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Q6PAM1

- TXLNA_MOUSE

UniProt

Q6PAM1 - TXLNA_MOUSE

Protein

Alpha-taxilin

Gene

Txlna

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.By similarity

    GO - Biological processi

    1. B cell activation Source: MGI
    2. exocytosis Source: UniProtKB-KW

    Keywords - Biological processi

    Exocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-taxilin
    Gene namesi
    Name:Txlna
    Synonyms:Txln
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:105968. Txlna.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Alpha-taxilinPRO_0000189422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei523 – 5231PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PAM1.
    PaxDbiQ6PAM1.
    PRIDEiQ6PAM1.

    PTM databases

    PhosphoSiteiQ6PAM1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PAM1.
    BgeeiQ6PAM1.
    CleanExiMM_TXLNA.
    GenevestigatoriQ6PAM1.

    Interactioni

    Subunit structurei

    Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PAM1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili186 – 491306Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the taxilin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG252790.
    GeneTreeiENSGT00390000001482.
    HOGENOMiHOG000231384.
    HOVERGENiHBG104385.
    InParanoidiQ6PAM1.
    OMAiVTIENLH.
    OrthoDBiEOG70KGP6.
    PhylomeDBiQ6PAM1.
    TreeFamiTF318595.

    Family and domain databases

    InterProiIPR026183. Taxilin_fam.
    [Graphical view]
    PANTHERiPTHR16127. PTHR16127. 1 hit.
    PfamiPF09728. Taxilin. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PAM1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKNQDKKNGP AKHSNSKGSP GQREAGPEGA HGRPRQTAPG AEAEGSTSQA    50
    PGKTEGARAK AAQPGALCDV SEELSRQLED ILSTYCVDNN QGGPAEEGAQ 100
    GEPTEPEDTE KSRTYAARNG EPEPGIPVVN GEKETSKGEP GTEEIRASDE 150
    VGDRDHRRPQ EKKKAKGLGK EITLLMQTLN TLSTPEEKLA ALCKKYAELL 200
    EEHRNSQKQM KLLQKKQSQL VQEKDHLRGE HSKAVLARSK LESLCRELQR 250
    HNRSLKEEGV QRAREEEEKR KEVTSHFQVT LNDIQLQMEQ HNERNSKLRQ 300
    ENMELAERLK KLIEQYELRE EHIDKVFKHK DLQQQLVDAK LQQAQEMLKE 350
    AEERHQREKE FLLKEAVESQ RMCELMKQQE THLKQQLALY TEKFEEFQNT 400
    LSKSSEVFTT FKQEMEKMTK KIKKLEKETT MYRSRWESSN KALLEMAEEK 450
    TVRDKELEGL QVKIQRLEKL CRALQTERND LNKRVQDLTA GGITDIGSER 500
    RPEATTASKE QGVESPGAQP ASSPRATDAP CCSGAPSTGT AGQTGPGEPT 550
    PATA 554
    Length:554
    Mass (Da):62,369
    Last modified:July 5, 2004 - v1
    Checksum:i5CFDD86C4E744D06
    GO
    Isoform 2 (identifier: Q6PAM1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         362-409: LLKEAVESQR...TLSKSSEVFT → VRLRPQGCGG...CLSRQQSESR
         410-554: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:409
    Mass (Da):46,271
    Checksum:i563972E2D2E28CFB
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei362 – 40948LLKEA…SEVFT → VRLRPQGCGGAGRKWAGFWL SSIYFLWMGEILPAQSSNCL SRQQSESR in isoform 2. 1 PublicationVSP_011833Add
    BLAST
    Alternative sequencei410 – 554145Missing in isoform 2. 1 PublicationVSP_011834Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060227 mRNA. Translation: AAH60227.1.
    BC065115 mRNA. Translation: AAH65115.1.
    CCDSiCCDS38887.1. [Q6PAM1-1]
    RefSeqiNP_001005506.2. NM_001005506.3. [Q6PAM1-1]
    NP_001186624.1. NM_001199695.1. [Q6PAM1-1]
    XP_006502722.1. XM_006502659.1. [Q6PAM1-1]
    UniGeneiMm.268863.

    Genome annotation databases

    EnsembliENSMUST00000046425; ENSMUSP00000042153; ENSMUSG00000053841. [Q6PAM1-1]
    ENSMUST00000084264; ENSMUSP00000081285; ENSMUSG00000053841. [Q6PAM1-1]
    GeneIDi109658.
    KEGGimmu:109658.
    UCSCiuc008uxx.2. mouse. [Q6PAM1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060227 mRNA. Translation: AAH60227.1 .
    BC065115 mRNA. Translation: AAH65115.1 .
    CCDSi CCDS38887.1. [Q6PAM1-1 ]
    RefSeqi NP_001005506.2. NM_001005506.3. [Q6PAM1-1 ]
    NP_001186624.1. NM_001199695.1. [Q6PAM1-1 ]
    XP_006502722.1. XM_006502659.1. [Q6PAM1-1 ]
    UniGenei Mm.268863.

    3D structure databases

    ProteinModelPortali Q6PAM1.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6PAM1.

    Proteomic databases

    MaxQBi Q6PAM1.
    PaxDbi Q6PAM1.
    PRIDEi Q6PAM1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046425 ; ENSMUSP00000042153 ; ENSMUSG00000053841 . [Q6PAM1-1 ]
    ENSMUST00000084264 ; ENSMUSP00000081285 ; ENSMUSG00000053841 . [Q6PAM1-1 ]
    GeneIDi 109658.
    KEGGi mmu:109658.
    UCSCi uc008uxx.2. mouse. [Q6PAM1-1 ]

    Organism-specific databases

    CTDi 200081.
    MGIi MGI:105968. Txlna.

    Phylogenomic databases

    eggNOGi NOG252790.
    GeneTreei ENSGT00390000001482.
    HOGENOMi HOG000231384.
    HOVERGENi HBG104385.
    InParanoidi Q6PAM1.
    OMAi VTIENLH.
    OrthoDBi EOG70KGP6.
    PhylomeDBi Q6PAM1.
    TreeFami TF318595.

    Miscellaneous databases

    NextBioi 362523.
    PROi Q6PAM1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PAM1.
    Bgeei Q6PAM1.
    CleanExi MM_TXLNA.
    Genevestigatori Q6PAM1.

    Family and domain databases

    InterProi IPR026183. Taxilin_fam.
    [Graphical view ]
    PANTHERi PTHR16127. PTHR16127. 1 hit.
    Pfami PF09728. Taxilin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiTXLNA_MOUSE
    AccessioniPrimary (citable) accession number: Q6PAM1
    Secondary accession number(s): Q6P1E5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3