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Protein
Submitted name:

Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)

Gene

ube2d1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.3.2.B5 928
ReactomeiR-DRE-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DRE-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DRE-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DRE-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DRE-174154 APC/C:Cdc20 mediated degradation of Securin
R-DRE-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DRE-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DRE-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DRE-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DRE-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DRE-176412 Phosphorylation of the APC/C
R-DRE-179409 APC-Cdc20 mediated degradation of Nek2A
R-DRE-201451 Signaling by BMP
R-DRE-202424 Downstream TCR signaling
R-DRE-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-DRE-2467813 Separation of Sister Chromatids
R-DRE-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DRE-2871837 FCERI mediated NF-kB activation
R-DRE-5607764 CLEC7A (Dectin-1) signaling
R-DRE-5689896 Ovarian tumor domain proteases
R-DRE-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DRE-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DRE-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-DRE-8951664 Neddylation
R-DRE-9033241 Peroxisomal protein import
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)Imported
Submitted name:
Ubiquitin-conjugating enzyme E2D 1bImported
Gene namesi
Name:ube2d1bImported
Synonyms:ube2d1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-030131-2735 ube2d1b

Expressioni

Gene expression databases

BgeeiENSDARG00000038576

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000033537

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OXQX-ray2.90A/B1-147[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 136UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST133

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
KOiK06689
OMAiREWTANW
OrthoDBiEOG091G0GF8
TreeFamiTF101108

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PC58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKRIQKEL QDLQRDPPAQ CSAGPVGDDL FHWQATIMGP SDSPYQGGVF
60 70 80 90 100
FLTIHFPTDY PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS
110 120 130 140
KVLLSICSLL CDPNPDDPLV PDIAHIYKSD KEKYNRLARE WTQKYAM
Length:147
Mass (Da):16,635
Last modified:July 5, 2004 - v1
Checksum:i8D89C316FEF98497
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU326359 Genomic DNA No translation available.
BC059465 mRNA Translation: AAH59465.1
RefSeqiNP_955958.1, NM_199664.1
UniGeneiDr.76236

Genome annotation databases

EnsembliENSDART00000035762; ENSDARP00000033537; ENSDARG00000038576
GeneIDi324015
KEGGidre:324015

Similar proteinsi

Entry informationi

Entry nameiQ6PC58_DANRE
AccessioniPrimary (citable) accession number: Q6PC58
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health