Q6PCB7 (S27A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Long-chain fatty acid transport protein 1
Short name=FATP-1
Short name=Fatty acid transport protein 1
EC=6.2.1.-

Alternative name(s):
Solute carrier family 27 member 1

Gene names

Name:	SLC27A1
Synonyms:	ACSVL5, FATP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	646 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids By similarity. Ref.5
Subunit structure	Self-associates. May function as an homodimer By similarity.
Subcellular location	Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm By similarity. Note: Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes By similarity. Ref.5
Tissue specificity	Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Ref.4
Miscellaneous	FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism Lipid transport Transport
Cellular component	Cell membrane Cytoplasm Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cardiolipin biosynthetic process Inferred from mutant phenotype. Source: UniProtKB fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid transport Traceable author statement. Source: Reactome negative regulation of phospholipid biosynthetic process Inferred from mutant phenotype. Source: UniProtKB phosphatidic acid biosynthetic process Inferred from mutant phenotype. Source: UniProtKB phosphatidylcholine biosynthetic process Inferred from mutant phenotype. Source: UniProtKB phosphatidylethanolamine biosynthetic process Inferred from mutant phenotype. Source: UniProtKB phosphatidylinositol biosynthetic process Inferred from mutant phenotype. Source: UniProtKB phosphatidylserine biosynthetic process Inferred from mutant phenotype. Source: UniProtKB transmembrane transport Traceable author statement. Source: Reactome
Cellular component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 646	646	Long-chain fatty acid transport protein 1		PRO_0000193201
Regions
	Topological domain	1 – 13	13	Extracellular Potential
	Transmembrane	14 – 34	21	Helical; Potential
	Topological domain	35 – 646	612	Cytoplasmic Potential
	Nucleotide binding	246 – 257	12	AMP By similarity
	Region	191 – 475	285	Sufficient for oligomerization By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6PCB7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0E1FBA81922567E0	FASTA	646	71,108
	10 20 30 40 50 60 MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT ARRDLFGLSV 70 80 90 100 110 120 LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT GECWTFAQLD AYSNAVANLF 130 140 150 160 170 180 RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK AGMEAALLNV NLRREPLAFC LGTSGAKALI 190 200 210 220 230 240 FGGEMVAAVA EVSGHLGKSL IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM 250 260 270 280 290 300 DDRLFYIYTS GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG 310 320 330 340 350 360 VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR EAERRHRVRL 370 380 390 400 410 420 AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD GKVGSCGFNS RILPHVYPIR 430 440 450 460 470 480 LVKVNEDTME LLRDAQGLCI PCQAGEPGLL VGQINQQDPL RRFDGYVSES ATSKKIAHSV 490 500 510 520 530 540 FSKGDSAYLS GDVLVMDELG YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY 550 560 570 580 590 600 GVAVPGVEGK AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ 610 620 630 640 KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression." Martin G., Nemoto M., Gelman L., Geffroy S., Najib J., Fruchart J.-C., Roevens P., de Martinville B., Deeb S., Auwerx J. Genomics 66:296-304(2000) [PubMed: 10873384] [Abstract] Cited for: TISSUE SPECIFICITY.
[5]	"FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells." Hatch G.M., Smith A.J., Xu F.Y., Hall A.M., Bernlohr D.A. J. Lipid Res. 43:1380-1389(2002) [PubMed: 12235169] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010618 Genomic DNA. No translation available. CH471106 Genomic DNA. Translation: EAW84611.1. BC059399 mRNA. Translation: AAH59399.1.
IPI	IPI00442344.
RefSeq	NP_940982.1. NM_198580.1.
UniGene	Hs.363138.
3D structure databases
ProteinModelPortal	Q6PCB7.
SMR	Q6PCB7. Positions 77-593.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6PCB7.
PTM databases
PhosphoSite	Q6PCB7.
Polymorphism databases
DMDM	74749156.
Proteomic databases
PRIDE	Q6PCB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252595; ENSP00000252595; ENSG00000130304. ENST00000442725; ENSP00000413424; ENSG00000130304.
GeneID	376497.
KEGG	hsa:376497.
UCSC	uc002ngu.1. human.
Organism-specific databases
CTD	376497.
GeneCards	GC19P017579.
H-InvDB	HIX0019674.
HGNC	HGNC:10995. SLC27A1.
HPA	HPA008255.
MIM	600691. gene.
neXtProt	NX_Q6PCB7.
PharmGKB	PA35869.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07946.
GeneTree	ENSGT00550000074420.
HOGENOM	HBG712034.
HOVERGEN	HBG005642.
InParanoid	Q6PCB7.
OMA	YTRICSG.
OrthoDB	EOG473PQW.
PhylomeDB	Q6PCB7.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q6PCB7.
Bgee	Q6PCB7.
CleanEx	HS_SLC27A1.
Genevestigator	Q6PCB7.
GermOnline	ENSG00000130304. Homo sapiens.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K08745.
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	100645.
SOURCE	Search...

Entry information

Entry name

S27A1_HUMAN

Accession

Primary (citable) accession number: Q6PCB7
Secondary accession number(s): A6NIH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.