SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6PAZ3

- DGAT2_XENLA

UniProt

Q6PAZ3 - DGAT2_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Diacylglycerol O-acyltransferase 2
Gene
dgat2
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation By similarity.

Catalytic activityi

Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.

Pathwayi

GO - Molecular functioni

  1. diacylglycerol O-acyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycerol metabolic process Source: UniProtKB-KW
  2. triglyceride biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Glycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00282.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol O-acyltransferase 2 (EC:2.3.1.20)
Alternative name(s):
Diglyceride acyltransferase 2
Gene namesi
Name:dgat2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6078761. dgat2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei43 – 6119Helical; Reviewed prediction
Add
BLAST
Topological domaini62 – 654Lumenal Reviewed prediction
Transmembranei66 – 8520Helical; Reviewed prediction
Add
BLAST
Topological domaini86 – 361276Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Diacylglycerol O-acyltransferase 2
PRO_0000249049Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG065791.
KOiK11160.

Family and domain databases

InterProiIPR007130. DAGAT.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12317. PTHR12317. 1 hit.
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PAZ3-1 [UniParc]FASTAAdd to Basket

« Hide

MKTIIAAYSG VLRGTGSSLL SAVHDLPSIP WLSKSSVVRH LQIISVLQWV    50
LSFLILGVAC TAVLVYIFCT DLWLIAALYF TWMVLDWNTP YKGGRRSSWV 100
RNWAVWRYFR DYFPVKLVKT HNLLPSRNYI FGYHPHGIMC LGAFCNFGTE 150
ATGVSKKFPG IKCHLATLAG NFRMPVLREY LMSGGICPVN RDTINYILSK 200
NGTGNAVVIA VGGAAESLNC RPGKNTVTLL HRKGFVKVAL QHGADLVPIY 250
SFGENETYKQ VVFEEGSWGR WIQQKFQKYV GFAPCLFHGC SFFSSNSWGL 300
VPYANPITTV VGEPITVPKI EQPTQKDVEL YHSMYLSSLH RLFDKYKTKL 350
GLPDSETLEF I 361
Length:361
Mass (Da):40,568
Last modified:July 5, 2004 - v1
Checksum:i05DAFBB1037282A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC059991 mRNA. Translation: AAH59991.1.
RefSeqiNP_001083204.1. NM_001089735.1.
UniGeneiXl.25952.

Genome annotation databases

GeneIDi398800.
KEGGixla:398800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC059991 mRNA. Translation: AAH59991.1 .
RefSeqi NP_001083204.1. NM_001089735.1.
UniGenei Xl.25952.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398800.
KEGGi xla:398800.

Organism-specific databases

CTDi 84649.
Xenbasei XB-GENE-6078761. dgat2.

Phylogenomic databases

HOVERGENi HBG065791.
KOi K11160.

Enzyme and pathway databases

UniPathwayi UPA00282 .

Family and domain databases

InterProi IPR007130. DAGAT.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view ]
PANTHERi PTHR12317. PTHR12317. 1 hit.
Pfami PF03982. DAGAT. 1 hit.
[Graphical view ]
SMARTi SM00563. PlsC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiDGAT2_XENLA
AccessioniPrimary (citable) accession number: Q6PAZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi