Q6PCB5 (RSBNL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Round spermatid basic protein 1-like protein

Gene names

Name:

RSBN1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	846 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the round spermatid basic protein 1 family.
Sequence caution	The sequence AAH46353.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAC85872.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PCB5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PCB5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-270: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 846	846	Round spermatid basic protein 1-like protein		PRO_0000299414
Regions
	Compositional bias	12 – 15	4	Poly-Ala
	Compositional bias	76 – 121	46	Ser-rich
	Compositional bias	146 – 155	10	Poly-Ala
	Compositional bias	197 – 274	78	Lys-rich
Amino acid modifications
	Modified residue	28	1	N6-acetyllysine Ref.6
Natural variations
	Alternative sequence	1 – 270	270	Missing in isoform 2.		VSP_027658
Experimental info
	Sequence conflict	38	1	G → V in AAH46353. Ref.4
	Sequence conflict	216	1	H → K in AAH46353. Ref.4
	Sequence conflict	375	1	M → V in BAC87096. Ref.1
	Sequence conflict	428 – 431	4	Missing in EAL24197. Ref.3
	Sequence conflict	428 – 431	4	Missing in AAH59402. Ref.4
	Sequence conflict	808	1	N → S in BAC85872. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 591E3AC544227B27	FASTA	846	94,870
	10 20 30 40 50 60 MAEPPSPVHC VAAAAPTATV SEKEPFGKLQ LSSRDPPGSL SAKKVRTEEK KAPRRVNGEG 70 80 90 100 110 120 GSGGNSRQLQ PPAAPSPQSY GSPASWSFAP LSAAPSPSSS RSSFSFSAGT AVPSSASASL 130 140 150 160 170 180 SQPVPRKLLV PPTLLHAQPH HLLLPAAAAA ASANAKSRRP KEKREKERRR HGLGGAREAG 190 200 210 220 230 240 GASREENGEV KPLPRDKIKD KIKERDKEKE REKKKHKVMN EIKKENGEVK ILLKSGKEKP 250 260 270 280 290 300 KTNIEDLQIK KVKKKKKKKH KENEKRKRPK MYSKSIQTIC SGLLTDVEDQ AAKGILNDNI 310 320 330 340 350 360 KDYVGKNLDT KNYDSKIPEN SEFPFVSLKE PRVQNNLKRL DTLEFKQLIH IEHQPNGGAS 370 380 390 400 410 420 VIHAYSNELS HLSPMEMERF AEEFVGLVFS ENENSAAFYV MGIVHGAATY LPDFLDYFSF 430 440 450 460 470 480 NFPNSPVKME ILGKKDIETT TMSNFHAQVK RTYSHGTYRA GPMRQISLVG AVDEEVGDYF 490 500 510 520 530 540 PEFLDMLEES PFLKCTLPWG TLSSLKLQSR KDSDDGPIMW VRPGEQMIPV ADMPKSPFKR 550 560 570 580 590 600 KRTTNEIKNL QYLPRTSEPR EMLFEDRTRA HADHIGQGFE RQTTAAVGVL KAVHCGEWPD 610 620 630 640 650 660 QPRITKDVIC FHAEDFLEVV QRMQLDLHEP PLSQCVQWVD DAKLNQLRRE GIRYARIQLY 670 680 690 700 710 720 DNDIYFIPRN VVHQFKTVSA VCSLAWHIRL KLYHSEEDTS QNTATHETGT SSDSTSSVLG 730 740 750 760 770 780 PHTDNMICAV SKASLDSVFS DKLHSKYELQ QIKHEPIASV RIKEEPVNVN IPEKTTALNN 790 800 810 820 830 840 MDGKNVKAKL DHVQFAEFKI DMDSKFENSN KDLKEELCPG NLSLVDTRQH SSAHSNQDKK DDDILC
	Isoform 2 [UniParc]. Checksum: 9DAD61A320DA69C3	FASTA	576	65,582
	10 20 30 40 50 60 MYSKSIQTIC SGLLTDVEDQ AAKGILNDNI KDYVGKNLDT KNYDSKIPEN SEFPFVSLKE 70 80 90 100 110 120 PRVQNNLKRL DTLEFKQLIH IEHQPNGGAS VIHAYSNELS HLSPMEMERF AEEFVGLVFS 130 140 150 160 170 180 ENENSAAFYV MGIVHGAATY LPDFLDYFSF NFPNSPVKME ILGKKDIETT TMSNFHAQVK 190 200 210 220 230 240 RTYSHGTYRA GPMRQISLVG AVDEEVGDYF PEFLDMLEES PFLKCTLPWG TLSSLKLQSR 250 260 270 280 290 300 KDSDDGPIMW VRPGEQMIPV ADMPKSPFKR KRTTNEIKNL QYLPRTSEPR EMLFEDRTRA 310 320 330 340 350 360 HADHIGQGFE RQTTAAVGVL KAVHCGEWPD QPRITKDVIC FHAEDFLEVV QRMQLDLHEP 370 380 390 400 410 420 PLSQCVQWVD DAKLNQLRRE GIRYARIQLY DNDIYFIPRN VVHQFKTVSA VCSLAWHIRL 430 440 450 460 470 480 KLYHSEEDTS QNTATHETGT SSDSTSSVLG PHTDNMICAV SKASLDSVFS DKLHSKYELQ 490 500 510 520 530 540 QIKHEPIASV RIKEEPVNVN IPEKTTALNN MDGKNVKAKL DHVQFAEFKI DMDSKFENSN 550 560 570 KDLKEELCPG NLSLVDTRQH SSAHSNQDKK DDDILC

