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Q6PCB5

- RSBNL_HUMAN

UniProt

Q6PCB5 - RSBNL_HUMAN

Protein

Round spermatid basic protein 1-like protein

Gene

RSBN1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Round spermatid basic protein 1-like protein
    Gene namesi
    Name:RSBN1L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:24765. RSBN1L.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134948776.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 846845Round spermatid basic protein 1-like proteinPRO_0000299414Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei28 – 281N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ6PCB5.
    PaxDbiQ6PCB5.
    PRIDEiQ6PCB5.

    PTM databases

    PhosphoSiteiQ6PCB5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PCB5.
    BgeeiQ6PCB5.
    CleanExiHS_RSBN1L.
    GenevestigatoriQ6PCB5.

    Organism-specific databases

    HPAiHPA020406.
    HPA020413.

    Interactioni

    Protein-protein interaction databases

    BioGridi128788. 4 interactions.
    IntActiQ6PCB5. 1 interaction.
    STRINGi9606.ENSP00000334040.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PCB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi12 – 154Poly-Ala
    Compositional biasi76 – 12146Ser-richAdd
    BLAST
    Compositional biasi146 – 15510Poly-Ala
    Compositional biasi197 – 27478Lys-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG306264.
    HOGENOMiHOG000043117.
    HOVERGENiHBG097689.
    InParanoidiQ6PCB5.
    OMAiYELQQIK.
    OrthoDBiEOG7HTHGN.
    PhylomeDBiQ6PCB5.
    TreeFamiTF323256.

    Family and domain databases

    InterProiIPR026306. RSBN1.
    [Graphical view]
    PANTHERiPTHR13354. PTHR13354. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PCB5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEPPSPVHC VAAAAPTATV SEKEPFGKLQ LSSRDPPGSL SAKKVRTEEK    50
    KAPRRVNGEG GSGGNSRQLQ PPAAPSPQSY GSPASWSFAP LSAAPSPSSS 100
    RSSFSFSAGT AVPSSASASL SQPVPRKLLV PPTLLHAQPH HLLLPAAAAA 150
    ASANAKSRRP KEKREKERRR HGLGGAREAG GASREENGEV KPLPRDKIKD 200
    KIKERDKEKE REKKKHKVMN EIKKENGEVK ILLKSGKEKP KTNIEDLQIK 250
    KVKKKKKKKH KENEKRKRPK MYSKSIQTIC SGLLTDVEDQ AAKGILNDNI 300
    KDYVGKNLDT KNYDSKIPEN SEFPFVSLKE PRVQNNLKRL DTLEFKQLIH 350
    IEHQPNGGAS VIHAYSNELS HLSPMEMERF AEEFVGLVFS ENENSAAFYV 400
    MGIVHGAATY LPDFLDYFSF NFPNSPVKME ILGKKDIETT TMSNFHAQVK 450
    RTYSHGTYRA GPMRQISLVG AVDEEVGDYF PEFLDMLEES PFLKCTLPWG 500
    TLSSLKLQSR KDSDDGPIMW VRPGEQMIPV ADMPKSPFKR KRTTNEIKNL 550
    QYLPRTSEPR EMLFEDRTRA HADHIGQGFE RQTTAAVGVL KAVHCGEWPD 600
    QPRITKDVIC FHAEDFLEVV QRMQLDLHEP PLSQCVQWVD DAKLNQLRRE 650
    GIRYARIQLY DNDIYFIPRN VVHQFKTVSA VCSLAWHIRL KLYHSEEDTS 700
    QNTATHETGT SSDSTSSVLG PHTDNMICAV SKASLDSVFS DKLHSKYELQ 750
    QIKHEPIASV RIKEEPVNVN IPEKTTALNN MDGKNVKAKL DHVQFAEFKI 800
    DMDSKFENSN KDLKEELCPG NLSLVDTRQH SSAHSNQDKK DDDILC 846
    Length:846
    Mass (Da):94,870
    Last modified:November 30, 2010 - v2
    Checksum:i591E3AC544227B27
    GO
    Isoform 2 (identifier: Q6PCB5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-270: Missing.

