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Protein

Round spermatid basic protein 1-like protein

Gene

RSBN1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33359-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Round spermatid basic protein 1-like protein
Gene namesi
Name:RSBN1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:24765. RSBN1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi222194.
OpenTargetsiENSG00000187257.
PharmGKBiPA134948776.

Polymorphism and mutation databases

BioMutaiRSBN1L.
DMDMi313104176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002994142 – 846Round spermatid basic protein 1-like proteinAdd BLAST845

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei28N6-acetyllysineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Cross-linki753Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki763Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki814Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PCB5.
MaxQBiQ6PCB5.
PaxDbiQ6PCB5.
PeptideAtlasiQ6PCB5.
PRIDEiQ6PCB5.

PTM databases

iPTMnetiQ6PCB5.
PhosphoSitePlusiQ6PCB5.

Expressioni

Gene expression databases

BgeeiENSG00000187257.
CleanExiHS_RSBN1L.
ExpressionAtlasiQ6PCB5. baseline and differential.
GenevisibleiQ6PCB5. HS.

Organism-specific databases

HPAiHPA020406.
HPA020413.

Interactioni

Protein-protein interaction databases

BioGridi128788. 24 interactors.
IntActiQ6PCB5. 5 interactors.
STRINGi9606.ENSP00000334040.

Structurei

3D structure databases

ProteinModelPortaliQ6PCB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 15Poly-Ala4
Compositional biasi76 – 121Ser-richAdd BLAST46
Compositional biasi146 – 155Poly-Ala10
Compositional biasi197 – 274Lys-richAdd BLAST78

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4425. Eukaryota.
ENOG410XSZP. LUCA.
GeneTreeiENSGT00390000001969.
HOGENOMiHOG000043117.
HOVERGENiHBG097689.
InParanoidiQ6PCB5.
OMAiYELQQIK.
OrthoDBiEOG091G026S.
PhylomeDBiQ6PCB5.
TreeFamiTF323256.

Family and domain databases

InterProiIPR026306. RSBN1.
[Graphical view]
PANTHERiPTHR13354. PTHR13354. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PCB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPPSPVHC VAAAAPTATV SEKEPFGKLQ LSSRDPPGSL SAKKVRTEEK
60 70 80 90 100
KAPRRVNGEG GSGGNSRQLQ PPAAPSPQSY GSPASWSFAP LSAAPSPSSS
110 120 130 140 150
RSSFSFSAGT AVPSSASASL SQPVPRKLLV PPTLLHAQPH HLLLPAAAAA
160 170 180 190 200
ASANAKSRRP KEKREKERRR HGLGGAREAG GASREENGEV KPLPRDKIKD
210 220 230 240 250
KIKERDKEKE REKKKHKVMN EIKKENGEVK ILLKSGKEKP KTNIEDLQIK
260 270 280 290 300
KVKKKKKKKH KENEKRKRPK MYSKSIQTIC SGLLTDVEDQ AAKGILNDNI
310 320 330 340 350
KDYVGKNLDT KNYDSKIPEN SEFPFVSLKE PRVQNNLKRL DTLEFKQLIH
360 370 380 390 400
IEHQPNGGAS VIHAYSNELS HLSPMEMERF AEEFVGLVFS ENENSAAFYV
410 420 430 440 450
MGIVHGAATY LPDFLDYFSF NFPNSPVKME ILGKKDIETT TMSNFHAQVK
460 470 480 490 500
RTYSHGTYRA GPMRQISLVG AVDEEVGDYF PEFLDMLEES PFLKCTLPWG
510 520 530 540 550
TLSSLKLQSR KDSDDGPIMW VRPGEQMIPV ADMPKSPFKR KRTTNEIKNL
560 570 580 590 600
QYLPRTSEPR EMLFEDRTRA HADHIGQGFE RQTTAAVGVL KAVHCGEWPD
610 620 630 640 650
QPRITKDVIC FHAEDFLEVV QRMQLDLHEP PLSQCVQWVD DAKLNQLRRE
660 670 680 690 700
GIRYARIQLY DNDIYFIPRN VVHQFKTVSA VCSLAWHIRL KLYHSEEDTS
710 720 730 740 750
QNTATHETGT SSDSTSSVLG PHTDNMICAV SKASLDSVFS DKLHSKYELQ
760 770 780 790 800
QIKHEPIASV RIKEEPVNVN IPEKTTALNN MDGKNVKAKL DHVQFAEFKI
810 820 830 840
DMDSKFENSN KDLKEELCPG NLSLVDTRQH SSAHSNQDKK DDDILC
Length:846
Mass (Da):94,870
Last modified:November 30, 2010 - v2
Checksum:i591E3AC544227B27
GO
Isoform 2 (identifier: Q6PCB5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.

Show »
Length:576
Mass (Da):65,582
Checksum:i9DAD61A320DA69C3
GO

Sequence cautioni

The sequence AAH46353 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC85872 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38G → V in AAH46353 (PubMed:15489334).Curated1
Sequence conflicti216H → K in AAH46353 (PubMed:15489334).Curated1
Sequence conflicti375M → V in BAC87096 (PubMed:14702039).Curated1
Sequence conflicti428 – 431Missing in EAL24197 (PubMed:12690205).Curated4
Sequence conflicti428 – 431Missing in AAH59402 (PubMed:15489334).Curated4
Sequence conflicti808N → S in BAC85872 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0276581 – 270Missing in isoform 2. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124517 mRNA. Translation: BAC85872.1. Different initiation.
AK127713 mRNA. Translation: BAC87096.1.
AC004955 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24197.1.
BC046353 mRNA. Translation: AAH46353.1. Sequence problems.
BC059402 mRNA. Translation: AAH59402.1.
CCDSiCCDS43607.1. [Q6PCB5-1]
RefSeqiNP_940869.2. NM_198467.2. [Q6PCB5-1]
UniGeneiHs.592289.
Hs.72451.

Genome annotation databases

EnsembliENST00000334955; ENSP00000334040; ENSG00000187257. [Q6PCB5-1]
ENST00000445288; ENSP00000393888; ENSG00000187257. [Q6PCB5-2]
GeneIDi222194.
KEGGihsa:222194.
UCSCiuc010ldt.2. human. [Q6PCB5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124517 mRNA. Translation: BAC85872.1. Different initiation.
AK127713 mRNA. Translation: BAC87096.1.
AC004955 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24197.1.
BC046353 mRNA. Translation: AAH46353.1. Sequence problems.
BC059402 mRNA. Translation: AAH59402.1.
CCDSiCCDS43607.1. [Q6PCB5-1]
RefSeqiNP_940869.2. NM_198467.2. [Q6PCB5-1]
UniGeneiHs.592289.
Hs.72451.

3D structure databases

ProteinModelPortaliQ6PCB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128788. 24 interactors.
IntActiQ6PCB5. 5 interactors.
STRINGi9606.ENSP00000334040.

PTM databases

iPTMnetiQ6PCB5.
PhosphoSitePlusiQ6PCB5.

Polymorphism and mutation databases

BioMutaiRSBN1L.
DMDMi313104176.

Proteomic databases

EPDiQ6PCB5.
MaxQBiQ6PCB5.
PaxDbiQ6PCB5.
PeptideAtlasiQ6PCB5.
PRIDEiQ6PCB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334955; ENSP00000334040; ENSG00000187257. [Q6PCB5-1]
ENST00000445288; ENSP00000393888; ENSG00000187257. [Q6PCB5-2]
GeneIDi222194.
KEGGihsa:222194.
UCSCiuc010ldt.2. human. [Q6PCB5-1]

Organism-specific databases

CTDi222194.
DisGeNETi222194.
GeneCardsiRSBN1L.
H-InvDBHIX0025298.
HGNCiHGNC:24765. RSBN1L.
HPAiHPA020406.
HPA020413.
neXtProtiNX_Q6PCB5.
OpenTargetsiENSG00000187257.
PharmGKBiPA134948776.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4425. Eukaryota.
ENOG410XSZP. LUCA.
GeneTreeiENSGT00390000001969.
HOGENOMiHOG000043117.
HOVERGENiHBG097689.
InParanoidiQ6PCB5.
OMAiYELQQIK.
OrthoDBiEOG091G026S.
PhylomeDBiQ6PCB5.
TreeFamiTF323256.

Enzyme and pathway databases

BioCyciZFISH:G66-33359-MONOMER.

Miscellaneous databases

ChiTaRSiRSBN1L. human.
GenomeRNAii222194.
PROiQ6PCB5.

Gene expression databases

BgeeiENSG00000187257.
CleanExiHS_RSBN1L.
ExpressionAtlasiQ6PCB5. baseline and differential.
GenevisibleiQ6PCB5. HS.

Family and domain databases

InterProiIPR026306. RSBN1.
[Graphical view]
PANTHERiPTHR13354. PTHR13354. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRSBNL_HUMAN
AccessioniPrimary (citable) accession number: Q6PCB5
Secondary accession number(s): C9K0P1
, Q6ZS58, Q6ZVI9, Q86X48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.