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Protein

40S ribosomal protein S12

Gene

rps12

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal proteinUniRule annotationImported

Enzyme and pathway databases

ReactomeiR-DRE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DRE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DRE-6791226. Major pathway of rRNA processing in the nucleolus.
R-DRE-72649. Translation initiation complex formation.
R-DRE-72689. Formation of a pool of free 40S subunits.
R-DRE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DRE-72702. Ribosomal scanning and start codon recognition.
R-DRE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DRE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S12UniRule annotation
Gene namesi
Name:rps12Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-030131-8951. rps12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053541.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 11094Ribosomal_L7AeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S12e family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000018318.
HOGENOMiHOG000210688.
HOVERGENiHBG001720.
KOiK02951.
OMAiNCDEPTY.
OrthoDBiEOG7H1JP3.
PhylomeDBiQ6PC90.
TreeFamiTF300196.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PC90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEGIAAGG VMDVNTALPE VLKTALIHDG LARGIREAAK ALDKRQAHLC
60 70 80 90 100
VLAANCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWVG LCKIDREGKP
110 120 130
RKVVGCSCVV IKDYGKESQA KDVIEEYFKS KK
Length:132
Mass (Da):14,466
Last modified:July 5, 2004 - v1
Checksum:iF453D1888392ED8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759830 Genomic DNA. No translation available.
BC059433 mRNA. Translation: AAH59433.1.
AY561510 mRNA. Translation: AAS66963.1.
RefSeqiNP_001269106.1. NM_001282177.1.
NP_956340.1. NM_200046.3.
UniGeneiDr.75550.

Genome annotation databases

EnsembliENSDART00000053542; ENSDARP00000053541; ENSDARG00000036875.
ENSDART00000138350; ENSDARP00000120403; ENSDARG00000036875.
GeneIDi337007.
KEGGidre:337007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759830 Genomic DNA. No translation available.
BC059433 mRNA. Translation: AAH59433.1.
AY561510 mRNA. Translation: AAS66963.1.
RefSeqiNP_001269106.1. NM_001282177.1.
NP_956340.1. NM_200046.3.
UniGeneiDr.75550.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000053542; ENSDARP00000053541; ENSDARG00000036875.
ENSDART00000138350; ENSDARP00000120403; ENSDARG00000036875.
GeneIDi337007.
KEGGidre:337007.

Organism-specific databases

CTDi6206.
ZFINiZDB-GENE-030131-8951. rps12.

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000018318.
HOGENOMiHOG000210688.
HOVERGENiHBG001720.
KOiK02951.
OMAiNCDEPTY.
OrthoDBiEOG7H1JP3.
PhylomeDBiQ6PC90.
TreeFamiTF300196.

Enzyme and pathway databases

ReactomeiR-DRE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DRE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DRE-6791226. Major pathway of rRNA processing in the nucleolus.
R-DRE-72649. Translation initiation complex formation.
R-DRE-72689. Formation of a pool of free 40S subunits.
R-DRE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DRE-72702. Ribosomal scanning and start codon recognition.
R-DRE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DRE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Wild-typeImported.
    Tissue: EyeImported.
  2. "Many ribosomal protein genes are cancer genes in zebrafish."
    Amsterdam A., Sadler K.C., Lai K., Farrington S., Bronson R.T., Lees J.A., Hopkins N.
    PLoS Biol. 2:690-698(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ6PC90_DANRE
AccessioniPrimary (citable) accession number: Q6PC90
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.