Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable G-protein coupled receptor 156

Gene

Gpr156

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 156
Alternative name(s):
GABAB-related G-protein coupled receptor
Gene namesi
Name:Gpr156
Synonyms:Gababl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2653880. Gpr156.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949ExtracellularSequence analysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini71 – 8616CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini108 – 11811ExtracellularSequence analysisAdd
BLAST
Transmembranei119 – 13921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini140 – 16425CytoplasmicSequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini186 – 22237ExtracellularSequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini244 – 25714CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini279 – 28810ExtracellularSequence analysis
Transmembranei289 – 30921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini310 – 798489CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 798798Probable G-protein coupled receptor 156PRO_0000206900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PCP7.
PRIDEiQ6PCP7.

PTM databases

iPTMnetiQ6PCP7.
PhosphoSiteiQ6PCP7.

Expressioni

Gene expression databases

BgeeiQ6PCP7.
CleanExiMM_GPR156.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055958.

Structurei

3D structure databases

ProteinModelPortaliQ6PCP7.
SMRiQ6PCP7. Positions 344-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili353 – 39038Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi266 – 2694Poly-Leu
Compositional biasi584 – 5874Poly-Arg
Compositional biasi730 – 7356Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
HOGENOMiHOG000168413.
HOVERGENiHBG081567.
InParanoidiQ6PCP7.
KOiK04617.
OrthoDBiEOG7BW0J0.
PhylomeDBiQ6PCP7.
TreeFamiTF313965.

Family and domain databases

InterProiIPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PCP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEINCSEF CDSFPGQELD RRPLHDLCKT TITESQHSST AASPLSPALL
60 70 80 90 100
GIMWTFLSCG LLLVLFFLAF TIRCRKNRIV KMSSPNLNVV TLLGSCLTYI
110 120 130 140 150
SAYLFGIQDA LEGSSVEALI QTRLSLLCIG TSLVFGPILG KSWRLYKVFT
160 170 180 190 200
QRVPDKRVII KDLQLLGLVA ALVVADVILL VTWVLTDPIQ CLQMLGVSMK
210 220 230 240 250
VTGRDVSCSL TNTHFCASRY SDVWIALVLG CKGLLLLYGA YLAGLTNHVS
260 270 280 290 300
SPPVNQSLTI MVGVNLLLLT AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
310 320 330 340 350
TTVNCCVFIP QLKQWKAFEG ENQTMRHMAK YFSTPSKSFH SQFDEDPSCH
360 370 380 390 400
LRDEKSCMER LLTEKNAVIE SLQEQVSNAK EKLVKLMSAE CTYDSPEWAV
410 420 430 440 450
PDAASARGLA LPGPSECPAV SENESGAAAR DSLHVPAACQ HVQGPGASRR
460 470 480 490 500
DTSPSPAQQD NMPLKQYCDH LDTGCNQKPK AEQSEGPERG DQEPMAPSQR
510 520 530 540 550
LMADGVACEP HKPRQSPEGL PKKLPGVSSV VREKLQEVLQ ELDLGSEAPL
560 570 580 590 600
SPLPCPQQLW KSTTSRSPQK LSPSKLGFSP YVVRRRRAAQ RARSHIPGSV
610 620 630 640 650
GLNVGHQANS TVSSSQSGLI VQNRDSPRLD HHNARSKVPR SSSVKPSPLS
660 670 680 690 700
EPRRKQGTLE GSKQCETEPQ EAGGACNVAF PCQSSASVQA QSPAAPCLPS
710 720 730 740 750
SPALPRQRQP RPRLSPGCPS LSSGCYNLDS ESSSSDEFFC RCHRPYCEIC
760 770 780 790
FQSSLDSNDS DTSDSDLEQA SGLASWEKLW ARSKPVVNFK DDLKPTLV
Length:798
Mass (Da):87,040
Last modified:August 16, 2005 - v2
Checksum:iA4DDCA5F42752BAC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti341 – 3411S → G in AAH59227 (PubMed:15489334).Curated
Sequence conflicti484 – 4841S → R in AAN03796 (PubMed:12591167).Curated
Sequence conflicti569 – 5691Q → R in AAN03796 (PubMed:12591167).Curated
Sequence conflicti573 – 5731P → T in AAN03796 (PubMed:12591167).Curated
Sequence conflicti621 – 6211V → I in AAN03796 (PubMed:12591167).Curated
Sequence conflicti629 – 6291L → Q in AAN03796 (PubMed:12591167).Curated
Sequence conflicti632 – 6321H → N in AAH59227 (PubMed:15489334).Curated
Sequence conflicti777 – 7771E → G in AAH59227 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488740 mRNA. Translation: AAN03796.1.
BC059227 mRNA. Translation: AAH59227.1.
CCDSiCCDS28162.1.
RefSeqiNP_700443.2. NM_153394.2.
UniGeneiMm.228018.

Genome annotation databases

GeneIDi239845.
KEGGimmu:239845.
UCSCiuc007zel.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488740 mRNA. Translation: AAN03796.1.
BC059227 mRNA. Translation: AAH59227.1.
CCDSiCCDS28162.1.
RefSeqiNP_700443.2. NM_153394.2.
UniGeneiMm.228018.

3D structure databases

ProteinModelPortaliQ6PCP7.
SMRiQ6PCP7. Positions 344-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055958.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6PCP7.
PhosphoSiteiQ6PCP7.

Proteomic databases

PaxDbiQ6PCP7.
PRIDEiQ6PCP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi239845.
KEGGimmu:239845.
UCSCiuc007zel.1. mouse.

Organism-specific databases

CTDi165829.
MGIiMGI:2653880. Gpr156.

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
HOGENOMiHOG000168413.
HOVERGENiHBG081567.
InParanoidiQ6PCP7.
KOiK04617.
OrthoDBiEOG7BW0J0.
PhylomeDBiQ6PCP7.
TreeFamiTF313965.

Miscellaneous databases

PROiQ6PCP7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PCP7.
CleanExiMM_GPR156.

Family and domain databases

InterProiIPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiGP156_MOUSE
AccessioniPrimary (citable) accession number: Q6PCP7
Secondary accession number(s): Q8K452
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: June 8, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.