Q6PCB6 (F108C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Abhydrolase domain-containing protein FAM108C1
EC=3.-.-.-

Gene names

Name:

FAM108C1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the AB hydrolase superfamily. FAM108 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PCB6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PCB6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     223-256: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Abhydrolase domain-containing protein FAM108C1		PRO_0000297513
Regions
	Compositional bias	52 – 86	35	Ala-rich
Sites
	Active site	211	1	Charge relay system By similarity
	Active site	276	1	Charge relay system By similarity
	Active site	305	1	Charge relay system By similarity
Natural variations
	Alternative sequence	223 – 256	34	Missing in isoform 2.		VSP_027273

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: A5EE8ED4291EC49F	FASTA	329	35,831
	10 20 30 40 50 60 MPEPGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLAPEQR GAGASAPAPA 70 80 90 100 110 120 QATAAAAAAQ PAPQQPEEGA GAGPGACSLH LSERADWQYS QRELDAVEVF FSRTARDNRL 130 140 150 160 170 180 GCMFVRCAPS SRYTLLFSHG NAVDLGQMCS FYIGLGSRIN CNIFSYDYSG YGVSSGKPSE 190 200 210 220 230 240 KNLYADIDAA WQALRTRYGV SPENIILYGQ SIGTVPTVDL ASRYECAAVI LHSPLMSGLR 250 260 270 280 290 300 VAFPDTRKTY CFDAFPSIDK ISKVTSPVLV IHGTEDEVID FSHGLAMYER CPRAVEPLWV 310 320 EGAGHNDIEL YAQYLERLKQ FISHELPNS
	Isoform 2 [UniParc]. Checksum: 5789593A6137B4E1	FASTA	295	31,972
	10 20 30 40 50 60 MPEPGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLAPEQR GAGASAPAPA 70 80 90 100 110 120 QATAAAAAAQ PAPQQPEEGA GAGPGACSLH LSERADWQYS QRELDAVEVF FSRTARDNRL 130 140 150 160 170 180 GCMFVRCAPS SRYTLLFSHG NAVDLGQMCS FYIGLGSRIN CNIFSYDYSG YGVSSGKPSE 190 200 210 220 230 240 KNLYADIDAA WQALRTRYGV SPENIILYGQ SIGTVPTVDL ASSIDKISKV TSPVLVIHGT 250 260 270 280 290 EDEVIDFSHG LAMYERCPRA VEPLWVEGAG HNDIELYAQY LERLKQFISH ELPNS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Embryonic stem cell and Placenta.
[2]	The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-329.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC059401 mRNA. Translation: AAH59401.2. BC115003 mRNA. Translation: AAI15004.1. AL390079 mRNA. Translation: CAB98203.1.
IPI	IPI00747290. IPI00853483.
RefSeq	NP_067037.1. NM_021214.1.
UniGene	Hs.459072.
3D structure databases
ProteinModelPortal	Q6PCB6.
SMR	Q6PCB6. Positions 130-234.
ModBase	Search...
Protein family/group databases
MEROPS	S09.053.
Polymorphism databases
DMDM	156630444.
Proteomic databases
PRIDE	Q6PCB6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258884; ENSP00000258884; ENSG00000136379.
GeneID	58489.
KEGG	hsa:58489.
UCSC	uc002bft.1. human. uc002bfu.1. human.
Organism-specific databases
CTD	58489.
GeneCards	GC15P080987.
HGNC	HGNC:26925. FAM108C1.
neXtProt	NX_Q6PCB6.
PharmGKB	PA162385639.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19229.
GeneTree	ENSGT00390000000948.
HOGENOM	HBG678036.
HOVERGEN	HBG061270.
InParanoid	Q6PCB6.
OMA	QRINCNI.
PhylomeDB	Q6PCB6.
Gene expression databases
ArrayExpress	Q6PCB6.
Bgee	Q6PCB6.
CleanEx	HS_FAM108C1.
Genevestigator	Q6PCB6.
Family and domain databases
ProtoNet	Search...
Other
NextBio	64956.

Entry information

Entry name

F108C_HUMAN

Accession

Primary (citable) accession number: Q6PCB6
Secondary accession number(s): Q1RMD6, Q9NPM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.