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Q6PBI4 (HDA9B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 9-B

EC=3.5.1.98
Gene names
Name:hdac9b
Synonyms:hdac9
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subunit structure

Homodimer. Interacts with mef2 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Sequence caution

The sequence AAQ97977.1 differs from that shown. Reason: Frameshift at positions 348 and 532.

The sequence AAQ97977.1 differs from that shown. Reason: Intron retention.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PBI4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q6PBI4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     140-142: Missing.
     182-183: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Histone deacetylase 9-B
PRO_0000280537

Regions

Region146 – 19550Interaction with mef2 By similarity

Natural variations

Alternative sequence140 – 1423Missing in isoform 2.
VSP_029171
Alternative sequence182 – 1832Missing in isoform 2.
VSP_029172

Experimental info

Sequence conflict3061E → K in AAQ97977. Ref.1
Sequence conflict364 – 3652AV → PD in AAQ97977. Ref.1
Sequence conflict3891S → I in AAQ97977. Ref.1
Sequence conflict4491P → T in AAQ97977. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BD2CEF4E205C5EDD

FASTA58265,117
        10         20         30         40         50         60 
MHNVNNSVDI KPEVPLALDP GSPLDLRTDI RMQGSASEVT VWERQLQQEL LLIQKQQQIQ 

        70         80         90        100        110        120 
KQLLITEFQK QHENLVRQHQ AQIQEHLKLQ QELHVMKQQQ EQLEKERKLE LQSQERELER 

       130        140        150        160        170        180 
HRREQQVLVL RNRERTRESL TGAVASNEVK QKLQEFLLSK STKDITLNGI PQKITQSSKL 

       190        200        210        220        230        240 
WYTASHHTSL EQSSPPLGGA SSSCKISLPS PQDYRDDFPL RKTVSEPNLK VRSRLKQKVA 

       250        260        270        280        290        300 
ERRSSPLLRR KEGNIMTPFK KRALELLEST ASSSAPGSGP SSPNGACSAL GAENGPSSLP 

       310        320        330        340        350        360 
VTTRTERWPS QSRLLGPESS VSMLNLYTSP SLPNISLGFS AASSPISAAL GLQEKHVDNG 

       370        380        390        400        410        420 
AVSAVIQGLP TQLLGPVPLS VMETKVSSSH QALLQHLLQK EQLRHQKILS SGQSPVHPPS 

       430        440        450        460        470        480 
PLAMMENSPS STRPKLPRHR PLNRTQSAPL PQSTLAQLVI QQQHQNFLEK QKQYQQQVHI 

       490        500        510        520        530        540 
NKMLSKSIEQ LRQPNVHLQE SEEEEGEDCQ EHAMQEESSP SGGVIRKHSP QNTSRSPTIP 

       550        560        570        580 
LDSHPGVIRV KEEPGASDDE TMANQSSYIH QVKGRMVIQA MI 

« Hide

Isoform 2 [UniParc].

Checksum: E1F30E2C776D83D8
Show »

FASTA57764,581

References

[1]"Hematopoietic gene expression profile in zebrafish kidney marrow."
Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Kidney marrow.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY423001 mRNA. Translation: AAQ97977.1. Sequence problems.
BC059696 mRNA. Translation: AAH59696.1.
RefSeqNP_957110.2. NM_200816.2.
UniGeneDr.25756.

3D structure databases

ProteinModelPortalQ6PBI4.
SMRQ6PBI4. Positions 37-104.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000094362.

Proteomic databases

PRIDEQ6PBI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID393789.
KEGGdre:393789.

Organism-specific databases

CTD393789.
ZFINZDB-GENE-040109-7. hdac9b.

Phylogenomic databases

eggNOGNOG302232.
HOGENOMHOG000232065.
HOVERGENHBG057100.
InParanoidQ6PBI4.
KOK11409.
PhylomeDBQ6PBI4.

Family and domain databases

InterProIPR000286. His_deacetylse.
IPR024643. Hist_deacetylase_Gln_rich_N.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF12203. HDAC4_Gln. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20814785.

Entry information

Entry nameHDA9B_DANRE
AccessionPrimary (citable) accession number: Q6PBI4
Secondary accession number(s): Q6TEP8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families