Q6PCE1 (Q6PCE1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
RALGDS protein EMBL AAH59362.1

Submitted name:
Ral guanine nucleotide dissociation stimulator EMBL CAI13416.1
Submitted name:
Uncharacterized protein Ensembl ENSP00000361117

Gene names

Name:	RALGDS EMBL AAH59362.1 Ensembl ENSP00000361117
ORF Names:	RP11-326L24.1-002 EMBL CAI13416.1

Organism

Homo sapiens (Human) EMBL AAH59362.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	902 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 N-terminal Ras-GEF domain. SAAS SAAS000651 Contains 1 Ras-GEF domain. SAAS SAAS000651

Ontologies

Keywords
Molecular function	Guanine-nucleotide releasing factor SAAS SAAS000651
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6PCE1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5A4C99EB60D095DC	FASTA	902	99,325
	10 20 30 40 50 60 MVQRMWAEAA GPAGGAEPLF PGSRRSRSVW DAVRLEVGVP DSCPVVLHSF TQLDPDLPRP 70 80 90 100 110 120 ESSTQEIGEE LINGVIYSIS LRKVQLHHGG NKGQRWLGYE NESALNLYET CKVRTVKAGT 130 140 150 160 170 180 LEKLVEHLVP AFQGSDLSYV TIFLCTYRAF TTTQQVLDLL FKRYGCILPY SDEDGGPQDQ 190 200 210 220 230 240 LKNAISSILG TWLDQYSEDF CQPPDFPCLK QLVAYVQLNM PGSDLERRAH LLLAQLEHSE 250 260 270 280 290 300 PIEAEPEALS PVPALKPTPE LELALTPARA PSPVPAPAPE PEPAPTPAPG SELEVAPAPA 310 320 330 340 350 360 PELQQAPEPA VGLESAPAPA LELEPAPEQD PAPSQTLELE PAPAPVPSLQ PSWPSPVVAE 370 380 390 400 410 420 NGLSEEKPHL LVFPPDLVAE QFTLMDAELF KKVVPYHCLG SIWSQRDKKG KEHLAPTIRA 430 440 450 460 470 480 TVTQFNSVAN CVITTCLGNR STKAPDRARV VEHWIEVARE CRILKNFSSL YAILSALQSN 490 500 510 520 530 540 SIHRLKKTWE DVSRDSFRIF QKLSEIFSDE NNYSLSRELL IKEGTSKFAT LEMNPKRAQK 550 560 570 580 590 600 RPKETGIIQG TVPYLGTFLT DLVMLDTAMK DYLYGRLINF EKRRKEFEVI AQIKLLQSAC 610 620 630 640 650 660 NNYSIAPDEQ FGAWFRAVER LSETESYNLS CELEPPSESA SNTLRTKKNT AIVKRWSDRQ 670 680 690 700 710 720 APSTELSTSG SSHSKSCDQL RCGPYLSSGD IADALSVHSA GSSSSDVEEI NISFVPESPD 730 740 750 760 770 780 GQEKKFWESA SQSSPETSGI SSASSSTSSS SASTTPVAAT RTHKRSVSGL CNSSSALPLY 790 800 810 820 830 840 NQQVGDCCII RVSLDVDNGN MYKSILVTSQ DKAPAVIRKA MDKHNLEEEE PEDYELLQIL 850 860 870 880 890 900 SDDRKLKIPE NANVFYAMNS TANYDFVLKK RTFTKGVKVK HGASSTLPRM KQKGLKIAKG IF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta EMBL AAH59362.1.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Kimberley A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC059362 mRNA. Translation: AAH59362.1. AL162417 Genomic DNA. Translation: CAI13416.1.
IPI	IPI00550528.
RefSeq	NP_001035827.1. NM_001042368.1. NP_006257.1. NM_006266.2.
UniGene	Hs.106185.
3D structure databases
ProteinModelPortal	Q6PCE1.
SMR	Q6PCE1. Positions 373-636, 781-873.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6PCE1.
Proteomic databases
PRIDE	Q6PCE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372047; ENSP00000361117; ENSG00000160271.
GeneID	5900.
KEGG	hsa:5900.
UCSC	uc004ccq.1. human.
Organism-specific databases
CTD	5900.
HGNC	HGNC:9842. RALGDS.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG005864.
Gene expression databases
ArrayExpress	Q6PCE1.
Bgee	Q6PCE1.
Family and domain databases
InterPro	IPR015758. RalGDS. IPR000159. Ras-assoc. IPR000651. Ras-like_Gua-exchang_fac_N. IPR019804. Ras_G-nucl-exch_fac_CS. IPR008937. Ras_GEF. IPR023578. Ras_GEF_dom. IPR001895. RasGRF_CDC25. [Graphical view]
Gene3D	G3DSA:1.10.840.10. RasGRF_CDC25. 1 hit.
KO	K08732.
PANTHER	PTHR23113:SF35. RalGDS. 1 hit. PTHR23113. Ras_GEF. 1 hit.
Pfam	PF00788. RA. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. [Graphical view]
SMART	SM00314. RA. 1 hit. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. [Graphical view]
SUPFAM	SSF48366. Ras_GEF. 1 hit.
PROSITE	PS50200. RA. 1 hit. PS00720. RASGEF. 1 hit. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	22950.

Entry information

Entry name

Q6PCE1_HUMAN

Accession

Primary (citable) accession number: Q6PCE1

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.