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Protein

RNA exonuclease 4

Gene

Rexo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an exonuclease.

GO - Molecular functioni

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 4 (EC:3.1.-.-)
Alternative name(s):
Exonuclease XPMC2
Prevents mitotic catastrophe 2 protein homolog
Gene namesi
Name:Rexo4
Synonyms:Gm111, Pmc2, Xpmc2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2684957. Rexo4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317041 – 432RNA exonuclease 4Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineBy similarity1
Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PAQ4.
MaxQBiQ6PAQ4.
PaxDbiQ6PAQ4.
PeptideAtlasiQ6PAQ4.
PRIDEiQ6PAQ4.

PTM databases

iPTMnetiQ6PAQ4.
PhosphoSitePlusiQ6PAQ4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052406.
CleanExiMM_REXO4.
ExpressionAtlasiQ6PAQ4. baseline and differential.
GenevisibleiQ6PAQ4. MM.

Interactioni

Subunit structurei

Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment (By similarity).By similarity

Protein-protein interaction databases

BioGridi230657. 1 interactor.
IntActiQ6PAQ4. 1 interactor.
MINTiMINT-4114366.
STRINGi10090.ENSMUSP00000109653.

Structurei

3D structure databases

ProteinModelPortaliQ6PAQ4.
SMRiQ6PAQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 381ExonucleaseAdd BLAST152

Sequence similaritiesi

Belongs to the REXO4 family.Curated

Phylogenomic databases

eggNOGiKOG2249. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00520000055542.
HOGENOMiHOG000231626.
HOVERGENiHBG000999.
InParanoidiQ6PAQ4.
KOiK18327.
OMAiAMRLYVM.
OrthoDBiEOG091G0I6S.
PhylomeDBiQ6PAQ4.
TreeFamiTF313504.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
PfamiView protein in Pfam
PF00929. RNase_T. 1 hit.
SMARTiView protein in SMART
SM00479. EXOIII. 1 hit.
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PAQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCACAVAGVA VSSLVVPTAE SGEMKTKATA PVPQPGPIRK LARKKAKKKF
60 70 80 90 100
RKSKALAGSG VPGSHPAAVA GRPPKAPENF SQNWKALQEL LKQKSQAAEK
110 120 130 140 150
PLVSQMDDKM HPQIIQQNRK KASDKSKGDK QRTEKAKSTR GSVTSAPTDR
160 170 180 190 200
KILVPPTDTS GTEQKKGAKK RTYSDISSHQ GALKPKWKAT EAAVILNQPT
210 220 230 240 250
PTEEDIWFDD VDPDDIEDAI GPEAAMLVRK RLGQKKRTIS LEKEQAFGGL
260 270 280 290 300
TKALALDCEM VGVGPKGEES IAARVSIVNQ YGKCVYDKYV KPTEPVTDYR
310 320 330 340 350
TAVSGIRPEN LKQGEEFEVV KKEVAEMLKG RILVGHALHN DLKVLFLDHP
360 370 380 390 400
KKKIRDTQKF KPFRSRVKSG RPSLKRLSEK ILGIRVQQAE HCSIQDAQAA
410 420 430
MRLYVMVKRE WESSTANRRA PAATPQHRIK NS
Length:432
Mass (Da):47,599
Last modified:July 19, 2005 - v2
Checksum:iAFEFA9DFCFB4819B
GO

Sequence cautioni

The sequence AAH60147 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK079733 differs from that shown. Intron retention.Curated
The sequence BAE23812 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079733 mRNA. No translation available.
AK138894 mRNA. Translation: BAE23812.1. Different initiation.
BC060147 mRNA. Translation: AAH60147.1. Different initiation.
CCDSiCCDS15819.1.
RefSeqiNP_997117.2. NM_207234.2.
UniGeneiMm.291874.

Genome annotation databases

EnsembliENSMUST00000114020; ENSMUSP00000109653; ENSMUSG00000052406.
GeneIDi227656.
KEGGimmu:227656.
UCSCiuc008iwn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiREXO4_MOUSE
AccessioniPrimary (citable) accession number: Q6PAQ4
Secondary accession number(s): Q3UU17, Q8C524
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 25, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families