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Q6PAZ3

- DGAT2_XENLA

UniProt

Q6PAZ3 - DGAT2_XENLA

Protein

Diacylglycerol O-acyltransferase 2

Gene

dgat2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. diacylglycerol O-acyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol metabolic process Source: UniProtKB-KW
    2. triglyceride biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Glycerol metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00282.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol O-acyltransferase 2 (EC:2.3.1.20)
    Alternative name(s):
    Diglyceride acyltransferase 2
    Gene namesi
    Name:dgat2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6078761. dgat2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Diacylglycerol O-acyltransferase 2PRO_0000249049Add
    BLAST

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini62 – 654LumenalSequence Analysis
    Topological domaini86 – 361276CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6119HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8520HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG065791.
    KOiK11160.

    Family and domain databases

    InterProiIPR007130. DAGAT.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view]
    PANTHERiPTHR12317. PTHR12317. 1 hit.
    PfamiPF03982. DAGAT. 1 hit.
    [Graphical view]
    SMARTiSM00563. PlsC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PAZ3-1 [UniParc]FASTAAdd to Basket

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    MKTIIAAYSG VLRGTGSSLL SAVHDLPSIP WLSKSSVVRH LQIISVLQWV    50
    LSFLILGVAC TAVLVYIFCT DLWLIAALYF TWMVLDWNTP YKGGRRSSWV 100
    RNWAVWRYFR DYFPVKLVKT HNLLPSRNYI FGYHPHGIMC LGAFCNFGTE 150
    ATGVSKKFPG IKCHLATLAG NFRMPVLREY LMSGGICPVN RDTINYILSK 200
    NGTGNAVVIA VGGAAESLNC RPGKNTVTLL HRKGFVKVAL QHGADLVPIY 250
    SFGENETYKQ VVFEEGSWGR WIQQKFQKYV GFAPCLFHGC SFFSSNSWGL 300
    VPYANPITTV VGEPITVPKI EQPTQKDVEL YHSMYLSSLH RLFDKYKTKL 350
    GLPDSETLEF I 361
    Length:361
    Mass (Da):40,568
    Last modified:July 5, 2004 - v1
    Checksum:i05DAFBB1037282A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC059991 mRNA. Translation: AAH59991.1.
    RefSeqiNP_001083204.1. NM_001089735.1.
    UniGeneiXl.25952.

    Genome annotation databases

    GeneIDi398800.
    KEGGixla:398800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC059991 mRNA. Translation: AAH59991.1 .
    RefSeqi NP_001083204.1. NM_001089735.1.
    UniGenei Xl.25952.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 398800.
    KEGGi xla:398800.

    Organism-specific databases

    CTDi 84649.
    Xenbasei XB-GENE-6078761. dgat2.

    Phylogenomic databases

    HOVERGENi HBG065791.
    KOi K11160.

    Enzyme and pathway databases

    UniPathwayi UPA00282 .

    Family and domain databases

    InterProi IPR007130. DAGAT.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view ]
    PANTHERi PTHR12317. PTHR12317. 1 hit.
    Pfami PF03982. DAGAT. 1 hit.
    [Graphical view ]
    SMARTi SM00563. PlsC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiDGAT2_XENLA
    AccessioniPrimary (citable) accession number: Q6PAZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3