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Protein

Protocadherin beta-14

Gene

Pcdhb14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-14
Short name:
PCDH-beta-14
Gene namesi
Name:Pcdhb14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2136749. Pcdhb14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 690661ExtracellularSequence analysisAdd
BLAST
Transmembranei691 – 71121HelicalSequence analysisAdd
BLAST
Topological domaini712 – 79685CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 796771Protocadherin beta-14PRO_0000271745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi96 ↔ 1021 Publication
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6PB90.
PaxDbiQ6PB90.
PRIDEiQ6PB90.

PTM databases

iPTMnetiQ6PB90.
PhosphoSiteiQ6PB90.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044043.
CleanExiMM_PCDHB14.
GenevisibleiQ6PB90. MM.

Structurei

Secondary structure

1
796
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 353Combined sources
Beta strandi44 – 485Combined sources
Turni49 – 535Combined sources
Helixi56 – 616Combined sources
Beta strandi65 – 673Combined sources
Beta strandi69 – 724Combined sources
Beta strandi74 – 774Combined sources
Beta strandi79 – 8810Combined sources
Turni93 – 953Combined sources
Beta strandi107 – 1104Combined sources
Turni111 – 1144Combined sources
Beta strandi115 – 1173Combined sources
Beta strandi121 – 1233Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WYJNMR-A26-137[»]
ProteinModelPortaliQ6PB90.
SMRiQ6PB90. Positions 30-660.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PB90.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 13399Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 242105Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 347101Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini352 – 451100Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 561106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini568 – 671104Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ6PB90.
KOiK16494.
OMAiVQFIQGE.
OrthoDBiEOG091G024L.
PhylomeDBiQ6PB90.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PB90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSLHKAPQ KRQVTAIIFL LLLWEAGSAT ITYSVLEETD RGSLVGNLAK
60 70 80 90 100
DLGLSLRELI TRGAQILSKG NKQLLQLEQK SGNLLLKEKL DREELCGSTN
110 120 130 140 150
PCILHFQVLL KSPVQFIQGE IQLQDVNDHA PEFMEDEILL KILESSLPGA
160 170 180 190 200
VFPLKIAQDL DVGSNTVQNY TISTNAHFHL LTRNHSDGRK YPELVLDKAL
210 220 230 240 250
DREEQAQIRL TLTAMDSGSP PKTGTTQVVI VVLDINDNAP EFAQGLYEVQ
260 270 280 290 300
VQENSPVGSL VLTVSARDLD AGTHGELSYS LFQSSNQVLQ AFEVNTDTGE
310 320 330 340 350
IRVRKLLDFE EIQSYRMEIE ASDGGGLSGK CTVVIHVMDV NDNAPELTMS
360 370 380 390 400
VLISEIPENS PETIVAIFGI SDPDSGDNGK MVCSVQDRLP FLLKPNEENF
410 420 430 440 450
YTLVTERALD RESRAEYNIT ITVSDMGTPR LTTQHTITVQ VSDINDNAPA
460 470 480 490 500
FTHTSYTMFV RENNSPALHI GTISATDSDS GSNAHITYSL LPPHDPQLAL
510 520 530 540 550
NSLISINADN GQLFALRALD YEALQAFEFH VGATDGGSPA LSSQALVRVV
560 570 580 590 600
VLDDNDNAPF VLYPMQNASA PCTELLPRAA EPGYLVTKVV AVDRDSGQNA
610 620 630 640 650
WLSFQLLKTT EPGLFSVWAH NGEVRTTRLL SERDVPKHRL LLLVKDNGEP
660 670 680 690 700
PHSASVTLHV LLVDGFSQPY LPLPEVARDP AQEDVLTLYL VIALASVSSL
710 720 730 740 750
FLVSVLLFVG VRLCRKAGET SLGGCSVPEG HFPGHLVDVS GTGTLSQSYQ
760 770 780 790
YEVCLTGGTG TNEFKFLKPV LPNFLNEGGY RNTEENSNFR DSLGFS
Length:796
Mass (Da):87,022
Last modified:January 9, 2007 - v2
Checksum:iE5457BFED7E7254B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221Q → K in BAC27730 (PubMed:16141072).Curated
Sequence conflicti704 – 7041S → A in AAH59821 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013775 mRNA. Translation: AAK26064.1.
AK032156 mRNA. Translation: BAC27730.1.
BC059821 mRNA. Translation: AAH59821.1.
CCDSiCCDS29180.1.
RefSeqiNP_444369.3. NM_053139.3.
UniGeneiMm.196699.

Genome annotation databases

EnsembliENSMUST00000052387; ENSMUSP00000054111; ENSMUSG00000044043.
GeneIDi93885.
KEGGimmu:93885.
UCSCiuc008epz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013775 mRNA. Translation: AAK26064.1.
AK032156 mRNA. Translation: BAC27730.1.
BC059821 mRNA. Translation: AAH59821.1.
CCDSiCCDS29180.1.
RefSeqiNP_444369.3. NM_053139.3.
UniGeneiMm.196699.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WYJNMR-A26-137[»]
ProteinModelPortaliQ6PB90.
SMRiQ6PB90. Positions 30-660.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6PB90.
PhosphoSiteiQ6PB90.

Proteomic databases

MaxQBiQ6PB90.
PaxDbiQ6PB90.
PRIDEiQ6PB90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052387; ENSMUSP00000054111; ENSMUSG00000044043.
GeneIDi93885.
KEGGimmu:93885.
UCSCiuc008epz.1. mouse.

Organism-specific databases

CTDi56122.
MGIiMGI:2136749. Pcdhb14.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ6PB90.
KOiK16494.
OMAiVQFIQGE.
OrthoDBiEOG091G024L.
PhylomeDBiQ6PB90.
TreeFamiTF332299.

Miscellaneous databases

EvolutionaryTraceiQ6PB90.
PROiQ6PB90.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044043.
CleanExiMM_PCDHB14.
GenevisibleiQ6PB90. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBE_MOUSE
AccessioniPrimary (citable) accession number: Q6PB90
Secondary accession number(s): Q8CCT0, Q91Y05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.