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Q6PCB7

- S27A1_HUMAN

UniProt

Q6PCB7 - S27A1_HUMAN

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Protein

Long-chain fatty acid transport protein 1

Gene

SLC27A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 25712AMPBy similarityAdd
BLAST

GO - Molecular functioni

  1. fatty acid transporter activity Source: Ensembl
  2. nucleotide binding Source: UniProtKB-KW
  3. very long-chain fatty acid-CoA ligase activity Source: Ensembl

GO - Biological processi

  1. adiponectin-activated signaling pathway Source: Ensembl
  2. cardiolipin biosynthetic process Source: UniProtKB
  3. cellular lipid metabolic process Source: Reactome
  4. fatty acid metabolic process Source: UniProtKB-KW
  5. long-chain fatty acid transport Source: Reactome
  6. medium-chain fatty acid transport Source: Ensembl
  7. negative regulation of phospholipid biosynthetic process Source: UniProtKB
  8. phosphatidic acid biosynthetic process Source: UniProtKB
  9. phosphatidylcholine biosynthetic process Source: UniProtKB
  10. phosphatidylethanolamine biosynthetic process Source: UniProtKB
  11. phosphatidylglycerol biosynthetic process Source: UniProtKB
  12. phosphatidylinositol biosynthetic process Source: UniProtKB
  13. phosphatidylserine biosynthetic process Source: UniProtKB
  14. positive regulation of heat generation Source: Ensembl
  15. positive regulation of protein serine/threonine kinase activity Source: Ensembl
  16. response to cold Source: Ensembl
  17. response to insulin Source: Ensembl
  18. small molecule metabolic process Source: Reactome
  19. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_23892. Transport of fatty acids.

Protein family/group databases

TCDBi4.C.1.1.9. the proposed fatty acid transporter (fat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 1 (EC:6.2.1.-)
Short name:
FATP-1
Short name:
Fatty acid transport protein 1
Alternative name(s):
Solute carrier family 27 member 1
Gene namesi
Name:SLC27A1
Synonyms:ACSVL5, FATP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10995. SLC27A1.

Subcellular locationi

Cell membrane 1 Publication; Single-pass membrane protein 1 Publication. Endomembrane system 1 Publication; Single-pass membrane protein 1 Publication. Cytoplasm By similarity
Note: Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes (By similarity).By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 646646Long-chain fatty acid transport protein 1PRO_0000193201Add
BLAST

Proteomic databases

MaxQBiQ6PCB7.
PaxDbiQ6PCB7.
PRIDEiQ6PCB7.

PTM databases

PhosphoSiteiQ6PCB7.

Expressioni

Tissue specificityi

Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.1 Publication

Gene expression databases

BgeeiQ6PCB7.
CleanExiHS_SLC27A1.
ExpressionAtlasiQ6PCB7. baseline and differential.
GenevestigatoriQ6PCB7.

Organism-specific databases

HPAiHPA008255.

Interactioni

Subunit structurei

Self-associates. May function as a homodimer (By similarity).By similarity

Protein-protein interaction databases

BioGridi132009. 2 interactions.
STRINGi9606.ENSP00000252595.

Structurei

3D structure databases

ProteinModelPortaliQ6PCB7.
SMRiQ6PCB7. Positions 67-605.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313ExtracellularSequence AnalysisAdd
BLAST
Topological domaini35 – 646612CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 475285Sufficient for oligomerizationBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
GeneTreeiENSGT00550000074420.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiQ6PCB7.
KOiK08745.
OMAiIWEEFTE.
OrthoDBiEOG7W6WKB.
PhylomeDBiQ6PCB7.
TreeFamiTF313430.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PCB7) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT
60 70 80 90 100
ARRDLFGLSV LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT
110 120 130 140 150
GECWTFAQLD AYSNAVANLF RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK
160 170 180 190 200
AGMEAALLNV NLRREPLAFC LGTSGAKALI FGGEMVAAVA EVSGHLGKSL
210 220 230 240 250
IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM DDRLFYIYTS
260 270 280 290 300
GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG
310 320 330 340 350
VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR
360 370 380 390 400
EAERRHRVRL AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD
410 420 430 440 450
GKVGSCGFNS RILPHVYPIR LVKVNEDTME LLRDAQGLCI PCQAGEPGLL
460 470 480 490 500
VGQINQQDPL RRFDGYVSES ATSKKIAHSV FSKGDSAYLS GDVLVMDELG
510 520 530 540 550
YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY GVAVPGVEGK
560 570 580 590 600
AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ
610 620 630 640
KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL
Length:646
Mass (Da):71,108
Last modified:July 5, 2004 - v1
Checksum:i0E1FBA81922567E0
GO
Isoform 2 (identifier: Q6PCB7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MRAPGAGA → MTHVLGTT
     9-187: Missing.

