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Q6PAZ3 (DGAT2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Diacylglycerol O-acyltransferase 2

EC=2.3.1.20
Alternative name(s):
Diglyceride acyltransferase 2
Gene names
Name:dgat2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation By similarity.

Catalytic activity

Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.

Pathway

Glycerolipid metabolism; triacylglycerol biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the diacylglycerol acyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Diacylglycerol O-acyltransferase 2
PRO_0000249049

Regions

Topological domain1 – 4242Cytoplasmic Potential
Transmembrane43 – 6119Helical; Potential
Topological domain62 – 654Lumenal Potential
Transmembrane66 – 8520Helical; Potential
Topological domain86 – 361276Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q6PAZ3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 05DAFBB1037282A1

FASTA36140,568
        10         20         30         40         50         60 
MKTIIAAYSG VLRGTGSSLL SAVHDLPSIP WLSKSSVVRH LQIISVLQWV LSFLILGVAC 

        70         80         90        100        110        120 
TAVLVYIFCT DLWLIAALYF TWMVLDWNTP YKGGRRSSWV RNWAVWRYFR DYFPVKLVKT 

       130        140        150        160        170        180 
HNLLPSRNYI FGYHPHGIMC LGAFCNFGTE ATGVSKKFPG IKCHLATLAG NFRMPVLREY 

       190        200        210        220        230        240 
LMSGGICPVN RDTINYILSK NGTGNAVVIA VGGAAESLNC RPGKNTVTLL HRKGFVKVAL 

       250        260        270        280        290        300 
QHGADLVPIY SFGENETYKQ VVFEEGSWGR WIQQKFQKYV GFAPCLFHGC SFFSSNSWGL 

       310        320        330        340        350        360 
VPYANPITTV VGEPITVPKI EQPTQKDVEL YHSMYLSSLH RLFDKYKTKL GLPDSETLEF 


I 

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC059991 mRNA. Translation: AAH59991.1.
RefSeqNP_001083204.1. NM_001089735.1.
UniGeneXl.25952.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID398800.
KEGGxla:398800.

Organism-specific databases

CTD84649.
XenbaseXB-GENE-6078761. dgat2.

Phylogenomic databases

HOVERGENHBG065791.
KOK11160.

Enzyme and pathway databases

UniPathwayUPA00282.

Family and domain databases

InterProIPR007130. DAGAT.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERPTHR12317. PTHR12317. 1 hit.
PfamPF03982. DAGAT. 1 hit.
[Graphical view]
SMARTSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDGAT2_XENLA
AccessionPrimary (citable) accession number: Q6PAZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways