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Q6PBI4

- HDA9B_DANRE

UniProt

Q6PBI4 - HDA9B_DANRE

Protein

Histone deacetylase 9-B

Gene

hdac9b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 9-B (EC:3.5.1.98)
    Gene namesi
    Name:hdac9b
    Synonyms:hdac9
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040109-7. hdac9b.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Histone deacetylase 9-BPRO_0000280537Add
    BLAST

    Proteomic databases

    PRIDEiQ6PBI4.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with mef2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000094362.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PBI4.
    SMRiQ6PBI4. Positions 37-104.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni146 – 19550Interaction with mef2By similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG302232.
    HOGENOMiHOG000232065.
    HOVERGENiHBG057100.
    InParanoidiQ6PBI4.
    KOiK11409.
    PhylomeDBiQ6PBI4.

    Family and domain databases

    InterProiIPR000286. His_deacetylse.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF12203. HDAC4_Gln. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PBI4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHNVNNSVDI KPEVPLALDP GSPLDLRTDI RMQGSASEVT VWERQLQQEL    50
    LLIQKQQQIQ KQLLITEFQK QHENLVRQHQ AQIQEHLKLQ QELHVMKQQQ 100
    EQLEKERKLE LQSQERELER HRREQQVLVL RNRERTRESL TGAVASNEVK 150
    QKLQEFLLSK STKDITLNGI PQKITQSSKL WYTASHHTSL EQSSPPLGGA 200
    SSSCKISLPS PQDYRDDFPL RKTVSEPNLK VRSRLKQKVA ERRSSPLLRR 250
    KEGNIMTPFK KRALELLEST ASSSAPGSGP SSPNGACSAL GAENGPSSLP 300
    VTTRTERWPS QSRLLGPESS VSMLNLYTSP SLPNISLGFS AASSPISAAL 350
    GLQEKHVDNG AVSAVIQGLP TQLLGPVPLS VMETKVSSSH QALLQHLLQK 400
    EQLRHQKILS SGQSPVHPPS PLAMMENSPS STRPKLPRHR PLNRTQSAPL 450
    PQSTLAQLVI QQQHQNFLEK QKQYQQQVHI NKMLSKSIEQ LRQPNVHLQE 500
    SEEEEGEDCQ EHAMQEESSP SGGVIRKHSP QNTSRSPTIP LDSHPGVIRV 550
    KEEPGASDDE TMANQSSYIH QVKGRMVIQA MI 582

    Note: No experimental confirmation available.

    Length:582
    Mass (Da):65,117
    Last modified:July 5, 2004 - v1
    Checksum:iBD2CEF4E205C5EDD
    GO
    Isoform 2 (identifier: Q6PBI4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         140-142: Missing.
         182-183: Missing.

    Show »
    Length:577
    Mass (Da):64,581
    Checksum:iE1F30E2C776D83D8
    GO

    Sequence cautioni

    The sequence AAQ97977.1 differs from that shown. Reason: Intron retention.
    The sequence AAQ97977.1 differs from that shown. Reason: Frameshift at positions 348 and 532.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti306 – 3061E → K in AAQ97977. (PubMed:15520368)Curated
    Sequence conflicti364 – 3652AV → PD in AAQ97977. (PubMed:15520368)Curated
    Sequence conflicti389 – 3891S → I in AAQ97977. (PubMed:15520368)Curated
    Sequence conflicti449 – 4491P → T in AAQ97977. (PubMed:15520368)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei140 – 1423Missing in isoform 2. 1 PublicationVSP_029171
    Alternative sequencei182 – 1832Missing in isoform 2. 1 PublicationVSP_029172

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY423001 mRNA. Translation: AAQ97977.1. Sequence problems.
    BC059696 mRNA. Translation: AAH59696.1.
    RefSeqiNP_957110.2. NM_200816.2. [Q6PBI4-1]
    UniGeneiDr.25756.

    Genome annotation databases

    GeneIDi393789.
    KEGGidre:393789.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY423001 mRNA. Translation: AAQ97977.1 . Sequence problems.
    BC059696 mRNA. Translation: AAH59696.1 .
    RefSeqi NP_957110.2. NM_200816.2. [Q6PBI4-1 ]
    UniGenei Dr.25756.

    3D structure databases

    ProteinModelPortali Q6PBI4.
    SMRi Q6PBI4. Positions 37-104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000094362.

    Proteomic databases

    PRIDEi Q6PBI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 393789.
    KEGGi dre:393789.

    Organism-specific databases

    CTDi 393789.
    ZFINi ZDB-GENE-040109-7. hdac9b.

    Phylogenomic databases

    eggNOGi NOG302232.
    HOGENOMi HOG000232065.
    HOVERGENi HBG057100.
    InParanoidi Q6PBI4.
    KOi K11409.
    PhylomeDBi Q6PBI4.

    Miscellaneous databases

    NextBioi 20814785.

    Family and domain databases

    InterProi IPR000286. His_deacetylse.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF12203. HDAC4_Gln. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney marrow.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Retina.

    Entry informationi

    Entry nameiHDA9B_DANRE
    AccessioniPrimary (citable) accession number: Q6PBI4
    Secondary accession number(s): Q6TEP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3