Q6PC19 (SSU72_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Short name=CTD phosphatase SSU72
EC=3.1.3.16

Gene names

Name:	ssu72
ORF Names:	zgc:73143

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly in the cytosol By similarity.
Sequence similarities	Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
Biological process	mRNA processing
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	RNA polymerase II subunit A C-terminal domain phosphatase SSU72		PRO_0000330016
Regions
	Coiled coil	160 – 185	26	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6PC19 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 288F8BE70DBD7880	FASTA	194	22,793
	10 20 30 40 50 60 MPPHPLRVAV VCSSNQNRSM EAHNILSKRG FDVRSFGTGT HVKLPGPAPD KPNIYDFKTT 70 80 90 100 110 120 YEQMYNDLVR KDKELYTQNG ILHMLDRNKR IKSRPERFQS CRDQFDLVIT CEERVYDQVL 130 140 150 160 170 180 EDLNSREQES FQPVHVINVD IQDNHEEATL GAFLICELCQ CIQHTDDMEN EMDELLQEFE 190 EKSHRPFLHS VCFY

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Wild-type. Tissue: Eye.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC059504 mRNA. Translation: AAH59504.1.
IPI	IPI00491577.
RefSeq	NP_957022.1. NM_200728.1.
UniGene	Dr.76327.
3D structure databases
ProteinModelPortal	Q6PC19.
ModBase	Search...
Proteomic databases
PRIDE	Q6PC19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000041895; ENSDARP00000041894; ENSDARG00000031216.
GeneID	393701.
KEGG	dre:393701.
Organism-specific databases
CTD	29101.
ZFIN	ZDB-GENE-040426-1689. ssu72.
Phylogenomic databases
GeneTree	ENSGT00390000010165.
HOGENOM	HOG000183445.
HOVERGEN	HBG059831.
InParanoid	Q6PC19.
KO	K15544.
Gene expression databases
Bgee	Q6PC19.
Family and domain databases
InterPro	IPR006811. RNA_pol_II_suA. [Graphical view]
PANTHER	PTHR20383. PTHR20383. 1 hit.
Pfam	PF04722. Ssu72. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20814704.

Entry information

Entry name

SSU72_DANRE

Accession

Primary (citable) accession number: Q6PC19

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 5, 2004
Last modified:	October 3, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program