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Protein

DDB1- and CUL4-associated factor 13

Gene

Dcaf13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-8951664 Neddylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 13
Alternative name(s):
WD repeat and SOF domain-containing protein 1
Gene namesi
Name:Dcaf13
Synonyms:Gm83, Wdsof1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:2684929 Dcaf13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104291 – 445DDB1- and CUL4-associated factor 13Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6PAC3
MaxQBiQ6PAC3
PaxDbiQ6PAC3
PeptideAtlasiQ6PAC3
PRIDEiQ6PAC3

PTM databases

iPTMnetiQ6PAC3
PhosphoSitePlusiQ6PAC3

Expressioni

Gene expression databases

BgeeiENSMUSG00000022300
CleanExiMM_WDSOF1
GenevisibleiQ6PAC3 MM

Interactioni

Subunit structurei

Interacts with DDB1. Interacts with ESR1 and LATS1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230153, 1 interactor
IntActiQ6PAC3, 1 interactor
STRINGi10090.ENSMUSP00000022909

Structurei

3D structure databases

ProteinModelPortaliQ6PAC3
SMRiQ6PAC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 104WD 1Add BLAST41
Repeati107 – 146WD 2Add BLAST40
Repeati149 – 191WD 3Add BLAST43
Repeati194 – 234WD 4Add BLAST41
Repeati236 – 276WD 5Add BLAST41
Repeati280 – 319WD 6Add BLAST40
Repeati323 – 362WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat DCAF13/WDSOF1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0268 Eukaryota
ENOG410XNX6 LUCA
GeneTreeiENSGT00390000005711
HOGENOMiHOG000210082
HOVERGENiHBG056998
InParanoidiQ6PAC3
KOiK11806
OMAiVMDVEFS
OrthoDBiEOG091G07IG
TreeFamiTF300844

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR007287 Sof1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF04158 Sof1, 1 hit
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PAC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKMLSRNP DNYVRETKLD IQRVPRNYDP TLHPFEVPRE YVRALNATKL
60 70 80 90 100
ERVFAKPFLA SLDGHRDGVN CLAKHPKSLA SVLSGACDGE VKIWNLTKRK
110 120 130 140 150
CIRTIQAHEG FVRGMCTRFC GTSFFTVGDD KTVKQWKMDG PGYGEEEEPL
160 170 180 190 200
YTVLGKTVYT GIDHHWKDPV FATCGQQVDI WDEQRTSPVC SMNWGFDSIS
210 220 230 240 250
SVKFNPVETF LLGSCASDRN IVLYDMRQAT PLKKVILEMR TNTICWNPME
260 270 280 290 300
AFNFTAANED YNLYTFDMRA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
310 320 330 340 350
SFDKSIRIFP VDKSRSREVY HTKRMQHVMC VKWTSDSKYI MCGSDEMNIR
360 370 380 390 400
LWKANASEKL GVLTSREKAA NDYNQKLKEK FQYHPHVKRI ARHRHLPKSI
410 420 430 440
YSQIQEQRVM KEARRRKEMN RRKHSKPGSV PIVSERKKHV VAVVK
Length:445
Mass (Da):51,456
Last modified:July 27, 2011 - v2
Checksum:i30D2210E047B93FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81S → T in AAH60375 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164883 Genomic DNA No translation available.
AC165352 Genomic DNA No translation available.
BC060375 mRNA Translation: AAH60375.1
CCDSiCCDS37066.1
RefSeqiNP_941008.2, NM_198606.2
UniGeneiMm.321937

Genome annotation databases

EnsembliENSMUST00000022909; ENSMUSP00000022909; ENSMUSG00000022300
ENSMUST00000201446; ENSMUSP00000144194; ENSMUSG00000106903
GeneIDi223499
KEGGimmu:223499
UCSCiuc007voc.2 mouse

Entry informationi

Entry nameiDCA13_MOUSE
AccessioniPrimary (citable) accession number: Q6PAC3
Secondary accession number(s): E9QPL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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