Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin beta-14

Gene

Pcdhb14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-14
Short name:
PCDH-beta-14
Gene namesi
Name:Pcdhb14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2136749. Pcdhb14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 690ExtracellularSequence analysisAdd BLAST661
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 796CytoplasmicSequence analysisAdd BLAST85

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000027174526 – 796Protocadherin beta-14Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi96 ↔ 1021 Publication
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6PB90.
PRIDEiQ6PB90.

PTM databases

iPTMnetiQ6PB90.
PhosphoSitePlusiQ6PB90.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044043.
CleanExiMM_PCDHB14.
GenevisibleiQ6PB90. MM.

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 35Combined sources3
Beta strandi44 – 48Combined sources5
Turni49 – 53Combined sources5
Helixi56 – 61Combined sources6
Beta strandi65 – 67Combined sources3
Beta strandi69 – 72Combined sources4
Beta strandi74 – 77Combined sources4
Beta strandi79 – 88Combined sources10
Turni93 – 95Combined sources3
Beta strandi107 – 110Combined sources4
Turni111 – 114Combined sources4
Beta strandi115 – 117Combined sources3
Beta strandi121 – 123Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYJNMR-A26-137[»]
ProteinModelPortaliQ6PB90.
SMRiQ6PB90.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PB90.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ6PB90.
KOiK16494.
OMAiVQFIQGE.
OrthoDBiEOG091G024L.
PhylomeDBiQ6PB90.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PB90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSLHKAPQ KRQVTAIIFL LLLWEAGSAT ITYSVLEETD RGSLVGNLAK
60 70 80 90 100
DLGLSLRELI TRGAQILSKG NKQLLQLEQK SGNLLLKEKL DREELCGSTN
110 120 130 140 150
PCILHFQVLL KSPVQFIQGE IQLQDVNDHA PEFMEDEILL KILESSLPGA
160 170 180 190 200
VFPLKIAQDL DVGSNTVQNY TISTNAHFHL LTRNHSDGRK YPELVLDKAL
210 220 230 240 250
DREEQAQIRL TLTAMDSGSP PKTGTTQVVI VVLDINDNAP EFAQGLYEVQ
260 270 280 290 300
VQENSPVGSL VLTVSARDLD AGTHGELSYS LFQSSNQVLQ AFEVNTDTGE
310 320 330 340 350
IRVRKLLDFE EIQSYRMEIE ASDGGGLSGK CTVVIHVMDV NDNAPELTMS
360 370 380 390 400
VLISEIPENS PETIVAIFGI SDPDSGDNGK MVCSVQDRLP FLLKPNEENF
410 420 430 440 450
YTLVTERALD RESRAEYNIT ITVSDMGTPR LTTQHTITVQ VSDINDNAPA
460 470 480 490 500
FTHTSYTMFV RENNSPALHI GTISATDSDS GSNAHITYSL LPPHDPQLAL
510 520 530 540 550
NSLISINADN GQLFALRALD YEALQAFEFH VGATDGGSPA LSSQALVRVV
560 570 580 590 600
VLDDNDNAPF VLYPMQNASA PCTELLPRAA EPGYLVTKVV AVDRDSGQNA
610 620 630 640 650
WLSFQLLKTT EPGLFSVWAH NGEVRTTRLL SERDVPKHRL LLLVKDNGEP
660 670 680 690 700
PHSASVTLHV LLVDGFSQPY LPLPEVARDP AQEDVLTLYL VIALASVSSL
710 720 730 740 750
FLVSVLLFVG VRLCRKAGET SLGGCSVPEG HFPGHLVDVS GTGTLSQSYQ
760 770 780 790
YEVCLTGGTG TNEFKFLKPV LPNFLNEGGY RNTEENSNFR DSLGFS
Length:796
Mass (Da):87,022
Last modified:January 9, 2007 - v2
Checksum:iE5457BFED7E7254B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122Q → K in BAC27730 (PubMed:16141072).Curated1
Sequence conflicti704S → A in AAH59821 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013775 mRNA. Translation: AAK26064.1.
AK032156 mRNA. Translation: BAC27730.1.
BC059821 mRNA. Translation: AAH59821.1.
CCDSiCCDS29180.1.
RefSeqiNP_444369.3. NM_053139.3.
UniGeneiMm.196699.

Genome annotation databases

EnsembliENSMUST00000052387; ENSMUSP00000054111; ENSMUSG00000044043.
GeneIDi93885.
KEGGimmu:93885.
UCSCiuc008epz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013775 mRNA. Translation: AAK26064.1.
AK032156 mRNA. Translation: BAC27730.1.
BC059821 mRNA. Translation: AAH59821.1.
CCDSiCCDS29180.1.
RefSeqiNP_444369.3. NM_053139.3.
UniGeneiMm.196699.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYJNMR-A26-137[»]
ProteinModelPortaliQ6PB90.
SMRiQ6PB90.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6PB90.
PhosphoSitePlusiQ6PB90.

Proteomic databases

PaxDbiQ6PB90.
PRIDEiQ6PB90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052387; ENSMUSP00000054111; ENSMUSG00000044043.
GeneIDi93885.
KEGGimmu:93885.
UCSCiuc008epz.1. mouse.

Organism-specific databases

CTDi56122.
MGIiMGI:2136749. Pcdhb14.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ6PB90.
KOiK16494.
OMAiVQFIQGE.
OrthoDBiEOG091G024L.
PhylomeDBiQ6PB90.
TreeFamiTF332299.

Miscellaneous databases

EvolutionaryTraceiQ6PB90.
PROiQ6PB90.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044043.
CleanExiMM_PCDHB14.
GenevisibleiQ6PB90. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBE_MOUSE
AccessioniPrimary (citable) accession number: Q6PB90
Secondary accession number(s): Q8CCT0, Q91Y05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.