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Protein
Submitted name:

S-phase kinase-associated protein 1

Gene

skp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-DRE-1169091 Activation of NF-kappaB in B cells
R-DRE-1170546 Prolactin receptor signaling
R-DRE-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DRE-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DRE-195253 Degradation of beta-catenin by the destruction complex
R-DRE-202424 Downstream TCR signaling
R-DRE-2565942 Regulation of PLK1 Activity at G2/M Transition
R-DRE-2871837 FCERI mediated NF-kB activation
R-DRE-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DRE-5607764 CLEC7A (Dectin-1) signaling
R-DRE-5610780 Degradation of GLI1 by the proteasome
R-DRE-5610785 GLI3 is processed to GLI3R by the proteasome
R-DRE-5676590 NIK-->noncanonical NF-kB signaling
R-DRE-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-DRE-69231 Cyclin D associated events in G1
R-DRE-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DRE-8939902 Regulation of RUNX2 expression and activity
R-DRE-8951664 Neddylation
R-DRE-9020702 Interleukin-1 signaling
R-DRE-917937 Iron uptake and transport
R-DRE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
S-phase kinase-associated protein 1Imported
Submitted name:
S-phase kinase-associated protein 1AImported
Gene namesi
Name:skp1Imported
Synonyms:skp1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-040426-1707 skp1

Expressioni

Gene expression databases

BgeeiENSDARG00000003151

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015887

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 67Skp1_POZInterPro annotationAdd BLAST65
Domaini113 – 160Skp1InterPro annotationAdd BLAST48

Sequence similaritiesi

Belongs to the SKP1 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1724 Eukaryota
COG5201 LUCA
GeneTreeiENSGT00390000012652
HOGENOMiHOG000172184
HOVERGENiHBG057008
KOiK03094
OMAiENKWCEE
OrthoDBiEOG091G0OU2
TreeFamiTF354233

Family and domain databases

InterProiView protein in InterPro
IPR016897 SKP1
IPR001232 SKP1-like
IPR036296 SKP1-like_dim_sf
IPR011333 SKP1/BTB/POZ_sf
IPR016072 Skp1_comp_dimer
IPR016073 Skp1_comp_POZ
PfamiView protein in Pfam
PF01466 Skp1, 1 hit
PF03931 Skp1_POZ, 1 hit
PIRSFiPIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit
SMARTiView protein in SMART
SM00512 Skp1, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF81382 SSF81382, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PBY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTIKLQSSD GEMFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV
60 70 80 90 100
NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL
110 120 130 140 150
FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE
160
AQVRKENQWC EEK
Length:163
Mass (Da):18,690
Last modified:July 5, 2004 - v1
Checksum:i74980800BA2511F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP017197 Genomic DNA No translation available.
BC059536 mRNA Translation: AAH59536.1
AY648843 mRNA Translation: AAT68161.1
RefSeqiNP_957037.1, NM_200743.1
UniGeneiDr.83245

Genome annotation databases

EnsembliENSDART00000008454; ENSDARP00000015887; ENSDARG00000003151
GeneIDi393716
KEGGidre:393716

Similar proteinsi

Entry informationi

Entry nameiQ6PBY8_DANRE
AccessioniPrimary (citable) accession number: Q6PBY8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health