Q6PAY6 (PROD2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable proline dehydrogenase 2
EC=1.5.99.8

Alternative name(s):
Probable proline oxidase 2

Gene names

Name:

prodh2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts proline to delta-1-pyrroline-5-carboxylate Probable.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Sequence similarities	Belongs to the proline oxidase family.

Ontologies

Keywords
Biological process	Proline metabolism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro proline catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	proline dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Probable proline dehydrogenase 2		PRO_0000308626

Sequences

	Sequence		Length	Mass (Da)
	Q6PAY6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 873A4E7B7B336E99	FASTA	466	52,329
	10 20 30 40 50 60 MRLLGRYLRL GSPRLCSRVW PTLPPSCSPH STAAAAQAQG ALSFSDGGVF KLKSSWEVAR 70 80 90 100 110 120 GLLIFRMCSF PSLVKHSEKM LSVSRRLLGR RLFEWGMKGS VYGQFVAGET LPEIRVCVDR 130 140 150 160 170 180 LRQLGIHPML AVPIEEDLGQ AKSGERWYEQ NESIMLDCVD LSAAGGDRPM MQLKITALMS 190 200 210 220 230 240 AELCKLLSVH LSHPSNGPQL CPRSIVSIME GKESAFSFLS EGENSHLRNS VRRLSRIAKH 250 260 270 280 290 300 ATANRVRVLV DAEYTYMNPA LSLVTMAMMS QCNQSEPWIW NTYQCYLKDS FSLLSLDLDT 310 320 330 340 350 360 ARSLGLCFGV KLVRGAYMDK ERKLSKQKGY ADPIQHDWEA TNRSYQRSLD KMLDLIGQNG 370 380 390 400 410 420 QRHNLIVASH NEESVLHAVT RMAELGIDKG SGSVSFGQLL GMCDHVSLTL GQAGYLVYKS 430 440 450 460 LPYGSVDSVL PYLIRRAQEN QSVLQGIRKE RDLLRRELKR RLFNQR

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC059998 mRNA. Translation: AAH59998.1.
RefSeq	NP_001083128.1. NM_001089659.1.
UniGene	Xl.34459.
3D structure databases
ProteinModelPortal	Q6PAY6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	398760.
KEGG	xla:398760.
Organism-specific databases
CTD	58510.
Xenbase	XB-GENE-5784821. prodh2.
Phylogenomic databases
HOVERGEN	HBG108294.
Family and domain databases
InterPro	IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view]
KO	K11394.
PANTHER	PTHR13914. Proline_oxidase. 1 hit.
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROD2_XENLA

Accession

Primary (citable) accession number: Q6PAY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program