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Q6PAR5

- GAPD1_MOUSE

UniProt

Q6PAR5 - GAPD1_MOUSE

Protein

GTPase-activating protein and VPS9 domain-containing protein 1

Gene

Gapvd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.3 Publications

    GO - Molecular functioni

    1. GTPase activating protein binding Source: UniProtKB
    2. GTPase activator activity Source: UniProtKB-KW
    3. guanyl-nucleotide exchange factor activity Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. positive regulation of GTPase activity Source: GOC
    3. regulation of protein transport Source: UniProtKB
    4. regulation of small GTPase mediated signal transduction Source: InterPro
    5. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation, Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase-activating protein and VPS9 domain-containing protein 1
    Alternative name(s):
    GAPex-5
    Rab5-activating protein 6
    Gene namesi
    Name:Gapvd1
    Synonyms:Gapex5, Kiaa1521
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1913941. Gapvd1.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication. Endosome By similarity
    Note: Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endosome Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14581458GTPase-activating protein and VPS9 domain-containing protein 1PRO_0000324772Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei390 – 3901PhosphothreonineBy similarity
    Modified residuei458 – 4581PhosphothreonineBy similarity
    Modified residuei466 – 4661PhosphoserineBy similarity
    Modified residuei470 – 4701PhosphothreonineBy similarity
    Modified residuei566 – 5661PhosphoserineBy similarity
    Modified residuei766 – 7661PhosphoserineBy similarity
    Modified residuei902 – 9021Phosphoserine2 Publications
    Modified residuei903 – 9031PhosphoserineBy similarity
    Modified residuei964 – 9641PhosphoserineBy similarity
    Modified residuei1017 – 10171PhosphoserineBy similarity
    Modified residuei1076 – 10761PhosphoserineBy similarity
    Modified residuei1085 – 10851Phosphoserine

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PAR5.
    PaxDbiQ6PAR5.
    PRIDEiQ6PAR5.

    PTM databases

    PhosphoSiteiQ6PAR5.

    Expressioni

    Tissue specificityi

    Present in adipocytes and fibroblasts (at protein level). Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ6PAR5.
    BgeeiQ6PAR5.
    CleanExiMM_GAPVD1.
    GenevestigatoriQ6PAR5.

    Interactioni

    Subunit structurei

    Interacts with RAB5A By similarity. Interacts with TRIP10/CIP4.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi211649. 1 interaction.
    IntActiQ6PAR5. 1 interaction.
    MINTiMINT-4125168.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PAR5.
    SMRiQ6PAR5. Positions 1243-1457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini131 – 353223Ras-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini1318 – 1458141VPS9PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GAPVD1 family.Curated
    Contains 1 Ras-GAP domain.PROSITE-ProRule annotation
    Contains 1 VPS9 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG275317.
    GeneTreeiENSGT00530000063341.
    HOVERGENiHBG107936.
    InParanoidiQ6PAR5.
    OMAiEMVDSNE.
    PhylomeDBiQ6PAR5.
    TreeFamiTF105908.

    Family and domain databases

    Gene3Di1.10.506.10. 1 hit.
    InterProiIPR001936. RasGAP.
    IPR008936. Rho_GTPase_activation_prot.
    IPR003123. VPS9.
    IPR013995. VPS9_subgr.
    [Graphical view]
    PfamiPF00616. RasGAP. 1 hit.
    PF02204. VPS9. 1 hit.
    [Graphical view]
    SMARTiSM00167. VPS9. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS51205. VPS9. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PAR5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVKLDIHTLA HHLKQERLYV SSEKQLIQRL NADVLKTAEK LYRTAWIAKQ     50
    QRINLDRLII TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL 100
    SRLRENPRLI ASSLVAGEKL NQENTQSVIY TVFTSLYGNC IMQEDESYLL 150
    QVLRYLIEFE LKESDNPRRL LRRGTCAFSI LFKLFSEGLF SAKLFLTATL 200
    HEPIMQLLVE DEDHLETDPN KLIERFSPAQ QEKLFGEKGS DRFRQKVQEM 250
    VDSNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG 300
    EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ 350
    LAMTGTEEGD PRTKNSLGKF DKGCVAAFLD VVIGGRAVET PPMSSVNLLE 400
    GLSRTVVYIS YSQLITLVNF MKSVMSGDQL KEDRMALDNL LANLPQAKPG 450
    KSSSLDMTPY STPQMSPATT PANKKNRLPI ATRSRSRSNM LMDLHMDHEG 500
    SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL SDGGQGDVPV 550
    DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG 600
    AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET 650
    VSETWSTDVL GSDFDPNVDE DRLQEIAGAA AENVLGSLLC LPGSGSVLLD 700
    PCTGSTISET TSEAWSVEVL PSDSEAPDLK QEERLQELES CSGLGSTSDD 750
    TDVREVSSRP STPGLSVVSG ISATSEDIPN KIEDLRSECS SDFGGKDSVT 800
    SPDMDDIAHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV VRPKVHYARP 850
    SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT AAEMEAFKQR HSYPERLVRS 900
    RSSDIVSSVR RPMSDPSWNR RPGNEELPPA AATGATSLVA APHSSSSSPS 950
    KDSSRGETEE RKDSDDERSD RSRPWWRKRF VSAMPKAPIP FRKKEKQEKD 1000
    KDDLGPDRFS TLTDEPSPRL SAQAQVAEDI LDKYRNAIKR TSPSEGAMAN 1050
    DESAEVMGDG ESAHDSPREE ALQNISADDL PDSASQAAHP QDSAFSYRDV 1100
    KKKLRLALCS ADSVAFPVLT HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI 1150
    NLQDKSLMAQ LQETMRCVCR FDNRTCRKLL ASIAEDYRKR APYIAYLTRC 1200
    RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES KEKKIREFIQ 1250
    DFQKLTAADD KTAQVEDFLQ FLYGVMAQDV IWQNASEEQL QDAQLAIERS 1300
    VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR 1350
    EAPWPSAQSE IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD 1400
    DFVPVLVFVL IKANPPCLLS TVQYISSFYA SCLSGEESYW WMQFTAAVEF 1450
    IKTIDDRK 1458
    Length:1,458
    Mass (Da):162,402
    Last modified:March 18, 2008 - v2
    Checksum:iCA3D2EAF22051FD7
    GO
    Isoform 2 (identifier: Q6PAR5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         557-577: Missing.

    Show »
    Length:1,437
    Mass (Da):160,111
    Checksum:i99CB3966DC97D605
    GO
    Isoform 3 (identifier: Q6PAR5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         373-379: GCVAAFL → VGMSVVS
         380-1458: Missing.

    Show »
    Length:379
    Mass (Da):43,381
    Checksum:i7123D700EE30972C
    GO
    Isoform 4 (identifier: Q6PAR5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         480-480: I → IGQQLAAITAWDSSATNLTAHIPLVTPF
         557-577: Missing.

    Show »
    Length:1,464
    Mass (Da):162,917
    Checksum:iC34EEFDA11081BA7
    GO
    Isoform 5 (identifier: Q6PAR5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         557-577: Missing.
         1202-1202: Missing.

    Show »
    Length:1,436
    Mass (Da):159,982
    Checksum:i4367B45EA4C2D537
    GO
    Isoform 6 (identifier: Q6PAR5-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1055-1055: Missing.

    Show »
    Length:1,457
    Mass (Da):162,273
    Checksum:i67DC7B5E4E46334D
    GO

    Sequence cautioni

    The sequence AAH31478.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH48847.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAE29251.1 differs from that shown. Reason: Frameshift at position 811.
    The sequence AAH43715.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH57164.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB29377.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC98191.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE22277.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAM15445.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM15446.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM15455.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM15456.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM24604.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM24605.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti581 – 5811N → D in BAE29251. (PubMed:16141072)Curated
    Sequence conflicti661 – 6611G → E in AAH31478. (PubMed:15489334)Curated
    Sequence conflicti893 – 8931Y → H in BAE22277. (PubMed:16141072)Curated
    Sequence conflicti1257 – 12571A → V in BAC98191. (PubMed:14621295)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei373 – 3797GCVAAFL → VGMSVVS in isoform 3. 1 PublicationVSP_032363
    Alternative sequencei380 – 14581079Missing in isoform 3. 1 PublicationVSP_032364Add
    BLAST
    Alternative sequencei480 – 4801I → IGQQLAAITAWDSSATNLTA HIPLVTPF in isoform 4. 1 PublicationVSP_032365
    Alternative sequencei557 – 57721Missing in isoform 2, isoform 4 and isoform 5. 4 PublicationsVSP_032366Add
    BLAST
    Alternative sequencei1055 – 10551Missing in isoform 6. 1 PublicationVSP_032367
    Alternative sequencei1202 – 12021Missing in isoform 5. 1 PublicationVSP_032368

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF155419 mRNA. Translation: ABM68541.1.
    AK129381 Transcribed RNA. Translation: BAC98191.1. Different initiation.
    AK014474 mRNA. Translation: BAB29377.2. Different initiation.
    AK088851 mRNA. Translation: BAC40613.1.
    AK003521 mRNA. Translation: BAB22834.1.
    AK134776 mRNA. Translation: BAE22277.1. Different initiation.
    AK150026 mRNA. Translation: BAE29251.1. Frameshift.
    AK165047 mRNA. Translation: BAE38017.1.
    AL845262, AL929106 Genomic DNA. Translation: CAM15445.1. Sequence problems.
    AL845262, AL929106 Genomic DNA. Translation: CAM15446.1. Sequence problems.
    AL845262, AL929106 Genomic DNA. Translation: CAM15447.1.
    AL845262 Genomic DNA. Translation: CAM15455.1. Sequence problems.
    AL845262 Genomic DNA. Translation: CAM15456.1. Sequence problems.
    AL929106, AL845262 Genomic DNA. Translation: CAM24604.1. Sequence problems.
    AL929106, AL845262 Genomic DNA. Translation: CAM24605.1. Sequence problems.
    AL929106, AL845262 Genomic DNA. Translation: CAM24606.1.
    BC031478 mRNA. Translation: AAH31478.1. Sequence problems.
    BC043715 mRNA. Translation: AAH43715.1. Different initiation.
    BC048847 mRNA. Translation: AAH48847.1. Sequence problems.
    BC057164 mRNA. Translation: AAH57164.1. Different initiation.
    BC060123 mRNA. Translation: AAH60123.1.
    CCDSiCCDS15949.1. [Q6PAR5-2]
    RefSeqiNP_079985.2. NM_025709.2. [Q6PAR5-2]
    XP_006498294.1. XM_006498231.1. [Q6PAR5-4]
    XP_006498295.1. XM_006498232.1. [Q6PAR5-1]
    UniGeneiMm.156452.
    Mm.393397.

    Genome annotation databases

    EnsembliENSMUST00000028224; ENSMUSP00000028224; ENSMUSG00000026867. [Q6PAR5-2]
    ENSMUST00000102800; ENSMUSP00000099864; ENSMUSG00000026867. [Q6PAR5-2]
    ENSMUST00000113099; ENSMUSP00000108723; ENSMUSG00000026867. [Q6PAR5-1]
    GeneIDi66691.
    KEGGimmu:66691.
    UCSCiuc008jiq.2. mouse. [Q6PAR5-2]
    uc008jir.1. mouse. [Q6PAR5-3]
    uc012bug.1. mouse. [Q6PAR5-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF155419 mRNA. Translation: ABM68541.1 .
    AK129381 Transcribed RNA. Translation: BAC98191.1 . Different initiation.
    AK014474 mRNA. Translation: BAB29377.2 . Different initiation.
    AK088851 mRNA. Translation: BAC40613.1 .
    AK003521 mRNA. Translation: BAB22834.1 .
    AK134776 mRNA. Translation: BAE22277.1 . Different initiation.
    AK150026 mRNA. Translation: BAE29251.1 . Frameshift.
    AK165047 mRNA. Translation: BAE38017.1 .
    AL845262 , AL929106 Genomic DNA. Translation: CAM15445.1 . Sequence problems.
    AL845262 , AL929106 Genomic DNA. Translation: CAM15446.1 . Sequence problems.
    AL845262 , AL929106 Genomic DNA. Translation: CAM15447.1 .
    AL845262 Genomic DNA. Translation: CAM15455.1 . Sequence problems.
    AL845262 Genomic DNA. Translation: CAM15456.1 . Sequence problems.
    AL929106 , AL845262 Genomic DNA. Translation: CAM24604.1 . Sequence problems.
    AL929106 , AL845262 Genomic DNA. Translation: CAM24605.1 . Sequence problems.
    AL929106 , AL845262 Genomic DNA. Translation: CAM24606.1 .
    BC031478 mRNA. Translation: AAH31478.1 . Sequence problems.
    BC043715 mRNA. Translation: AAH43715.1 . Different initiation.
    BC048847 mRNA. Translation: AAH48847.1 . Sequence problems.
    BC057164 mRNA. Translation: AAH57164.1 . Different initiation.
    BC060123 mRNA. Translation: AAH60123.1 .
    CCDSi CCDS15949.1. [Q6PAR5-2 ]
    RefSeqi NP_079985.2. NM_025709.2. [Q6PAR5-2 ]
    XP_006498294.1. XM_006498231.1. [Q6PAR5-4 ]
    XP_006498295.1. XM_006498232.1. [Q6PAR5-1 ]
    UniGenei Mm.156452.
    Mm.393397.

    3D structure databases

    ProteinModelPortali Q6PAR5.
    SMRi Q6PAR5. Positions 1243-1457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211649. 1 interaction.
    IntActi Q6PAR5. 1 interaction.
    MINTi MINT-4125168.

    PTM databases

    PhosphoSitei Q6PAR5.

    Proteomic databases

    MaxQBi Q6PAR5.
    PaxDbi Q6PAR5.
    PRIDEi Q6PAR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028224 ; ENSMUSP00000028224 ; ENSMUSG00000026867 . [Q6PAR5-2 ]
    ENSMUST00000102800 ; ENSMUSP00000099864 ; ENSMUSG00000026867 . [Q6PAR5-2 ]
    ENSMUST00000113099 ; ENSMUSP00000108723 ; ENSMUSG00000026867 . [Q6PAR5-1 ]
    GeneIDi 66691.
    KEGGi mmu:66691.
    UCSCi uc008jiq.2. mouse. [Q6PAR5-2 ]
    uc008jir.1. mouse. [Q6PAR5-3 ]
    uc012bug.1. mouse. [Q6PAR5-4 ]

    Organism-specific databases

    CTDi 26130.
    MGIi MGI:1913941. Gapvd1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG275317.
    GeneTreei ENSGT00530000063341.
    HOVERGENi HBG107936.
    InParanoidi Q6PAR5.
    OMAi EMVDSNE.
    PhylomeDBi Q6PAR5.
    TreeFami TF105908.

    Miscellaneous databases

    ChiTaRSi GAPVD1. mouse.
    NextBioi 322389.
    PROi Q6PAR5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PAR5.
    Bgeei Q6PAR5.
    CleanExi MM_GAPVD1.
    Genevestigatori Q6PAR5.

    Family and domain databases

    Gene3Di 1.10.506.10. 1 hit.
    InterProi IPR001936. RasGAP.
    IPR008936. Rho_GTPase_activation_prot.
    IPR003123. VPS9.
    IPR013995. VPS9_subgr.
    [Graphical view ]
    Pfami PF00616. RasGAP. 1 hit.
    PF02204. VPS9. 1 hit.
    [Graphical view ]
    SMARTi SM00167. VPS9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS51205. VPS9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes."
      Lodhi I.J., Chiang S.-H., Chang L., Vollenweider D., Watson R.T., Inoue M., Pessin J.E., Saltiel A.R.
      Cell Metab. 5:59-72(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TRIP10.
      Strain: Swiss albino.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 973-1458 (ISOFORM 6).
      Strain: C57BL/6J and NOD.
      Tissue: Eye, Liver, Medulla oblongata and Thymus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6, FVB/N and FVB/N-3.
      Tissue: Brain, Kidney and Mammary tumor.
    6. "Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5."
      Su X., Lodhi I.J., Saltiel A.R., Stahl P.D.
      J. Biol. Chem. 281:27982-27990(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor."
      Su X., Kong C., Stahl P.D.
      J. Biol. Chem. 282:21278-21284(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiGAPD1_MOUSE
    AccessioniPrimary (citable) accession number: Q6PAR5
    Secondary accession number(s): A0PJI8
    , A2AR09, A2AR10, A2AR17, A2AR18, Q3TNS1, Q3UDL0, Q3UYD5, Q6ZPP0, Q80V37, Q80ZK4, Q8BTS5, Q9CRS2, Q9CTI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3