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Q6PCB5

- RSBNL_HUMAN

UniProt

Q6PCB5 - RSBNL_HUMAN

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Protein

Round spermatid basic protein 1-like protein

Gene
RSBN1L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Round spermatid basic protein 1-like protein
Gene namesi
Name:RSBN1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:24765. RSBN1L.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948776.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 846845Round spermatid basic protein 1-like proteinPRO_0000299414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei28 – 281N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6PCB5.
PaxDbiQ6PCB5.
PRIDEiQ6PCB5.

PTM databases

PhosphoSiteiQ6PCB5.

Expressioni

Gene expression databases

ArrayExpressiQ6PCB5.
BgeeiQ6PCB5.
CleanExiHS_RSBN1L.
GenevestigatoriQ6PCB5.

Organism-specific databases

HPAiHPA020406.
HPA020413.

Interactioni

Protein-protein interaction databases

BioGridi128788. 4 interactions.
IntActiQ6PCB5. 1 interaction.
STRINGi9606.ENSP00000334040.

Structurei

3D structure databases

ProteinModelPortaliQ6PCB5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 154Poly-Ala
Compositional biasi76 – 12146Ser-richAdd
BLAST
Compositional biasi146 – 15510Poly-Ala
Compositional biasi197 – 27478Lys-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG306264.
HOGENOMiHOG000043117.
HOVERGENiHBG097689.
InParanoidiQ6PCB5.
OMAiYELQQIK.
OrthoDBiEOG7HTHGN.
PhylomeDBiQ6PCB5.
TreeFamiTF323256.

Family and domain databases

InterProiIPR026306. RSBN1.
[Graphical view]
PANTHERiPTHR13354. PTHR13354. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PCB5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEPPSPVHC VAAAAPTATV SEKEPFGKLQ LSSRDPPGSL SAKKVRTEEK    50
KAPRRVNGEG GSGGNSRQLQ PPAAPSPQSY GSPASWSFAP LSAAPSPSSS 100
RSSFSFSAGT AVPSSASASL SQPVPRKLLV PPTLLHAQPH HLLLPAAAAA 150
ASANAKSRRP KEKREKERRR HGLGGAREAG GASREENGEV KPLPRDKIKD 200
KIKERDKEKE REKKKHKVMN EIKKENGEVK ILLKSGKEKP KTNIEDLQIK 250
KVKKKKKKKH KENEKRKRPK MYSKSIQTIC SGLLTDVEDQ AAKGILNDNI 300
KDYVGKNLDT KNYDSKIPEN SEFPFVSLKE PRVQNNLKRL DTLEFKQLIH 350
IEHQPNGGAS VIHAYSNELS HLSPMEMERF AEEFVGLVFS ENENSAAFYV 400
MGIVHGAATY LPDFLDYFSF NFPNSPVKME ILGKKDIETT TMSNFHAQVK 450
RTYSHGTYRA GPMRQISLVG AVDEEVGDYF PEFLDMLEES PFLKCTLPWG 500
TLSSLKLQSR KDSDDGPIMW VRPGEQMIPV ADMPKSPFKR KRTTNEIKNL 550
QYLPRTSEPR EMLFEDRTRA HADHIGQGFE RQTTAAVGVL KAVHCGEWPD 600
QPRITKDVIC FHAEDFLEVV QRMQLDLHEP PLSQCVQWVD DAKLNQLRRE 650
GIRYARIQLY DNDIYFIPRN VVHQFKTVSA VCSLAWHIRL KLYHSEEDTS 700
QNTATHETGT SSDSTSSVLG PHTDNMICAV SKASLDSVFS DKLHSKYELQ 750
QIKHEPIASV RIKEEPVNVN IPEKTTALNN MDGKNVKAKL DHVQFAEFKI 800
DMDSKFENSN KDLKEELCPG NLSLVDTRQH SSAHSNQDKK DDDILC 846
Length:846
Mass (Da):94,870
Last modified:November 30, 2010 - v2
Checksum:i591E3AC544227B27
GO
Isoform 2 (identifier: Q6PCB5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.

