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Protein

Probable G-protein coupled receptor 156

Gene

Gpr156

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 156
Alternative name(s):
GABAB-related G-protein coupled receptor
Gene namesi
Name:Gpr156
Synonyms:Gababl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2653880. Gpr156.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini71 – 86CytoplasmicSequence analysisAdd BLAST16
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 118ExtracellularSequence analysisAdd BLAST11
Transmembranei119 – 139Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini140 – 164CytoplasmicSequence analysisAdd BLAST25
Transmembranei165 – 185Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini186 – 222ExtracellularSequence analysisAdd BLAST37
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini244 – 257CytoplasmicSequence analysisAdd BLAST14
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 288ExtracellularSequence analysis10
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 798CytoplasmicSequence analysisAdd BLAST489

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002069001 – 798Probable G-protein coupled receptor 156Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PCP7.
PRIDEiQ6PCP7.

PTM databases

iPTMnetiQ6PCP7.
PhosphoSitePlusiQ6PCP7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046961.
CleanExiMM_GPR156.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055958.

Structurei

3D structure databases

ProteinModelPortaliQ6PCP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili353 – 390Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi266 – 269Poly-Leu4
Compositional biasi584 – 587Poly-Arg4
Compositional biasi730 – 735Poly-Ser6

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
HOGENOMiHOG000168413.
HOVERGENiHBG081567.
InParanoidiQ6PCP7.
KOiK04617.
PhylomeDBiQ6PCP7.
TreeFamiTF313965.

Family and domain databases

InterProiIPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PCP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEINCSEF CDSFPGQELD RRPLHDLCKT TITESQHSST AASPLSPALL
60 70 80 90 100
GIMWTFLSCG LLLVLFFLAF TIRCRKNRIV KMSSPNLNVV TLLGSCLTYI
110 120 130 140 150
SAYLFGIQDA LEGSSVEALI QTRLSLLCIG TSLVFGPILG KSWRLYKVFT
160 170 180 190 200
QRVPDKRVII KDLQLLGLVA ALVVADVILL VTWVLTDPIQ CLQMLGVSMK
210 220 230 240 250
VTGRDVSCSL TNTHFCASRY SDVWIALVLG CKGLLLLYGA YLAGLTNHVS
260 270 280 290 300
SPPVNQSLTI MVGVNLLLLT AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
310 320 330 340 350
TTVNCCVFIP QLKQWKAFEG ENQTMRHMAK YFSTPSKSFH SQFDEDPSCH
360 370 380 390 400
LRDEKSCMER LLTEKNAVIE SLQEQVSNAK EKLVKLMSAE CTYDSPEWAV
410 420 430 440 450
PDAASARGLA LPGPSECPAV SENESGAAAR DSLHVPAACQ HVQGPGASRR
460 470 480 490 500
DTSPSPAQQD NMPLKQYCDH LDTGCNQKPK AEQSEGPERG DQEPMAPSQR
510 520 530 540 550
LMADGVACEP HKPRQSPEGL PKKLPGVSSV VREKLQEVLQ ELDLGSEAPL
560 570 580 590 600
SPLPCPQQLW KSTTSRSPQK LSPSKLGFSP YVVRRRRAAQ RARSHIPGSV
610 620 630 640 650
GLNVGHQANS TVSSSQSGLI VQNRDSPRLD HHNARSKVPR SSSVKPSPLS
660 670 680 690 700
EPRRKQGTLE GSKQCETEPQ EAGGACNVAF PCQSSASVQA QSPAAPCLPS
710 720 730 740 750
SPALPRQRQP RPRLSPGCPS LSSGCYNLDS ESSSSDEFFC RCHRPYCEIC
760 770 780 790
FQSSLDSNDS DTSDSDLEQA SGLASWEKLW ARSKPVVNFK DDLKPTLV
Length:798
Mass (Da):87,040
Last modified:August 16, 2005 - v2
Checksum:iA4DDCA5F42752BAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti341S → G in AAH59227 (PubMed:15489334).Curated1
Sequence conflicti484S → R in AAN03796 (PubMed:12591167).Curated1
Sequence conflicti569Q → R in AAN03796 (PubMed:12591167).Curated1
Sequence conflicti573P → T in AAN03796 (PubMed:12591167).Curated1
Sequence conflicti621V → I in AAN03796 (PubMed:12591167).Curated1
Sequence conflicti629L → Q in AAN03796 (PubMed:12591167).Curated1
Sequence conflicti632H → N in AAH59227 (PubMed:15489334).Curated1
Sequence conflicti777E → G in AAH59227 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488740 mRNA. Translation: AAN03796.1.
BC059227 mRNA. Translation: AAH59227.1.
CCDSiCCDS28162.1.
RefSeqiNP_700443.2. NM_153394.2.
UniGeneiMm.228018.

Genome annotation databases

GeneIDi239845.
KEGGimmu:239845.
UCSCiuc007zel.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488740 mRNA. Translation: AAN03796.1.
BC059227 mRNA. Translation: AAH59227.1.
CCDSiCCDS28162.1.
RefSeqiNP_700443.2. NM_153394.2.
UniGeneiMm.228018.

3D structure databases

ProteinModelPortaliQ6PCP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055958.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6PCP7.
PhosphoSitePlusiQ6PCP7.

Proteomic databases

PaxDbiQ6PCP7.
PRIDEiQ6PCP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi239845.
KEGGimmu:239845.
UCSCiuc007zel.1. mouse.

Organism-specific databases

CTDi165829.
MGIiMGI:2653880. Gpr156.

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
HOGENOMiHOG000168413.
HOVERGENiHBG081567.
InParanoidiQ6PCP7.
KOiK04617.
PhylomeDBiQ6PCP7.
TreeFamiTF313965.

Miscellaneous databases

PROiQ6PCP7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046961.
CleanExiMM_GPR156.

Family and domain databases

InterProiIPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP156_MOUSE
AccessioniPrimary (citable) accession number: Q6PCP7
Secondary accession number(s): Q8K452
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.