ID   SSU72_DANRE             Reviewed;         194 AA.
AC   Q6PC19;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=RNA polymerase II subunit A C-terminal domain phosphatase SSU72;
DE            Short=CTD phosphatase SSU72;
DE            EC=3.1.3.16;
GN   Name=ssu72; ORFNames=zgc:73143;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Wild-type; TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the C-terminal domain of RNA polymerase II
CC       dephosphorylation, RNA processing and termination. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83421; EC=3.1.3.16;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Predominantly in the cytosol. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SSU72 phosphatase family. {ECO:0000305}.
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DR   EMBL; BC059504; AAH59504.1; -; mRNA.
DR   RefSeq; NP_957022.1; NM_200728.1.
DR   AlphaFoldDB; Q6PC19; -.
DR   SMR; Q6PC19; -.
DR   STRING; 7955.ENSDARP00000041894; -.
DR   PaxDb; 7955-ENSDARP00000041894; -.
DR   GeneID; 393701; -.
DR   KEGG; dre:393701; -.
DR   AGR; ZFIN:ZDB-GENE-040426-1689; -.
DR   CTD; 29101; -.
DR   ZFIN; ZDB-GENE-040426-1689; ssu72.
DR   eggNOG; KOG2424; Eukaryota.
DR   HOGENOM; CLU_062463_2_1_1; -.
DR   InParanoid; Q6PC19; -.
DR   OMA; PNCYEFG; -.
DR   OrthoDB; 63608at2759; -.
DR   PhylomeDB; Q6PC19; -.
DR   TreeFam; TF300194; -.
DR   Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q6PC19; -.
DR   Proteomes; UP000000437; Chromosome 22.
DR   Bgee; ENSDARG00000031216; Expressed in granulocyte and 30 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008420; F:RNA polymerase II CTD heptapeptide repeat phosphatase activity; IBA:GO_Central.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   InterPro; IPR006811; RNA_pol_II_suA.
DR   PANTHER; PTHR20383; RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE; 1.
DR   PANTHER; PTHR20383:SF9; RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72; 1.
DR   Pfam; PF04722; Ssu72; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Hydrolase; mRNA processing; Nucleus;
KW   Protein phosphatase; Reference proteome.
FT   CHAIN           1..194
FT                   /note="RNA polymerase II subunit A C-terminal domain
FT                   phosphatase SSU72"
FT                   /id="PRO_0000330016"
FT   COILED          160..185
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   194 AA;  22793 MW;  288F8BE70DBD7880 CRC64;
     MPPHPLRVAV VCSSNQNRSM EAHNILSKRG FDVRSFGTGT HVKLPGPAPD KPNIYDFKTT
     YEQMYNDLVR KDKELYTQNG ILHMLDRNKR IKSRPERFQS CRDQFDLVIT CEERVYDQVL
     EDLNSREQES FQPVHVINVD IQDNHEEATL GAFLICELCQ CIQHTDDMEN EMDELLQEFE
     EKSHRPFLHS VCFY
//