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Protein

F-box/LRR-repeat protein 19

Gene

Fbxl19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 58CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri65 – 131PHD-typePROSITE-ProRule annotationAdd BLAST67

GO - Molecular functioni

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 19
Alternative name(s):
F-box and leucine-rich repeat protein 19
Gene namesi
Name:Fbxl19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3039600. Fbxl19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198691 – 674F-box/LRR-repeat protein 19Add BLAST674

Proteomic databases

PaxDbiQ6PB97.
PeptideAtlasiQ6PB97.
PRIDEiQ6PB97.

PTM databases

iPTMnetiQ6PB97.
PhosphoSitePlusiQ6PB97.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030811.
CleanExiMM_FBXL19.
ExpressionAtlasiQ6PB97. baseline and differential.
GenevisibleiQ6PB97. MM.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi231472. 1 interactor.
IntActiQ6PB97. 1 interactor.
STRINGi10090.ENSMUSP00000033081.

Structurei

3D structure databases

ProteinModelPortaliQ6PB97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 444F-boxAdd BLAST47
Repeati472 – 497LRR 1Add BLAST26
Repeati498 – 521LRR 2Add BLAST24
Repeati561 – 586LRR 3Add BLAST26
Repeati587 – 616LRR 4Add BLAST30
Repeati617 – 641LRR 5Add BLAST25
Repeati642 – 674LRR 6Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 5Poly-Ser4
Compositional biasi13 – 27Arg-richAdd BLAST15
Compositional biasi166 – 282Pro-richAdd BLAST117
Compositional biasi304 – 322Ser-richAdd BLAST19
Compositional biasi355 – 405Pro-richAdd BLAST51

Sequence similaritiesi

Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation
Contains 1 F-box domain.Curated
Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 58CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri65 – 131PHD-typePROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

Leucine-rich repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1633. Eukaryota.
KOG1947. Eukaryota.
ENOG410ZJED. LUCA.
GeneTreeiENSGT00550000074396.
HOGENOMiHOG000112677.
HOVERGENiHBG061227.
InParanoidiQ6PB97.
KOiK10285.
OMAiMCQMLER.
OrthoDBiEOG091G04FK.
PhylomeDBiQ6PB97.
TreeFamiTF338452.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF16866. PHD_4. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 2 hits.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PB97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSSRGPGA GARRRRTRCR RCRACVRTEC GDCHFCRDMK KFGGPGRMKQ
60 70 80 90 100
SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV EGEDEKFSLS LMECTICNEI
110 120 130 140 150
VHPGCLKMGK AEGVINSEIP NCWECPRCTQ EGRTSKDAGE GPGRRRADNG
160 170 180 190 200
EEGANLGGGW KLTEEPPPPP PLPRRKGPLP AGPTPDDVPG PPKRKEREGG
210 220 230 240 250
NEPPTPRKKV KGGRERHLKK VGGDACLLRG ADPGSPGLLP PRVLNPSQAF
260 270 280 290 300
SSCHPGLPPE NWEKPKPPIA SAEGPAVPSP SPQREKLERF KRMCQLLERV
310 320 330 340 350
PDTSSSSSDS DSDSDSSGTS LSEDEAPGEA RNGRRPARGS SGEKENRGGR
360 370 380 390 400
RAIRPGTGGP LLSWPLGPAP PPRPPQLERH VVRPPPRSPE PDTLPLAAGS
410 420 430 440 450
DHPLPRAAWL RVFQHLGPRE LCVCMRVCRT WSRWCYDKRL WPRMDLSRRK
460 470 480 490 500
SLTPPMLSGV VRRQPRALDL SWTGVSKKQL MWLLNRLQGL QELVLSGCSW
510 520 530 540 550
LSVSALGSAP LPALRLLDLR WIEDVKDSQL RELLLPPPDT KPGQTESRGR
560 570 580 590 600
LQGVAELRLA GLELTDASLR LLLRHAPQLS ALDLSHCAHV GDPSVHLLTA
610 620 630 640 650
PTSPLRETLV HLNLAGCHRL TDHCLPLFRR CPRLRRLDLR SCRQLSPEAC
660 670
ARLAAAGPPG PFRCPEEKLL LKDS
Note: No experimental confirmation available.
Length:674
Mass (Da):73,788
Last modified:July 5, 2004 - v1
Checksum:i1986A31BA4E2A55A
GO
Isoform 2 (identifier: Q6PB97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-263: Missing.

