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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene

anp32a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Gene namesi
Name:anp32a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-982555. anp32a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002401861 – 244Acidic leucine-rich nuclear phosphoprotein 32 family member AAdd BLAST244

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PAF6.

Interactioni

Protein-protein interaction databases

IntActiQ6PAF6. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6PAF6.
SMRiQ6PAF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 41LRR 1Add BLAST24
Repeati43 – 64LRR 2Add BLAST22
Repeati65 – 87LRR 3Add BLAST23
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 244Asp-richAdd BLAST99
Compositional biasi161 – 241Glu-richAdd BLAST81

Sequence similaritiesi

Belongs to the ANP32 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOVERGENiHBG053102.
KOiK18646.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 4 hits.

Sequencei

Sequence statusi: Complete.

Q6PAF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMKKRIHLE LRNRTPADVK ELVLDNCRSK EGKIEGLTDE FEGLEFLSTI
60 70 80 90 100
NVCLSSIANL PKLNKLKKLE LSDNNISGGL EVLAEKCPNL THLNLSGNRI
110 120 130 140 150
KDLSTIEPLK KLEHLKSLDL FNCEVTNLND YRENLFKLLP QLTYLDGYDR
160 170 180 190 200
DDKEAPDSDA EGYVEGLDDD EDDEDEDDYD EDVPPGEEGE DDDDEEEGEE
210 220 230 240
EEVSGEEEED EDASREGEED EGDEEAEHGE KRKRDQDDEG EDDD
Length:244
Mass (Da):27,772
Last modified:July 5, 2004 - v1
Checksum:i7BFF5E9C2E66AB13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060336 mRNA. Translation: AAH60336.1.
RefSeqiNP_001083156.1. NM_001089687.1.
UniGeneiXl.32951.

Genome annotation databases

GeneIDi398775.
KEGGixla:398775.

Similar proteinsi

Entry informationi

Entry nameiAN32A_XENLA
AccessioniPrimary (citable) accession number: Q6PAF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families