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Protein

RNA exonuclease 4

Gene

Rexo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an exonuclease.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 4 (EC:3.1.-.-)
Alternative name(s):
Exonuclease XPMC2
Prevents mitotic catastrophe 2 protein homolog
Gene namesi
Name:Rexo4
Synonyms:Gm111, Pmc2, Xpmc2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2684957. Rexo4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432RNA exonuclease 4PRO_0000131704Add
BLAST

Proteomic databases

EPDiQ6PAQ4.
MaxQBiQ6PAQ4.
PaxDbiQ6PAQ4.
PRIDEiQ6PAQ4.

PTM databases

iPTMnetiQ6PAQ4.
PhosphoSiteiQ6PAQ4.

Expressioni

Gene expression databases

BgeeiQ6PAQ4.
CleanExiMM_REXO4.
ExpressionAtlasiQ6PAQ4. baseline and differential.
GenevisibleiQ6PAQ4. MM.

Interactioni

Subunit structurei

Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment (By similarity).By similarity

Protein-protein interaction databases

BioGridi230657. 1 interaction.
IntActiQ6PAQ4. 1 interaction.
MINTiMINT-4114366.
STRINGi10090.ENSMUSP00000109653.

Structurei

3D structure databases

ProteinModelPortaliQ6PAQ4.
SMRiQ6PAQ4. Positions 205-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini230 – 381152ExonucleaseAdd
BLAST

Sequence similaritiesi

Belongs to the REXO4 family.Curated
Contains 1 exonuclease domain.Curated

Phylogenomic databases

eggNOGiKOG2249. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00520000055542.
HOGENOMiHOG000231626.
HOVERGENiHBG000999.
InParanoidiQ6PAQ4.
KOiK18327.
OMAiKEWESMA.
PhylomeDBiQ6PAQ4.
TreeFamiTF313504.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PAQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCACAVAGVA VSSLVVPTAE SGEMKTKATA PVPQPGPIRK LARKKAKKKF
60 70 80 90 100
RKSKALAGSG VPGSHPAAVA GRPPKAPENF SQNWKALQEL LKQKSQAAEK
110 120 130 140 150
PLVSQMDDKM HPQIIQQNRK KASDKSKGDK QRTEKAKSTR GSVTSAPTDR
160 170 180 190 200
KILVPPTDTS GTEQKKGAKK RTYSDISSHQ GALKPKWKAT EAAVILNQPT
210 220 230 240 250
PTEEDIWFDD VDPDDIEDAI GPEAAMLVRK RLGQKKRTIS LEKEQAFGGL
260 270 280 290 300
TKALALDCEM VGVGPKGEES IAARVSIVNQ YGKCVYDKYV KPTEPVTDYR
310 320 330 340 350
TAVSGIRPEN LKQGEEFEVV KKEVAEMLKG RILVGHALHN DLKVLFLDHP
360 370 380 390 400
KKKIRDTQKF KPFRSRVKSG RPSLKRLSEK ILGIRVQQAE HCSIQDAQAA
410 420 430
MRLYVMVKRE WESSTANRRA PAATPQHRIK NS
Length:432
Mass (Da):47,599
Last modified:July 19, 2005 - v2
Checksum:iAFEFA9DFCFB4819B
GO

Sequence cautioni

The sequence AAH60147.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AK079733 differs from that shown.Intron retention.Curated
The sequence BAE23812.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079733 mRNA. No translation available.
AK138894 mRNA. Translation: BAE23812.1. Different initiation.
BC060147 mRNA. Translation: AAH60147.1. Different initiation.
CCDSiCCDS15819.1.
RefSeqiNP_997117.2. NM_207234.2.
UniGeneiMm.291874.

Genome annotation databases

EnsembliENSMUST00000114020; ENSMUSP00000109653; ENSMUSG00000052406.
GeneIDi227656.
KEGGimmu:227656.
UCSCiuc008iwn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079733 mRNA. No translation available.
AK138894 mRNA. Translation: BAE23812.1. Different initiation.
BC060147 mRNA. Translation: AAH60147.1. Different initiation.
CCDSiCCDS15819.1.
RefSeqiNP_997117.2. NM_207234.2.
UniGeneiMm.291874.

3D structure databases

ProteinModelPortaliQ6PAQ4.
SMRiQ6PAQ4. Positions 205-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230657. 1 interaction.
IntActiQ6PAQ4. 1 interaction.
MINTiMINT-4114366.
STRINGi10090.ENSMUSP00000109653.

PTM databases

iPTMnetiQ6PAQ4.
PhosphoSiteiQ6PAQ4.

Proteomic databases

EPDiQ6PAQ4.
MaxQBiQ6PAQ4.
PaxDbiQ6PAQ4.
PRIDEiQ6PAQ4.

Protocols and materials databases

DNASUi227656.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114020; ENSMUSP00000109653; ENSMUSG00000052406.
GeneIDi227656.
KEGGimmu:227656.
UCSCiuc008iwn.1. mouse.

Organism-specific databases

CTDi57109.
MGIiMGI:2684957. Rexo4.

Phylogenomic databases

eggNOGiKOG2249. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00520000055542.
HOGENOMiHOG000231626.
HOVERGENiHBG000999.
InParanoidiQ6PAQ4.
KOiK18327.
OMAiKEWESMA.
PhylomeDBiQ6PAQ4.
TreeFamiTF313504.

Miscellaneous databases

ChiTaRSiRexo4. mouse.
PROiQ6PAQ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PAQ4.
CleanExiMM_REXO4.
ExpressionAtlasiQ6PAQ4. baseline and differential.
GenevisibleiQ6PAQ4. MM.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-350.
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-432.
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiREXO4_MOUSE
AccessioniPrimary (citable) accession number: Q6PAQ4
Secondary accession number(s): Q3UU17, Q8C524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 8, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.