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Cerebellum.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye and Placenta.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-28, MASS SPECTROMETRY.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK124517 mRNA. Translation: BAC85872.1. Different initiation. AK127713 mRNA. Translation: BAC87096.1. AC004955 Genomic DNA. No translation available. CH236949 Genomic DNA. Translation: EAL24197.1. BC046353 mRNA. Translation: AAH46353.1. Sequence problems. BC059402 mRNA. Translation: AAH59402.1.
IPI	IPI00856118. IPI00925255.
RefSeq	NP_940869.2. NM_198467.2.
UniGene	Hs.592289. Hs.72451.
3D structure databases
ProteinModelPortal	Q6PCB5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000334040.
PTM databases
PhosphoSite	Q6PCB5.
Polymorphism databases
DMDM	74737559.
Proteomic databases
PaxDb	Q6PCB5.
PRIDE	Q6PCB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334955; ENSP00000334040; ENSG00000187257. ENST00000445288; ENSP00000393888; ENSG00000187257.
GeneID	222194.
KEGG	hsa:222194.
UCSC	uc010ldt.1. human.
Organism-specific databases
CTD	222194.
GeneCards	GC07P077325.
H-InvDB	HIX0025298.
HGNC	HGNC:24765. RSBN1L.
HPA	HPA020406. HPA020413.
neXtProt	NX_Q6PCB5.
PharmGKB	PA134948776.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG306264.
HOGENOM	HOG000043117.
HOVERGEN	HBG097689.
InParanoid	Q6PCB5.
OMA	ELQQIKH.
OrthoDB	EOG41C6VW.
Gene expression databases
ArrayExpress	Q6PCB5.
Bgee	Q6PCB5.
CleanEx	HS_RSBN1L.
Genevestigator	Q6PCB5.
Family and domain databases
InterPro	IPR026306. RSBN1. [Graphical view]
PANTHER	PTHR13354. PTHR13354. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	222194.
NextBio	91567.

Entry information

Entry name

RSBNL_HUMAN

Accession

Primary (citable) accession number: Q6PCB5
Secondary accession number(s): C9K0P1 , Q6ZS58, Q6ZVI9, Q86X48

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	November 30, 2010
Last modified:	April 3, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.