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Protein

Tyrosine-protein phosphatase non-receptor type 23

Gene

Ptpn23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1448Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 23 (EC:3.1.3.48)
Gene namesi
Name:Ptpn23
Synonyms:Kiaa1471
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2144837 Ptpn23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947781 – 1692Tyrosine-protein phosphatase non-receptor type 23Add BLAST1692

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei744PhosphothreonineCombined sources1
Modified residuei974Omega-N-methylarginineBy similarity1
Modified residuei1178PhosphoserineBy similarity1
Modified residuei1179PhosphoserineBy similarity1
Modified residuei1187PhosphothreonineBy similarity1
Modified residuei1671Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6PB44
PeptideAtlasiQ6PB44
PRIDEiQ6PB44

PTM databases

iPTMnetiQ6PB44
PhosphoSitePlusiQ6PB44
SwissPalmiQ6PB44

Expressioni

Gene expression databases

BgeeiENSMUSG00000036057
ExpressionAtlasiQ6PB44 baseline and differential
GenevisibleiQ6PB44 MM

Interactioni

Subunit structurei

Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Grap2O891003EBI-4284816,EBI-642151

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222711, 40 interactors
DIPiDIP-48351N
IntActiQ6PB44, 44 interactors
MINTiQ6PB44
STRINGi10090.ENSMUSP00000039580

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W10X-ray1.90C/D719-730[»]
ProteinModelPortaliQ6PB44
SMRiQ6PB44
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PB44

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 394BRO1PROSITE-ProRule annotationAdd BLAST387
Repeati250 – 283TPR 1Add BLAST34
Repeati374 – 407TPR 2Add BLAST34
Repeati977 – 97812
Repeati979 – 98022
Repeati981 – 98232
Repeati983 – 98442
Repeati985 – 98652
Repeati987 – 98862
Repeati989 – 99072
Repeati991 – 99282
Repeati993 – 99492
Repeati995 – 996102
Repeati997 – 998112
Repeati999 – 1000122
Repeati1001 – 1002132
Repeati1003 – 1004142
Repeati1005 – 1006152
Repeati1007 – 1008162
Repeati1009 – 1010172
Repeati1011 – 1012182
Repeati1013 – 1014192
Repeati1015 – 1016202
Repeati1017 – 1018212
Domaini1248 – 1508Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni773 – 1186HisAdd BLAST414
Regioni977 – 101821 X 2 AA approximate tandem repeats of P-QAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili552 – 639Sequence analysisAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi719 – 1164Pro-richAdd BLAST446
Compositional biasi1572 – 1629Pro-richAdd BLAST58

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
KOG2220 Eukaryota
ENOG410XQX6 LUCA
GeneTreeiENSGT00780000121909
HOGENOMiHOG000012993
HOVERGENiHBG082231
InParanoidiQ6PB44
KOiK18040
OMAiMKMACTH
OrthoDBiEOG091G02XV
PhylomeDBiQ6PB44
TreeFamiTF323502

