Reviewed, UniProtKB/Swiss-Prot Q8TDR0 (MIPT3_HUMAN)

Names and origin

Protein names

Recommended name:
    TRAF3-interacting protein 1
Alternative name(s):
    Microtubule-interacting protein associated with TRAF3
      Short name=MIP-T3
    Interleukin 13 receptor alpha 1-binding protein 1

Gene names

Name:	TRAF3IP1
Synonyms:	MIPT3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	691 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Play an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Ref.1 Ref.2 Ref.8
Subunit structure	Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1. Ref.1 Ref.2 Ref.8
Subcellular location	Cytoplasm › cytoskeleton. Note= Microtubules. Ref.2
Tissue specificity	Ubiquitous. Ref.2
Sequence similarities	Belongs to the TRAF3IP1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TDR0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TDR0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     355-420: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 691	691	TRAF3-interacting protein 1		PRO_0000299544
Regions
	Region	1 – 323	323	Abolishes microtubules-binding when missing
	Region	223 – 691	469	DISC1-interaction domain
	Coiled coil	571 – 666	96	Potential
	Compositional bias	211 – 281	71	Arg-rich
Amino acid modifications
	Modified residue	476	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	355 – 420	66	Missing in isoform 2.		VSP_027734
	Natural variant	228	1	N → S: dbSNP rs3769110. Ref.5		VAR_034841
	Natural variant	239	1	R → W: dbSNP rs34723381.		VAR_034842
	Natural variant	295	1	K → N: dbSNP rs12464423.		VAR_051185
	Natural variant	620	1	M → L: dbSNP rs3739070.		VAR_034843

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 0675AA0E5319D2EB	FASTA	691	78,632
	10 20 30 40 50 60 MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK GLYTDAEMKS 70 80 90 100 110 120 DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE PERTNELLQI IGKCCLNKLS 130 140 150 160 170 180 SDDAVRRVLA GEKGEVKGRA SLTSRSQELD NKNVREEESR VHKNTEDRGD AEIKERSTSR 190 200 210 220 230 240 DRKQKEELKE DRKPREKDKD KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD 250 260 270 280 290 300 RDSERKKETE RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD 310 320 330 340 350 360 KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK NSVEGRKEDN 370 380 390 400 410 420 ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD DNSASLRCEN IQPNPTEKQK 430 440 450 460 470 480 GDSTSDAEGD AGPAGQDKSE VPETPEIPNE LSSNIRRIPR PGSARPAPPR VKRQDSMEAL 490 500 510 520 530 540 QMDRSGSGKT VSNVITESHN SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL 550 560 570 580 590 600 VKKILETKKD YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL 610 620 630 640 650 660 GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL AELEQLIKDQ 670 680 690 QDKICAVKAN ILKNEEKIQK MVYSINLTSR R
	Isoform 2. Checksum: FDF49249C140E026		625	71,529
	10 20 30 40 50 60 MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK GLYTDAEMKS 70 80 90 100 110 120 DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE PERTNELLQI IGKCCLNKLS 130 140 150 160 170 180 SDDAVRRVLA GEKGEVKGRA SLTSRSQELD NKNVREEESR VHKNTEDRGD AEIKERSTSR 190 200 210 220 230 240 DRKQKEELKE DRKPREKDKD KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD 250 260 270 280 290 300 RDSERKKETE RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD 310 320 330 340 350 360 KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK NSVEGDSTSD 370 380 390 400 410 420 AEGDAGPAGQ DKSEVPETPE IPNELSSNIR RIPRPGSARP APPRVKRQDS MEALQMDRSG 430 440 450 460 470 480 SGKTVSNVIT ESHNSDNEED DQFVVEAAPQ LSEMSEIEMV TAVELEEEEK HGGLVKKILE 490 500 510 520 530 540 TKKDYEKLQQ SPKPGEKERS LFESAWKKEK DIVSKEIEKL RTSIQTLCKS ALPLGKIMDY 550 560 570 580 590 600 IQEDVDAMQN ELQMWHSENR QHAEALQQEQ RITDCAVEPL KAELAELEQL IKDQQDKICA 610 620 VKANILKNEE KIQKMVYSIN LTSRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network." Ling L., Goeddel D.V. J. Biol. Chem. 275:23852-23860(2000) [PubMed: 10791955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH IL13RA1.
[2]	"MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation." Niu Y., Murata T., Watanabe K., Kawakami K., Yoshimura A., Inoue J., Puri R.K., Kobayashi N. FEBS Lett. 550:139-143(2003) [PubMed: 12935900] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION, REGION, INTERACTION WITH TRAF3. Tissue: Testis.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-228. Tissue: PNS.
[6]	The German cDNA consortium Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-691 (ISOFORM 2). Tissue: Testis.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-476, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation." Morris J.A., Kandpal G., Ma L., Austin C.P. Hum. Mol. Genet. 12:1591-1608(2003) [PubMed: 12812986] [Abstract] Cited for: FUNCTION, INTERACTION WITH DISC1, REGION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF230877 mRNA. Translation: AAF76984.1. AF242456 mRNA. Translation: AAL90444.1. AC012485 Genomic DNA. Translation: AAX88977.1. CH471063 Genomic DNA. Translation: EAW71157.1. BC059174 mRNA. Translation: AAH59174.1. AL080153 mRNA. Translation: CAB45744.1.
PIR	T12536.
RefSeq	NP_056465.2.
UniGene	Hs.631898
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8TDR0.
Proteomic databases
PRIDE	Q8TDR0.
Genome annotation databases
Ensembl	ENSG00000204104. Homo sapiens. [Contig view]
GeneID	26146.
KEGG	hsa:26146.
Organism-specific databases
GeneCards	GC02P238893.
HGNC	HGNC:17861. TRAF3IP1.
MIM	607380. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8TDR0.
HOVERGEN	Q8TDR0.
Gene expression databases
ArrayExpress	Q8TDR0.
CleanEx	HS_TRAF3IP1.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	48201.
SOURCE	Search...

Entry information

Entry name

MIPT3_HUMAN

Accession

Primary (citable) accession number: Q8TDR0
Secondary accession number(s): Q6PCT1 , Q7L8N9, Q9NRD6, Q9Y4Q1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 1, 2002
Last modified:	December 16, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)