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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene

anp32a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Gene namesi
Name:anp32a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-982555. anp32a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Acidic leucine-rich nuclear phosphoprotein 32 family member APRO_0000240186Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6PAF6.

Interactioni

Protein-protein interaction databases

IntActiQ6PAF6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6PAF6.
SMRiQ6PAF6. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 4124LRR 1Add
BLAST
Repeati43 – 6422LRR 2Add
BLAST
Repeati65 – 8723LRR 3Add
BLAST
Repeati89 – 11022LRR 4Add
BLAST
Domaini123 – 16139LRRCTAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi146 – 24499Asp-richAdd
BLAST
Compositional biasi161 – 24181Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the ANP32 family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOVERGENiHBG053102.
KOiK18646.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PAF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMKKRIHLE LRNRTPADVK ELVLDNCRSK EGKIEGLTDE FEGLEFLSTI
60 70 80 90 100
NVCLSSIANL PKLNKLKKLE LSDNNISGGL EVLAEKCPNL THLNLSGNRI
110 120 130 140 150
KDLSTIEPLK KLEHLKSLDL FNCEVTNLND YRENLFKLLP QLTYLDGYDR
160 170 180 190 200
DDKEAPDSDA EGYVEGLDDD EDDEDEDDYD EDVPPGEEGE DDDDEEEGEE
210 220 230 240
EEVSGEEEED EDASREGEED EGDEEAEHGE KRKRDQDDEG EDDD
Length:244
Mass (Da):27,772
Last modified:July 5, 2004 - v1
Checksum:i7BFF5E9C2E66AB13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060336 mRNA. Translation: AAH60336.1.
RefSeqiNP_001083156.1. NM_001089687.1.
UniGeneiXl.32951.

Genome annotation databases

GeneIDi398775.
KEGGixla:398775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060336 mRNA. Translation: AAH60336.1.
RefSeqiNP_001083156.1. NM_001089687.1.
UniGeneiXl.32951.

3D structure databases

ProteinModelPortaliQ6PAF6.
SMRiQ6PAF6. Positions 1-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PAF6. 1 interaction.

Proteomic databases

PRIDEiQ6PAF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398775.
KEGGixla:398775.

Organism-specific databases

CTDi8125.
XenbaseiXB-GENE-982555. anp32a.

Phylogenomic databases

HOVERGENiHBG053102.
KOiK18646.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "The Anp32 family of proteins containing leucine-rich repeats."
    Matilla A., Radrizzani M.
    Cerebellum 4:7-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiAN32A_XENLA
AccessioniPrimary (citable) accession number: Q6PAF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.