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Q6PB44 (PTN23_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 23

EC=3.1.3.48
Gene names
Name:Ptpn23
Synonyms:Kiaa1471
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1692 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Endosome By similarity. Cytoplasmcytoskeletoncilium basal body By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 BRO1 domain.

Contains 2 TPR repeats.

Contains 1 tyrosine-protein phosphatase domain.

Sequence caution

The sequence BAD32456.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCilium biogenesis/degradation
Protein transport
Transport
   Cellular componentCell projection
Cilium
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Endosome
Nucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Repeat
TPR repeat
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcilium morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of cell migration

Inferred from electronic annotation. Source: InterPro

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentciliary basal body

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

early endosome

Inferred from sequence or structural similarity. Source: UniProtKB

endosome

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PB44-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PB44-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1352-1353: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16921692Tyrosine-protein phosphatase non-receptor type 23
PRO_0000094778

Regions

Domain8 – 394387BRO1
Repeat250 – 28334TPR 1
Repeat374 – 40734TPR 2
Repeat977 – 97821
Repeat979 – 98022
Repeat981 – 98223
Repeat983 – 98424
Repeat985 – 98625
Repeat987 – 98826
Repeat989 – 99027
Repeat991 – 99228
Repeat993 – 99429
Repeat995 – 996210
Repeat997 – 998211
Repeat999 – 1000212
Repeat1001 – 1002213
Repeat1003 – 1004214
Repeat1005 – 1006215
Repeat1007 – 1008216
Repeat1009 – 1010217
Repeat1011 – 1012218
Repeat1013 – 1014219
Repeat1015 – 1016220
Repeat1017 – 1018221
Domain1248 – 1508261Tyrosine-protein phosphatase
Region773 – 1186414His
Region977 – 10184221 X 2 AA approximate tandem repeats of P-Q
Coiled coil552 – 63988 Potential
Compositional bias719 – 1164446Pro-rich
Compositional bias1572 – 162958Pro-rich

Sites

Active site14481Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue11791Phosphoserine By similarity

Natural variations

Alternative sequence1352 – 13532Missing in isoform 2.
VSP_014195

Experimental info

Sequence conflict1353 – 13542Missing in AAH06582. Ref.3

Secondary structure

... 1692
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: 331363C917E9C4D2

FASTA1,692185,216
        10         20         30         40         50         60 
MEAVPRMPMI WLDLKEAGDF HFQSAVKKFV LKNYGENPEA YNEELKKLEL LRQNAIRVAR 

        70         80         90        100        110        120 
DFEGCSVLRK YLGQLHYLQS RVPMGSGQEA AVAVTWTEIF SGKSVSHEDI KYEQACILYN 

       130        140        150        160        170        180 
LGALHSMLGA MDKRVSEEGM KVSCTHFQCA AGAFAYLREH FPQAFSVDMS RQILTLNVNL 

       190        200        210        220        230        240 
MLGQAQECLL EKSMLDNRKS FLVARISAQV VDYYKEACRA LENPDTASLL GRIQKDWKKL 

       250        260        270        280        290        300 
VQMKIYYFAA VAHLHMGKQA EEQQKFGERV AYFQSALDKL NEAIKLAKGQ PDTVQDALRF 

       310        320        330        340        350        360 
AMDVIGGKYN SAKKDNDFIY HEAVPALDTL QPVKGAPLVK PLPVNPTDPA VTGPDIFAKL 

       370        380        390        400        410        420 
VPMAAHEASS LYSEEKAKLL REMLAKIEDK NEVLDQFMDS MQLDPETVDN LDAYNHIPPQ 

       430        440        450        460        470        480 
LMEKCAALSV RPDTVKNLVQ SMQVLSGVFT DVEASLKDIR DLLEEDELQE QKLQETLGQA 

       490        500        510        520        530        540 
GAGPGPSVAK AELAEVRREW AKYMEVHEKA SFTNSELHRA MNLHVGNLRL LSGPLDQVRA 

       550        560        570        580        590        600 
ALPTPALTPE DKAVLQNLKR ILAKVQEMRD QRVSLEQQLR ELIQKDDITA SLVTTDHSEM 

       610        620        630        640        650        660 
KKLFEEQLKK YDQLKVYLEQ NLAAQDNVLR ALTEANVQYA AVRRVLSELD QKWNSTLQTL 

       670        680        690        700        710        720 
VASYEAYEDL MKKSQEGKDF YADLESKVAT LLERAQSICR AQEAARQQLL DRELKKKAPP 

       730        740        750        760        770        780 
PRPTAPKPLL SRREEGEAVE AGDTPEELRS LPPDMMVGPR LPDPFLGTTA PLHFSPGPFP 

       790        800        810        820        830        840 
SSTGPATHYL SGPLPPGTYS GPTQLMQPRA AVPMAPATVL YPAPAYTSEL GLVPRSSPQH 

       850        860        870        880        890        900 
GIVSSPYAGV GPPQPVVGLP SAPPPQLSGP ELAMTVRPAT TTVDSVQAPI SSHTAPRPNP 

       910        920        930        940        950        960 
TPALPQPCFP VPQPVPQSVP QPQPLPVPYT YSIGTKQPLP APYTYSIGTK QHLTGPLPQH 

       970        980        990       1000       1010       1020 
QFPPGIPTGF PVPRTGPQAQ AQPQPQPQPQ PQPQPQPQPQ PQPQSQSQPQ PQPQPQPQRP 

      1030       1040       1050       1060       1070       1080 
AFGPQPTQQP LPFQHPHLFP SQAPGILPPP PPTPYHFTPQ PGVLGQPPPT LHTQLYPGPS 

      1090       1100       1110       1120       1130       1140 
QDPLPPHSGA LPFPSPGPPH PHPTLAYGPA PSPRPLGPQA TPVSIRGPPP ASQPTPSPHL 

      1150       1160       1170       1180       1190       1200 
VPSPAPSPGP GPVPSRPPTA EPPPCLRRGA AAADLLSSSP ESQHGGTQPP GGGQPLLQPT 

      1210       1220       1230       1240       1250       1260 
KVDAAEGRRP QALRLIEQDP YEHPERLQQL QQELEAFRGQ LGDAGALDAI WRELQEAQEH 

      1270       1280       1290       1300       1310       1320 
DARGRSIAIA RCYSLKNRHQ DVMPYDSNRV VLRSGKDDYI NASCVEGLSP YCPPLVATQA 

      1330       1340       1350       1360       1370       1380 
PLPGTAADFW LMVHEQKVSV IVMLVSEAEM EKQKVARYFP TERGQPMVHG ALSVALSSIR 

      1390       1400       1410       1420       1430       1440 
TTETHVERVL SLQFRDQSLK RSLVHLHFPT WPELGLPDSP GNLLRFIQEV HAHYLHQRPL 

      1450       1460       1470       1480       1490       1500 
HTPIVVHCSS GVGRTGAFAL LYAAVQEVEA GNGIPELPQL VRRMRQQRKH MLQEKLHLKF 

      1510       1520       1530       1540       1550       1560 
CHEALVRHVE QVLQRHGVPP PGKPVASVNI SQKNHLPQDS QDLVLGGDVP ISSIQATIAK 

      1570       1580       1590       1600       1610       1620 
LSIRPLGGLD SPAASLPGLV EPPGLPPASL PESTPVPSSS PPPLSSPLPE APQPEEEPSV 

      1630       1640       1650       1660       1670       1680 
PEAPSLGPPS SSLELLASLT PEAFSLDSSL RGKQRMSKQN FLQAHNGQGL RAAQPTDDPL 

      1690 
SLLDPLWTLN KT 

« Hide

Isoform 2 [UniParc].

Checksum: 825FCB196DE71ECC
Show »

FASTA1,690184,960

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-193.
Tissue: Dendritic cell.
[2]The MGC Project Team
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-438.
Tissue: Fetal brain and Fetal eye.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 394-1692 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1183-1692 (ISOFORM 2).
Strain: C57BL/6.
Tissue: Brain, Eye and Mammary tumor.
[4]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 712-1439.
Tissue: Thymus.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BY750106 mRNA. No translation available.
CF734421 mRNA. No translation available.
CB248963 mRNA. No translation available.
BC006582 mRNA. Translation: AAH06582.1.
BC022721 mRNA. Translation: AAH22721.1.
BC059902 mRNA. Translation: AAH59902.1.
AK173178 mRNA. Translation: BAD32456.1. Different initiation.
CCDSCCDS40780.1. [Q6PB44-1]
RefSeqNP_001074512.1. NM_001081043.1. [Q6PB44-1]
UniGeneMm.335477.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2W10X-ray1.90C/D719-730[»]
ProteinModelPortalQ6PB44.
SMRQ6PB44. Positions 4-699, 1194-1515.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-48351N.
IntActQ6PB44. 2 interactions.
MINTMINT-4122877.

PTM databases

PhosphoSiteQ6PB44.

Proteomic databases

MaxQBQ6PB44.
PaxDbQ6PB44.
PRIDEQ6PB44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040021; ENSMUSP00000039580; ENSMUSG00000036057. [Q6PB44-1]
GeneID104831.
KEGGmmu:104831.
UCSCuc009rty.1. mouse. [Q6PB44-1]
uc012hbi.1. mouse. [Q6PB44-2]

Organism-specific databases

CTD25930.
MGIMGI:2144837. Ptpn23.
RougeSearch...

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117459.
HOGENOMHOG000012993.
HOVERGENHBG082231.
InParanoidQ6PB44.
KOK18040.
OMAIARCYTM.
OrthoDBEOG72C4ZH.
PhylomeDBQ6PB44.
TreeFamTF323502.

Gene expression databases

BgeeQ6PB44.
GenevestigatorQ6PB44.

Family and domain databases

Gene3D1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERPTHR19134:SF27. PTHR19134:SF27. 1 hit.
PfamPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPTPN23. mouse.
EvolutionaryTraceQ6PB44.
NextBio357310.
PROQ6PB44.
SOURCESearch...

Entry information

Entry namePTN23_MOUSE
AccessionPrimary (citable) accession number: Q6PB44
Secondary accession number(s): Q69ZJ0, Q8R1Z5, Q923E6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot