Q6PA90 (LRG2A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycosyltransferase-like protein LARGE2-A
EC=2.4.-.-

Alternative name(s):
Glycosyltransferase-like 1B-A

Gene names

Name:

gyltl1b-a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Glycosyltransferase which participates in glycosylation of alpha-dystroglycan. May carry out the synthesis of glycoprotein and glycosphingolipid sugar chains By similarity.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 8 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 723	723	Glycosyltransferase-like protein LARGE2-A		PRO_0000226816
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	32 – 723	692	Lumenal Potential
Amino acid modifications
	Glycosylation	91	1	N-linked (GlcNAc...) Potential
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
	Glycosylation	241	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6PA90 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7AC84BE1AB5C91BA	FASTA	723	83,148
	10 20 30 40 50 60 MLFSCRSKAK LLALTLLLLS AATWLYLSVG ETEYGQSLGP VAPRFSATPS FQMELEIRLR 70 80 90 100 110 120 EAKEENRRLR QQLGEVRNEE QSTGGGTEGD NSSHCEHRSL TEKCELIHVA IVCAGHNSSR 130 140 150 160 170 180 DVVTLVKSIL FHRRNPLHLH LITDDVALRV LGNLFNTWMV PSLQISFYNA SELKPDVAWI 190 200 210 220 230 240 PNKHYSGIYG LLKLTLTKAL PSDLSKVIVL DTDITFATDI AELWAIFKKF TGEQVLGLVE 250 260 270 280 290 300 NQSDWYLGNL WKNHKPWPAL GRGFNTGVIL LLLDKLRLIG WEEMWRLTAE RELMNMLSTS 310 320 330 340 350 360 LADQDIFNAV IKSSPTLVYQ LPCYWNVQLS DHTRSEQCYS ELADLKVIHW NSPHKLRVKN 370 380 390 400 410 420 KHVELFRTLY LTFLEYDGSL LRRELIGCPS EGEQQGGSQA TLSQLDEEDP CYDFRRESVA 430 440 450 460 470 480 SHRVHLSFLP HLTPPPDPYD VTLVAQLSMD RLQMLELICR HWEGPMSLAL YLSDAEAQQF 490 500 510 520 530 540 LRYAQASEVL QSRTNIGYHV VYKEGQLYPV NLLRNVALKN SHTPYVFLSD IDFLPMYGLY 550 560 570 580 590 600 EYLRKSIAQQ DPAGSPRALI VPAFETLRYR LSFPKSKADL LSMLDTGALY TFRYHVWEKG 610 620 630 640 650 660 HAPTDYAKWR TATTPYRVEW APDFEPYVVV RRDCPEYDQR FLGFGWNKVS HIMELDAQEY 670 680 690 700 710 720 ELVVLPNAFI VHMPHAPSFD ISKFRSSENY RLCVQALKEE FHQDLSRRYG SAALKYLTAE RNR

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC060410 mRNA. Translation: AAH60410.1.
RefSeq	NP_001083457.1. NM_001089988.1.
UniGene	Xl.11508.
3D structure databases
ProteinModelPortal	Q6PA90.
ModBase	Search...
Protein family/group databases
CAZy	GT49. Glycosyltransferase Family 49. GT8. Glycosyltransferase Family 8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	398936.
KEGG	xla:398936.
Organism-specific databases
CTD	120071.
Xenbase	XB-GENE-5872007. gyltl1b.
Phylogenomic databases
HOVERGEN	HBG052308.
Family and domain databases
InterPro	IPR002495. Glyco_trans_8. [Graphical view]
KO	K09668.
Pfam	PF01501. Glyco_transf_8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LRG2A_XENLA

Accession

Primary (citable) accession number: Q6PA90

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program