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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

ssu72

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-DRE-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Gene namesi
Name:ssu72
ORF Names:zgc:73143
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-040426-1689. ssu72.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Predominantly in the cytosol.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300161 – 194RNA polymerase II subunit A C-terminal domain phosphatase SSU72Add BLAST194

Proteomic databases

PaxDbiQ6PC19.
PRIDEiQ6PC19.

Expressioni

Gene expression databases

BgeeiENSDARG00000031216.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000041894.

Structurei

3D structure databases

ProteinModelPortaliQ6PC19.
SMRiQ6PC19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili160 – 185Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2424. Eukaryota.
COG5211. LUCA.
GeneTreeiENSGT00390000010165.
HOGENOMiHOG000183445.
HOVERGENiHBG059831.
InParanoidiQ6PC19.
KOiK15544.
OMAiNRRIKKC.
OrthoDBiEOG091G0MLX.
PhylomeDBiQ6PC19.
TreeFamiTF300194.

Family and domain databases

InterProiView protein in InterPro
IPR006811. RNA_pol_II_suA.
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiView protein in Pfam
PF04722. Ssu72. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PC19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPHPLRVAV VCSSNQNRSM EAHNILSKRG FDVRSFGTGT HVKLPGPAPD
60 70 80 90 100
KPNIYDFKTT YEQMYNDLVR KDKELYTQNG ILHMLDRNKR IKSRPERFQS
110 120 130 140 150
CRDQFDLVIT CEERVYDQVL EDLNSREQES FQPVHVINVD IQDNHEEATL
160 170 180 190
GAFLICELCQ CIQHTDDMEN EMDELLQEFE EKSHRPFLHS VCFY
Length:194
Mass (Da):22,793
Last modified:July 5, 2004 - v1
Checksum:i288F8BE70DBD7880
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059504 mRNA. Translation: AAH59504.1.
RefSeqiNP_957022.1. NM_200728.1.
UniGeneiDr.76327.

Genome annotation databases

EnsembliENSDART00000041895; ENSDARP00000041894; ENSDARG00000031216.
GeneIDi393701.
KEGGidre:393701.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSSU72_DANRE
AccessioniPrimary (citable) accession number: Q6PC19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families