Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6PCB7

- S27A1_HUMAN

UniProt

Q6PCB7 - S27A1_HUMAN

Protein

Long-chain fatty acid transport protein 1

Gene

SLC27A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 25712AMPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. fatty acid transporter activity Source: Ensembl
    3. nucleotide binding Source: UniProtKB-KW
    4. very long-chain fatty acid-CoA ligase activity Source: Ensembl

    GO - Biological processi

    1. adiponectin-activated signaling pathway Source: Ensembl
    2. cardiolipin biosynthetic process Source: UniProtKB
    3. cellular lipid metabolic process Source: Reactome
    4. fatty acid metabolic process Source: UniProtKB-KW
    5. long-chain fatty acid transport Source: Reactome
    6. medium-chain fatty acid transport Source: Ensembl
    7. negative regulation of phospholipid biosynthetic process Source: UniProtKB
    8. phosphatidic acid biosynthetic process Source: UniProtKB
    9. phosphatidylcholine biosynthetic process Source: UniProtKB
    10. phosphatidylethanolamine biosynthetic process Source: UniProtKB
    11. phosphatidylglycerol biosynthetic process Source: UniProtKB
    12. phosphatidylinositol biosynthetic process Source: UniProtKB
    13. phosphatidylserine biosynthetic process Source: UniProtKB
    14. positive regulation of heat generation Source: Ensembl
    15. positive regulation of protein serine/threonine kinase activity Source: Ensembl
    16. response to cold Source: Ensembl
    17. response to insulin Source: Ensembl
    18. small molecule metabolic process Source: Reactome
    19. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport

    Keywords - Ligandi

    Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_23892. Transport of fatty acids.

    Protein family/group databases

    TCDBi4.C.1.1.9. the proposed fatty acid transporter (fat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain fatty acid transport protein 1 (EC:6.2.1.-)
    Short name:
    FATP-1
    Short name:
    Fatty acid transport protein 1
    Alternative name(s):
    Solute carrier family 27 member 1
    Gene namesi
    Name:SLC27A1
    Synonyms:ACSVL5, FATP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10995. SLC27A1.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass membrane protein 1 Publication. Endomembrane system 1 Publication; Single-pass membrane protein 1 Publication. Cytoplasm By similarity
    Note: Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes By similarity.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35869.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 646646Long-chain fatty acid transport protein 1PRO_0000193201Add
    BLAST

    Proteomic databases

    MaxQBiQ6PCB7.
    PaxDbiQ6PCB7.
    PRIDEiQ6PCB7.

    PTM databases

    PhosphoSiteiQ6PCB7.

    Expressioni

    Tissue specificityi

    Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.1 Publication

    Gene expression databases

    ArrayExpressiQ6PCB7.
    BgeeiQ6PCB7.
    CleanExiHS_SLC27A1.
    GenevestigatoriQ6PCB7.

    Organism-specific databases

    HPAiHPA008255.

    Interactioni

    Subunit structurei

    Self-associates. May function as a homodimer By similarity.By similarity

    Protein-protein interaction databases

    BioGridi132009. 2 interactions.
    STRINGi9606.ENSP00000252595.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PCB7.
    SMRiQ6PCB7. Positions 67-605.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini35 – 646612CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni191 – 475285Sufficient for oligomerizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000044189.
    HOVERGENiHBG005642.
    InParanoidiQ6PCB7.
    KOiK08745.
    OMAiIWEEFTE.
    OrthoDBiEOG7W6WKB.
    PhylomeDBiQ6PCB7.
    TreeFamiTF313430.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PCB7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT    50
    ARRDLFGLSV LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT 100
    GECWTFAQLD AYSNAVANLF RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK 150
    AGMEAALLNV NLRREPLAFC LGTSGAKALI FGGEMVAAVA EVSGHLGKSL 200
    IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM DDRLFYIYTS 250
    GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG 300
    VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR 350
    EAERRHRVRL AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD 400
    GKVGSCGFNS RILPHVYPIR LVKVNEDTME LLRDAQGLCI PCQAGEPGLL 450
    VGQINQQDPL RRFDGYVSES ATSKKIAHSV FSKGDSAYLS GDVLVMDELG 500
    YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY GVAVPGVEGK 550
    AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ 600
    KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL 646
    Length:646
    Mass (Da):71,108
    Last modified:July 5, 2004 - v1
    Checksum:i0E1FBA81922567E0
    GO
    Isoform 2 (identifier: Q6PCB7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-8: MRAPGAGA → MTHVLGTT
         9-187: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:467
    Mass (Da):51,780
    Checksum:i64DADFBD278E5282
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 88MRAPGAGA → MTHVLGTT in isoform 2. 1 PublicationVSP_055806
    Alternative sequencei9 – 187179Missing in isoform 2. 1 PublicationVSP_055807Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299852 mRNA. Translation: BAH13148.1.
    AC010319 Genomic DNA. No translation available.
    AC010618 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84611.1.
    BC059399 mRNA. Translation: AAH59399.1.
    CCDSiCCDS32953.1.
    RefSeqiNP_940982.1. NM_198580.1.
    UniGeneiHs.363138.

