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Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateUniRule annotation1
Metal bindingi35Divalent metal cationUniRule annotation1
Active sitei37Proton acceptorUniRule annotation1
Metal bindingi37Divalent metal cationUniRule annotation1
Metal bindingi70Divalent metal cationUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Active sitei175Proton donorUniRule annotation1
Metal bindingi175Divalent metal cationUniRule annotation1
Binding sitei177Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Keywords - Ligandi

CobaltUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimeraseUniRule annotation (EC:5.1.3.1UniRule annotation)
Gene namesi
Name:rpeImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-030131-6837. rpe.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSDARG00000005251.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000023863.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 149Substrate bindingUniRule annotation4
Regioni197 – 198Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ribulose-phosphate 3-epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3111. Eukaryota.
COG0036. LUCA.
GeneTreeiENSGT00390000001447.
HOGENOMiHOG000259349.
HOVERGENiHBG044821.
KOiK01783.
OMAiKTIDVCA.
OrthoDBiEOG091G0JMQ.
TreeFamiTF300157.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PBW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYTAKIGPS ILSSDLSQLG RECERMMECG ADYLHLDVMD GHFVPNITFG
60 70 80 90 100
HPMVECLRSC IGPDPFFDMH MMVSRPEQWV KPMAAAGANQ YTFHLEATSN
110 120 130 140 150
PGNLIKEIRE SGMKVGLAIK PGTTVEELAP WAGQIDMALV MTVEPGFGGQ
160 170 180 190 200
KFMEDMMPKV SWLRGQFPSL DIEVDGGVGP DSIHRCAEAG ANMIVSGSAV
210 220
VSSDDPRSVI ALLKNVVMEA IQKRSLDR
Length:228
Mass (Da):24,846
Last modified:July 5, 2004 - v1
Checksum:i790B6019D4D2D217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR545476 Genomic DNA. No translation available.
BC059555 mRNA. Translation: AAH59555.1.
RefSeqiNP_001230353.1. NM_001243424.1.
UniGeneiDr.75331.

Genome annotation databases

EnsembliENSDART00000021218; ENSDARP00000023863; ENSDARG00000005251.
GeneIDi334897.
KEGGidre:334897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR545476 Genomic DNA. No translation available.
BC059555 mRNA. Translation: AAH59555.1.
RefSeqiNP_001230353.1. NM_001243424.1.
UniGeneiDr.75331.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000023863.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000021218; ENSDARP00000023863; ENSDARG00000005251.
GeneIDi334897.
KEGGidre:334897.

Organism-specific databases

CTDi6120.
ZFINiZDB-GENE-030131-6837. rpe.

Phylogenomic databases

eggNOGiKOG3111. Eukaryota.
COG0036. LUCA.
GeneTreeiENSGT00390000001447.
HOGENOMiHOG000259349.
HOVERGENiHBG044821.
KOiK01783.
OMAiKTIDVCA.
OrthoDBiEOG091G0JMQ.
TreeFamiTF300157.

Enzyme and pathway databases

ReactomeiR-DRE-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Gene expression databases

BgeeiENSDARG00000005251.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PBW9_DANRE
AccessioniPrimary (citable) accession number: Q6PBW9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.