Note: No experimental confirmation available.

Show »
Length:467
Mass (Da):51,780
Checksum:i64DADFBD278E5282
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MRAPGAGA → MTHVLGTT in isoform 2. 1 PublicationVSP_055806
Alternative sequencei9 – 187179Missing in isoform 2. 1 PublicationVSP_055807Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK299852 mRNA. Translation: BAH13148.1.
AC010319 Genomic DNA. No translation available.
AC010618 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84611.1.
BC059399 mRNA. Translation: AAH59399.1.
CCDSiCCDS32953.1. [Q6PCB7-1]
RefSeqiNP_940982.1. NM_198580.1. [Q6PCB7-1]
UniGeneiHs.363138.

Genome annotation databases

EnsembliENST00000252595; ENSP00000252595; ENSG00000130304. [Q6PCB7-1]
ENST00000598424; ENSP00000472313; ENSG00000130304. [Q6PCB7-2]
GeneIDi376497.
KEGGihsa:376497.
UCSCiuc002ngu.1. human. [Q6PCB7-1]

Polymorphism databases

DMDMi74749156.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK299852 mRNA. Translation: BAH13148.1 .
AC010319 Genomic DNA. No translation available.
AC010618 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84611.1 .
BC059399 mRNA. Translation: AAH59399.1 .
CCDSi CCDS32953.1. [Q6PCB7-1 ]
RefSeqi NP_940982.1. NM_198580.1. [Q6PCB7-1 ]
UniGenei Hs.363138.

3D structure databases

ProteinModelPortali Q6PCB7.
SMRi Q6PCB7. Positions 67-605.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 132009. 2 interactions.
STRINGi 9606.ENSP00000252595.

Chemistry

ChEMBLi CHEMBL2052038.

Protein family/group databases

TCDBi 4.C.1.1.9. the proposed fatty acid transporter (fat) family.

PTM databases

PhosphoSitei Q6PCB7.

Polymorphism databases

DMDMi 74749156.

Proteomic databases

MaxQBi Q6PCB7.
PaxDbi Q6PCB7.
PRIDEi Q6PCB7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252595 ; ENSP00000252595 ; ENSG00000130304 . [Q6PCB7-1 ]
ENST00000598424 ; ENSP00000472313 ; ENSG00000130304 . [Q6PCB7-2 ]
GeneIDi 376497.
KEGGi hsa:376497.
UCSCi uc002ngu.1. human. [Q6PCB7-1 ]

Organism-specific databases

CTDi 376497.
GeneCardsi GC19P017579.
HGNCi HGNC:10995. SLC27A1.
HPAi HPA008255.
MIMi 600691. gene.
neXtProti NX_Q6PCB7.
PharmGKBi PA35869.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0318.
GeneTreei ENSGT00550000074420.
HOGENOMi HOG000044189.
HOVERGENi HBG005642.
InParanoidi Q6PCB7.
KOi K08745.
OMAi IWEEFTE.
OrthoDBi EOG7W6WKB.
PhylomeDBi Q6PCB7.
TreeFami TF313430.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.
REACT_23892. Transport of fatty acids.

Miscellaneous databases

ChiTaRSi SLC27A1. human.
GeneWikii SLC27A1.
GenomeRNAii 376497.
NextBioi 100645.
PROi Q6PCB7.
SOURCEi Search...

Gene expression databases

Bgeei Q6PCB7.
CleanExi HS_SLC27A1.
ExpressionAtlasi Q6PCB7. baseline and differential.
Genevestigatori Q6PCB7.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression."
    Martin G., Nemoto M., Gelman L., Geffroy S., Najib J., Fruchart J.-C., Roevens P., de Martinville B., Deeb S., Auwerx J.
    Genomics 66:296-304(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells."
    Hatch G.M., Smith A.J., Xu F.Y., Hall A.M., Bernlohr D.A.
    J. Lipid Res. 43:1380-1389(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS27A1_HUMAN
AccessioniPrimary (citable) accession number: Q6PCB7
Secondary accession number(s): A6NIH2, B7Z662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3