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Q6PAJ1

- BCR_MOUSE

UniProt

Q6PAJ1 - BCR_MOUSE

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Protein
Breakpoint cluster region protein
Gene
Bcr, Kiaa3017
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTPase activator activity Source: MGI
  3. Rac GTPase activator activity Source: MGI
  4. Rho guanyl-nucleotide exchange factor activity Source: InterPro
  5. protein binding Source: MGI
  6. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. brain development Source: MGI
  3. inner ear morphogenesis Source: MGI
  4. intracellular signal transduction Source: InterPro
  5. negative regulation of cell migration Source: MGI
  6. negative regulation of inflammatory response Source: MGI
  7. negative regulation of neutrophil degranulation Source: MGI
  8. neuromuscular process controlling balance Source: MGI
  9. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  10. positive regulation of GTPase activity Source: GOC
  11. positive regulation of Rac GTPase activity Source: GOC
  12. positive regulation of phagocytosis Source: MGI
  13. protein autophosphorylation Source: Ensembl
  14. regulation of cell cycle Source: MGI
  15. response to lipopolysaccharide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196460. Signaling by FGFR1 fusion mutants.
REACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Breakpoint cluster region protein (EC:2.7.11.1)
Gene namesi
Name:Bcr
Synonyms:Kiaa3017
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:88141. Bcr.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. plasma membrane Source: MGI
  3. protein complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12701270Breakpoint cluster region protein
PRO_0000273731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei122 – 1221Phosphoserine By similarity
Modified residuei178 – 1781Phosphotyrosine; by HCK By similarity
Modified residuei216 – 2161Phosphoserine By similarity
Modified residuei237 – 2371Phosphoserine1 Publication
Modified residuei247 – 2471Phosphotyrosine; by FES1 Publication
Modified residuei461 – 4611Phosphoserine By similarity
Modified residuei1263 – 12631Phosphoserine By similarity

Post-translational modificationi

Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-178 by HCK is important for interaction with GRB2 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6PAJ1.
PaxDbiQ6PAJ1.
PRIDEiQ6PAJ1.

PTM databases

PhosphoSiteiQ6PAJ1.

Expressioni

Gene expression databases

ArrayExpressiQ6PAJ1.
BgeeiQ6PAJ1.
CleanExiMM_BCR.
GenevestigatoriQ6PAJ1.

Interactioni

Subunit structurei

Homotetramer. Interacts with PDZK1. Interacts with HCK, FES/FPS, ABL1, PIK3R1 and GRB2 By similarity. May interact with CCPG1.1 Publication

Protein-protein interaction databases

BioGridi225455. 10 interactions.
IntActiQ6PAJ1. 1 interaction.
STRINGi10090.ENSMUSP00000039247.

Structurei

3D structure databases

ProteinModelPortaliQ6PAJ1.
SMRiQ6PAJ1. Positions 5-66.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini497 – 690194DH
Add
BLAST
Domaini707 – 865159PH
Add
BLAST
Domaini869 – 1001133C2
Add
BLAST
Domaini1053 – 1247195Rho-GAP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni198 – 387190Binding to ABL SH2-domain By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1406Poly-Ala
Compositional biasi317 – 38468Ser-rich
Add
BLAST

Domaini

The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase By similarity.
The DH domain is involved in interaction with CCPG1.

Sequence similaritiesi

Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Rho-GAP domain.

Phylogenomic databases

eggNOGiNOG267747.
GeneTreeiENSGT00730000110473.
HOGENOMiHOG000006779.
HOVERGENiHBG004165.
InParanoidiQ6PAJ1.
KOiK08878.
OMAiKRANSHS.
OrthoDBiEOG7BP81P.
TreeFamiTF105082.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
4.10.280.30. 1 hit.
InterProiIPR015123. Bcr-Abl_oncoprot_oligo.
IPR000008. C2_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF09036. Bcr-Abl_Oligo. 1 hit.
PF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF69036. SSF69036. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PAJ1-1 [UniParc]FASTAAdd to Basket

