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Protein

DDB1- and CUL4-associated factor 13

Gene

Dcaf13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 13
Alternative name(s):
WD repeat and SOF domain-containing protein 1
Gene namesi
Name:Dcaf13
Synonyms:Gm83, Wdsof1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2684929. Dcaf13.

Subcellular locationi

  • Nucleusnucleolus By similarity

  • Note: In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445DDB1- and CUL4-associated factor 13PRO_0000310429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6PAC3.
MaxQBiQ6PAC3.
PaxDbiQ6PAC3.
PRIDEiQ6PAC3.

PTM databases

iPTMnetiQ6PAC3.
PhosphoSiteiQ6PAC3.

Expressioni

Gene expression databases

BgeeiQ6PAC3.
CleanExiMM_WDSOF1.
GenevisibleiQ6PAC3. MM.

Interactioni

Subunit structurei

Interacts with DDB1.By similarity

Protein-protein interaction databases

BioGridi230153. 1 interaction.
IntActiQ6PAC3. 1 interaction.
STRINGi10090.ENSMUSP00000022909.

Structurei

3D structure databases

ProteinModelPortaliQ6PAC3.
SMRiQ6PAC3. Positions 40-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 10441WD 1Add
BLAST
Repeati107 – 14640WD 2Add
BLAST
Repeati149 – 19143WD 3Add
BLAST
Repeati194 – 23441WD 4Add
BLAST
Repeati236 – 27641WD 5Add
BLAST
Repeati280 – 31940WD 6Add
BLAST
Repeati323 – 36240WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat DCAF13/WDSOF1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0268. Eukaryota.
ENOG410XNX6. LUCA.
GeneTreeiENSGT00390000005711.
HOGENOMiHOG000210082.
HOVERGENiHBG056998.
InParanoidiQ6PAC3.
KOiK11806.
OMAiIQRVPRN.
OrthoDBiEOG7JQBN7.
TreeFamiTF300844.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007287. Sof1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04158. Sof1. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PAC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKMLSRNP DNYVRETKLD IQRVPRNYDP TLHPFEVPRE YVRALNATKL
60 70 80 90 100
ERVFAKPFLA SLDGHRDGVN CLAKHPKSLA SVLSGACDGE VKIWNLTKRK
110 120 130 140 150
CIRTIQAHEG FVRGMCTRFC GTSFFTVGDD KTVKQWKMDG PGYGEEEEPL
160 170 180 190 200
YTVLGKTVYT GIDHHWKDPV FATCGQQVDI WDEQRTSPVC SMNWGFDSIS
210 220 230 240 250
SVKFNPVETF LLGSCASDRN IVLYDMRQAT PLKKVILEMR TNTICWNPME
260 270 280 290 300
AFNFTAANED YNLYTFDMRA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
310 320 330 340 350
SFDKSIRIFP VDKSRSREVY HTKRMQHVMC VKWTSDSKYI MCGSDEMNIR
360 370 380 390 400
LWKANASEKL GVLTSREKAA NDYNQKLKEK FQYHPHVKRI ARHRHLPKSI
410 420 430 440
YSQIQEQRVM KEARRRKEMN RRKHSKPGSV PIVSERKKHV VAVVK
Length:445
Mass (Da):51,456
Last modified:July 27, 2011 - v2
Checksum:i30D2210E047B93FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811S → T in AAH60375 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164883 Genomic DNA. No translation available.
AC165352 Genomic DNA. No translation available.
BC060375 mRNA. Translation: AAH60375.1.
CCDSiCCDS37066.1.
RefSeqiNP_941008.2. NM_198606.2.
UniGeneiMm.321937.

Genome annotation databases

EnsembliENSMUST00000022909; ENSMUSP00000022909; ENSMUSG00000022300.
ENSMUST00000201446; ENSMUSP00000144194; ENSMUSG00000106903.
GeneIDi223499.
KEGGimmu:223499.
UCSCiuc007voc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164883 Genomic DNA. No translation available.
AC165352 Genomic DNA. No translation available.
BC060375 mRNA. Translation: AAH60375.1.
CCDSiCCDS37066.1.
RefSeqiNP_941008.2. NM_198606.2.
UniGeneiMm.321937.

3D structure databases

ProteinModelPortaliQ6PAC3.
SMRiQ6PAC3. Positions 40-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230153. 1 interaction.
IntActiQ6PAC3. 1 interaction.
STRINGi10090.ENSMUSP00000022909.

PTM databases

iPTMnetiQ6PAC3.
PhosphoSiteiQ6PAC3.

Proteomic databases

EPDiQ6PAC3.
MaxQBiQ6PAC3.
PaxDbiQ6PAC3.
PRIDEiQ6PAC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022909; ENSMUSP00000022909; ENSMUSG00000022300.
ENSMUST00000201446; ENSMUSP00000144194; ENSMUSG00000106903.
GeneIDi223499.
KEGGimmu:223499.
UCSCiuc007voc.2. mouse.

Organism-specific databases

CTDi25879.
MGIiMGI:2684929. Dcaf13.

Phylogenomic databases

eggNOGiKOG0268. Eukaryota.
ENOG410XNX6. LUCA.
GeneTreeiENSGT00390000005711.
HOGENOMiHOG000210082.
HOVERGENiHBG056998.
InParanoidiQ6PAC3.
KOiK11806.
OMAiIQRVPRN.
OrthoDBiEOG7JQBN7.
TreeFamiTF300844.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi376735.
PROiQ6PAC3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PAC3.
CleanExiMM_WDSOF1.
GenevisibleiQ6PAC3. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007287. Sof1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04158. Sof1. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiDCA13_MOUSE
AccessioniPrimary (citable) accession number: Q6PAC3
Secondary accession number(s): E9QPL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.