    Genome annotation databases

    EnsembliENST00000252595; ENSP00000252595; ENSG00000130304. [Q6PCB7-1]
    ENST00000598424; ENSP00000472313; ENSG00000130304. [Q6PCB7-2]
    GeneIDi376497.
    KEGGihsa:376497.
    UCSCiuc002ngu.1. human.

    Polymorphism databases

    DMDMi74749156.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK299852 mRNA. Translation: BAH13148.1 .
    AC010319 Genomic DNA. No translation available.
    AC010618 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84611.1 .
    BC059399 mRNA. Translation: AAH59399.1 .
    CCDSi CCDS32953.1.
    RefSeqi NP_940982.1. NM_198580.1.
    UniGenei Hs.363138.

    3D structure databases

    ProteinModelPortali Q6PCB7.
    SMRi Q6PCB7. Positions 67-605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132009. 2 interactions.
    STRINGi 9606.ENSP00000252595.

    Chemistry

    ChEMBLi CHEMBL2052038.

    Protein family/group databases

    TCDBi 4.C.1.1.9. the proposed fatty acid transporter (fat) family.

    PTM databases

    PhosphoSitei Q6PCB7.

    Polymorphism databases

    DMDMi 74749156.

    Proteomic databases

    MaxQBi Q6PCB7.
    PaxDbi Q6PCB7.
    PRIDEi Q6PCB7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252595 ; ENSP00000252595 ; ENSG00000130304 . [Q6PCB7-1 ]
    ENST00000598424 ; ENSP00000472313 ; ENSG00000130304 . [Q6PCB7-2 ]
    GeneIDi 376497.
    KEGGi hsa:376497.
    UCSCi uc002ngu.1. human.

    Organism-specific databases

    CTDi 376497.
    GeneCardsi GC19P017579.
    HGNCi HGNC:10995. SLC27A1.
    HPAi HPA008255.
    MIMi 600691. gene.
    neXtProti NX_Q6PCB7.
    PharmGKBi PA35869.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000044189.
    HOVERGENi HBG005642.
    InParanoidi Q6PCB7.
    KOi K08745.
    OMAi IWEEFTE.
    OrthoDBi EOG7W6WKB.
    PhylomeDBi Q6PCB7.
    TreeFami TF313430.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_23892. Transport of fatty acids.

    Miscellaneous databases

    ChiTaRSi SLC27A1. human.
    GeneWikii SLC27A1.
    GenomeRNAii 376497.
    NextBioi 100645.
    PROi Q6PCB7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PCB7.
    Bgeei Q6PCB7.
    CleanExi HS_SLC27A1.
    Genevestigatori Q6PCB7.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    5. "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression."
      Martin G., Nemoto M., Gelman L., Geffroy S., Najib J., Fruchart J.-C., Roevens P., de Martinville B., Deeb S., Auwerx J.
      Genomics 66:296-304(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells."
      Hatch G.M., Smith A.J., Xu F.Y., Hall A.M., Bernlohr D.A.
      J. Lipid Res. 43:1380-1389(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiS27A1_HUMAN
    AccessioniPrimary (citable) accession number: Q6PCB7
    Secondary accession number(s): A6NIH2, B7Z662
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3