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Protein

Alpha-taxilin

Gene

Txlna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.By similarity

GO - Biological processi

  1. B cell activation Source: MGI
  2. exocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-taxilin
Gene namesi
Name:Txlna
Synonyms:Txln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:105968. Txlna.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Alpha-taxilinPRO_0000189422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei523 – 5231PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PAM1.
PaxDbiQ6PAM1.
PRIDEiQ6PAM1.

PTM databases

PhosphoSiteiQ6PAM1.

Expressioni

Gene expression databases

BgeeiQ6PAM1.
CleanExiMM_TXLNA.
ExpressionAtlasiQ6PAM1. baseline and differential.
GenevestigatoriQ6PAM1.

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6PAM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili186 – 491306Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG252790.
GeneTreeiENSGT00390000001482.
HOGENOMiHOG000231384.
HOVERGENiHBG104385.
InParanoidiQ6PAM1.
OMAiVTIENLH.
OrthoDBiEOG70KGP6.
PhylomeDBiQ6PAM1.
TreeFamiTF318595.

Family and domain databases

InterProiIPR026183. Taxilin_fam.
[Graphical view]
PANTHERiPTHR16127. PTHR16127. 1 hit.
PfamiPF09728. Taxilin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PAM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKNQDKKNGP AKHSNSKGSP GQREAGPEGA HGRPRQTAPG AEAEGSTSQA
60 70 80 90 100
PGKTEGARAK AAQPGALCDV SEELSRQLED ILSTYCVDNN QGGPAEEGAQ
110 120 130 140 150
GEPTEPEDTE KSRTYAARNG EPEPGIPVVN GEKETSKGEP GTEEIRASDE
160 170 180 190 200
VGDRDHRRPQ EKKKAKGLGK EITLLMQTLN TLSTPEEKLA ALCKKYAELL
210 220 230 240 250
EEHRNSQKQM KLLQKKQSQL VQEKDHLRGE HSKAVLARSK LESLCRELQR
260 270 280 290 300
HNRSLKEEGV QRAREEEEKR KEVTSHFQVT LNDIQLQMEQ HNERNSKLRQ
310 320 330 340 350
ENMELAERLK KLIEQYELRE EHIDKVFKHK DLQQQLVDAK LQQAQEMLKE
360 370 380 390 400
AEERHQREKE FLLKEAVESQ RMCELMKQQE THLKQQLALY TEKFEEFQNT
410 420 430 440 450
LSKSSEVFTT FKQEMEKMTK KIKKLEKETT MYRSRWESSN KALLEMAEEK
460 470 480 490 500
TVRDKELEGL QVKIQRLEKL CRALQTERND LNKRVQDLTA GGITDIGSER
510 520 530 540 550
RPEATTASKE QGVESPGAQP ASSPRATDAP CCSGAPSTGT AGQTGPGEPT

PATA
Length:554
Mass (Da):62,369
Last modified:July 5, 2004 - v1
Checksum:i5CFDD86C4E744D06
GO
Isoform 2 (identifier: Q6PAM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-409: LLKEAVESQR...TLSKSSEVFT → VRLRPQGCGG...CLSRQQSESR
     410-554: Missing.

Note: No experimental confirmation available.

Show »
Length:409
Mass (Da):46,271
Checksum:i563972E2D2E28CFB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei362 – 40948LLKEA…SEVFT → VRLRPQGCGGAGRKWAGFWL SSIYFLWMGEILPAQSSNCL SRQQSESR in isoform 2. 1 PublicationVSP_011833Add
BLAST
Alternative sequencei410 – 554145Missing in isoform 2. 1 PublicationVSP_011834Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060227 mRNA. Translation: AAH60227.1.
BC065115 mRNA. Translation: AAH65115.1.
CCDSiCCDS38887.1. [Q6PAM1-1]
RefSeqiNP_001005506.2. NM_001005506.3. [Q6PAM1-1]
NP_001186624.1. NM_001199695.1. [Q6PAM1-1]
XP_006502722.1. XM_006502659.2. [Q6PAM1-1]
UniGeneiMm.268863.

Genome annotation databases

EnsembliENSMUST00000046425; ENSMUSP00000042153; ENSMUSG00000053841. [Q6PAM1-1]
ENSMUST00000084264; ENSMUSP00000081285; ENSMUSG00000053841. [Q6PAM1-1]
GeneIDi109658.
KEGGimmu:109658.
UCSCiuc008uxx.2. mouse. [Q6PAM1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060227 mRNA. Translation: AAH60227.1.
BC065115 mRNA. Translation: AAH65115.1.
CCDSiCCDS38887.1. [Q6PAM1-1]
RefSeqiNP_001005506.2. NM_001005506.3. [Q6PAM1-1]
NP_001186624.1. NM_001199695.1. [Q6PAM1-1]
XP_006502722.1. XM_006502659.2. [Q6PAM1-1]
UniGeneiMm.268863.

3D structure databases

ProteinModelPortaliQ6PAM1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6PAM1.

Proteomic databases

MaxQBiQ6PAM1.
PaxDbiQ6PAM1.
PRIDEiQ6PAM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046425; ENSMUSP00000042153; ENSMUSG00000053841. [Q6PAM1-1]
ENSMUST00000084264; ENSMUSP00000081285; ENSMUSG00000053841. [Q6PAM1-1]
GeneIDi109658.
KEGGimmu:109658.
UCSCiuc008uxx.2. mouse. [Q6PAM1-1]

Organism-specific databases

CTDi200081.
MGIiMGI:105968. Txlna.

Phylogenomic databases

eggNOGiNOG252790.
GeneTreeiENSGT00390000001482.
HOGENOMiHOG000231384.
HOVERGENiHBG104385.
InParanoidiQ6PAM1.
OMAiVTIENLH.
OrthoDBiEOG70KGP6.
PhylomeDBiQ6PAM1.
TreeFamiTF318595.

Miscellaneous databases

NextBioi362523.
PROiQ6PAM1.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PAM1.
CleanExiMM_TXLNA.
ExpressionAtlasiQ6PAM1. baseline and differential.
GenevestigatoriQ6PAM1.

Family and domain databases

InterProiIPR026183. Taxilin_fam.
[Graphical view]
PANTHERiPTHR16127. PTHR16127. 1 hit.
PfamiPF09728. Taxilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiTXLNA_MOUSE
AccessioniPrimary (citable) accession number: Q6PAM1
Secondary accession number(s): Q6P1E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.