001282351.1.
UniGeneiHs.152149.

3D structure databases

ProteinModelPortaliQ6PCT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120078. 19 interactors.
IntActiQ6PCT2. 17 interactors.
STRINGi9606.ENSP00000369666.

PTM databases

iPTMnetiQ6PCT2.
PhosphoSitePlusiQ6PCT2.

Polymorphism and mutation databases

BioMutaiFBXL19.
DMDMi322510127.

Proteomic databases

EPDiQ6PCT2.
MaxQBiQ6PCT2.
PaxDbiQ6PCT2.
PeptideAtlasiQ6PCT2.
PRIDEiQ6PCT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380310; ENSP00000369666; ENSG00000099364. [Q6PCT2-1]
GeneIDi54620.
KEGGihsa:54620.
UCSCiuc002eab.2. human. [Q6PCT2-1]

Organism-specific databases

CTDi54620.
DisGeNETi54620.
GeneCardsiFBXL19.
H-InvDBHIX0020867.
HGNCiHGNC:25300. FBXL19.
HPAiHPA035317.
MIMi609085. gene.
neXtProtiNX_Q6PCT2.
OpenTargetsiENSG00000099364.
PharmGKBiPA134911396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1633. Eukaryota.
KOG1947. Eukaryota.
ENOG410ZJED. LUCA.
GeneTreeiENSGT00550000074396.
HOGENOMiHOG000112677.
HOVERGENiHBG061227.
InParanoidiQ6PCT2.
KOiK10285.
OMAiMCQMLER.
OrthoDBiEOG091G04FK.
PhylomeDBiQ6PCT2.
TreeFamiTF338452.

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXL19. human.
GenomeRNAii54620.
PROiQ6PCT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099364.
ExpressionAtlasiQ6PCT2. baseline and differential.
GenevisibleiQ6PCT2. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF16866. PHD_4. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 2 hits.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXL19_HUMAN
AccessioniPrimary (citable) accession number: Q6PCT2
Secondary accession number(s): A8MT10, Q8N789, Q9NT14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 8, 2011
Last modified: November 30, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.