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Protein
Submitted name:

Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)

Gene

ube2d1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.3.2.B5. 928.
ReactomeiR-DRE-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DRE-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-DRE-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-DRE-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DRE-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DRE-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DRE-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DRE-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-DRE-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-DRE-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-DRE-176412. Phosphorylation of the APC/C.
R-DRE-179409. APC-Cdc20 mediated degradation of Nek2A.
R-DRE-201451. Signaling by BMP.
R-DRE-202424. Downstream TCR signaling.
R-DRE-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ube2d1bImported
Synonyms:ube2d1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-030131-2735. ube2d1b.

Expressioni

Gene expression databases

BgeeiENSDARG00000038576.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033537.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OXQX-ray2.90A/B1-147[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 136133UBIQUITIN_CONJUGAT_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0417. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
KOiK06689.
OMAiQEIAREW.
OrthoDBiEOG091G0GF8.
TreeFamiTF101108.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PC58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKRIQKEL QDLQRDPPAQ CSAGPVGDDL FHWQATIMGP SDSPYQGGVF
60 70 80 90 100
FLTIHFPTDY PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS
110 120 130 140
KVLLSICSLL CDPNPDDPLV PDIAHIYKSD KEKYNRLARE WTQKYAM
Length:147
Mass (Da):16,635
Last modified:July 5, 2004 - v1
Checksum:i8D89C316FEF98497
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU326359 Genomic DNA. No translation available.
BC059465 mRNA. Translation: AAH59465.1.
RefSeqiNP_955958.1. NM_199664.1.
UniGeneiDr.76236.

Genome annotation databases

EnsembliENSDART00000035762; ENSDARP00000033537; ENSDARG00000038576.
GeneIDi324015.
KEGGidre:324015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU326359 Genomic DNA. No translation available.
BC059465 mRNA. Translation: AAH59465.1.
RefSeqiNP_955958.1. NM_199664.1.
UniGeneiDr.76236.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OXQX-ray2.90A/B1-147[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033537.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000035762; ENSDARP00000033537; ENSDARG00000038576.
GeneIDi324015.
KEGGidre:324015.

Organism-specific databases

CTDi324015.
ZFINiZDB-GENE-030131-2735. ube2d1b.

Phylogenomic databases

eggNOGiKOG0417. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
KOiK06689.
OMAiQEIAREW.
OrthoDBiEOG091G0GF8.
TreeFamiTF101108.

Enzyme and pathway databases

BRENDAi2.3.2.B5. 928.
ReactomeiR-DRE-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DRE-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-DRE-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-DRE-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DRE-174154. APC/C:Cdc20 mediated degradation of Securin.
R-DRE-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DRE-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DRE-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-DRE-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-DRE-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-DRE-176412. Phosphorylation of the APC/C.
R-DRE-179409. APC-Cdc20 mediated degradation of Nek2A.
R-DRE-201451. Signaling by BMP.
R-DRE-202424. Downstream TCR signaling.
R-DRE-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-DRE-2467813. Separation of Sister Chromatids.
R-DRE-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.

Gene expression databases

BgeeiENSDARG00000038576.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PC58_DANRE
AccessioniPrimary (citable) accession number: Q6PC58
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.