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Protein

L-lactate dehydrogenase

Gene

ldhb

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldha), L-lactate dehydrogenase (ldha), L-lactate dehydrogenase (ldha), L-lactate dehydrogenase (ldhb)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107SubstrateUniRule annotation1
Binding sitei139SubstrateUniRule annotation1
Binding sitei170SubstrateUniRule annotation1
Active sitei194Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-XTR-70268. Pyruvate metabolism.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:ldhbImported
ORF Names:TGas073h07.1-001Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5908187. ldhb.

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSXETG00000016974.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000036972.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 161Ldh_1_NInterPro annotationAdd BLAST139
Domaini164 – 325Ldh_1_CInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
OMAiTHKAVVD.
OrthoDBiEOG091G0HME.
TreeFamiTF314963.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PBE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVQEKLIT PVCQDKAAKP KNKITVVGVG QVGMACAVSV LQKDLCDELA
60 70 80 90 100
LVDILEDKLK GEMMDLQHGS LFLKTSVIVA DKDYSVTANS RIVVVTGGVR
110 120 130 140 150
QQEGESRLNL VQRNVNVFKF IIPQVVKYSP DCIIIVVSNP VDILTYVTWK
160 170 180 190 200
LSGLPKHRII GSGTNLDSAR FRYLIGERLG IHPSSCHGFI LGEHGDSSVA
210 220 230 240 250
VWSGVNVAGV GLQSLNPEVG SDQDSSKWKE VHKQVVDSAY EVIKLKGYTN
260 270 280 290 300
WAIGFSVADI IESITKNMSR VHPVSTMVKG MYGIENEVFL SLPCVLNGNG
310 320 330
LTSVINQKLK DEEVGQLQKS AETLWGIQKD LKDL
Length:334
Mass (Da):36,461
Last modified:July 5, 2004 - v1
Checksum:i5CC8BE52A32CFDFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01083681 Genomic DNA. No translation available.
BC059747 mRNA. Translation: AAH59747.1.
CR761876 mRNA. Translation: CAJ83453.1.
RefSeqiNP_988882.1. NM_203551.1.
XP_012814194.1. XM_012958740.2.
UniGeneiStr.69180.

Genome annotation databases

EnsembliENSXETT00000036972; ENSXETP00000036972; ENSXETG00000016974.
GeneIDi394477.

Similar proteinsi

Entry informationi

Entry nameiQ6PBE7_XENTR
AccessioniPrimary (citable) accession number: Q6PBE7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported