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Protein

Protein BHLHb9

Gene

Bhlhb9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the control of cellular aging and survival.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • learning or memory Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • positive regulation of dendritic spine morphogenesis Source: UniProtKB
  • positive regulation of neurogenesis Source: UniProtKB
  • positive regulation of synapse assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BHLHb9
Short name:
bHLHb9
Gene namesi
Name:Bhlhb9
Synonyms:Kiaa1701
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1917487. Bhlhb9.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Mainly cytoplasmic, and nuclear at lower level.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Protein BHLHb9PRO_0000334664Add
BLAST

Proteomic databases

MaxQBiQ6PB60.
PaxDbiQ6PB60.
PRIDEiQ6PB60.

PTM databases

iPTMnetiQ6PB60.
PhosphoSiteiQ6PB60.

Expressioni

Gene expression databases

BgeeiQ6PB60.
ExpressionAtlasiQ6PB60. baseline and differential.
GenevisibleiQ6PB60. MM.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068067.

Structurei

3D structure databases

ProteinModelPortaliQ6PB60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPRASP family.Curated

Phylogenomic databases

eggNOGiENOG410IPU4. Eukaryota.
ENOG41115S9. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000095228.
HOVERGENiHBG098352.
InParanoidiQ6PB60.
OMAiSDPCIQT.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ6PB60.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PB60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSKNKARA QAKLEKRASA QARAVAEREA ANANRGAGKS RDKGKGKAGS
60 70 80 90 100
KSDAVAEVKA GSKGKVVAET KEGARPESKA LVKGTSDFNH RTENKFARST
110 120 130 140 150
RKDKPSSDNW FWAGEDSGIN SWFWKGEELS NNSVAKCENK PSTSIQARAE
160 170 180 190 200
EPAPRTSHKS RSGAEEEEEE NVIGNWFWEG DDTGFDTDPK PVFKIVKPQP
210 220 230 240 250
VDEINEKDRP KDWSEVTIWP KAPAVTPAVL GYRSQDSSEA RSSSYIVLAS
260 270 280 290 300
NEEETSTACT KNTRSSLQSI PEYPFGSDPC IQTLDEIRQQ IKIREENGIK
310 320 330 340 350
PFACPCKLEC YLDSPEFEKL VNILKSTTDP LIHKIAQIAM GIHKVHPFAQ
360 370 380 390 400
EFINEVGVVT LIESLLSFSS PEVSIKKAVI TLNSSGDDRY NKVEFHVKHM
410 420 430 440 450
CKETVSFPLN SPGQQSGLKI IGQLTTESVH HYIVVSYFSE LFHLLSQGNR
460 470 480 490 500
KTRNLVLKVF LNMSENPKAA RDMINMKALA ALKLIFNQKE AKANLVSAVA
510 520 530
IFINIKEHIR KGSIVVVDHL SYNTLTAIFR EVKGIIERM
Length:539
Mass (Da):59,823
Last modified:July 5, 2004 - v1
Checksum:i9484323DCF690453
GO

Sequence cautioni

The sequence BAD32514.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD32514.1 differs from that shown. Reason: Erroneous termination at position 350. Translated as Gln.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173236 mRNA. Translation: BAD32514.1. Sequence problems.
AL683822 Genomic DNA. Translation: CAM27378.1.
BC059871 mRNA. Translation: AAH59871.1.
AK143861 mRNA. Translation: BAE25572.1.
AK157023 mRNA. Translation: BAE33934.1.
CCDSiCCDS30410.1.
RefSeqiNP_001091692.1. NM_001098222.1.
NP_937804.1. NM_198161.2.
XP_006528670.1. XM_006528607.2.
XP_006528671.1. XM_006528608.2.
XP_011246062.1. XM_011247760.1.
UniGeneiMm.440847.

Genome annotation databases

EnsembliENSMUST00000068755; ENSMUSP00000068067; ENSMUSG00000072964.
ENSMUST00000180025; ENSMUSP00000137213; ENSMUSG00000072964.
GeneIDi70237.
KEGGimmu:70237.
UCSCiuc009uhv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173236 mRNA. Translation: BAD32514.1. Sequence problems.
AL683822 Genomic DNA. Translation: CAM27378.1.
BC059871 mRNA. Translation: AAH59871.1.
AK143861 mRNA. Translation: BAE25572.1.
AK157023 mRNA. Translation: BAE33934.1.
CCDSiCCDS30410.1.
RefSeqiNP_001091692.1. NM_001098222.1.
NP_937804.1. NM_198161.2.
XP_006528670.1. XM_006528607.2.
XP_006528671.1. XM_006528608.2.
XP_011246062.1. XM_011247760.1.
UniGeneiMm.440847.

3D structure databases

ProteinModelPortaliQ6PB60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068067.

PTM databases

iPTMnetiQ6PB60.
PhosphoSiteiQ6PB60.

Proteomic databases

MaxQBiQ6PB60.
PaxDbiQ6PB60.
PRIDEiQ6PB60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068755; ENSMUSP00000068067; ENSMUSG00000072964.
ENSMUST00000180025; ENSMUSP00000137213; ENSMUSG00000072964.
GeneIDi70237.
KEGGimmu:70237.
UCSCiuc009uhv.1. mouse.

Organism-specific databases

CTDi80823.
MGIiMGI:1917487. Bhlhb9.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IPU4. Eukaryota.
ENOG41115S9. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000095228.
HOVERGENiHBG098352.
InParanoidiQ6PB60.
OMAiSDPCIQT.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ6PB60.
TreeFamiTF335652.

Miscellaneous databases

ChiTaRSiBhlhb9. mouse.
NextBioi331224.
PROiQ6PB60.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PB60.
ExpressionAtlasiQ6PB60. baseline and differential.
GenevisibleiQ6PB60. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreatic islet.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-220.
    Strain: C57BL/6J and NOD.
    Tissue: Spleen.

Entry informationi

Entry nameiBHLH9_MOUSE
AccessioniPrimary (citable) accession number: Q6PB60
Secondary accession number(s): Q3U0C1, Q69ZD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: January 20, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.