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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

ppiab

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: InterPro
  • response to hypoxia Source: ZFIN

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:ppiabImported
Synonyms:ppialImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-030131-7459. ppiab.

Expressioni

Gene expression databases

BgeeiENSDARG00000103994.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061957.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 163PPIase cyclophilin-typeInterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119119.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
KOiK03767.
OMAiASQRPKV.
OrthoDBiEOG091G0BGL.
TreeFamiTF312801.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PC53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPKVFFDI TIDGKEAGRI VMELRADVVP KTAENFRALC TGEKGFGYKG
60 70 80 90 100
SGFHRVIPQF MCQGGDFTNH NGTGGKSIYG NKFEDENFTL KHGGKGTLSM
110 120 130 140 150
ANAGPNTNGS QFFICTADTN WLDGKHVVFG KVVDGLDVVD AIEKKGSSSG
160
KCSAKVVIAN CGQL
Length:164
Mass (Da):17,489
Last modified:July 5, 2004 - v1
Checksum:iB8755219F1BF91F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP074878 Genomic DNA. No translation available.
BC059470 mRNA. Translation: AAH59470.1.
BC071370 mRNA. Translation: AAH71370.1.
RefSeqiNP_001315353.1. NM_001328424.1.
UniGeneiDr.78109.

Genome annotation databases

EnsembliENSDART00000166085; ENSDARP00000134856; ENSDARG00000103994.
GeneIDi335519.
KEGGidre:335519.

Similar proteinsi

Entry informationi

Entry nameiQ6PC53_DANRE
AccessioniPrimary (citable) accession number: Q6PC53
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported