Retinoblastoma-like 1 (P107)

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cell cycle Source: InterPro
• regulation of cell cycle Source: InterPro
• regulation of transcription from RNA polymerase II promoter Source: InterPro

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• nucleus Source: InterPro
• transcription factor complex Source: InterPro

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	70 – 212	143	DUF3452InterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi SMART:SM01367			Add BLAST
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	385 – 578	194	RB_AInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi SMART:SM01368			Add BLAST
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	800 – 934	135	CYCLINInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi SMART:SM00385			Add BLAST
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	947 – 1063	117	Rb_CInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi SMART:SM01369			Add BLAST

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFEDEPHAEG AAAVAAAREA LQALCQELNL DEGSAAEALD DFTAIRGNYS 
        60         70         80         90        100
LEGEVIHWLA CSLYVACRKS IIPTVGKGVM EGNCVSLTRI LRSAKLSLIQ 
       110        120        130        140        150
FFSKMKKWMD MSNLPQEFRE RIERLERNFE VSTVIFKKFE PIFLDIFQNP 
       160        170        180        190        200
YEEPPKLPRS RKQRRIPCSV RDLFNFCWTL FVYTKGNFRM IGDDLVNSYH 
       210        220        230        240        250
LLLCCLDLIF ANAIMCPNRR DLLNPSFKGL PSDFHAPDFK AAEEPPCIIA 
       260        270        280        290        300
VLCDLHDGLL VEAKGIKEHY FKPYISKLFD KKILKGECLL DLSSFTDNSK 
       310        320        330        340        350
AVNKEYEEYV LTVGDFDERI FLGADAEEEI GTPRKFTADT PFGKLTSQAS 
       360        370        380        390        400
VECNLQQHFE KKRSFAPSTP LTGRRYLQEK EAVTTPVASA TQSVSRLQSI 
       410        420        430        440        450
VAGLKSAPSE QLLNIFESCM RNPMGNIIKI VKGIGETFCQ HYTQSTDKQP 
       460        470        480        490        500
GSHIDFAVNR LKLAEILYYK ILETIMVQET RRLHGMDMSV LLEQDIFHKS 
       510        520        530        540        550
LMACCLEIVL FAYSSPRTFP WIIEVLDLQP FYFYKVIEVV IRSEEGLSRD 
       560        570        580        590        600
MVKHLNSIEE QILESLAWTN NSALWEALHA SANRVPPCEE VIFPNNFEIG 
       610        620        630        640        650
NGGNVQGHLP MMPMSPIIHP RVKEVRTDSG SLRQDMQPLS PISVHERYSS 
       660        670        680        690        700
PAAGSAKRRL FGDDPPKDTL MDKIMAEGTK LKIAPSSVTA ESLSISPGQA 
       710        720        730        740        750
LLTMATTTVT GTTGRKVTVP LHGIANDAGE ITLVPISMNP TQESTAESPV 
       760        770        780        790        800
SLTAQSLIGT SPKQTHLTKA QDAHLTGVSK PKRTGSLALF YRKVYHLASV 
       810        820        830        840        850
RLRDLCLKLD VSNELRRKIW TCFEFTLVHC PDLMKDRHLD QLLLCAFYIM 
       860        870        880        890        900
AKVTKEERTF QEIMKSYRNQ PQANSHVYRS VLLKSIPGGV VVYNGDCEMT 
       910        920        930        940        950
DGDIEDATKT PNCSSEPVKE ERGDLIKFYN TVYVGRVKSF ALKYDLSNQD 
       960        970        980        990       1000
HIMDAPPLSP FPHIKQQPGS PRRISQQHSL YVSPHKNGAG LTPRSALLYK 
      1010       1020       1030       1040       1050
FNGSPSKSLK DINNMIRQGE QKTKKRVIAI SGDADSPAKR LCQENDDVLL 
      1060 
KRLQDVVSER ANH                                  

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>Provides links to the UniProt Reference Clusters (<a href="/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.</p><p><a href='../manual/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