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Protein

Long-chain fatty acid transport protein 1

Gene

SLC27A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 25712AMPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • adiponectin-activated signaling pathway Source: Ensembl
  • cardiolipin biosynthetic process Source: UniProtKB
  • cellular lipid metabolic process Source: Reactome
  • long-chain fatty acid transport Source: Reactome
  • medium-chain fatty acid transport Source: Ensembl
  • negative regulation of phospholipid biosynthetic process Source: UniProtKB
  • phosphatidic acid biosynthetic process Source: UniProtKB
  • phosphatidylcholine biosynthetic process Source: UniProtKB
  • phosphatidylethanolamine biosynthetic process Source: UniProtKB
  • phosphatidylglycerol biosynthetic process Source: UniProtKB
  • phosphatidylinositol biosynthetic process Source: UniProtKB
  • phosphatidylserine biosynthetic process Source: UniProtKB
  • positive regulation of heat generation Source: Ensembl
  • positive regulation of protein serine/threonine kinase activity Source: Ensembl
  • response to cold Source: Ensembl
  • response to insulin Source: Ensembl
  • small molecule metabolic process Source: Reactome
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_23892. Transport of fatty acids.

Protein family/group databases

TCDBi4.C.1.1.9. the proposed fatty acid transporter (fat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 1 (EC:6.2.1.-)
Short name:
FATP-1
Short name:
Fatty acid transport protein 1
Alternative name(s):
Solute carrier family 27 member 1
Gene namesi
Name:SLC27A1
Synonyms:ACSVL5, FATP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10995. SLC27A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Topological domaini35 – 646612CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35869.

Polymorphism and mutation databases

BioMutaiSLC27A1.
DMDMi74749156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 646646Long-chain fatty acid transport protein 1PRO_0000193201Add
BLAST

Proteomic databases

MaxQBiQ6PCB7.
PaxDbiQ6PCB7.
PRIDEiQ6PCB7.

PTM databases

PhosphoSiteiQ6PCB7.

Expressioni

Tissue specificityi

Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.1 Publication

Gene expression databases

BgeeiQ6PCB7.
CleanExiHS_SLC27A1.
ExpressionAtlasiQ6PCB7. baseline and differential.
GenevestigatoriQ6PCB7.

Organism-specific databases

HPAiHPA008255.

Interactioni

Subunit structurei

Self-associates. May function as a homodimer (By similarity).By similarity

Protein-protein interaction databases

BioGridi132009. 2 interactions.
STRINGi9606.ENSP00000252595.

Structurei

3D structure databases

ProteinModelPortaliQ6PCB7.
SMRiQ6PCB7. Positions 67-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 475285Sufficient for oligomerizationBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
GeneTreeiENSGT00550000074420.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiQ6PCB7.
KOiK08745.
OMAiVFSKGDS.
OrthoDBiEOG7W6WKB.
PhylomeDBiQ6PCB7.
TreeFamiTF313430.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR030308. FATP1.
[Graphical view]
PANTHERiPTHR24096:SF148. PTHR24096:SF148. 1 hit.
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PCB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT
60 70 80 90 100
ARRDLFGLSV LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT
110 120 130 140 150
GECWTFAQLD AYSNAVANLF RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK
160 170 180 190 200
AGMEAALLNV NLRREPLAFC LGTSGAKALI FGGEMVAAVA EVSGHLGKSL
210 220 230 240 250
IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM DDRLFYIYTS
260 270 280 290 300
GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG
310 320 330 340 350
VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR
360 370 380 390 400
EAERRHRVRL AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD
410 420 430 440 450
GKVGSCGFNS RILPHVYPIR LVKVNEDTME LLRDAQGLCI PCQAGEPGLL
460 470 480 490 500
VGQINQQDPL RRFDGYVSES ATSKKIAHSV FSKGDSAYLS GDVLVMDELG
510 520 530 540 550
YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY GVAVPGVEGK
560 570 580 590 600
AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ
610 620 630 640
KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL
Length:646
Mass (Da):71,108
Last modified:July 5, 2004 - v1
Checksum:i0E1FBA81922567E0
GO
Isoform 2 (identifier: Q6PCB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MRAPGAGA → MTHVLGTT
     9-187: Missing.

