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Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

ube2z

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation (By similarity).PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ligase activity Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene namesi
Name:ube2z
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-990991. ube2z.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Ubiquitin-conjugating enzyme E2 ZPRO_0000280519Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6PCF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG083204.
KOiK10585.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PCF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESPAAEAI ILPGAAAGGG VVPHLSGLQT PGTSLLTTSS VWDPSASADW
60 70 80 90 100
DNERASTQCV LRIKRDIMSI YKEPPPGMFV VPDPHDMTKI HALITGPFDT
110 120 130 140 150
PYEGGFFLFL FRCPPDYPIH PPRVKLMTTG NNTVRFNPNF YRNGKVCLSI
160 170 180 190 200
LGTWTGPAWS PAQSLSSVLI SIQSLMTENP YHNEPGFEQE RHSGDSKNYN
210 220 230 240 250
ECIRHETIRV AVCEMLEGKC QCPDALRSVM EKSFMEYYDF YEAVCKDRFH
260 270 280 290 300
LQGQNMQDPF GEKRGHFDYQ SLLSRLQTIH QRVREKHRRE TVDIDSDSSS
310
SETETDTQGS SNP
Length:313
Mass (Da):35,110
Last modified:March 20, 2007 - v2
Checksum:iE9D3186D6AFAA73D
GO

Sequence cautioni

The sequence AAH59343.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059343 mRNA. Translation: AAH59343.1. Different initiation.
RefSeqiNP_001080034.2. NM_001086565.1.
UniGeneiXl.19240.

Genome annotation databases

GeneIDi379726.
KEGGixla:379726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059343 mRNA. Translation: AAH59343.1. Different initiation.
RefSeqiNP_001080034.2. NM_001086565.1.
UniGeneiXl.19240.

3D structure databases

ProteinModelPortaliQ6PCF7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379726.
KEGGixla:379726.

Organism-specific databases

CTDi65264.
XenbaseiXB-GENE-990991. ube2z.

Phylogenomic databases

HOVERGENiHBG083204.
KOiK10585.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiUBE2Z_XENLA
AccessioniPrimary (citable) accession number: Q6PCF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: March 4, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.