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Protein

Tau-tubulin kinase 1

Gene

Ttbk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Divalent metal cations. Mg2+ or, to a lesser extent, Mn2+, but not Ca2+ or Zn2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATPPROSITE-ProRule annotation1
Active sitei154Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 48ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tau-tubulin kinase 1 (EC:2.7.11.1)
Gene namesi
Name:Ttbk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2147036. Ttbk1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002785421 – 1308Tau-tubulin kinase 1Add BLAST1308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei441PhosphoserineCombined sources1
Modified residuei541PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PCN3.
PaxDbiQ6PCN3.
PeptideAtlasiQ6PCN3.
PRIDEiQ6PCN3.

PTM databases

iPTMnetiQ6PCN3.
PhosphoSitePlusiQ6PCN3.

Expressioni

Tissue specificityi

Expressed in the brain. Strong expression in the cortical layers, the CA1 layers of the hippocampus and the granular layer of the cerebellum. Also expressed in the large cortical pyramidal cells in the temporal cortex, the CA1 pyramidal neurons and the cerebellum granular neurons.1 Publication

Gene expression databases

BgeeiENSMUSG00000015599.
CleanExiMM_TTBK1.
GenevisibleiQ6PCN3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044580.

Structurei

3D structure databases

ProteinModelPortaliQ6PCN3.
SMRiQ6PCN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 297Protein kinasePROSITE-ProRule annotationAdd BLAST264

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi734 – 796Glu-richAdd BLAST63
Compositional biasi1103 – 1107Poly-Ser5

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1164. Eukaryota.
ENOG410XPGP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000154701.
HOVERGENiHBG094095.
InParanoidiQ6PCN3.
KOiK08815.
OMAiATTKGRA.
OrthoDBiEOG091G03H8.
PhylomeDBiQ6PCN3.
TreeFamiTF351646.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PCN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCLAAALKD ETNMSGGGEQ ADILPANYVV KDRWKVLKKI GGGGFGEIYE
60 70 80 90 100
AMDLLTRENV ALKVESAQQP KQVLKMEVAV LKKLQGKDHV CRFIGCGRNE
110 120 130 140 150
KFNYVVMQLQ GRNLADLRRS QPRGTFTLST TLRLGKQILE SIEAIHSVGF
160 170 180 190 200
LHRDIKPSNF AMGRLPSTYR KCYMLDFGLA RQYTNTTGDV RPPRNVAGFR
210 220 230 240 250
GTVRYASVNA HKNREMGRHD DLWSLFYMLV EFAVGQLPWR KIKDKEQVGM
260 270 280 290 300
IKEKYEHRML LKHMPSEFHL FLDHIASLDY FTKPDYQLIM SVFENSMKER
310 320 330 340 350
GIAENEAFDW EKAGTDALLS TSTSTPPQQN TRQTAAMFGV VNVTPVPGDL
360 370 380 390 400
LRENTEDVLQ GEHLSDQENA PPILPGRPPE GLGPGPHLVP HPGGPEAEVW
410 420 430 440 450
EETDVNRNKL RINIGKTPCV EEEQSRGVGV PSSPVRAPPD SPTTPVRSLC
460 470 480 490 500
YRRVNSPESE RLSTAADGRV ELQERRSRMD LPGSPSRQAC SSQPAQMLSV
510 520 530 540 550
DTGHADRQAS GRMDVSASVE QEALSNAFRS VPLAEEEDFD SKEWVIIDKE
560 570 580 590 600
TELKDFPPGA EPSTSGTTDE EPEELRPLPE EGEERRRLGT EPTVRPRGRG
610 620 630 640 650
MHTLTEEDPR QMLPQPAPPQ LSQADGRSET SQPPTPGSPS HSPLHSGPRP
660 670 680 690 700
RRRESDPTGP QRQVFSVAPP FEVNGLPRAV PLALPYQDFK RDLSDYRERA
710 720 730 740 750
RLLNRVRRVG FSHMLLTAPQ VPLAPFQPQA NGKEGEEEEE EEEEEEEEEE
760 770 780 790 800
EEEEEEEEEE EEEEEEEEAG ALGEVLGPRS GSSSEGSERS TERSQEGAPS
810 820 830 840 850
TLLADDQKEA RGRASMADGD LEPEEGSKTL VLVSPGDMKK SPVTAELAPD
860 870 880 890 900
PDLGTLAALT PQHERPQPTG SQLDVSEPGT LSSILKSEPK PSGPGAGGGV
910 920 930 940 950
GLVAPGAGVT AVTSPFTKVE RTFVHIAEKS HLNVMSSGGQ ASRPEELSTG
960 970 980 990 1000
GELGLEVLSE GGIAEEGAPA PLENGMALAG LDGTEMESCA LSGPPGETPS
1010 1020 1030 1040 1050
EVVTDSLPNG PALADGPAPA SQQEPVTKKG TTISPSRHAM PGSRPRSRIP
1060 1070 1080 1090 1100
VLLSEEDTGS EPSGSLSAKE RWSKRARPQQ DLARLVMEKR QGRLLLRLAS
1110 1120 1130 1140 1150
GASSSSSEEQ RRASETLSGT GSEEDTPASE PTTALPRKAV RAATTRSRIP
1160 1170 1180 1190 1200
RPISVSMPVE GQQLPGRPHG AASATDLAIT SRLQLQKPSG LAPAADLRPK
1210 1220 1230 1240 1250
QSASRGPGPG RAQVSKPAAP RSPGLPASTA RHPSGSPRSQ SLSRKESSSP
1260 1270 1280 1290 1300
SHQARPGVPP SRGVLQVRSQ PEASPVAPKK GPKGKQLQTQ RAATKGRAVV