Note: No experimental confirmation available.

Show »
Length:467
Mass (Da):51,780
Checksum:i64DADFBD278E5282
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MRAPGAGA → MTHVLGTT in isoform 2. 1 PublicationVSP_055806
Alternative sequencei9 – 187179Missing in isoform 2. 1 PublicationVSP_055807Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299852 mRNA. Translation: BAH13148.1.
AC010319 Genomic DNA. No translation available.
AC010618 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84611.1.
BC059399 mRNA. Translation: AAH59399.1.
CCDSiCCDS32953.1. [Q6PCB7-1]
RefSeqiNP_940982.1. NM_198580.2. [Q6PCB7-1]
UniGeneiHs.363138.

Genome annotation databases

EnsembliENST00000252595; ENSP00000252595; ENSG00000130304. [Q6PCB7-1]
ENST00000598424; ENSP00000472313; ENSG00000130304. [Q6PCB7-2]
GeneIDi376497.
KEGGihsa:376497.
UCSCiuc002ngu.1. human. [Q6PCB7-1]
uc010xpp.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299852 mRNA. Translation: BAH13148.1.
AC010319 Genomic DNA. No translation available.
AC010618 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84611.1.
BC059399 mRNA. Translation: AAH59399.1.
CCDSiCCDS32953.1. [Q6PCB7-1]
RefSeqiNP_940982.1. NM_198580.2. [Q6PCB7-1]
UniGeneiHs.363138.

3D structure databases

ProteinModelPortaliQ6PCB7.
SMRiQ6PCB7. Positions 67-605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132009. 2 interactions.
STRINGi9606.ENSP00000252595.

Chemistry

BindingDBiQ6PCB7.
ChEMBLiCHEMBL2052038.

Protein family/group databases

TCDBi4.C.1.1.9. the proposed fatty acid transporter (fat) family.

PTM databases

PhosphoSiteiQ6PCB7.

Polymorphism and mutation databases

BioMutaiSLC27A1.
DMDMi74749156.

Proteomic databases

MaxQBiQ6PCB7.
PaxDbiQ6PCB7.
PRIDEiQ6PCB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252595; ENSP00000252595; ENSG00000130304. [Q6PCB7-1]
ENST00000598424; ENSP00000472313; ENSG00000130304. [Q6PCB7-2]
GeneIDi376497.
KEGGihsa:376497.
UCSCiuc002ngu.1. human. [Q6PCB7-1]
uc010xpp.1. human.

Organism-specific databases

CTDi376497.
GeneCardsiGC19P017579.
HGNCiHGNC:10995. SLC27A1.
HPAiHPA008255.
MIMi600691. gene.
neXtProtiNX_Q6PCB7.
PharmGKBiPA35869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0318.
GeneTreeiENSGT00550000074420.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiQ6PCB7.
KOiK08745.
OMAiVFSKGDS.
OrthoDBiEOG7W6WKB.
PhylomeDBiQ6PCB7.
TreeFamiTF313430.

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_23892. Transport of fatty acids.

Miscellaneous databases

ChiTaRSiSLC27A1. human.
GeneWikiiSLC27A1.
GenomeRNAii376497.
NextBioi100645.
PROiQ6PCB7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PCB7.
CleanExiHS_SLC27A1.
ExpressionAtlasiQ6PCB7. baseline and differential.
GenevestigatoriQ6PCB7.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR030308. FATP1.
[Graphical view]
PANTHERiPTHR24096:SF148. PTHR24096:SF148. 1 hit.
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression."
    Martin G., Nemoto M., Gelman L., Geffroy S., Najib J., Fruchart J.-C., Roevens P., de Martinville B., Deeb S., Auwerx J.
    Genomics 66:296-304(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells."
    Hatch G.M., Smith A.J., Xu F.Y., Hall A.M., Bernlohr D.A.
    J. Lipid Res. 43:1380-1389(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS27A1_HUMAN
AccessioniPrimary (citable) accession number: Q6PCB7
Secondary accession number(s): A6NIH2, B7Z662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.