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Q6PB44

- PTN23_MOUSE

UniProt

Q6PB44 - PTN23_MOUSE

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Protein
Tyrosine-protein phosphatase non-receptor type 23
Gene
Ptpn23, Kiaa1471
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1448 – 14481Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cilium morphogenesis Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. regulation of cell migration Source: InterPro
  4. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 23 (EC:3.1.3.48)
Gene namesi
Name:Ptpn23
Synonyms:Kiaa1471
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2144837. Ptpn23.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Endosome By similarity. Cytoplasmcytoskeletoncilium basal body By similarity

GO - Cellular componenti

  1. ciliary basal body Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  4. early endosome Source: UniProtKB
  5. endosome Source: UniProtKB
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16921692Tyrosine-protein phosphatase non-receptor type 23
PRO_0000094778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1179 – 11791Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PB44.
PaxDbiQ6PB44.
PRIDEiQ6PB44.

PTM databases

PhosphoSiteiQ6PB44.

Expressioni

Gene expression databases

BgeeiQ6PB44.
GenevestigatoriQ6PB44.

Interactioni

Subunit structurei

Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B By similarity.

Protein-protein interaction databases

DIPiDIP-48351N.
IntActiQ6PB44. 2 interactions.
MINTiMINT-4122877.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi724 – 7263

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2W10X-ray1.90C/D719-730[»]
ProteinModelPortaliQ6PB44.
SMRiQ6PB44. Positions 4-699, 1194-1515.

Miscellaneous databases

EvolutionaryTraceiQ6PB44.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 394387BRO1
Add
BLAST
Repeati250 – 28334TPR 1
Add
BLAST
Repeati374 – 40734TPR 2
Add
BLAST
Repeati977 – 97821
Repeati979 – 98022
Repeati981 – 98223
Repeati983 – 98424
Repeati985 – 98625
Repeati987 – 98826
Repeati989 – 99027
Repeati991 – 99228
Repeati993 – 99429
Repeati995 – 996210
Repeati997 – 998211
Repeati999 – 1000212
Repeati1001 – 1002213
Repeati1003 – 1004214
Repeati1005 – 1006215
Repeati1007 – 1008216
Repeati1009 – 1010217
Repeati1011 – 1012218
Repeati1013 – 1014219
Repeati1015 – 1016220
Repeati1017 – 1018221
Domaini1248 – 1508261Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni773 – 1186414His
Add
BLAST
Regioni977 – 10184221 X 2 AA approximate tandem repeats of P-Q
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili552 – 63988 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi719 – 1164446Pro-rich
Add
BLAST
Compositional biasi1572 – 162958Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 BRO1 domain.
Contains 2 TPR repeats.

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117459.
HOGENOMiHOG000012993.
HOVERGENiHBG082231.
InParanoidiQ6PB44.
KOiK18040.
OMAiIARCYTM.
OrthoDBiEOG72C4ZH.
PhylomeDBiQ6PB44.
TreeFamiTF323502.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERiPTHR19134:SF27. PTHR19134:SF27. 1 hit.
PfamiPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PB44-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAVPRMPMI WLDLKEAGDF HFQSAVKKFV LKNYGENPEA YNEELKKLEL     50
LRQNAIRVAR DFEGCSVLRK YLGQLHYLQS RVPMGSGQEA AVAVTWTEIF 100
SGKSVSHEDI KYEQACILYN LGALHSMLGA MDKRVSEEGM KVSCTHFQCA 150
AGAFAYLREH FPQAFSVDMS RQILTLNVNL MLGQAQECLL EKSMLDNRKS 200
FLVARISAQV VDYYKEACRA LENPDTASLL GRIQKDWKKL VQMKIYYFAA 250
VAHLHMGKQA EEQQKFGERV AYFQSALDKL NEAIKLAKGQ PDTVQDALRF 300
AMDVIGGKYN SAKKDNDFIY HEAVPALDTL QPVKGAPLVK PLPVNPTDPA 350
VTGPDIFAKL VPMAAHEASS LYSEEKAKLL REMLAKIEDK NEVLDQFMDS 400
MQLDPETVDN LDAYNHIPPQ LMEKCAALSV RPDTVKNLVQ SMQVLSGVFT 450
DVEASLKDIR DLLEEDELQE QKLQETLGQA GAGPGPSVAK AELAEVRREW 500
AKYMEVHEKA SFTNSELHRA MNLHVGNLRL LSGPLDQVRA ALPTPALTPE 550
DKAVLQNLKR ILAKVQEMRD QRVSLEQQLR ELIQKDDITA SLVTTDHSEM 600
KKLFEEQLKK YDQLKVYLEQ NLAAQDNVLR ALTEANVQYA AVRRVLSELD 650
QKWNSTLQTL VASYEAYEDL MKKSQEGKDF YADLESKVAT LLERAQSICR 700
AQEAARQQLL DRELKKKAPP PRPTAPKPLL SRREEGEAVE AGDTPEELRS 750
LPPDMMVGPR LPDPFLGTTA PLHFSPGPFP SSTGPATHYL SGPLPPGTYS 800
GPTQLMQPRA AVPMAPATVL YPAPAYTSEL GLVPRSSPQH GIVSSPYAGV 850
GPPQPVVGLP SAPPPQLSGP ELAMTVRPAT TTVDSVQAPI SSHTAPRPNP 900
TPALPQPCFP VPQPVPQSVP QPQPLPVPYT YSIGTKQPLP APYTYSIGTK 950
QHLTGPLPQH QFPPGIPTGF PVPRTGPQAQ AQPQPQPQPQ PQPQPQPQPQ 1000
PQPQSQSQPQ PQPQPQPQRP AFGPQPTQQP LPFQHPHLFP SQAPGILPPP 1050
PPTPYHFTPQ PGVLGQPPPT LHTQLYPGPS QDPLPPHSGA LPFPSPGPPH 1100
PHPTLAYGPA PSPRPLGPQA TPVSIRGPPP ASQPTPSPHL VPSPAPSPGP 1150
GPVPSRPPTA EPPPCLRRGA AAADLLSSSP ESQHGGTQPP GGGQPLLQPT 1200
KVDAAEGRRP QALRLIEQDP YEHPERLQQL QQELEAFRGQ LGDAGALDAI 1250
WRELQEAQEH DARGRSIAIA RCYSLKNRHQ DVMPYDSNRV VLRSGKDDYI 1300
NASCVEGLSP YCPPLVATQA PLPGTAADFW LMVHEQKVSV IVMLVSEAEM 1350
EKQKVARYFP TERGQPMVHG ALSVALSSIR TTETHVERVL SLQFRDQSLK 1400
RSLVHLHFPT WPELGLPDSP GNLLRFIQEV HAHYLHQRPL HTPIVVHCSS 1450
GVGRTGAFAL LYAAVQEVEA GNGIPELPQL VRRMRQQRKH MLQEKLHLKF 1500
CHEALVRHVE QVLQRHGVPP PGKPVASVNI SQKNHLPQDS QDLVLGGDVP 1550
ISSIQATIAK LSIRPLGGLD SPAASLPGLV EPPGLPPASL PESTPVPSSS 1600
PPPLSSPLPE APQPEEEPSV PEAPSLGPPS SSLELLASLT PEAFSLDSSL 1650
RGKQRMSKQN FLQAHNGQGL RAAQPTDDPL SLLDPLWTLN KT 1692
Length:1,692
Mass (Da):185,216
Last modified:June 21, 2005 - v2
Checksum:i331363C917E9C4D2
GO
Isoform 2 (identifier: Q6PB44-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1352-1353: Missing.

