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Protein

Draxin

Gene

Draxin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.UniRule annotation1 Publication

GO - Biological processi

  • axon guidance Source: UniProtKB
  • commissural neuron differentiation in spinal cord Source: UniProtKB
  • dorsal spinal cord development Source: UniProtKB
  • forebrain development Source: UniProtKB
  • negative regulation of axon extension Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: MGI
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
DraxinUniRule annotation
Alternative name(s):
Dorsal inhibitory axon guidance proteinUniRule annotation
Dorsal repulsive axon guidance proteinUniRule annotation
Neucrin
Gene namesi
Name:Draxin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917683 Draxin

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile. They however show a defasciculation of spinal cord commissural axons and absence of all forebrain commissures.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_000027324426 – 343DraxinAdd BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi258N-linked (GlcNAc...) asparagineUniRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PAL1
PRIDEiQ6PAL1

PTM databases

PhosphoSitePlusiQ6PAL1

Expressioni

Tissue specificityi

Predominantly expressed in developing neural tissues. Expressed in many brain regions, including the olfactory bulb, cortex, midbrain, cerebellum and pontine nuclei in postnatal day 0 (P0). Detected in the dorsal spinal cord and commissural axons. In the forebrain commissures, it is expressed in the regions that surround the corpus callosum, hippocampal commissure, and anterior commissure, such as the midline glial cells, indusium griseum glia, and glial wedge.2 Publications

Gene expression databases

BgeeiENSMUSG00000029005
CleanExiMM_2610109H07RIK
GenevisibleiQ6PAL1 MM

Interactioni

Subunit structurei

Interacts with LRP6.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030862

Structurei

3D structure databases

ProteinModelPortaliQ6PAL1
SMRiQ6PAL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the draxin family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDT Eukaryota
ENOG4111MNU LUCA
GeneTreeiENSGT00390000013828
HOGENOMiHOG000112267
HOVERGENiHBG107824
InParanoidiQ6PAL1
OMAiCMEGLRC
OrthoDBiEOG091G0GRL
PhylomeDBiQ6PAL1
TreeFamiTF333255

Family and domain databases

HAMAPiMF_03060 Draxin, 1 hit
InterProiView protein in InterPro
IPR029094 Draxin
PANTHERiPTHR28610 PTHR28610, 1 hit
PfamiView protein in Pfam
PF15550 Draxin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PAL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGCPVLRVP TLFLILLLFP ELHTAGTLAS GSSARNLPET HSHLPSSALW
60 70 80 90 100
VSQASHHGRR GLGKKDRGPG RPSRAQEGAV VTATKQASQM TLGQPPAGLL
110 120 130 140 150
QNKELLLGLT LPYPEKEARS PAWERVKKRG REHKRRRDRL RLHRGRAAIR
160 170 180 190 200
GPSSLMKKVE PSEDRMLEGT MEESSTSLAP TMFFLTMTDG ATPTTEESRI
210 220 230 240 250
LPVTSLRPQT QPRSDGEVMP TLDMALFDWT DYEDLKPEVW PSAKKKEKHW
260 270 280 290 300
SHFTSDGNET SPAEGDPCDH HQDCLPGTCC DLREHLCTPH NRGLNNKCFD
310 320 330 340
DCMCMEGLRC YAKFHRNRRV TRRKGRCVEP ETANGDQGSF INI
Length:343
Mass (Da):38,363
Last modified:March 29, 2005 - v2
Checksum:i50C71A3654664B93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82T → S in BAG80560 (PubMed:16141072).Curated1
Sequence conflicti82T → S in CAQ51921 (PubMed:15489334).Curated1
Sequence conflicti122A → G in BAG80560 (PubMed:16141072).Curated1
Sequence conflicti122A → G in CAQ51921 (PubMed:15489334).Curated1
Sequence conflicti186T → N in BAC39628 (PubMed:19468303).Curated1
Sequence conflicti188T → A in BAG80560 (PubMed:16141072).Curated1
Sequence conflicti188T → A in CAQ51921 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB301918 mRNA Translation: BAG80560.1
AK086198 mRNA Translation: BAC39628.1
AL606929 Genomic DNA Translation: CAM14900.1
CU207376 Genomic DNA Translation: CAQ51921.1
BC060239 mRNA Translation: AAH60239.2
CCDSiCCDS18931.1
RefSeqiNP_081702.2, NM_027426.3
UniGeneiMm.275288

Genome annotation databases

EnsembliENSMUST00000030862; ENSMUSP00000030862; ENSMUSG00000029005
GeneIDi70433
KEGGimmu:70433
UCSCiuc008vua.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDRAXI_MOUSE
AccessioniPrimary (citable) accession number: Q6PAL1
Secondary accession number(s): A2A7G4, B2KFL9, Q8C3D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 29, 2005
Last modified: April 25, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health