Note: No experimental confirmation available.
Show »
Length:631
Mass (Da):69,396
Checksum:i153091DC5F96D722
GO
Isoform 3 (identifier: Q6PB97-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-209: Missing.
     221-263: Missing.

Note: No experimental confirmation available.
Show »
Length:558
Mass (Da):61,726
Checksum:i577B1158B216C433
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34H → R in BAC27400 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013016137 – 209Missing in isoform 3. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_013017221 – 263Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031431 mRNA. Translation: BAC27400.1.
BC053109 mRNA. Translation: AAH53109.1.
BC059812 mRNA. Translation: AAH59812.1.
CCDSiCCDS21877.1. [Q6PB97-1]
RefSeqiNP_766336.2. NM_172748.2. [Q6PB97-1]
UniGeneiMm.259353.

Genome annotation databases

EnsembliENSMUST00000033081; ENSMUSP00000033081; ENSMUSG00000030811. [Q6PB97-1]
ENSMUST00000186207; ENSMUSP00000140303; ENSMUSG00000030811. [Q6PB97-1]
ENSMUST00000188580; ENSMUSP00000140021; ENSMUSG00000030811. [Q6PB97-3]
ENSMUST00000206893; ENSMUSP00000145616; ENSMUSG00000030811. [Q6PB97-2]
GeneIDi233902.
KEGGimmu:233902.
UCSCiuc009jwo.1. mouse. [Q6PB97-1]
uc009jwp.1. mouse. [Q6PB97-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031431 mRNA. Translation: BAC27400.1.
BC053109 mRNA. Translation: AAH53109.1.
BC059812 mRNA. Translation: AAH59812.1.
CCDSiCCDS21877.1. [Q6PB97-1]
RefSeqiNP_766336.2. NM_172748.2. [Q6PB97-1]
UniGeneiMm.259353.

3D structure databases

ProteinModelPortaliQ6PB97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231472. 1 interactor.
IntActiQ6PB97. 1 interactor.
STRINGi10090.ENSMUSP00000033081.

PTM databases

iPTMnetiQ6PB97.
PhosphoSitePlusiQ6PB97.

Proteomic databases

PaxDbiQ6PB97.
PeptideAtlasiQ6PB97.
PRIDEiQ6PB97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033081; ENSMUSP00000033081; ENSMUSG00000030811. [Q6PB97-1]
ENSMUST00000186207; ENSMUSP00000140303; ENSMUSG00000030811. [Q6PB97-1]
ENSMUST00000188580; ENSMUSP00000140021; ENSMUSG00000030811. [Q6PB97-3]
ENSMUST00000206893; ENSMUSP00000145616; ENSMUSG00000030811. [Q6PB97-2]
GeneIDi233902.
KEGGimmu:233902.
UCSCiuc009jwo.1. mouse. [Q6PB97-1]
uc009jwp.1. mouse. [Q6PB97-3]

Organism-specific databases

CTDi54620.
MGIiMGI:3039600. Fbxl19.

Phylogenomic databases

eggNOGiKOG1633. Eukaryota.
KOG1947. Eukaryota.
ENOG410ZJED. LUCA.
GeneTreeiENSGT00550000074396.
HOGENOMiHOG000112677.
HOVERGENiHBG061227.
InParanoidiQ6PB97.
KOiK10285.
OMAiMCQMLER.
OrthoDBiEOG091G04FK.
PhylomeDBiQ6PB97.
TreeFamiTF338452.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ6PB97.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030811.
CleanExiMM_FBXL19.
ExpressionAtlasiQ6PB97. baseline and differential.
GenevisibleiQ6PB97. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF16866. PHD_4. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 2 hits.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXL19_MOUSE
AccessioniPrimary (citable) accession number: Q6PB97
Secondary accession number(s): Q7TSH0, Q8BIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.