Note: No experimental confirmation available.

Show »
Length:1,690
Mass (Da):184,960
Checksum:i825FCB196DE71ECC
GO

Sequence cautioni

The sequence BAD32456.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1352 – 13532Missing in isoform 2.
VSP_014195

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1353 – 13542Missing in AAH06582. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BY750106 mRNA. No translation available.
CF734421 mRNA. No translation available.
CB248963 mRNA. No translation available.
BC006582 mRNA. Translation: AAH06582.1.
BC022721 mRNA. Translation: AAH22721.1.
BC059902 mRNA. Translation: AAH59902.1.
AK173178 mRNA. Translation: BAD32456.1. Different initiation.
CCDSiCCDS40780.1. [Q6PB44-1]
RefSeqiNP_001074512.1. NM_001081043.1. [Q6PB44-1]
UniGeneiMm.335477.

Genome annotation databases

EnsembliENSMUST00000040021; ENSMUSP00000039580; ENSMUSG00000036057. [Q6PB44-1]
GeneIDi104831.
KEGGimmu:104831.
UCSCiuc009rty.1. mouse. [Q6PB44-1]
uc012hbi.1. mouse. [Q6PB44-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BY750106 mRNA. No translation available.
CF734421 mRNA. No translation available.
CB248963 mRNA. No translation available.
BC006582 mRNA. Translation: AAH06582.1 .
BC022721 mRNA. Translation: AAH22721.1 .
BC059902 mRNA. Translation: AAH59902.1 .
AK173178 mRNA. Translation: BAD32456.1 . Different initiation.
CCDSi CCDS40780.1. [Q6PB44-1 ]
RefSeqi NP_001074512.1. NM_001081043.1. [Q6PB44-1 ]
UniGenei Mm.335477.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2W10 X-ray 1.90 C/D 719-730 [» ]
ProteinModelPortali Q6PB44.
SMRi Q6PB44. Positions 4-699, 1194-1515.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48351N.
IntActi Q6PB44. 2 interactions.
MINTi MINT-4122877.

PTM databases

PhosphoSitei Q6PB44.

Proteomic databases

MaxQBi Q6PB44.
PaxDbi Q6PB44.
PRIDEi Q6PB44.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040021 ; ENSMUSP00000039580 ; ENSMUSG00000036057 . [Q6PB44-1 ]
GeneIDi 104831.
KEGGi mmu:104831.
UCSCi uc009rty.1. mouse. [Q6PB44-1 ]
uc012hbi.1. mouse. [Q6PB44-2 ]

Organism-specific databases

CTDi 25930.
MGIi MGI:2144837. Ptpn23.
Rougei Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117459.
HOGENOMi HOG000012993.
HOVERGENi HBG082231.
InParanoidi Q6PB44.
KOi K18040.
OMAi IARCYTM.
OrthoDBi EOG72C4ZH.
PhylomeDBi Q6PB44.
TreeFami TF323502.

Miscellaneous databases

ChiTaRSi PTPN23. mouse.
EvolutionaryTracei Q6PB44.
NextBioi 357310.
PROi Q6PB44.
SOURCEi Search...

Gene expression databases

Bgeei Q6PB44.
Genevestigatori Q6PB44.

Family and domain databases

Gene3Di 1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
PANTHERi PTHR19134:SF27. PTHR19134:SF27. 1 hit.
Pfami PF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-193.
    Tissue: Dendritic cell.
  2. The MGC Project Team
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-438.
    Tissue: Fetal brain and Fetal eye.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 394-1692 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1183-1692 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain, Eye and Mammary tumor.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 712-1439.
    Tissue: Thymus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPTN23_MOUSE
AccessioniPrimary (citable) accession number: Q6PB44
Secondary accession number(s): Q69ZJ0, Q8R1Z5, Q923E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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