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Protein
Submitted name:

S-phase kinase-associated protein 1

Gene

skp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-DRE-1169091. Activation of NF-kappaB in B cells.
R-DRE-1170546. Prolactin receptor signaling.
R-DRE-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DRE-195253. Degradation of beta-catenin by the destruction complex.
R-DRE-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-DRE-446652. Interleukin-1 signaling.
R-DRE-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DRE-5610780. Degradation of GLI1 by the proteasome.
R-DRE-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DRE-5676590. NIK-->noncanonical NF-kB signaling.
R-DRE-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-DRE-69231. Cyclin D associated events in G1.
R-DRE-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DRE-8951664. Neddylation.
R-DRE-917937. Iron uptake and transport.
R-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
S-phase kinase-associated protein 1Imported
Submitted name:
S-phase kinase-associated protein 1AImported
Gene namesi
Name:skp1Imported
Synonyms:skp1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-040426-1707. skp1.

Expressioni

Gene expression databases

BgeeiENSDARG00000003151.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015887.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 67Skp1_POZInterPro annotationAdd BLAST65
Domaini113 – 160Skp1InterPro annotationAdd BLAST48

Sequence similaritiesi

Belongs to the SKP1 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1724. Eukaryota.
COG5201. LUCA.
GeneTreeiENSGT00390000012652.
HOGENOMiHOG000172184.
HOVERGENiHBG057008.
KOiK03094.
OMAiENKWCEE.
OrthoDBiEOG091G0OU2.
TreeFamiTF354233.

Family and domain databases

InterProiView protein in InterPro
IPR016897. SKP1.
IPR001232. SKP1-like.
IPR011333. SKP1/BTB/POZ.
IPR016072. Skp1_comp_dimer.
IPR016073. Skp1_comp_POZ.
PfamiView protein in Pfam
PF01466. Skp1. 1 hit.
PF03931. Skp1_POZ. 1 hit.
PIRSFiPIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit.
SMARTiView protein in SMART
SM00512. Skp1. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF81382. SSF81382. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PBY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTIKLQSSD GEMFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV
60 70 80 90 100
NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL
110 120 130 140 150
FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE
160
AQVRKENQWC EEK
Length:163
Mass (Da):18,690
Last modified:July 5, 2004 - v1
Checksum:i74980800BA2511F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP017197 Genomic DNA. No translation available.
BC059536 mRNA. Translation: AAH59536.1.
AY648843 mRNA. Translation: AAT68161.1.
RefSeqiNP_957037.1. NM_200743.1.
UniGeneiDr.83245.

Genome annotation databases

EnsembliENSDART00000008454; ENSDARP00000015887; ENSDARG00000003151.
GeneIDi393716.
KEGGidre:393716.

Similar proteinsi

Entry informationi

Entry nameiQ6PBY8_DANRE
AccessioniPrimary (citable) accession number: Q6PBY8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported