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Q6PCB8

- EMB_HUMAN

UniProt

Q6PCB8 - EMB_HUMAN

Protein

Embigin

Gene

EMB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane By similarity.By similarity

    GO - Molecular functioni

    1. organic cyclic compound binding Source: Ensembl

    GO - Biological processi

    1. cell adhesion Source: Ensembl
    2. plasma membrane lactate transport Source: UniProtKB

    Protein family/group databases

    TCDBi8.A.23.1.2. the basigin (basigin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Embigin
    Gene namesi
    Name:EMB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30465. EMB.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity
    Note: Localizes to the neuromuscular junctions.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of plasma membrane Source: UniProtKB
    3. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134917460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 327295EmbiginPRO_0000014749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi88 ↔ 142PROSITE-ProRule annotation
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi180 ↔ 237PROSITE-ProRule annotation
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi213 – 2131N-linked (GlcNAc...)1 Publication
    Glycosylationi218 – 2181N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ6PCB8.
    PaxDbiQ6PCB8.
    PRIDEiQ6PCB8.

    PTM databases

    PhosphoSiteiQ6PCB8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PCB8.
    BgeeiQ6PCB8.
    CleanExiHS_EMB.
    GenevestigatoriQ6PCB8.

    Organism-specific databases

    HPAiHPA017740.

    Interactioni

    Subunit structurei

    Interacts with SLC16A1 and SLC16A7.By similarity

    Protein-protein interaction databases

    BioGridi126358. 1 interaction.
    STRINGi9606.ENSP00000302289.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PCB8.
    SMRiQ6PCB8. Positions 159-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 260228ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini282 – 32746CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini71 – 15888Ig-like V-type 1Add
    BLAST
    Domaini159 – 25395Ig-like V-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26218.
    HOGENOMiHOG000082417.
    HOVERGENiHBG051471.
    InParanoidiQ6PCB8.
    OMAiQMGSYSC.
    OrthoDBiEOG7ZKSC2.
    PhylomeDBiQ6PCB8.
    TreeFamiTF326759.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR027114. Embigin.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    [Graphical view]
    PANTHERiPTHR10075:SF4. PTHR10075:SF4. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PCB8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRALPGLLEA RARTPRLLLL QCLLAAARPS SADGSAPDSP FTSPPLREEI    50
    MANNFSLESH NISLTEHSSM PVEKNITLER PSNVNLTCQF TTSGDLNAVN 100
    VTWKKDGEQL ENNYLVSATG STLYTQYRFT IINSKQMGSY SCFFREEKEQ 150
    RGTFNFKVPE LHGKNKPLIS YVGDSTVLTC KCQNCFPLNW TWYSSNGSVK 200
    VPVGVQMNKY VINGTYANET KLKITQLLEE DGESYWCRAL FQLGESEEHI 250
    ELVVLSYLVP LKPFLVIVAE VILLVATILL CEKYTQKKKK HSDEGKEFEQ 300
    IEQLKSDDSN GIENNVPRHR KNESLGQ 327
    Length:327
    Mass (Da):36,881
    Last modified:July 5, 2004 - v1
    Checksum:iE6B933DAF6A3B0D4
    GO
    Isoform 2 (identifier: Q6PCB8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-50: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:277
    Mass (Da):31,572
    Checksum:i58C794555A8D61E8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5050Missing in isoform 2. 1 PublicationVSP_055593Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300860 mRNA. Translation: BAH13359.1.
    AK304226 mRNA. Translation: BAH14138.1.
    AC035145 Genomic DNA. No translation available.
    AC091833 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54853.1.
    CH471123 Genomic DNA. Translation: EAW54854.1.
    BC059398 mRNA. Translation: AAH59398.1.
    CCDSiCCDS3953.1.
    RefSeqiNP_940851.1. NM_198449.2.
    UniGeneiHs.561411.

    Genome annotation databases

    EnsembliENST00000303221; ENSP00000302289; ENSG00000170571. [Q6PCB8-1]
    ENST00000514111; ENSP00000426404; ENSG00000170571. [Q6PCB8-2]
    GeneIDi133418.
    KEGGihsa:133418.
    UCSCiuc003jol.3. human.

    Polymorphism databases

    DMDMi83286878.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300860 mRNA. Translation: BAH13359.1 .
    AK304226 mRNA. Translation: BAH14138.1 .
    AC035145 Genomic DNA. No translation available.
    AC091833 Genomic DNA. No translation available.
    CH471123 Genomic DNA. Translation: EAW54853.1 .
    CH471123 Genomic DNA. Translation: EAW54854.1 .
    BC059398 mRNA. Translation: AAH59398.1 .
    CCDSi CCDS3953.1.
    RefSeqi NP_940851.1. NM_198449.2.
    UniGenei Hs.561411.

    3D structure databases

    ProteinModelPortali Q6PCB8.
    SMRi Q6PCB8. Positions 159-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126358. 1 interaction.
    STRINGi 9606.ENSP00000302289.

    Protein family/group databases

    TCDBi 8.A.23.1.2. the basigin (basigin) family.

    PTM databases

    PhosphoSitei Q6PCB8.

    Polymorphism databases

    DMDMi 83286878.

    Proteomic databases

    MaxQBi Q6PCB8.
    PaxDbi Q6PCB8.
    PRIDEi Q6PCB8.

    Protocols and materials databases

    DNASUi 133418.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303221 ; ENSP00000302289 ; ENSG00000170571 . [Q6PCB8-1 ]
    ENST00000514111 ; ENSP00000426404 ; ENSG00000170571 . [Q6PCB8-2 ]
    GeneIDi 133418.
    KEGGi hsa:133418.
    UCSCi uc003jol.3. human.

    Organism-specific databases

    CTDi 133418.
    GeneCardsi GC05M049693.
    HGNCi HGNC:30465. EMB.
    HPAi HPA017740.
    MIMi 615669. gene.
    neXtProti NX_Q6PCB8.
    PharmGKBi PA134917460.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26218.
    HOGENOMi HOG000082417.
    HOVERGENi HBG051471.
    InParanoidi Q6PCB8.
    OMAi QMGSYSC.
    OrthoDBi EOG7ZKSC2.
    PhylomeDBi Q6PCB8.
    TreeFami TF326759.

    Miscellaneous databases

    ChiTaRSi EMB. human.
    GenomeRNAii 133418.
    NextBioi 83214.
    PROi Q6PCB8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PCB8.
    Bgeei Q6PCB8.
    CleanExi HS_EMB.
    Genevestigatori Q6PCB8.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR027114. Embigin.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    [Graphical view ]
    PANTHERi PTHR10075:SF4. PTHR10075:SF4. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Small intestine and Trachea.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-213 AND ASN-218.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiEMB_HUMAN
    AccessioniPrimary (citable) accession number: Q6PCB8
    Secondary accession number(s): B7Z6S3, B7Z902
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3