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Protein
Submitted name:

MGC68756 protein

Gene

MGC68756

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108PROSITE-ProRule annotation1
Active sitei265PROSITE-ProRule annotation1
Active sitei289PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi589 – 600PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi619 – 630PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Protein family/group databases

MEROPSiC02.003.

Names & Taxonomyi

Protein namesi
Submitted name:
MGC68756 proteinImported
Gene namesi
Name:MGC68756Imported
ORF Names:XELAEV_18026416mgImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
Proteomesi
  • UP000186698 Componenti: Chromosome 5l

Organism-specific databases

XenbaseiXB-GENE-940597.

Subcellular locationi

GO - Cellular componenti

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 347Calpain catalyticInterPro annotationAdd BLAST300
Domaini576 – 602EF-handInterPro annotationAdd BLAST27
Domaini606 – 641EF-handInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

HOVERGENiHBG012645.
KOiK01367.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029643. CAPN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF343. PTHR10183:SF343. 1 hit.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PAF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPFGGIASK LKIDRLKASG VGSHDCAIKY QNQDYESLKQ QCLESGILFE
60 70 80 90 100
DPHFPATPSS LGFKELGPGS SKTRGVQWKR PSEIVDDPQF IVGGATRTDI
110 120 130 140 150
CQGALGDCWL LAAIGSLTLN EDLLHRVVPH GQSFQEEYAG IFHFQIWQFG
160 170 180 190 200
EWVDVVIDDR LPVKDGELVF VHSAECTEFW SGLLEKAYAK LNSSYESLSG
210 220 230 240 250
GSTTEGFEDF TGGVAEMYEL RKAPRDLDKI IKRALERGSL LGCSIDITSA
260 270 280 290 300
FDMEAVTFKK LVKGHAYSVT ALKEVDYRGG MEKLIRIRNP WGQVEWTGAW
310 320 330 340 350
SDNSSEWNEV DPSEQEDLQL KMEDGEFWMS FQEFLRQFSR LEICNLTPDA
360 370 380 390 400
LNKDGLGKWH TTLYDGTWRR GSTAGGCRNN PATFWINPQF KITLMEEDDD
410 420 430 440 450
PDDNELACSF LVALMQKNRR KEMKAGQDTH TIGFAVYEVP DEFKGCQNVH
460 470 480 490 500
LKKDFFLRHQ SCARSETFIN LREVSTQIRL PPGEYIIVPS TFEPHKEADF
510 520 530 540 550
IIRIFTEKHS DTQELDEEVS ADLPDEEELT EDDVDDSFKA MFQHLAGDDM
560 570 580 590 600
EISVFELKTI LNRVVAKHKD LKTDGFGMEA CRQMVNLMDK DGSGKLGVLE
610 620 630 640 650
FQILWNKIRN WLTVFRQHDL DKSGTISAYE LRIALESTGY KLNNKLIQVL
660 670 680 690 700
VARYADSDMG IDFDNFVCCL VKLEAMFRFF KALDQGDGTA EMNLGEWLTM

TMCG
Length:704
Mass (Da):79,820
Last modified:July 5, 2004 - v1
Checksum:iCC2004073D46C1E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060341 mRNA. Translation: AAH60341.1.
CM004474 Genomic DNA. Translation: OCT79608.1.
RefSeqiNP_001083150.1. NM_001089681.1.
XP_018117241.1. XM_018261752.1.
UniGeneiXl.34461.

Genome annotation databases

GeneIDi398772.
KEGGixla:398772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060341 mRNA. Translation: AAH60341.1.
CM004474 Genomic DNA. Translation: OCT79608.1.
RefSeqiNP_001083150.1. NM_001089681.1.
XP_018117241.1. XM_018261752.1.
UniGeneiXl.34461.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC02.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398772.
KEGGixla:398772.

Organism-specific databases

XenbaseiXB-GENE-940597.

Phylogenomic databases

HOVERGENiHBG012645.
KOiK01367.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029643. CAPN1.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF343. PTHR10183:SF343. 1 hit.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PAF2_XENLA
AccessioniPrimary (citable) accession number: Q6PAF2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.