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Protein

Ancient ubiquitous protein 1

Gene

aup1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ancient ubiquitous protein 1
Gene namesi
Name:aup1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-030131-3375. aup1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919LumenalSequence analysisAdd
BLAST
Transmembranei20 – 4021Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini41 – 423383CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Ancient ubiquitous protein 1PRO_0000359871Add
BLAST

Proteomic databases

PaxDbiQ6PBN5.
PRIDEiQ6PBN5.

Expressioni

Gene expression databases

BgeeiENSDARG00000092609.
ExpressionAtlasiQ6PBN5. differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054866.

Structurei

3D structure databases

ProteinModelPortaliQ6PBN5.
SMRiQ6PBN5. Positions 302-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini304 – 34643CUEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AUP1 family.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2898. Eukaryota.
ENOG410Y6KF. LUCA.
GeneTreeiENSGT00390000016110.
HOGENOMiHOG000034232.
HOVERGENiHBG004321.
InParanoidiQ6PBN5.
KOiK19716.
OMAiLGIHVFL.
OrthoDBiEOG091G0CVF.
PhylomeDBiQ6PBN5.
TreeFamiTF313372.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PBN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRGIEQMF DFQRLPNDRF ILLLLLLYAP VGFCLMLLRI FIGVHVFLVS
60 70 80 90 100
CALPDSIVRR FIVRIMCSVL GLHVQQNSPR LRDKTTRLYV CNHVTHFDHN
110 120 130 140 150
IINLLTSCNT PLLEGPVGFL CWARGFMELG QGVGSRTELT ETLHRYCSSP
160 170 180 190 200
DTLPLLLFPE EDTTNGRTGL LKFSSWPFSV SDSIQPVALL VKRPFIAVST
210 220 230 240 250
PESSWLTELL WTFFVPFTVY HVRWLPPLSK EDGETHQEFA SKVQGLLATE
260 270 280 290 300
LGVISTQITK ADKAEHIKRK RHSAPQTAHS NLGARPRTVA QGFLGTSVGA
310 320 330 340 350
EDSRIARLAQ QVKEVLPDVP VSVITRDLLQ TNCVDTTITN LLERTDQFNS
360 370 380 390 400
EAAMTMPSGP GKAAASSTPS AMVSSPNLKP AAKSFGRSPI DRHMSLQERK
410 420
EALYEYARRR YIEKHGLNKE DDL
Length:423
Mass (Da):47,414
Last modified:January 20, 2009 - v2
Checksum:i53FFFCF5553FA067
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821D → E in AAH59643 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065447 mRNA. Translation: AAH65447.1.
BC059643 mRNA. Translation: AAH59643.1.
RefSeqiNP_955984.2. NM_199690.2.
UniGeneiDr.2621.

Genome annotation databases

EnsembliENSDART00000054867; ENSDARP00000054866; ENSDARG00000092609.
GeneIDi324654.
KEGGidre:324654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065447 mRNA. Translation: AAH65447.1.
BC059643 mRNA. Translation: AAH59643.1.
RefSeqiNP_955984.2. NM_199690.2.
UniGeneiDr.2621.

3D structure databases

ProteinModelPortaliQ6PBN5.
SMRiQ6PBN5. Positions 302-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054866.

Proteomic databases

PaxDbiQ6PBN5.
PRIDEiQ6PBN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000054867; ENSDARP00000054866; ENSDARG00000092609.
GeneIDi324654.
KEGGidre:324654.

Organism-specific databases

CTDi550.
ZFINiZDB-GENE-030131-3375. aup1.

Phylogenomic databases

eggNOGiKOG2898. Eukaryota.
ENOG410Y6KF. LUCA.
GeneTreeiENSGT00390000016110.
HOGENOMiHOG000034232.
HOVERGENiHBG004321.
InParanoidiQ6PBN5.
KOiK19716.
OMAiLGIHVFL.
OrthoDBiEOG091G0CVF.
PhylomeDBiQ6PBN5.
TreeFamiTF313372.

Miscellaneous databases

PROiQ6PBN5.

Gene expression databases

BgeeiENSDARG00000092609.
ExpressionAtlasiQ6PBN5. differential.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAUP1_DANRE
AccessioniPrimary (citable) accession number: Q6PBN5
Secondary accession number(s): Q6P0U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: September 7, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.