Family and domain databases

Gene3Di1.25.40.280, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR025304 ALIX_V_dom
IPR004328 BRO1_dom
IPR038499 BRO1_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR028770 PTPN23
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR19134:SF333 PTHR19134:SF333, 1 hit
PfamiView protein in Pfam
PF13949 ALIX_LYPXL_bnd, 1 hit
PF03097 BRO1, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01041 BRO1, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51180 BRO1, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PB44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAVPRMPMI WLDLKEAGDF HFQSAVKKFV LKNYGENPEA YNEELKKLEL
60 70 80 90 100
LRQNAIRVAR DFEGCSVLRK YLGQLHYLQS RVPMGSGQEA AVAVTWTEIF
110 120 130 140 150
SGKSVSHEDI KYEQACILYN LGALHSMLGA MDKRVSEEGM KVSCTHFQCA
160 170 180 190 200
AGAFAYLREH FPQAFSVDMS RQILTLNVNL MLGQAQECLL EKSMLDNRKS
210 220 230 240 250
FLVARISAQV VDYYKEACRA LENPDTASLL GRIQKDWKKL VQMKIYYFAA
260 270 280 290 300
VAHLHMGKQA EEQQKFGERV AYFQSALDKL NEAIKLAKGQ PDTVQDALRF
310 320 330 340 350
AMDVIGGKYN SAKKDNDFIY HEAVPALDTL QPVKGAPLVK PLPVNPTDPA
360 370 380 390 400
VTGPDIFAKL VPMAAHEASS LYSEEKAKLL REMLAKIEDK NEVLDQFMDS
410 420 430 440 450
MQLDPETVDN LDAYNHIPPQ LMEKCAALSV RPDTVKNLVQ SMQVLSGVFT
460 470 480 490 500
DVEASLKDIR DLLEEDELQE QKLQETLGQA GAGPGPSVAK AELAEVRREW
510 520 530 540 550
AKYMEVHEKA SFTNSELHRA MNLHVGNLRL LSGPLDQVRA ALPTPALTPE
560 570 580 590 600
DKAVLQNLKR ILAKVQEMRD QRVSLEQQLR ELIQKDDITA SLVTTDHSEM
610 620 630 640 650
KKLFEEQLKK YDQLKVYLEQ NLAAQDNVLR ALTEANVQYA AVRRVLSELD
660 670 680 690 700
QKWNSTLQTL VASYEAYEDL MKKSQEGKDF YADLESKVAT LLERAQSICR
710 720 730 740 750
AQEAARQQLL DRELKKKAPP PRPTAPKPLL SRREEGEAVE AGDTPEELRS
760 770 780 790 800
LPPDMMVGPR LPDPFLGTTA PLHFSPGPFP SSTGPATHYL SGPLPPGTYS
810 820 830 840 850
GPTQLMQPRA AVPMAPATVL YPAPAYTSEL GLVPRSSPQH GIVSSPYAGV
860 870 880 890 900
GPPQPVVGLP SAPPPQLSGP ELAMTVRPAT TTVDSVQAPI SSHTAPRPNP
910 920 930 940 950
TPALPQPCFP VPQPVPQSVP QPQPLPVPYT YSIGTKQPLP APYTYSIGTK
960 970 980 990 1000
QHLTGPLPQH QFPPGIPTGF PVPRTGPQAQ AQPQPQPQPQ PQPQPQPQPQ
1010 1020 1030 1040 1050
PQPQSQSQPQ PQPQPQPQRP AFGPQPTQQP LPFQHPHLFP SQAPGILPPP
1060 1070 1080 1090 1100
PPTPYHFTPQ PGVLGQPPPT LHTQLYPGPS QDPLPPHSGA LPFPSPGPPH
1110 1120 1130 1140 1150
PHPTLAYGPA PSPRPLGPQA TPVSIRGPPP ASQPTPSPHL VPSPAPSPGP
1160 1170 1180 1190 1200
GPVPSRPPTA EPPPCLRRGA AAADLLSSSP ESQHGGTQPP GGGQPLLQPT
1210 1220 1230 1240 1250
KVDAAEGRRP QALRLIEQDP YEHPERLQQL QQELEAFRGQ LGDAGALDAI
1260 1270 1280 1290 1300
WRELQEAQEH DARGRSIAIA RCYSLKNRHQ DVMPYDSNRV VLRSGKDDYI
1310 1320 1330 1340 1350
NASCVEGLSP YCPPLVATQA PLPGTAADFW LMVHEQKVSV IVMLVSEAEM
1360 1370 1380 1390 1400
EKQKVARYFP TERGQPMVHG ALSVALSSIR TTETHVERVL SLQFRDQSLK
1410 1420 1430 1440 1450
RSLVHLHFPT WPELGLPDSP GNLLRFIQEV HAHYLHQRPL HTPIVVHCSS
1460 1470 1480 1490 1500
GVGRTGAFAL LYAAVQEVEA GNGIPELPQL VRRMRQQRKH MLQEKLHLKF
1510 1520 1530 1540 1550
CHEALVRHVE QVLQRHGVPP PGKPVASVNI SQKNHLPQDS QDLVLGGDVP
1560 1570 1580 1590 1600
ISSIQATIAK LSIRPLGGLD SPAASLPGLV EPPGLPPASL PESTPVPSSS
1610 1620 1630 1640 1650
PPPLSSPLPE APQPEEEPSV PEAPSLGPPS SSLELLASLT PEAFSLDSSL
1660 1670 1680 1690
RGKQRMSKQN FLQAHNGQGL RAAQPTDDPL SLLDPLWTLN KT
Length:1,692
Mass (Da):185,216
Last modified:June 21, 2005 - v2
Checksum:i331363C917E9C4D2
GO
Isoform 2 (identifier: Q6PB44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1352-1353: Missing.

Note: No experimental confirmation available.
Show »
Length:1,690
Mass (Da):184,960
Checksum:i825FCB196DE71ECC
GO

Sequence cautioni

The sequence BAD32456 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1353 – 1354Missing in AAH06582 (PubMed:15489334).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0141951352 – 1353Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY750106 mRNA No translation available.
CF734421 mRNA No translation available.
CB248963 mRNA No translation available.
BC006582 mRNA Translation: AAH06582.1
BC022721 mRNA Translation: AAH22721.1
BC059902 mRNA Translation: AAH59902.1
AK173178 mRNA Translation: BAD32456.1 Different initiation.
CCDSiCCDS40780.1 [Q6PB44-1]
RefSeqiNP_001074512.1, NM_001081043.1 [Q6PB44-1]
UniGeneiMm.335477

Genome annotation databases

EnsembliENSMUST00000040021; ENSMUSP00000039580; ENSMUSG00000036057 [Q6PB44-1]
GeneIDi104831
KEGGimmu:104831
UCSCiuc009rty.1 mouse [Q6PB44-1]
uc012hbi.1 mouse [Q6PB44-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTN23_MOUSE
AccessioniPrimary (citable) accession number: Q6PB44
Secondary accession number(s): Q69ZJ0, Q8R1Z5, Q923E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health