    Show »
    Length:576
    Mass (Da):65,582
    Checksum:i9DAD61A320DA69C3
    GO

    Sequence cautioni

    The sequence AAH46353.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAC85872.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381G → V in AAH46353. (PubMed:15489334)Curated
    Sequence conflicti216 – 2161H → K in AAH46353. (PubMed:15489334)Curated
    Sequence conflicti375 – 3751M → V in BAC87096. (PubMed:14702039)Curated
    Sequence conflicti428 – 4314Missing in EAL24197. (PubMed:12690205)Curated
    Sequence conflicti428 – 4314Missing in AAH59402. (PubMed:15489334)Curated
    Sequence conflicti808 – 8081N → S in BAC85872. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 270270Missing in isoform 2. 1 PublicationVSP_027658Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK124517 mRNA. Translation: BAC85872.1. Different initiation.
    AK127713 mRNA. Translation: BAC87096.1.
    AC004955 Genomic DNA. No translation available.
    CH236949 Genomic DNA. Translation: EAL24197.1.
    BC046353 mRNA. Translation: AAH46353.1. Sequence problems.
    BC059402 mRNA. Translation: AAH59402.1.
    CCDSiCCDS43607.1. [Q6PCB5-1]
    RefSeqiNP_940869.2. NM_198467.2. [Q6PCB5-1]
    UniGeneiHs.592289.
    Hs.72451.

    Genome annotation databases

    EnsembliENST00000334955; ENSP00000334040; ENSG00000187257. [Q6PCB5-1]
    ENST00000445288; ENSP00000393888; ENSG00000187257. [Q6PCB5-2]
    GeneIDi222194.
    KEGGihsa:222194.
    UCSCiuc010ldt.1. human. [Q6PCB5-1]

    Polymorphism databases

    DMDMi313104176.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK124517 mRNA. Translation: BAC85872.1 . Different initiation.
    AK127713 mRNA. Translation: BAC87096.1 .
    AC004955 Genomic DNA. No translation available.
    CH236949 Genomic DNA. Translation: EAL24197.1 .
    BC046353 mRNA. Translation: AAH46353.1 . Sequence problems.
    BC059402 mRNA. Translation: AAH59402.1 .
    CCDSi CCDS43607.1. [Q6PCB5-1 ]
    RefSeqi NP_940869.2. NM_198467.2. [Q6PCB5-1 ]
    UniGenei Hs.592289.
    Hs.72451.

    3D structure databases

    ProteinModelPortali Q6PCB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128788. 4 interactions.
    IntActi Q6PCB5. 1 interaction.
    STRINGi 9606.ENSP00000334040.

    PTM databases

    PhosphoSitei Q6PCB5.

    Polymorphism databases

    DMDMi 313104176.

    Proteomic databases

    MaxQBi Q6PCB5.
    PaxDbi Q6PCB5.
    PRIDEi Q6PCB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334955 ; ENSP00000334040 ; ENSG00000187257 . [Q6PCB5-1 ]
    ENST00000445288 ; ENSP00000393888 ; ENSG00000187257 . [Q6PCB5-2 ]
    GeneIDi 222194.
    KEGGi hsa:222194.
    UCSCi uc010ldt.1. human. [Q6PCB5-1 ]

    Organism-specific databases

    CTDi 222194.
    GeneCardsi GC07P077325.
    H-InvDB HIX0025298.
    HGNCi HGNC:24765. RSBN1L.
    HPAi HPA020406.
    HPA020413.
    neXtProti NX_Q6PCB5.
    PharmGKBi PA134948776.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306264.
    HOGENOMi HOG000043117.
    HOVERGENi HBG097689.
    InParanoidi Q6PCB5.
    OMAi YELQQIK.
    OrthoDBi EOG7HTHGN.
    PhylomeDBi Q6PCB5.
    TreeFami TF323256.

    Miscellaneous databases

    GenomeRNAii 222194.
    NextBioi 91567.
    PROi Q6PCB5.

    Gene expression databases

    ArrayExpressi Q6PCB5.
    Bgeei Q6PCB5.
    CleanExi HS_RSBN1L.
    Genevestigatori Q6PCB5.

    Family and domain databases

    InterProi IPR026306. RSBN1.
    [Graphical view ]
    PANTHERi PTHR13354. PTHR13354. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Placenta.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRSBNL_HUMAN
    AccessioniPrimary (citable) accession number: Q6PCB5
    Secondary accession number(s): C9K0P1
    , Q6ZS58, Q6ZVI9, Q86X48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3