SEGRPGAR
Length:1,308
Mass (Da):141,613
Last modified:February 20, 2007 - v3
Checksum:i8940FE7A58889736
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC165445 Genomic DNA. No translation available.
CAAA01116144 Genomic DNA. No translation available.
BC059249 mRNA. Translation: AAH59249.3.
CCDSiCCDS50125.1.
RefSeqiNP_001156336.1. NM_001162864.1.
UniGeneiMm.297613.

Genome annotation databases

EnsembliENSMUST00000047034; ENSMUSP00000044580; ENSMUSG00000015599.
GeneIDi106763.
KEGGimmu:106763.
UCSCiuc008csx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC165445 Genomic DNA. No translation available.
CAAA01116144 Genomic DNA. No translation available.
BC059249 mRNA. Translation: AAH59249.3.
CCDSiCCDS50125.1.
RefSeqiNP_001156336.1. NM_001162864.1.
UniGeneiMm.297613.

3D structure databases

ProteinModelPortaliQ6PCN3.
SMRiQ6PCN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044580.

PTM databases

iPTMnetiQ6PCN3.
PhosphoSitePlusiQ6PCN3.

Proteomic databases

MaxQBiQ6PCN3.
PaxDbiQ6PCN3.
PeptideAtlasiQ6PCN3.
PRIDEiQ6PCN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047034; ENSMUSP00000044580; ENSMUSG00000015599.
GeneIDi106763.
KEGGimmu:106763.
UCSCiuc008csx.2. mouse.

Organism-specific databases

CTDi84630.
MGIiMGI:2147036. Ttbk1.

Phylogenomic databases

eggNOGiKOG1164. Eukaryota.
ENOG410XPGP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000154701.
HOVERGENiHBG094095.
InParanoidiQ6PCN3.
KOiK08815.
OMAiATTKGRA.
OrthoDBiEOG091G03H8.
PhylomeDBiQ6PCN3.
TreeFamiTF351646.

Miscellaneous databases

PROiQ6PCN3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015599.
CleanExiMM_TTBK1.
GenevisibleiQ6PCN3. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTBK1_MOUSE
AccessioniPrimary (citable) accession number: Q6PCN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.