Q6PAZ3 (DGAT2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diacylglycerol O-acyltransferase 2
EC=2.3.1.20

Alternative name(s):
Diglyceride acyltransferase 2

Gene names

Name:

dgat2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation By similarity.
Catalytic activity	Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the diacylglycerol acyltransferase family.

Ontologies

Keywords
Biological process	Glycerol metabolism Lipid metabolism Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	diacylglycerol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Diacylglycerol O-acyltransferase 2		PRO_0000249049
Regions
	Topological domain	1 – 42	42	Cytoplasmic Potential
	Transmembrane	43 – 61	19	Helical; Potential
	Topological domain	62 – 65	4	Lumenal Potential
	Transmembrane	66 – 85	20	Helical; Potential
	Topological domain	86 – 361	276	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6PAZ3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 05DAFBB1037282A1	FASTA	361	40,568
	10 20 30 40 50 60 MKTIIAAYSG VLRGTGSSLL SAVHDLPSIP WLSKSSVVRH LQIISVLQWV LSFLILGVAC 70 80 90 100 110 120 TAVLVYIFCT DLWLIAALYF TWMVLDWNTP YKGGRRSSWV RNWAVWRYFR DYFPVKLVKT 130 140 150 160 170 180 HNLLPSRNYI FGYHPHGIMC LGAFCNFGTE ATGVSKKFPG IKCHLATLAG NFRMPVLREY 190 200 210 220 230 240 LMSGGICPVN RDTINYILSK NGTGNAVVIA VGGAAESLNC RPGKNTVTLL HRKGFVKVAL 250 260 270 280 290 300 QHGADLVPIY SFGENETYKQ VVFEEGSWGR WIQQKFQKYV GFAPCLFHGC SFFSSNSWGL 310 320 330 340 350 360 VPYANPITTV VGEPITVPKI EQPTQKDVEL YHSMYLSSLH RLFDKYKTKL GLPDSETLEF I

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC059991 mRNA. Translation: AAH59991.1.
RefSeq	NP_001083204.1. NM_001089735.1.
UniGene	Xl.25952.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	398800.
KEGG	xla:398800.
Organism-specific databases
CTD	84649.
Xenbase	XB-GENE-6078761. dgat2.
Phylogenomic databases
HOVERGEN	HBG065791.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR007130. DAGAT. [Graphical view]
KO	K11160.
PANTHER	PTHR12317. DAGAT. 1 hit.
Pfam	PF03982. DAGAT. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DGAT2_XENLA

Accession

Primary (citable) accession number: Q6PAZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program