Show »
Length:576
Mass (Da):65,582
Checksum:i9DAD61A320DA69C3
GO

Sequence cautioni

The sequence AAH46353.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAC85872.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 270270Missing in isoform 2. VSP_027658Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381G → V in AAH46353. 1 Publication
Sequence conflicti216 – 2161H → K in AAH46353. 1 Publication
Sequence conflicti375 – 3751M → V in BAC87096. 1 Publication
Sequence conflicti428 – 4314Missing in EAL24197. 1 Publication
Sequence conflicti428 – 4314Missing in AAH59402. 1 Publication
Sequence conflicti808 – 8081N → S in BAC85872. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK124517 mRNA. Translation: BAC85872.1. Different initiation.
AK127713 mRNA. Translation: BAC87096.1.
AC004955 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24197.1.
BC046353 mRNA. Translation: AAH46353.1. Sequence problems.
BC059402 mRNA. Translation: AAH59402.1.
CCDSiCCDS43607.1. [Q6PCB5-1]
RefSeqiNP_940869.2. NM_198467.2. [Q6PCB5-1]
UniGeneiHs.592289.
Hs.72451.

Genome annotation databases

EnsembliENST00000334955; ENSP00000334040; ENSG00000187257. [Q6PCB5-1]
ENST00000445288; ENSP00000393888; ENSG00000187257. [Q6PCB5-2]
GeneIDi222194.
KEGGihsa:222194.
UCSCiuc010ldt.1. human. [Q6PCB5-1]

Polymorphism databases

DMDMi313104176.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK124517 mRNA. Translation: BAC85872.1 . Different initiation.
AK127713 mRNA. Translation: BAC87096.1 .
AC004955 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24197.1 .
BC046353 mRNA. Translation: AAH46353.1 . Sequence problems.
BC059402 mRNA. Translation: AAH59402.1 .
CCDSi CCDS43607.1. [Q6PCB5-1 ]
RefSeqi NP_940869.2. NM_198467.2. [Q6PCB5-1 ]
UniGenei Hs.592289.
Hs.72451.

3D structure databases

ProteinModelPortali Q6PCB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128788. 4 interactions.
IntActi Q6PCB5. 1 interaction.
STRINGi 9606.ENSP00000334040.

PTM databases

PhosphoSitei Q6PCB5.

Polymorphism databases

DMDMi 313104176.

Proteomic databases

MaxQBi Q6PCB5.
PaxDbi Q6PCB5.
PRIDEi Q6PCB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334955 ; ENSP00000334040 ; ENSG00000187257 . [Q6PCB5-1 ]
ENST00000445288 ; ENSP00000393888 ; ENSG00000187257 . [Q6PCB5-2 ]
GeneIDi 222194.
KEGGi hsa:222194.
UCSCi uc010ldt.1. human. [Q6PCB5-1 ]

Organism-specific databases

CTDi 222194.
GeneCardsi GC07P077325.
H-InvDB HIX0025298.
HGNCi HGNC:24765. RSBN1L.
HPAi HPA020406.
HPA020413.
neXtProti NX_Q6PCB5.
PharmGKBi PA134948776.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG306264.
HOGENOMi HOG000043117.
HOVERGENi HBG097689.
InParanoidi Q6PCB5.
OMAi YELQQIK.
OrthoDBi EOG7HTHGN.
PhylomeDBi Q6PCB5.
TreeFami TF323256.

Miscellaneous databases

GenomeRNAii 222194.
NextBioi 91567.
PROi Q6PCB5.

Gene expression databases

ArrayExpressi Q6PCB5.
Bgeei Q6PCB5.
CleanExi HS_RSBN1L.
Genevestigatori Q6PCB5.

Family and domain databases

InterProi IPR026306. RSBN1.
[Graphical view ]
PANTHERi PTHR13354. PTHR13354. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Placenta.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRSBNL_HUMAN
AccessioniPrimary (citable) accession number: Q6PCB5
Secondary accession number(s): C9K0P1
, Q6ZS58, Q6ZVI9, Q86X48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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