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Protein

Long-chain fatty acid transport protein 1

Gene

SLC27A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).By similarity1 Publication

Miscellaneous

FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 257AMPBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • adiponectin-activated signaling pathway Source: Ensembl
  • cardiolipin biosynthetic process Source: UniProtKB
  • long-chain fatty acid transport Source: Reactome
  • medium-chain fatty acid transport Source: Ensembl
  • negative regulation of phospholipid biosynthetic process Source: UniProtKB
  • phosphatidic acid biosynthetic process Source: UniProtKB
  • phosphatidylcholine biosynthetic process Source: UniProtKB
  • phosphatidylethanolamine biosynthetic process Source: UniProtKB
  • phosphatidylglycerol biosynthetic process Source: UniProtKB
  • phosphatidylinositol biosynthetic process Source: UniProtKB
  • phosphatidylserine biosynthetic process Source: UniProtKB
  • positive regulation of heat generation Source: Ensembl
  • positive regulation of protein serine/threonine kinase activity Source: Ensembl
  • regulation of lipid metabolic process Source: Reactome
  • response to cold Source: Ensembl
  • response to insulin Source: Ensembl

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism, Lipid transport, Transport
LigandNucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-804914 Transport of fatty acids

Protein family/group databases

TCDBi4.C.1.1.9 the fatty acid transporter (fat) family

Chemistry databases

SwissLipidsiSLP:000000427

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 1 (EC:6.2.1.-)
Short name:
FATP-1
Short name:
Fatty acid transport protein 1
Alternative name(s):
Solute carrier family 27 member 1
Gene namesi
Name:SLC27A1
Synonyms:ACSVL5, FATP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130304.16
HGNCiHGNC:10995 SLC27A1
MIMi600691 gene
neXtProtiNX_Q6PCB7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13ExtracellularSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 646CytoplasmicSequence analysisAdd BLAST612

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi376497
OpenTargetsiENSG00000130304
PharmGKBiPA35869

Chemistry databases

ChEMBLiCHEMBL2052038
GuidetoPHARMACOLOGYi1108

Polymorphism and mutation databases

BioMutaiSLC27A1
DMDMi74749156

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001932011 – 646Long-chain fatty acid transport protein 1Add BLAST646

Proteomic databases

EPDiQ6PCB7
MaxQBiQ6PCB7
PaxDbiQ6PCB7
PeptideAtlasiQ6PCB7
PRIDEiQ6PCB7

PTM databases

iPTMnetiQ6PCB7
PhosphoSitePlusiQ6PCB7

Expressioni

Tissue specificityi

Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.1 Publication

Gene expression databases

BgeeiENSG00000130304
CleanExiHS_SLC27A1
ExpressionAtlasiQ6PCB7 baseline and differential
GenevisibleiQ6PCB7 HS

Interactioni

Subunit structurei

Self-associates. May function as a homodimer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi132009, 1 interactor
IntActiQ6PCB7, 1 interactor
MINTiQ6PCB7
STRINGi9606.ENSP00000252595

Chemistry databases

BindingDBiQ6PCB7

Structurei

3D structure databases

ProteinModelPortaliQ6PCB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 475Sufficient for oligomerizationBy similarityAdd BLAST285

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
GeneTreeiENSGT00550000074420
HOGENOMiHOG000044189
HOVERGENiHBG005642
InParanoidiQ6PCB7
KOiK08745
OMAiYTRICSG
OrthoDBiEOG091G0B76
PhylomeDBiQ6PCB7
TreeFamiTF313430

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030308 FATP1
PANTHERiPTHR43107:SF7 PTHR43107:SF7, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PCB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT
60 70 80 90 100
ARRDLFGLSV LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT
110 120 130 140 150
GECWTFAQLD AYSNAVANLF RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK
160 170 180 190 200
AGMEAALLNV NLRREPLAFC LGTSGAKALI FGGEMVAAVA EVSGHLGKSL
210 220 230 240 250
IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM DDRLFYIYTS
260 270 280 290 300
GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG
310 320 330 340 350
VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR
360 370 380 390 400
EAERRHRVRL AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD
410 420 430 440 450
GKVGSCGFNS RILPHVYPIR LVKVNEDTME LLRDAQGLCI PCQAGEPGLL
460 470 480 490 500
VGQINQQDPL RRFDGYVSES ATSKKIAHSV FSKGDSAYLS GDVLVMDELG
510 520 530 540 550
YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY GVAVPGVEGK
560 570 580 590 600
AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ
610 620 630 640
KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL
Length:646
Mass (Da):71,108
Last modified:July 5, 2004 - v1
Checksum:i0E1FBA81922567E0
GO
Isoform 2 (identifier: Q6PCB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MRAPGAGA → MTHVLGTT
     9-187: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):51,780
Checksum:i64DADFBD278E5282
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558061 – 8MRAPGAGA → MTHVLGTT in isoform 2. 1 Publication8
Alternative sequenceiVSP_0558079 – 187Missing in isoform 2. 1 PublicationAdd BLAST179

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299852 mRNA Translation: BAH13148.1
AC010319 Genomic DNA No translation available.
AC010618 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84611.1
BC059399 mRNA Translation: AAH59399.1
CCDSiCCDS32953.1 [Q6PCB7-1]
RefSeqiNP_940982.1, NM_198580.2 [Q6PCB7-1]
XP_011526305.1, XM_011528003.2 [Q6PCB7-1]
UniGeneiHs.363138

Genome annotation databases

EnsembliENST00000252595; ENSP00000252595; ENSG00000130304 [Q6PCB7-1]
ENST00000598424; ENSP00000472313; ENSG00000130304 [Q6PCB7-2]
GeneIDi376497
KEGGihsa:376497
UCSCiuc002ngu.2 human [Q6PCB7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS27A1_HUMAN
AccessioniPrimary (citable) accession number: Q6PCB7
Secondary accession number(s): A6NIH2, B7Z662
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health