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Protein

Elongation of very long chain fatty acids protein 6

Gene

elovl6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.UniRule annotation

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DRE-2426168. Activation of gene expression by SREBF (SREBP).
R-DRE-75876. Synthesis of very long-chain fatty acyl-CoAs.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids protein 6UniRule annotationCurated (EC:2.3.1.199UniRule annotationBy similarity)
Alternative name(s):
3-keto acyl-CoA synthase elovl6UniRule annotation
ELOVL fatty acid elongase 6UniRule annotation
Short name:
ELOVL FA elongase 6UniRule annotation
Very long chain 3-ketoacyl-CoA synthase 6UniRule annotation
Very long chain 3-oxoacyl-CoA synthase 6UniRule annotation
Gene namesi
Name:elovl6UniRule annotation
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-030114-1. elovl6.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 4918HelicalUniRule annotationAdd
BLAST
Transmembranei61 – 8121HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12921HelicalUniRule annotationAdd
BLAST
Transmembranei134 – 15421HelicalUniRule annotationAdd
BLAST
Transmembranei157 – 17721HelicalUniRule annotationAdd
BLAST
Transmembranei194 – 21421HelicalUniRule annotationAdd
BLAST
Transmembranei231 – 25121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Elongation of very long chain fatty acids protein 6PRO_0000282848Add
BLAST

Post-translational modificationi

N-Glycosylated.UniRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PC64.

Expressioni

Gene expression databases

BgeeiENSDARG00000004402.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096379.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELO family. ELOVL6 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3072. Eukaryota.
ENOG410Z3FZ. LUCA.
GeneTreeiENSGT00760000119122.
HOGENOMiHOG000038943.
HOVERGENiHBG099423.
InParanoidiQ6PC64.
KOiK10203.
OMAiNDQCYSH.
OrthoDBiEOG091G0EKU.
PhylomeDBiQ6PC64.
TreeFamiTF106467.

Family and domain databases

HAMAPiMF_03206. VLCF_elongase_6. 1 hit.
InterProiIPR030457. ELO_CS.
IPR002076. ELO_fam.
IPR033675. ELOVL6.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PTHR11157:SF42. PTHR11157:SF42. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]
PROSITEiPS01188. ELO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PC64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLALQEYE FERQFNEDEA IRWMQENWKK SFLFSALYAA CILGGRHVMK
60 70 80 90 100
QREKFELRKP LVLWSLTLAA FSIFGAIRTG GYMVNILMTK GLKQSVCDQS
110 120 130 140 150
FYNGPVSKFW AYAFVLSKAP ELGDTLFIVL RKQKLIFLHW YHHITVLLYS
160 170 180 190 200
WYSYKDMVAG GGWFMTMNYL VHAVMYSYYA LRAAGFKISR KFAMFITLTQ
210 220 230 240 250
ITQMVMGCVV NYLVYLWMQQ GQECPSHVQN IVWSSLMYLS YFVLFCQFFF
260
EAYITKRKSN AAKKSQ
Length:266
Mass (Da):31,279
Last modified:July 5, 2004 - v1
Checksum:i03570E68621EE9FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059459 mRNA. Translation: AAH59459.1.
RefSeqiNP_955826.1. NM_199532.1.
UniGeneiDr.107502.

Genome annotation databases

EnsembliENSDART00000105602; ENSDARP00000096379; ENSDARG00000004402.
GeneIDi317738.
KEGGidre:317738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059459 mRNA. Translation: AAH59459.1.
RefSeqiNP_955826.1. NM_199532.1.
UniGeneiDr.107502.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096379.

Proteomic databases

PaxDbiQ6PC64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000105602; ENSDARP00000096379; ENSDARG00000004402.
GeneIDi317738.
KEGGidre:317738.

Organism-specific databases

CTDi79071.
ZFINiZDB-GENE-030114-1. elovl6.

Phylogenomic databases

eggNOGiKOG3072. Eukaryota.
ENOG410Z3FZ. LUCA.
GeneTreeiENSGT00760000119122.
HOGENOMiHOG000038943.
HOVERGENiHBG099423.
InParanoidiQ6PC64.
KOiK10203.
OMAiNDQCYSH.
OrthoDBiEOG091G0EKU.
PhylomeDBiQ6PC64.
TreeFamiTF106467.

Enzyme and pathway databases

UniPathwayiUPA00094.
ReactomeiR-DRE-2426168. Activation of gene expression by SREBF (SREBP).
R-DRE-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

PROiQ6PC64.

Gene expression databases

BgeeiENSDARG00000004402.

Family and domain databases

HAMAPiMF_03206. VLCF_elongase_6. 1 hit.
InterProiIPR030457. ELO_CS.
IPR002076. ELO_fam.
IPR033675. ELOVL6.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PTHR11157:SF42. PTHR11157:SF42. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]
PROSITEiPS01188. ELO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOV6_DANRE
AccessioniPrimary (citable) accession number: Q6PC64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.