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Q6PCB8 (EMB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Embigin
Gene names
Name:EMB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane By similarity.

Subunit structure

Interacts with SLC16A1 and SLC16A7 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity. Note: Localizes to the neuromuscular junctions By similarity.

Sequence similarities

Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 327295Embigin
PRO_0000014749

Regions

Topological domain33 – 260228Extracellular Potential
Transmembrane261 – 28121Helical; Potential
Topological domain282 – 32746Cytoplasmic Potential
Domain71 – 15888Ig-like V-type 1
Domain159 – 25395Ig-like V-type 2

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation1961N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Ref.4
Glycosylation2181N-linked (GlcNAc...) Ref.4
Disulfide bond88 ↔ 142 By similarity
Disulfide bond180 ↔ 237 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6PCB8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E6B933DAF6A3B0D4

FASTA32736,881
        10         20         30         40         50         60 
MRALPGLLEA RARTPRLLLL QCLLAAARPS SADGSAPDSP FTSPPLREEI MANNFSLESH 

        70         80         90        100        110        120 
NISLTEHSSM PVEKNITLER PSNVNLTCQF TTSGDLNAVN VTWKKDGEQL ENNYLVSATG 

       130        140        150        160        170        180 
STLYTQYRFT IINSKQMGSY SCFFREEKEQ RGTFNFKVPE LHGKNKPLIS YVGDSTVLTC 

       190        200        210        220        230        240 
KCQNCFPLNW TWYSSNGSVK VPVGVQMNKY VINGTYANET KLKITQLLEE DGESYWCRAL 

       250        260        270        280        290        300 
FQLGESEEHI ELVVLSYLVP LKPFLVIVAE VILLVATILL CEKYTQKKKK HSDEGKEFEQ 

       310        320 
IEQLKSDDSN GIENNVPRHR KNESLGQ 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-213 AND ASN-218.
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK300860 mRNA. Translation: BAH13359.1.
CH471123 Genomic DNA. Translation: EAW54853.1.
BC059398 mRNA. Translation: AAH59398.1.
RefSeqNP_940851.1. NM_198449.2.
UniGeneHs.561411.

3D structure databases

ProteinModelPortalQ6PCB8.
SMRQ6PCB8. Positions 73-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126358. 1 interaction.
STRING9606.ENSP00000302289.

Protein family/group databases

TCDB8.A.23.1.2. the basigin (basigin) family.

PTM databases

PhosphoSiteQ6PCB8.

Polymorphism databases

DMDM83286878.

Proteomic databases

PaxDbQ6PCB8.
PRIDEQ6PCB8.

Protocols and materials databases

DNASU133418.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303221; ENSP00000302289; ENSG00000170571.
GeneID133418.
KEGGhsa:133418.
UCSCuc003jol.3. human.

Organism-specific databases

CTD133418.
GeneCardsGC05M049693.
HGNCHGNC:30465. EMB.
HPAHPA017740.
MIM615669. gene.
neXtProtNX_Q6PCB8.
PharmGKBPA134917460.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26218.
HOGENOMHOG000082417.
HOVERGENHBG051471.
InParanoidQ6PCB8.
OMAPLNWTWY.
OrthoDBEOG7ZKSC2.
PhylomeDBQ6PCB8.
TreeFamTF326759.

Gene expression databases

ArrayExpressQ6PCB8.
BgeeQ6PCB8.
CleanExHS_EMB.
GenevestigatorQ6PCB8.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR027114. Embigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
[Graphical view]
PANTHERPTHR10075:SF4. PTHR10075:SF4. 1 hit.
PfamPF07679. I-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSEMB. human.
GenomeRNAi133418.
NextBio83214.
PROQ6PCB8.
SOURCESearch...

Entry information

Entry nameEMB_HUMAN
AccessionPrimary (citable) accession number: Q6PCB8
Secondary accession number(s): B7Z6S3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM