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Protein

Tyrosine-protein phosphatase non-receptor type 23

Gene

Ptpn23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1448 – 14481Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 23 (EC:3.1.3.48)
Gene namesi
Name:Ptpn23
Synonyms:Kiaa1471
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2144837. Ptpn23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16921692Tyrosine-protein phosphatase non-receptor type 23PRO_0000094778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1178 – 11781PhosphoserineBy similarity
Modified residuei1179 – 11791PhosphoserineBy similarity
Modified residuei1187 – 11871PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PB44.
PaxDbiQ6PB44.
PRIDEiQ6PB44.

PTM databases

PhosphoSiteiQ6PB44.

Expressioni

Gene expression databases

BgeeiQ6PB44.
GenevisibleiQ6PB44. MM.

Interactioni

Subunit structurei

Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-48351N.
IntActiQ6PB44. 2 interactions.
MINTiMINT-4122877.
STRINGi10090.ENSMUSP00000039580.

Structurei

Secondary structure

1
1692
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi724 – 7263

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2W10X-ray1.90C/D719-730[»]
ProteinModelPortaliQ6PB44.
SMRiQ6PB44. Positions 4-361.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PB44.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 394387BRO1PROSITE-ProRule annotationAdd
BLAST
Repeati250 – 28334TPR 1Add
BLAST
Repeati374 – 40734TPR 2Add
BLAST
Repeati977 – 97821
Repeati979 – 98022
Repeati981 – 98223
Repeati983 – 98424
Repeati985 – 98625
Repeati987 – 98826
Repeati989 – 99027
Repeati991 – 99228
Repeati993 – 99429
Repeati995 – 996210
Repeati997 – 998211
Repeati999 – 1000212
Repeati1001 – 1002213
Repeati1003 – 1004214
Repeati1005 – 1006215
Repeati1007 – 1008216
Repeati1009 – 1010217
Repeati1011 – 1012218
Repeati1013 – 1014219
Repeati1015 – 1016220
Repeati1017 – 1018221
Domaini1248 – 1508261Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni773 – 1186414HisAdd
BLAST
Regioni977 – 10184221 X 2 AA approximate tandem repeats of P-QAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili552 – 63988Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi719 – 1164446Pro-richAdd
BLAST
Compositional biasi1572 – 162958Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BRO1 domain.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121909.
HOGENOMiHOG000012993.
HOVERGENiHBG082231.
InParanoidiQ6PB44.
KOiK18040.
OMAiQSGKDDY.
OrthoDBiEOG72C4ZH.
PhylomeDBiQ6PB44.
TreeFamiTF323502.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERiPTHR19134:SF27. PTHR19134:SF27. 1 hit.
PfamiPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PB44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAVPRMPMI WLDLKEAGDF HFQSAVKKFV LKNYGENPEA YNEELKKLEL
60 70 80 90 100
LRQNAIRVAR DFEGCSVLRK YLGQLHYLQS RVPMGSGQEA AVAVTWTEIF
110 120 130 140 150
SGKSVSHEDI KYEQACILYN LGALHSMLGA MDKRVSEEGM KVSCTHFQCA
160 170 180 190 200
AGAFAYLREH FPQAFSVDMS RQILTLNVNL MLGQAQECLL EKSMLDNRKS
210 220 230 240 250
FLVARISAQV VDYYKEACRA LENPDTASLL GRIQKDWKKL VQMKIYYFAA
260 270 280 290 300
VAHLHMGKQA EEQQKFGERV AYFQSALDKL NEAIKLAKGQ PDTVQDALRF
310 320 330 340 350
AMDVIGGKYN SAKKDNDFIY HEAVPALDTL QPVKGAPLVK PLPVNPTDPA
360 370 380 390 400
VTGPDIFAKL VPMAAHEASS LYSEEKAKLL REMLAKIEDK NEVLDQFMDS
410 420 430 440 450
MQLDPETVDN LDAYNHIPPQ LMEKCAALSV RPDTVKNLVQ SMQVLSGVFT
460 470 480 490 500
DVEASLKDIR DLLEEDELQE QKLQETLGQA GAGPGPSVAK AELAEVRREW
510 520 530 540 550
AKYMEVHEKA SFTNSELHRA MNLHVGNLRL LSGPLDQVRA ALPTPALTPE
560 570 580 590 600
DKAVLQNLKR ILAKVQEMRD QRVSLEQQLR ELIQKDDITA SLVTTDHSEM
610 620 630 640 650
KKLFEEQLKK YDQLKVYLEQ NLAAQDNVLR ALTEANVQYA AVRRVLSELD
660 670 680 690 700
QKWNSTLQTL VASYEAYEDL MKKSQEGKDF YADLESKVAT LLERAQSICR
710 720 730 740 750
AQEAARQQLL DRELKKKAPP PRPTAPKPLL SRREEGEAVE AGDTPEELRS
760 770 780 790 800
LPPDMMVGPR LPDPFLGTTA PLHFSPGPFP SSTGPATHYL SGPLPPGTYS
810 820 830 840 850
GPTQLMQPRA AVPMAPATVL YPAPAYTSEL GLVPRSSPQH GIVSSPYAGV
860 870 880 890 900
GPPQPVVGLP SAPPPQLSGP ELAMTVRPAT TTVDSVQAPI SSHTAPRPNP
910 920 930 940 950
TPALPQPCFP VPQPVPQSVP QPQPLPVPYT YSIGTKQPLP APYTYSIGTK
960 970 980 990 1000
QHLTGPLPQH QFPPGIPTGF PVPRTGPQAQ AQPQPQPQPQ PQPQPQPQPQ
1010 1020 1030 1040 1050
PQPQSQSQPQ PQPQPQPQRP AFGPQPTQQP LPFQHPHLFP SQAPGILPPP
1060 1070 1080 1090 1100
PPTPYHFTPQ PGVLGQPPPT LHTQLYPGPS QDPLPPHSGA LPFPSPGPPH
1110 1120 1130 1140 1150
PHPTLAYGPA PSPRPLGPQA TPVSIRGPPP ASQPTPSPHL VPSPAPSPGP
1160 1170 1180 1190 1200
GPVPSRPPTA EPPPCLRRGA AAADLLSSSP ESQHGGTQPP GGGQPLLQPT
1210 1220 1230 1240 1250
KVDAAEGRRP QALRLIEQDP YEHPERLQQL QQELEAFRGQ LGDAGALDAI
1260 1270 1280 1290 1300
WRELQEAQEH DARGRSIAIA RCYSLKNRHQ DVMPYDSNRV VLRSGKDDYI
1310 1320 1330 1340 1350
NASCVEGLSP YCPPLVATQA PLPGTAADFW LMVHEQKVSV IVMLVSEAEM
1360 1370 1380 1390 1400
EKQKVARYFP TERGQPMVHG ALSVALSSIR TTETHVERVL SLQFRDQSLK
1410 1420 1430 1440 1450
RSLVHLHFPT WPELGLPDSP GNLLRFIQEV HAHYLHQRPL HTPIVVHCSS
1460 1470 1480 1490 1500
GVGRTGAFAL LYAAVQEVEA GNGIPELPQL VRRMRQQRKH MLQEKLHLKF
1510 1520 1530 1540 1550
CHEALVRHVE QVLQRHGVPP PGKPVASVNI SQKNHLPQDS QDLVLGGDVP
1560 1570 1580 1590 1600
ISSIQATIAK LSIRPLGGLD SPAASLPGLV EPPGLPPASL PESTPVPSSS
1610 1620 1630 1640 1650
PPPLSSPLPE APQPEEEPSV PEAPSLGPPS SSLELLASLT PEAFSLDSSL
1660 1670 1680 1690
RGKQRMSKQN FLQAHNGQGL RAAQPTDDPL SLLDPLWTLN KT
Length:1,692
Mass (Da):185,216
Last modified:June 21, 2005 - v2
Checksum:i331363C917E9C4D2
GO
Isoform 2 (identifier: Q6PB44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1352-1353: Missing.

Note: No experimental confirmation available.
Show »
Length:1,690
Mass (Da):184,960
Checksum:i825FCB196DE71ECC
GO

Sequence cautioni

The sequence BAD32456.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1353 – 13542Missing in AAH06582 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1352 – 13532Missing in isoform 2. 1 PublicationVSP_014195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY750106 mRNA. No translation available.
CF734421 mRNA. No translation available.
CB248963 mRNA. No translation available.
BC006582 mRNA. Translation: AAH06582.1.
BC022721 mRNA. Translation: AAH22721.1.
BC059902 mRNA. Translation: AAH59902.1.
AK173178 mRNA. Translation: BAD32456.1. Different initiation.
CCDSiCCDS40780.1. [Q6PB44-1]
RefSeqiNP_001074512.1. NM_001081043.1. [Q6PB44-1]
UniGeneiMm.335477.

Genome annotation databases

EnsembliENSMUST00000040021; ENSMUSP00000039580; ENSMUSG00000036057. [Q6PB44-1]
GeneIDi104831.
KEGGimmu:104831.
UCSCiuc009rty.1. mouse. [Q6PB44-1]
uc012hbi.1. mouse. [Q6PB44-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY750106 mRNA. No translation available.
CF734421 mRNA. No translation available.
CB248963 mRNA. No translation available.
BC006582 mRNA. Translation: AAH06582.1.
BC022721 mRNA. Translation: AAH22721.1.
BC059902 mRNA. Translation: AAH59902.1.
AK173178 mRNA. Translation: BAD32456.1. Different initiation.
CCDSiCCDS40780.1. [Q6PB44-1]
RefSeqiNP_001074512.1. NM_001081043.1. [Q6PB44-1]
UniGeneiMm.335477.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2W10X-ray1.90C/D719-730[»]
ProteinModelPortaliQ6PB44.
SMRiQ6PB44. Positions 4-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48351N.
IntActiQ6PB44. 2 interactions.
MINTiMINT-4122877.
STRINGi10090.ENSMUSP00000039580.

PTM databases

PhosphoSiteiQ6PB44.

Proteomic databases

MaxQBiQ6PB44.
PaxDbiQ6PB44.
PRIDEiQ6PB44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040021; ENSMUSP00000039580; ENSMUSG00000036057. [Q6PB44-1]
GeneIDi104831.
KEGGimmu:104831.
UCSCiuc009rty.1. mouse. [Q6PB44-1]
uc012hbi.1. mouse. [Q6PB44-2]

Organism-specific databases

CTDi25930.
MGIiMGI:2144837. Ptpn23.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121909.
HOGENOMiHOG000012993.
HOVERGENiHBG082231.
InParanoidiQ6PB44.
KOiK18040.
OMAiQSGKDDY.
OrthoDBiEOG72C4ZH.
PhylomeDBiQ6PB44.
TreeFamiTF323502.

Miscellaneous databases

ChiTaRSiPtpn23. mouse.
EvolutionaryTraceiQ6PB44.
NextBioi357310.
PROiQ6PB44.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PB44.
GenevisibleiQ6PB44. MM.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERiPTHR19134:SF27. PTHR19134:SF27. 1 hit.
PfamiPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-193.
    Tissue: Dendritic cell.
  2. The MGC Project Team
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-438.
    Tissue: Fetal brain and Fetal eye.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 394-1692 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1183-1692 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain, Eye and Mammary tumor.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 712-1439.
    Tissue: Thymus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPTN23_MOUSE
AccessioniPrimary (citable) accession number: Q6PB44
Secondary accession number(s): Q69ZJ0, Q8R1Z5, Q923E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: June 24, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.