Q6PBI4 (HDA9B_DANRE) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 57.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Histone deacetylase 9-B EC=3.5.1.98 | ||||
| Gene names |
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| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome] | ||||
| Taxonomic identifier | 7955 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 582 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription By similarity. |
| Catalytic activity | Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
| Subunit structure | Homodimer. Interacts with mef2 By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the histone deacetylase family. HD type 2 subfamily. |
| Sequence caution | The sequence AAQ97977.1 differs from that shown. Reason: Frameshift at positions 348 and 532. The sequence AAQ97977.1 differs from that shown. Reason: Intron retention. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q6PBI4-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 2 (identifier: Q6PBI4-2) The sequence of this isoform differs from the canonical sequence as follows: 140-142: Missing. 182-183: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 582 | 582 | Histone deacetylase 9-B | PRO_0000280537 | |||||
Regions | |||||||||
| Region | 146 – 195 | 50 | Interaction with mef2 By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 140 – 142 | 3 | Missing in isoform 2. | VSP_029171 | |||||
| Alternative sequence | 182 – 183 | 2 | Missing in isoform 2. | VSP_029172 | |||||
Experimental info | |||||||||
| Sequence conflict | 306 | 1 | E → K in AAQ97977. Ref.1 | ||||||
| Sequence conflict | 364 – 365 | 2 | AV → PD in AAQ97977. Ref.1 | ||||||
| Sequence conflict | 389 | 1 | S → I in AAQ97977. Ref.1 | ||||||
| Sequence conflict | 449 | 1 | P → T in AAQ97977. Ref.1 | ||||||
Sequences
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References
| [1] | "Hematopoietic gene expression profile in zebrafish kidney marrow." Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney marrow. |
| [2] | NIH - Zebrafish Gene Collection (ZGC) project Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Retina. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY423001 mRNA. Translation: AAQ97977.1. Sequence problems. BC059696 mRNA. Translation: AAH59696.1. |
| IPI | IPI00487523. IPI00972391. |
| RefSeq | NP_957110.2. NM_200816.2. |
| UniGene | Dr.25756. |
3D structure databases | |
| ProteinModelPortal | Q6PBI4. |
| SMR | Q6PBI4. Positions 37-104. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 7955.ENSDARP00000094362. |
Proteomic databases | |
| PRIDE | Q6PBI4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 393789. |
| KEGG | dre:393789. |
Organism-specific databases | |
| CTD | 393789. |
| ZFIN | ZDB-GENE-040109-7. hdac9b. |
Phylogenomic databases | |
| eggNOG | NOG302232. |
| HOGENOM | HOG000232065. |
| HOVERGEN | HBG057100. |
| InParanoid | Q6PBI4. |
| KO | K11409. |
| OrthoDB | EOG4R7VB0. |
Family and domain databases | |
| InterPro | IPR000286. His_deacetylse. IPR024643. Hist_deacetylase_Gln_rich_N. [Graphical view] |
| PANTHER | PTHR10625. PTHR10625. 1 hit. |
| Pfam | PF12203. HDAC4_Gln. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20814785. |
Entry information
| Entry name | HDA9B_DANRE | ||||||||
| Accession | Primary (citable) accession number: Q6PBI4 Secondary accession number(s): Q6TEP8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |