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Q6PCB8

- EMB_HUMAN

UniProt

Q6PCB8 - EMB_HUMAN

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Protein

Embigin

Gene

EMB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).By similarity

GO - Molecular functioni

  1. organic cyclic compound binding Source: Ensembl

GO - Biological processi

  1. cell adhesion Source: Ensembl
  2. plasma membrane lactate transport Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi8.A.23.1.2. the basigin (basigin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Embigin
Gene namesi
Name:EMB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:30465. EMB.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity
Note: Localizes to the neuromuscular junctions.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of plasma membrane Source: UniProtKB
  3. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 327295EmbiginPRO_0000014749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi88 ↔ 142PROSITE-ProRule annotation
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi180 ↔ 237PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi213 – 2131N-linked (GlcNAc...)1 Publication
Glycosylationi218 – 2181N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6PCB8.
PaxDbiQ6PCB8.
PRIDEiQ6PCB8.

PTM databases

PhosphoSiteiQ6PCB8.

Expressioni

Gene expression databases

BgeeiQ6PCB8.
CleanExiHS_EMB.
ExpressionAtlasiQ6PCB8. baseline and differential.
GenevestigatoriQ6PCB8.

Organism-specific databases

HPAiHPA017740.

Interactioni

Subunit structurei

Interacts with SLC16A1 and SLC16A7.By similarity

Protein-protein interaction databases

BioGridi126358. 10 interactions.
STRINGi9606.ENSP00000302289.

Structurei

3D structure databases

ProteinModelPortaliQ6PCB8.
SMRiQ6PCB8. Positions 168-246.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 260228ExtracellularSequence AnalysisAdd
BLAST
Topological domaini282 – 32746CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei261 – 28121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 15888Ig-like V-type 1Add
BLAST
Domaini159 – 25395Ig-like V-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26218.
GeneTreeiENSGT00390000010516.
HOGENOMiHOG000082417.
HOVERGENiHBG051471.
InParanoidiQ6PCB8.
OMAiQMGSYSC.
OrthoDBiEOG7ZKSC2.
PhylomeDBiQ6PCB8.
TreeFamiTF326759.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR027114. Embigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
[Graphical view]
PANTHERiPTHR10075:SF4. PTHR10075:SF4. 1 hit.
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PCB8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALPGLLEA RARTPRLLLL QCLLAAARPS SADGSAPDSP FTSPPLREEI
60 70 80 90 100
MANNFSLESH NISLTEHSSM PVEKNITLER PSNVNLTCQF TTSGDLNAVN
110 120 130 140 150
VTWKKDGEQL ENNYLVSATG STLYTQYRFT IINSKQMGSY SCFFREEKEQ
160 170 180 190 200
RGTFNFKVPE LHGKNKPLIS YVGDSTVLTC KCQNCFPLNW TWYSSNGSVK
210 220 230 240 250
VPVGVQMNKY VINGTYANET KLKITQLLEE DGESYWCRAL FQLGESEEHI
260 270 280 290 300
ELVVLSYLVP LKPFLVIVAE VILLVATILL CEKYTQKKKK HSDEGKEFEQ
310 320
IEQLKSDDSN GIENNVPRHR KNESLGQ
Length:327
Mass (Da):36,881
Last modified:July 5, 2004 - v1
Checksum:iE6B933DAF6A3B0D4
GO
Isoform 2 (identifier: Q6PCB8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: No experimental confirmation available.

Show »
Length:277
Mass (Da):31,572
Checksum:i58C794555A8D61E8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5050Missing in isoform 2. 1 PublicationVSP_055593Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK300860 mRNA. Translation: BAH13359.1.
AK304226 mRNA. Translation: BAH14138.1.
AC035145 Genomic DNA. No translation available.
AC091833 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54853.1.
CH471123 Genomic DNA. Translation: EAW54854.1.
BC059398 mRNA. Translation: AAH59398.1.
CCDSiCCDS3953.1. [Q6PCB8-1]
RefSeqiNP_940851.1. NM_198449.2. [Q6PCB8-1]
UniGeneiHs.561411.

Genome annotation databases

EnsembliENST00000303221; ENSP00000302289; ENSG00000170571. [Q6PCB8-1]
ENST00000514111; ENSP00000426404; ENSG00000170571. [Q6PCB8-2]
GeneIDi133418.
KEGGihsa:133418.
UCSCiuc003jol.3. human. [Q6PCB8-1]

Polymorphism databases

DMDMi83286878.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK300860 mRNA. Translation: BAH13359.1 .
AK304226 mRNA. Translation: BAH14138.1 .
AC035145 Genomic DNA. No translation available.
AC091833 Genomic DNA. No translation available.
CH471123 Genomic DNA. Translation: EAW54853.1 .
CH471123 Genomic DNA. Translation: EAW54854.1 .
BC059398 mRNA. Translation: AAH59398.1 .
CCDSi CCDS3953.1. [Q6PCB8-1 ]
RefSeqi NP_940851.1. NM_198449.2. [Q6PCB8-1 ]
UniGenei Hs.561411.

3D structure databases

ProteinModelPortali Q6PCB8.
SMRi Q6PCB8. Positions 168-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126358. 10 interactions.
STRINGi 9606.ENSP00000302289.

Protein family/group databases

TCDBi 8.A.23.1.2. the basigin (basigin) family.

PTM databases

PhosphoSitei Q6PCB8.

Polymorphism databases

DMDMi 83286878.

Proteomic databases

MaxQBi Q6PCB8.
PaxDbi Q6PCB8.
PRIDEi Q6PCB8.

Protocols and materials databases

DNASUi 133418.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303221 ; ENSP00000302289 ; ENSG00000170571 . [Q6PCB8-1 ]
ENST00000514111 ; ENSP00000426404 ; ENSG00000170571 . [Q6PCB8-2 ]
GeneIDi 133418.
KEGGi hsa:133418.
UCSCi uc003jol.3. human. [Q6PCB8-1 ]

Organism-specific databases

CTDi 133418.
GeneCardsi GC05M049693.
HGNCi HGNC:30465. EMB.
HPAi HPA017740.
MIMi 615669. gene.
neXtProti NX_Q6PCB8.
PharmGKBi PA134917460.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26218.
GeneTreei ENSGT00390000010516.
HOGENOMi HOG000082417.
HOVERGENi HBG051471.
InParanoidi Q6PCB8.
OMAi QMGSYSC.
OrthoDBi EOG7ZKSC2.
PhylomeDBi Q6PCB8.
TreeFami TF326759.

Miscellaneous databases

ChiTaRSi EMB. human.
GenomeRNAii 133418.
NextBioi 35480616.
PROi Q6PCB8.
SOURCEi Search...

Gene expression databases

Bgeei Q6PCB8.
CleanExi HS_EMB.
ExpressionAtlasi Q6PCB8. baseline and differential.
Genevestigatori Q6PCB8.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR027114. Embigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
[Graphical view ]
PANTHERi PTHR10075:SF4. PTHR10075:SF4. 1 hit.
Pfami PF07679. I-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Small intestine and Trachea.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-213 AND ASN-218.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiEMB_HUMAN
AccessioniPrimary (citable) accession number: Q6PCB8
Secondary accession number(s): B7Z6S3, B7Z902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3