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Protein

Putative chondrosarcoma-associated gene 1 protein

Gene

CSAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Putative chondrosarcoma-associated gene 1 protein
Alternative name(s):
Cancer/testis antigen 24.1
Short name:
CT24.1
Cancer/testis antigen CSAGE
Gene namesi
Name:CSAG1
Synonyms:CSAGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24294. CSAG1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134962241.

Polymorphism and mutation databases

BioMutaiCSAG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 7859Putative chondrosarcoma-associated gene 1 proteinPRO_0000291848Add
BLAST

Proteomic databases

PaxDbiQ6PB30.
PRIDEiQ6PB30.

PTM databases

iPTMnetiQ6PB30.
PhosphoSiteiQ6PB30.

Expressioni

Tissue specificityi

Expressed in chondrosarcoma, melanoma, cartilage and testis, but not in other normal tissues.1 Publication

Gene expression databases

BgeeiENSG00000198930.
CleanExiHS_CSAG1.
ExpressionAtlasiQ6PB30. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi127689. 3 interactions.
IntActiQ6PB30. 2 interactions.
STRINGi9606.ENSP00000359310.

Structurei

3D structure databases

ProteinModelPortaliQ6PB30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KCEY. Eukaryota.
ENOG4110P1E. LUCA.
GeneTreeiENSGT00390000012766.
HOGENOMiHOG000112006.
HOVERGENiHBG099380.
InParanoidiQ6PB30.
PhylomeDBiQ6PB30.
TreeFamiTF340411.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PB30-1) [UniParc]FASTAAdd to basket
Also known as: CSAG1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSATTACWPA FTVLGEARGD QVDWSRLYRD TGLVKMSRKP RASSPFSNNH
60 70
PSTPKRFPRQ PKREKGPVKE VPGTKGSP
Length:78
Mass (Da):8,669
Last modified:November 25, 2008 - v2
Checksum:i768BC8BDDB554575
GO
Isoform 2 (identifier: Q6PB30-2) [UniParc]FASTAAdd to basket
Also known as: CSAG1c

The sequence of this isoform differs from the canonical sequence as follows:
     57-78: FPRQPKREKGPVKEVPGTKGSP → RGRGKHPLIPGPEALSK

Show »
Length:73
Mass (Da):8,062
Checksum:iEA0C1F6E61B90ACB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281Y → C in AF195880 (PubMed:12039054).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281Y → F.
Corresponds to variant rs1894359 [ dbSNP | Ensembl ].
VAR_032868
Natural varianti62 – 621K → R.2 Publications
Corresponds to variant rs2515848 [ dbSNP | Ensembl ].
VAR_047336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei57 – 7822FPRQP…TKGSP → RGRGKHPLIPGPEALSK in isoform 2. 1 PublicationVSP_026267Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195880 mRNA. No translation available.
AF268419 mRNA. No translation available.
AF002997 Genomic DNA. No translation available.
BC059947 mRNA. Translation: AAH59947.1.
CCDSiCCDS76047.1. [Q6PB30-1]
RefSeqiNP_001096046.2. NM_001102576.2.
NP_705611.2. NM_153478.2.
UniGeneiHs.423718.

Genome annotation databases

EnsembliENST00000370291; ENSP00000359314; ENSG00000198930. [Q6PB30-2]
GeneIDi158511.
KEGGihsa:158511.
UCSCiuc065brz.1. human. [Q6PB30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195880 mRNA. No translation available.
AF268419 mRNA. No translation available.
AF002997 Genomic DNA. No translation available.
BC059947 mRNA. Translation: AAH59947.1.
CCDSiCCDS76047.1. [Q6PB30-1]
RefSeqiNP_001096046.2. NM_001102576.2.
NP_705611.2. NM_153478.2.
UniGeneiHs.423718.

3D structure databases

ProteinModelPortaliQ6PB30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127689. 3 interactions.
IntActiQ6PB30. 2 interactions.
STRINGi9606.ENSP00000359310.

PTM databases

iPTMnetiQ6PB30.
PhosphoSiteiQ6PB30.

Polymorphism and mutation databases

BioMutaiCSAG1.

Proteomic databases

PaxDbiQ6PB30.
PRIDEiQ6PB30.

Protocols and materials databases

DNASUi158511.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370291; ENSP00000359314; ENSG00000198930. [Q6PB30-2]
GeneIDi158511.
KEGGihsa:158511.
UCSCiuc065brz.1. human. [Q6PB30-1]

Organism-specific databases

CTDi158511.
GeneCardsiCSAG1.
HGNCiHGNC:24294. CSAG1.
MIMi300944. gene.
neXtProtiNX_Q6PB30.
PharmGKBiPA134962241.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCEY. Eukaryota.
ENOG4110P1E. LUCA.
GeneTreeiENSGT00390000012766.
HOGENOMiHOG000112006.
HOVERGENiHBG099380.
InParanoidiQ6PB30.
PhylomeDBiQ6PB30.
TreeFamiTF340411.

Miscellaneous databases

GenomeRNAii158511.
PROiQ6PB30.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198930.
CleanExiHS_CSAG1.
ExpressionAtlasiQ6PB30. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCSAG1_HUMAN
AccessioniPrimary (citable) accession number: Q6PB30
Secondary accession number(s): A6NE22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.