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Protein

Protein ABHD17C

Gene

ABHD17C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei211 – 2111Charge relay systemBy similarity
Active sitei276 – 2761Charge relay systemBy similarity
Active sitei305 – 3051Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-ABHD17C. 5_AlphaBeta_hydrolase.
MEROPSiS09.053.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD17CCurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 17CCurated
Short name:
Abhydrolase domain-containing protein 17CImported
Gene namesi
Name:ABHD17CImported
Synonyms:FAM108C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26925. ABHD17C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385639.

Polymorphism and mutation databases

BioMutaiABHD17C.
DMDMi156630444.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Protein ABHD17CPRO_0000297513Add
BLAST

Proteomic databases

EPDiQ6PCB6.
MaxQBiQ6PCB6.
PaxDbiQ6PCB6.
PeptideAtlasiQ6PCB6.
PRIDEiQ6PCB6.

PTM databases

iPTMnetiQ6PCB6.
PhosphoSiteiQ6PCB6.
SwissPalmiQ6PCB6.

Expressioni

Gene expression databases

BgeeiQ6PCB6.
CleanExiHS_FAM108C1.
ExpressionAtlasiQ6PCB6. baseline and differential.
GenevisibleiQ6PCB6. HS.

Organism-specific databases

HPAiHPA048890.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000258884.

Structurei

3D structure databases

ProteinModelPortaliQ6PCB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 8635Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD17 family.Curated

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000000948.
HOGENOMiHOG000007142.
HOVERGENiHBG061270.
InParanoidiQ6PCB6.
OMAiRMRDENE.
PhylomeDBiQ6PCB6.
TreeFamiTF314365.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
[Graphical view]
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PCB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEPGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLAPEQR
60 70 80 90 100
GAGASAPAPA QATAAAAAAQ PAPQQPEEGA GAGPGACSLH LSERADWQYS
110 120 130 140 150
QRELDAVEVF FSRTARDNRL GCMFVRCAPS SRYTLLFSHG NAVDLGQMCS
160 170 180 190 200
FYIGLGSRIN CNIFSYDYSG YGVSSGKPSE KNLYADIDAA WQALRTRYGV
210 220 230 240 250
SPENIILYGQ SIGTVPTVDL ASRYECAAVI LHSPLMSGLR VAFPDTRKTY
260 270 280 290 300
CFDAFPSIDK ISKVTSPVLV IHGTEDEVID FSHGLAMYER CPRAVEPLWV
310 320
EGAGHNDIEL YAQYLERLKQ FISHELPNS
Length:329
Mass (Da):35,831
Last modified:May 15, 2007 - v2
Checksum:iA5EE8ED4291EC49F
GO
Isoform 2 (identifier: Q6PCB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-256: Missing.

Show »
Length:295
Mass (Da):31,972
Checksum:i5789593A6137B4E1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei223 – 25634Missing in isoform 2. 1 PublicationVSP_027273Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059401 mRNA. Translation: AAH59401.2.
BC115003 mRNA. Translation: AAI15004.1.
AL390079 mRNA. Translation: CAB98203.1.
CCDSiCCDS45323.1. [Q6PCB6-1]
RefSeqiNP_067037.1. NM_021214.1. [Q6PCB6-1]
UniGeneiHs.459072.

Genome annotation databases

EnsembliENST00000258884; ENSP00000258884; ENSG00000136379. [Q6PCB6-1]
ENST00000558464; ENSP00000452778; ENSG00000136379. [Q6PCB6-2]
GeneIDi58489.
KEGGihsa:58489.
UCSCiuc002bfu.4. human. [Q6PCB6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059401 mRNA. Translation: AAH59401.2.
BC115003 mRNA. Translation: AAI15004.1.
AL390079 mRNA. Translation: CAB98203.1.
CCDSiCCDS45323.1. [Q6PCB6-1]
RefSeqiNP_067037.1. NM_021214.1. [Q6PCB6-1]
UniGeneiHs.459072.

3D structure databases

ProteinModelPortaliQ6PCB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000258884.

Protein family/group databases

ESTHERihuman-ABHD17C. 5_AlphaBeta_hydrolase.
MEROPSiS09.053.

PTM databases

iPTMnetiQ6PCB6.
PhosphoSiteiQ6PCB6.
SwissPalmiQ6PCB6.

Polymorphism and mutation databases

BioMutaiABHD17C.
DMDMi156630444.

Proteomic databases

EPDiQ6PCB6.
MaxQBiQ6PCB6.
PaxDbiQ6PCB6.
PeptideAtlasiQ6PCB6.
PRIDEiQ6PCB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258884; ENSP00000258884; ENSG00000136379. [Q6PCB6-1]
ENST00000558464; ENSP00000452778; ENSG00000136379. [Q6PCB6-2]
GeneIDi58489.
KEGGihsa:58489.
UCSCiuc002bfu.4. human. [Q6PCB6-1]

Organism-specific databases

CTDi58489.
GeneCardsiABHD17C.
HGNCiHGNC:26925. ABHD17C.
HPAiHPA048890.
neXtProtiNX_Q6PCB6.
PharmGKBiPA162385639.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000000948.
HOGENOMiHOG000007142.
HOVERGENiHBG061270.
InParanoidiQ6PCB6.
OMAiRMRDENE.
PhylomeDBiQ6PCB6.
TreeFamiTF314365.

Miscellaneous databases

ChiTaRSiABHD17C. human.
GenomeRNAii58489.
PROiQ6PCB6.

Gene expression databases

BgeeiQ6PCB6.
CleanExiHS_FAM108C1.
ExpressionAtlasiQ6PCB6. baseline and differential.
GenevisibleiQ6PCB6. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
[Graphical view]
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryonic stem cell and Placenta.
  2. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-329.

Entry informationi

Entry nameiAB17C_HUMAN
AccessioniPrimary (citable) accession number: Q6PCB6
Secondary accession number(s): Q1RMD6, Q9NPM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 15, 2007
Last modified: July 6, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.