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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

ssu72

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Gene namesi
Name:ssu72
ORF Names:zgc:73143
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-040426-1689. ssu72.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Predominantly in the cytosol.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000330016Add
BLAST

Proteomic databases

PRIDEiQ6PC19.

Expressioni

Gene expression databases

BgeeiQ6PC19.

Structurei

3D structure databases

ProteinModelPortaliQ6PC19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili160 – 18526Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000010165.
HOGENOMiHOG000183445.
HOVERGENiHBG059831.
InParanoidiQ6PC19.
KOiK15544.
OMAiNRPFLHT.
OrthoDBiEOG7C2R2M.
PhylomeDBiQ6PC19.
TreeFamiTF300194.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PC19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPHPLRVAV VCSSNQNRSM EAHNILSKRG FDVRSFGTGT HVKLPGPAPD
60 70 80 90 100
KPNIYDFKTT YEQMYNDLVR KDKELYTQNG ILHMLDRNKR IKSRPERFQS
110 120 130 140 150
CRDQFDLVIT CEERVYDQVL EDLNSREQES FQPVHVINVD IQDNHEEATL
160 170 180 190
GAFLICELCQ CIQHTDDMEN EMDELLQEFE EKSHRPFLHS VCFY
Length:194
Mass (Da):22,793
Last modified:July 4, 2004 - v1
Checksum:i288F8BE70DBD7880
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059504 mRNA. Translation: AAH59504.1.
RefSeqiNP_957022.1. NM_200728.1.
UniGeneiDr.76327.

Genome annotation databases

EnsembliENSDART00000041895; ENSDARP00000041894; ENSDARG00000031216.
GeneIDi393701.
KEGGidre:393701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC059504 mRNA. Translation: AAH59504.1.
RefSeqiNP_957022.1. NM_200728.1.
UniGeneiDr.76327.

3D structure databases

ProteinModelPortaliQ6PC19.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6PC19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000041895; ENSDARP00000041894; ENSDARG00000031216.
GeneIDi393701.
KEGGidre:393701.

Organism-specific databases

CTDi29101.
ZFINiZDB-GENE-040426-1689. ssu72.

Phylogenomic databases

GeneTreeiENSGT00390000010165.
HOGENOMiHOG000183445.
HOVERGENiHBG059831.
InParanoidiQ6PC19.
KOiK15544.
OMAiNRPFLHT.
OrthoDBiEOG7C2R2M.
PhylomeDBiQ6PC19.
TreeFamiTF300194.

Miscellaneous databases

NextBioi20814704.
PROiQ6PC19.

Gene expression databases

BgeeiQ6PC19.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Wild-type.
    Tissue: Eye.

Entry informationi

Entry nameiSSU72_DANRE
AccessioniPrimary (citable) accession number: Q6PC19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 28, 2008
Last sequence update: July 4, 2004
Last modified: January 6, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.