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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

ppiab

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: InterPro
  • response to hypoxia Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:ppiabImported
Synonyms:ppialImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-030131-7459. ppiab.

Expressioni

Gene expression databases

BgeeiENSDARG00000042247.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061957.

Structurei

3D structure databases

SMRiQ6PC53. Positions 2-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 163157PPIase cyclophilin-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation
Contains 1 PPIase cyclophilin-type domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119119.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
KOiK03767.
OMAiMGRITMQ.
OrthoDBiEOG091G0BGL.
TreeFamiTF312801.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PC53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPKVFFDI TIDGKEAGRI VMELRADVVP KTAENFRALC TGEKGFGYKG
60 70 80 90 100
SGFHRVIPQF MCQGGDFTNH NGTGGKSIYG NKFEDENFTL KHGGKGTLSM
110 120 130 140 150
ANAGPNTNGS QFFICTADTN WLDGKHVVFG KVVDGLDVVD AIEKKGSSSG
160
KCSAKVVIAN CGQL
Length:164
Mass (Da):17,489
Last modified:July 5, 2004 - v1
Checksum:iB8755219F1BF91F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP074878 Genomic DNA. No translation available.
BC059470 mRNA. Translation: AAH59470.1.
BC071370 mRNA. Translation: AAH71370.1.
RefSeqiNP_956251.1. NM_199957.1.
XP_005155533.1. XM_005155476.2.
UniGeneiDr.78109.

Genome annotation databases

EnsembliENSDART00000166085; ENSDARP00000134856; ENSDARG00000103994.
GeneIDi335519.
KEGGidre:335519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP074878 Genomic DNA. No translation available.
BC059470 mRNA. Translation: AAH59470.1.
BC071370 mRNA. Translation: AAH71370.1.
RefSeqiNP_956251.1. NM_199957.1.
XP_005155533.1. XM_005155476.2.
UniGeneiDr.78109.

3D structure databases

SMRiQ6PC53. Positions 2-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061957.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000166085; ENSDARP00000134856; ENSDARG00000103994.
GeneIDi335519.
KEGGidre:335519.

Organism-specific databases

CTDi335519.
ZFINiZDB-GENE-030131-7459. ppiab.

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119119.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
KOiK03767.
OMAiMGRITMQ.
OrthoDBiEOG091G0BGL.
TreeFamiTF312801.

Gene expression databases

BgeeiENSDARG00000042247.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PC53_DANRE
AccessioniPrimary (citable) accession number: Q6PC53
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.