« Hide

MVDSVGFAEA WRAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN     50
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQPPDGAAEP RASAPRPPPA 100
PADGADPAPV EESEARPDGE GSPSKGRSAS ARRPAAAASA DRDDRGPPTS 150
VAALRSNFEK IRKGPAQPGS ADAEKPFYVN VEFHHERGLV KVNDKEVSDR 200
ISSLGSQAMQ MERKKSQQSA GQGLGEAPRP HYRGRSSESS CGLDGDYEDA 250
ELNPRFLKDN LINANGGNRP PWPPLEYQPY QSIYVGGMMV EGEGKSPLLR 300
SQSTSEQEKR LTWPRRSYSP RSFEDSGGGY TPDCSSNENL TSSEEDFSSG 350
QSSRVSPSPT TYRMFRDKSR SPSQNSQQSF DSSSPPTPQC QKRHRQCQVV 400
VSEATIVGVR KTGQIWPSDG DSTFQGEADS SFGTPPGYGC AADQAEEQRR 450
HQDGLPYIDD SPSSSPHLSS KGRGSLASGA LDPTKVSELD LEKGLEMRKW 500
VLSGILASEE TYLSHLEALL LPMKPLKAAA TTSQPVLTSQ QIETIFFKVP 550
ELYEIHKEFY DGLFPRVQQW SHQQRVGDLF QKLASQLGVY RAFVDNYGVA 600
METAEKCCQA NAQFAEISEN LRARSNKDVK DSTTKNSLET LLYKPVDRVT 650
RSTLVLHDLL KHTPSSHPDH SLLQDALRIS QNFLSSINEE ITPRRQSMTV 700
KKGEHRQLLK DSFMVELVEG ARKLRHIFLF TDLLLCTKLK KQSGGKTQQY 750
DCKWYIPLTD LSFQMVDELE ALPNIPLVPD EELDALKIKI SQIKSDIQRE 800
KRANKGSKVM ERLRKKLSEQ ESLLLLMSPS MAFRVHSRNG KSYTFLISSD 850
YERAEWRESI REQQKKCFKS FSLTSVELQM LTNSCVKLQT VHHIPLTINK 900
EDDESPGLYG FLHVIVHSAT GFKQSSNLYC TLEVDSFGYF VNKAKTRVYR 950
DTTEPNWNEE FEIELEGSQT LRILCYEKCY NKMKMTKEDG ESADKLMGKG 1000
QVQLDPQTLQ DRDWQRTVID MNGIEVKLSV KFTSREFSLK RMPSRKQTGV 1050
FGVKIAVVTK RERSKVPYIV RQCVEEIERR GMEEVGIYRV SGVATDIQAL 1100
KAAFDVNNKD VSVMMSEMDV NAIAGTLKLY FRELPEPLFT DEFYPNFAEG 1150
IALSDPVAKE SCMLNLLLSL PEANLLTFLF LLDHLKRVAE KETVNKMSLH 1200
NLATVFGPTL LRPSEKESKL PANPSQPITM TDSWSLEVMS QVQVLLYFLQ 1250
LEAIPAPDSK RQSILFSTEV 1270
Length:1,270
Mass (Da):143,072
Last modified:July 27, 2011 - v3
Checksum:i2F3E6D8485DE6717
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti418 – 4181S → H in CAA37013. 1 Publication
Sequence conflicti1213 – 12131P → S in AAH60270. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC160402 Genomic DNA. No translation available.
BC002193 mRNA. Translation: AAH02193.1.
BC060270 mRNA. Translation: AAH60270.1.
X52831 Genomic DNA. Translation: CAA37013.1.
AK129482 mRNA. Translation: BAC98292.1.
CCDSiCCDS35935.1.
PIRiS14194. S14193.
RefSeqiNP_001074881.1. NM_001081412.2.
UniGeneiMm.333722.

Genome annotation databases

EnsembliENSMUST00000164107; ENSMUSP00000126377; ENSMUSG00000009681.
GeneIDi110279.
KEGGimmu:110279.
UCSCiuc007fqb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC160402 Genomic DNA. No translation available.
BC002193 mRNA. Translation: AAH02193.1 .
BC060270 mRNA. Translation: AAH60270.1 .
X52831 Genomic DNA. Translation: CAA37013.1 .
AK129482 mRNA. Translation: BAC98292.1 .
CCDSi CCDS35935.1.
PIRi S14194. S14193.
RefSeqi NP_001074881.1. NM_001081412.2.
UniGenei Mm.333722.

3D structure databases

ProteinModelPortali Q6PAJ1.
SMRi Q6PAJ1. Positions 5-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 225455. 10 interactions.
IntActi Q6PAJ1. 1 interaction.
STRINGi 10090.ENSMUSP00000039247.

PTM databases

PhosphoSitei Q6PAJ1.

Proteomic databases

MaxQBi Q6PAJ1.
PaxDbi Q6PAJ1.
PRIDEi Q6PAJ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000164107 ; ENSMUSP00000126377 ; ENSMUSG00000009681 .
GeneIDi 110279.
KEGGi mmu:110279.
UCSCi uc007fqb.2. mouse.

Organism-specific databases

CTDi 613.
MGIi MGI:88141. Bcr.
Rougei Search...

Phylogenomic databases

eggNOGi NOG267747.
GeneTreei ENSGT00730000110473.
HOGENOMi HOG000006779.
HOVERGENi HBG004165.
InParanoidi Q6PAJ1.
KOi K08878.
OMAi KRANSHS.
OrthoDBi EOG7BP81P.
TreeFami TF105082.

Enzyme and pathway databases

Reactomei REACT_196460. Signaling by FGFR1 fusion mutants.
REACT_210090. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi BCR. mouse.
NextBioi 363683.
PROi Q6PAJ1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PAJ1.
Bgeei Q6PAJ1.
CleanExi MM_BCR.
Genevestigatori Q6PAJ1.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
4.10.280.30. 1 hit.
InterProi IPR015123. Bcr-Abl_oncoprot_oligo.
IPR000008. C2_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view ]
Pfami PF09036. Bcr-Abl_Oligo. 1 hit.
PF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF69036. SSF69036. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-1270.
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary gland.
  3. "Unique organization of the human BCR gene promoter."
    Zhu Q.S., Heisterkamp N., Groffen J.
    Nucleic Acids Res. 18:7119-7125(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 276-428.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 561-1270.
    Tissue: Embryonic tail.
  5. "Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs."
    Kostenko E.V., Olabisi O.O., Sahay S., Rodriguez P.L., Whitehead I.P.
    Mol. Cell. Biol. 26:8964-8975(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INTERACTION WITH CCPG1.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND TYR-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBCR_MOUSE
AccessioniPrimary (citable) accession number: Q6PAJ1
Secondary accession number(s): E9PZL3
, Q61339, Q6ZPE5, Q99LW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi