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Q6PCL9

- PAPOG_MOUSE

UniProt

Q6PCL9 - PAPOG_MOUSE

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Protein

Poly(A) polymerase gamma

Gene
Papolg
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA By similarity.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Binds 2 magnesium ions. Also active with manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081ATP By similarity
Metal bindingi112 – 1121Magnesium 1; catalytic By similarity
Metal bindingi112 – 1121Magnesium 2; catalytic By similarity
Metal bindingi114 – 1141Magnesium 1; catalytic By similarity
Metal bindingi114 – 1141Magnesium 2; catalytic By similarity
Sitei152 – 1521Interaction with RNA By similarity
Sitei157 – 1571Interaction with RNA By similarity
Metal bindingi166 – 1661Magnesium 2; catalytic By similarity
Binding sitei166 – 1661ATP By similarity
Binding sitei227 – 2271ATP By similarity
Binding sitei236 – 2361ATP By similarity
Sitei327 – 3271Interaction with RNA By similarity
Sitei398 – 3981Interaction with RNA By similarity
Sitei531 – 5311Interaction with RNA By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi99 – 1013ATP By similarity
Nucleotide bindingi112 – 1143ATP By similarity
Nucleotide bindingi245 – 2462ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB
  3. polynucleotide adenylyltransferase activity Source: UniProtKB
  4. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA polyadenylation Source: RefGenome
  2. RNA polyadenylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase gamma (EC:2.7.7.19)
Short name:
PAP-gamma
Alternative name(s):
Polynucleotide adenylyltransferase gamma
SRP RNA 3'-adenylating enzyme
Gene namesi
Name:Papolg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2442119. Papolg.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Poly(A) polymerase gammaPRO_0000253025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N6-acetyllysine By similarity
Modified residuei23 – 231Phosphoserine By similarity
Modified residuei651 – 6511Phosphoserine By similarity
Modified residuei657 – 6571Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6PCL9.
PRIDEiQ6PCL9.

PTM databases

PhosphoSiteiQ6PCL9.

Expressioni

Gene expression databases

ArrayExpressiQ6PCL9.
BgeeiQ6PCL9.
CleanExiMM_PAPOLG.
GenevestigatoriQ6PCL9.

Structurei

3D structure databases

ProteinModelPortaliQ6PCL9.
SMRiQ6PCL9. Positions 17-501.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5186.
GeneTreeiENSGT00390000017928.
HOGENOMiHOG000204376.
HOVERGENiHBG053502.
InParanoidiQ6PCL9.
KOiK14376.
OMAiGECMPIP.
OrthoDBiEOG7XH6PT.
PhylomeDBiQ6PCL9.
TreeFamiTF300842.

Family and domain databases

Gene3Di3.30.70.590. 1 hit.
InterProiIPR002934. Nucleotidyltransferase.
IPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMiSSF55003. SSF55003. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PCL9-1 [UniParc]FASTAAdd to Basket

« Hide

MKEMSANTML DSQRQQKHYG ITSPISLACP KEIDHIYTQK LIDAMKPFGV    50
FEDEEELNHR LVVLGKLNNL VKEWISDISE SKNLPPSVVA TVGGKIFTFG 100
SYRLGVHTKG ADIDALCVAP RHVERSDFFQ SFFEKLKHQD GIRNLRAVED 150
AFVPVIKFEF DGIEIDLVFA RLAIQTISDN LDLRDDSRLR SLDIRCIRSL 200
NGCRVTDEIL HLVPNKETFR LTLRAVKLWA KRRGIYSNML GFLGGVSWAM 250
LVARTCQLYP NAAASTLVHK FFLVFSKWEW PNPVLLKQPE ESNLNLPVWD 300
PRVNPSDRYH LMPIITPAYP QQNSTYNVST STRTVMVEEF KQGLAVTDEI 350
LQGKSDWSKL LEPPNFFQKY RHYIVLTASA STEENHLEWV GLVESKIRVL 400
VGNLERNEFI TLAHVNPQSF PGNKEHHKAN NYVSMWFLGI IFRRVENAES 450
VNIDLTYDIQ SFTDTVYRQA NNINMLKDGM KIEATHVKKK QLHHYLPAEI 500
LQKKKKSLSD VSRSSGGLQS KRSSLDSTCL DSSRDTDSGT PFNSPVSANK 550
PSNPDSPTGE IERSSAEPVA VVVEKLPSVP PAQGLSIPVI GAKVDPTAKA 600
VSSPAVCTIP TVVGRNVIPR ITTPHNPVQG QPHLNGISNI TKNVTPKRSH 650
SPPTDGTSKR LKDIEKFIRL ESAFKESRAA EDRKRKPMDS IGGESMPIPT 700
IDTARKKRLP SKELPDSSSP VPANNIRVIK NSIRLTLNR 739
Length:739
Mass (Da):82,957
Last modified:July 5, 2004 - v1
Checksum:i603F1AB38DF985BE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti364 – 3641P → T in BAC29194. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ103505 mRNA. Translation: AAZ80292.1.
AK035810 mRNA. Translation: BAC29194.1.
AL662810 Genomic DNA. Translation: CAI25660.1.
BC059271 mRNA. Translation: AAH59271.1.
CCDSiCCDS24481.1.
RefSeqiNP_766143.2. NM_172555.2.
UniGeneiMm.470599.

Genome annotation databases

EnsembliENSMUST00000020513; ENSMUSP00000020513; ENSMUSG00000020273.
GeneIDi216578.
KEGGimmu:216578.
UCSCiuc007ifp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ103505 mRNA. Translation: AAZ80292.1 .
AK035810 mRNA. Translation: BAC29194.1 .
AL662810 Genomic DNA. Translation: CAI25660.1 .
BC059271 mRNA. Translation: AAH59271.1 .
CCDSi CCDS24481.1.
RefSeqi NP_766143.2. NM_172555.2.
UniGenei Mm.470599.

3D structure databases

ProteinModelPortali Q6PCL9.
SMRi Q6PCL9. Positions 17-501.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6PCL9.

Proteomic databases

PaxDbi Q6PCL9.
PRIDEi Q6PCL9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020513 ; ENSMUSP00000020513 ; ENSMUSG00000020273 .
GeneIDi 216578.
KEGGi mmu:216578.
UCSCi uc007ifp.2. mouse.

Organism-specific databases

CTDi 64895.
MGIi MGI:2442119. Papolg.

Phylogenomic databases

eggNOGi COG5186.
GeneTreei ENSGT00390000017928.
HOGENOMi HOG000204376.
HOVERGENi HBG053502.
InParanoidi Q6PCL9.
KOi K14376.
OMAi GECMPIP.
OrthoDBi EOG7XH6PT.
PhylomeDBi Q6PCL9.
TreeFami TF300842.

Miscellaneous databases

NextBioi 375224.
PROi Q6PCL9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PCL9.
Bgeei Q6PCL9.
CleanExi MM_PAPOLG.
Genevestigatori Q6PCL9.

Family and domain databases

Gene3Di 3.30.70.590. 1 hit.
InterProi IPR002934. Nucleotidyltransferase.
IPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view ]
Pfami PF01909. NTP_transf_2. 1 hit.
PF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view ]
PIRSFi PIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMi SSF55003. SSF55003. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the sequences of the SRP 3'-adenylating enzyme in human, mouse and Xenopus."
    Bhattacharya R., Gaikwad A., Reddy R.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPAPOG_MOUSE
AccessioniPrimary (citable) accession number: Q6PCL9
Secondary accession number(s): Q8BZC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi