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Q6PB03 (PLD3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospholipase D3
Short name=PLD 3
EC=3.1.4.4
Alternative name(s):
Choline phosphatase 3
Phosphatidylcholine-hydrolyzing phospholipase D3
Gene names
Name:pld3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphatidylcholine + H2O = choline + a phosphatidate.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the phospholipase D family.

Contains 2 PLD phosphodiesterase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Phospholipase D3
PRO_0000280331

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain59 – 493435Lumenal Potential
Domain197 – 22428PLD phosphodiesterase 1
Domain412 – 43827PLD phosphodiesterase 2

Sites

Active site2021 Potential
Active site2041 Potential
Active site2091 Potential
Active site4171 Potential
Active site4191 Potential
Active site4241 Potential

Amino acid modifications

Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Glycosylation3881N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation4501N-linked (GlcNAc...) Potential
Glycosylation4761N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6PB03 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 6D1DDB82B63B6A6A

FASTA49356,220
        10         20         30         40         50         60 
MSSKVEYKPI QPHEEAENHF LQHELHKVKA RKYYRCALVV AIIITLVFCI LASQLLLFPF 

        70         80         90        100        110        120 
LSITSQTTET VLNKDIRCDD QCRFVLVESI PEGLVYDANS TINPSIFQSW MNIITNAKSS 

       130        140        150        160        170        180 
IDIASFYWSL TNEDTQTKEP SAHQGELILQ ELLNLKQRGV SLRVAVNPPD SPIRSKDISA 

       190        200        210        220        230        240 
LKDRGADVRV VDMPKLTDGI LHTKFWVVDN EHFYIGSANM DWRSLTQVKE LGATIYNCSC 

       250        260        270        280        290        300 
LAQDLKKIFE AYWILGLPNA TLPSPWPANY STPYNKDTPM QVMLNSTASQ VYLSSSPPPL 

       310        320        330        340        350        360 
SATGRTDDLQ SIMNIIDDAK KFVYISVMDY SPTEEFSHPR RYWPEIDNHL RKAVYERNVN 

       370        380        390        400        410        420 
VRLLISCWKN SRPSMFTFLR SLAALHSNTS HYNIEVKIFV VPATEAQKKI PYARVNHNKY 

       430        440        450        460        470        480 
MVTDRVAYIG TSNWSGDYFI NTAGSALVVN QTQSAGTSDT IQMQLQTVFE RDWNSNYSLT 

       490 
FNTLSSWKEK CIF

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC059981 mRNA. Translation: AAH59981.1.
RefSeqNP_001083260.1. NM_001089791.1.
UniGeneXl.8361.

3D structure databases

ProteinModelPortalQ6PB03.
ModBaseSearch...

Proteomic databases

PRIDEQ6PB03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID398831.
KEGGxla:398831.

Organism-specific databases

CTD23646.
XenbaseXB-GENE-1006830. pld3.

Phylogenomic databases

HOVERGENHBG052880.

Family and domain databases

InterProIPR001736. PLipase_D/transphosphatidylase.
IPR013582. PLipase_D_envelope.
[Graphical view]
PfamPF08371. PLD_envelope. 1 hit.
PF00614. PLDc. 1 hit.
[Graphical view]
SMARTSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLD3_XENLA
AccessionPrimary (citable) accession number: Q6PB03
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: October 19, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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